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Cancer: Nasopharyngeal Cancer
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Total 152 results found since Jan 2013.
Serum Starvation Induces Matrix Metalloproteinase 9 Expression in Nasopharyngeal Carcinoma Cells Through the ERK-AP1 Pathway < em > In Vitro < /em >
CONCLUSION: Serum starvation could up-regulate MMP9 expression in NPC cells, contributing to NPC invasion. Therefore, serum starvation may promote malignancy of NPC cells but also support MMP9 as a potential therapeutic target to prevent NPC cell invasion and metastasis.PMID:37247927 | DOI:10.21873/anticanres.16425
Source: Cell Research - May 29, 2023 Category: Cytology Authors: Yen-Ting Wu Chung-Chi Hsu Bu-Miin Huang Yun-Ching Chang Cheng-Han Lin Yu-Yan Lan Source Type: research
Inhibition Mechanism of PinX1 Gene on Cancer Stem Cells of Nasopharyngeal Carcinoma
In this study, we found that the telomerase activity of the CD133 - + NC group was 1.001 ± 0.086, the CD133 - + pinx1sirna group was 0.974 ± 0.046, CD133+ + vector group was 0.928 ± 0.102, CD133+ + over PinX1 group was 0.703 ± 0.086. Therefore, the PinX1 gene can inhibit NPC stem cells by inhibiting telomerase activity.PMID:37114251 | DOI:10.14715/cmb/2022.68.10.28
Source: Cellular and Molecular Biology - April 28, 2023 Category: Molecular Biology Authors: Hua Xiang Linghui Liu Yuzhu Yuan Longqing Liu Zhiwei Chen Source Type: research
Cancers, Vol. 15, Pages 2189: THY1 (CD90) Maintains the Adherens Junctions in Nasopharyngeal Carcinoma via Inhibition of SRC Activation
In this study we show that tumor invasion could be suppressed by THY1 via adherens junction formation in a few NPC cell lines, and knockdown of THY1 would disrupt this cell-cell adhesion phenotype. Mechanistically, the activity of the SRC family kinase (SFK) member, SRC, and canonical Wnt signaling were dramatically reduced when THY1 was constitutively expressed. Previous studies by others have found that high levels of SRC activity in NPCs are associated with EMT and a poor prognosis. We hypothesized that THY1 can suppress tumor invasion in NPC via inhibition of SRC. By gene silencing of SRC, we found that the in vitro NP...
Source: Cancers - April 6, 2023 Category: Cancer & Oncology Authors: Luo Chen Wai Yin Chau Hei Tung Yuen Xiao Han Liu Robert Zhong Qi Maria Li Lung Hong Lok Lung Tags: Article Source Type: research
PRMT1 inhibits apoptosis of nasopharyngeal carcinoma cells by promoting RRM2 expression
CONCLUSION: The high expression of PRMT1 in NPC inhibits apoptosis of NPC cells by promoting the expression of RRM2.PMID:36651245 | DOI:10.12122/j.issn.1673-4254.2022.12.05
Source: Journal of Southern Medical University - January 18, 2023 Category: Universities & Medical Training Authors: L Zhou J Wu M Zhang B Zhao S Ma Source Type: research
