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Cancer: Oral Cavity Cancer
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Total 11 results found since Jan 2013.
Cancers, Vol. 15, Pages 2005: CDK4/6 Inhibition Induces Senescence and Enhances Radiation Response by Disabling DNA Damage Repair in Oral Cavity Squamous Cell Carcinoma
Conclusion: Targeting CDK4/6 can lead to improved efficacy when combined with radiation in OCSCC by inducing senescence and inhibiting DNA damage repair.
Source: Cancers - March 28, 2023 Category: Cancer & Oncology Authors: Nitisha Shrivastava Claudia Gutierrez Chavez Daniel Li Vikas Mehta Carlos Thomas Cory D. Fulcher Nicole Kawachi Danielle M. Bottalico Michael B. Prystowsky Indranil Basu Chandan Guha Thomas J. Ow Tags: Article Source Type: research
Expression of Ubiquitin-specific protease 7 in oral squamous cell carcinoma promotes tumor cell proliferation and invasion
In conclusion, data presented here suggests that USP7 promotes the progression of OSCC. USP7 may be used as a new therapeutic target for OSCC diagnosis and treatment.PMID:34812471 | DOI:10.1590/1678-4685-GMB-2021-0058
Source: Mol Biol Cell - November 23, 2021 Category: Molecular Biology Authors: Xiaojie Yang Jiamin Jin Jinfeng Yang Lihua Zhou Sisi Mi Guangying Qi Source Type: research
High expression of Notch2 drives tongue squamous cell carcinoma carcinogenesis.
Abstract
Tongue squamous cell carcinoma (TSCC) is one of the most common cancers in the oral cavity. Notch signaling is frequently dysregulated in cancer. However, the role of Notch2 in TSCC is not well understood. The aim of this study was to investigate the effect of abnormal expression of Notch2 in TSCC. The expression of Notch2 was tested in 47 pairs of tissues from tongue cancer and normal samples by using immunohistochemical staining. Tongue cancer cells were transfected with siRNA or plasmid. The proliferation of the cells was tested by the CCK8 assay and colony formation assay. Subcutaneous tumor model was...
Source: Experimental Cell Research - December 28, 2020 Category: Cytology Authors: Gan RH, Lin LS, Zheng DP, Zhao Y, Ding LC, Zheng DL, Lu YG Tags: Exp Cell Res Source Type: research
Systems Biology Approaches and Precision Oral Health: A Circadian Clock Perspective
Conclusion
Most head and neck pathologies show a broad cellular heterogeneity making it difficult to achieve an accurate diagnosis and efficient treatment (Graf and Zavodszky, 2017; Lo Nigro et al., 2017). Single cell analysis of circadian omics (Lande-Diner et al., 2015; Abraham et al., 2018), may be a crucial tool needed in the future to fully understand the circadian control of head and neck diseases. It becomes more obvious that there is only a small genetic component but a largely unknown epigenetics and/or environmental component for most of the head and neck pathologies (Moosavi and Motevalizadeh Ardekani, 2016; He...
Source: Frontiers in Physiology - April 15, 2019 Category: Physiology Source Type: research
Lymphotoxin ‐β receptor‐NIK signaling induces alternative RELB/NF‐κB2 activation to promote metastatic gene expression and cell migration in head and neck cancer
This article is protected by copyright. All rights reserved
Source: Molecular Carcinogenesis - November 22, 2018 Category: Molecular Biology Authors: Rita Das,
Jamie Coupar,
Paul E. Clavijo,
Anthony Saleh,
Tsu ‐Fan Cheng,
Xinping Yang,
Jianhong Chen,
Carter VanWaes,
Zhong Chen Tags: RESEARCH ARTICLE Source Type: research
Delivery of MTH1 inhibitor (TH287) and MDR1 siRNA via hyaluronic acid-based mesoporous silica nanoparticles for oral cancers treatment
Publication date: 1 January 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 173Author(s): Xiao-Lei Shi, Yuan Li, Lu-Ming Zhao, Lin-Wang Su, Gang DingAbstractOral cancer accounts for 95% of all maxillofacial malignant neoplasm. Presently, surgery and radiation (with and without chemotherapy) are the major treatments for oral cancer; however it met with limited therapeutic outcome. Overcoming the multidrug resistance and finding new therapeutic agents for oral cancer treatment are some of the serious challenges. Small molecule, TH287 potently and selectively inhibits the MTH1 protein in cells and could act as a ne...
Source: Colloids and Surfaces B: Biointerfaces - October 23, 2018 Category: Biochemistry Source Type: research
Decreased cytoplasmic X-box binding protein-1 expression is associated with poor prognosis and overall survival in patients with oral squamous cell carcinoma
Conclusion Our results suggest that XBP-1 expression may play an essential role in the pathogenesis of OSCC and that targeting XBP-1 may be a sound therapeutic strategy.
Source: Clinica Chimica Acta - January 3, 2018 Category: Laboratory Medicine Source Type: research
Decreased cytoplasmic X-box binding protein-1 expression is associated with poor prognosis and overall survival in patients with oral squamous cell carcinoma.
CONCLUSION: Our results suggest that XBP-1 expression may play an essential role in the pathogenesis of OSCC and that targeting XBP-1 may be a sound therapeutic strategy.
PMID: 29305191 [PubMed - as supplied by publisher]
Source: International Journal of Clinical Chemistry - January 2, 2018 Category: Chemistry Authors: Hsu HT, Hsing MT, Yeh CM, Chen CJ, Yang JS, Yeh KT Tags: Clin Chim Acta Source Type: research
Skp2 Regulates the Expression of MMP-2 and MMP-9, and Enhances the Invasion Potential of Oral Squamous Cell Carcinoma.
Abstract
Oral squamous cell carcinoma (OSCC) is the most common malignant tumor of the head and neck regions and accounts for more than 90 % of cancers in the oral cavity. S-phase kinase-associated protein-2 (Skp2) is a member of the F-box protein family and the substrate recognition subunit of the Skp1-Cullin-F box protein E3 ubiquitin ligase complex. Skp2 is oncogenic and overexpressed in human cancers. The aims of the present study were to determine the clinicopathological significance of Skp2 in OSCC and clarify its function in OSCC cell lines in vitro. Multiple methods including immunohistochemical staining,...
Source: Pathology Oncology Research - February 13, 2016 Category: Pathology Authors: Yamada SI, Yanamoto S, Naruse T, Matsushita Y, Takahashi H, Umeda M, Nemoto TK, Kurita H Tags: Pathol Oncol Res Source Type: research
Telomerase activity in the occurrence and progression of oral squamous cell carcinoma.
In this study, we used an immunohistochemical method to examine the expression of human telomerase reverse transcriptase (hTERT) in the dysplasia-carcinoma sequence in the oral cavity. Furthermore, the effects of inflammatory cytokines on the telomerase activity and migration of oral cancer cell lines (Ca9-22, HSC-3, and HSC-4) were examined. Immunoreactivity for hTERT was observed in squamous intraepithelial neoplasia 3 and squamous cell carcinoma. Telomerase activity in Ca9-22 cells was increased by treatment with TNF-α and INF-γ, while its activity in HSC-4 cells was decreased by IL-1β. Although inflammatory cytokine...
Source: Journal of oral science - December 18, 2015 Category: Dentistry Tags: J Oral Sci Source Type: research
Non-thermal atmospheric pressure plasma induces apoptosis in oral cavity squamous cell carcinoma: Involvement of DNA-damage-triggering sub-G1 arrest via the ATM/p53 pathway.
In this study, we report for the first time that NTP led to apoptotic cell death in oral cavity squamous cell carcinoma (OSCC). Interestingly, NTP induced a sub-G1 arrest in p53 wild-type OSCCs, but not in p53-mutated OSCCs. In addition, NTP increased the expression levels of ATM, p53 (Ser 15, 20 and 46), p21, and cyclin D1. A comet assay, Western blotting and immunocytochemistry of γH2AX suggested that NTP-induced apoptosis and sub-G1 arrest were associated with DNA damage and the ATM/p53 signaling pathway in SCC25 cells. Moreover, ATM knockdown using siRNA attenuated the effect of NTP on cell death, sub-G1 arrest and re...
Source: Archives of Biochemistry and Biophysics - January 29, 2014 Category: Biochemistry Authors: Chang JW, Kang SU, Shin YS, Kim KI, Seo SJ, Yang SS, Lee JS, Moon E, Baek SJ, Lee K, Kim CH Tags: Arch Biochem Biophys Source Type: research
