Demographics and clinical characteristics of patients of prescribing psychologists, psychiatrists, and primary care physicians
Am Psychol. 2024 Apr 18. doi: 10.1037/amp0001352. Online ahead of print.ABSTRACTTo describe the characteristics of patients receiving psychotropic medication from prescribing psychologists, psychiatrists, and primary care physicians. This descriptive study was conducted using private insurance claims of patients from New Mexico and Louisiana receiving psychotropic medications (anticonvulsants, antidepressants, antipsychotics, hypotensive agents, anxiolytics/sedatives/hypnotics, and stimulants) from 2004 to 2021 (N = 307,478). Patient characteristics were captured during the 6 months prior to their first psychotropic medica...
Source: The American Psychologist - April 18, 2024 Category: Psychiatry & Psychology Authors: Phillip M Hughes Joshua D Niznik Robert E McGrath Casey R Tak Robert B Christian Betsy L Sleath Kathleen C Thomas Source Type: research
Rapid Metabolism Underlying Subtherapeutic Serum Levels of Atypical Antipsychotics Preceding Clozapine Treatment: A Retrospective Analysis of Real-World Data
ConclusionLCD and associated rapid metabolism of non-clozapine antipsychotics is frequent before starting clozapine treatment. For olanzapine and quetiapine, this is associated with significantly increased risk of having subtherapeutic concentrations. (Source: CNS Drugs)
Source: CNS Drugs - April 18, 2024 Category: Neurology Source Type: research
Morphological heterogeneity of neurons in the human central amygdaloid nucleus
J Neurosci Res. 2024 Apr;102(4):e25319. doi: 10.1002/jnr.25319.ABSTRACTThe central amygdaloid nucleus (CeA) has an ancient phylogenetic development and functions relevant for animal survival. Local cells receive intrinsic amygdaloidal information that codes emotional stimuli of fear, integrate them, and send cortical and subcortical output projections that prompt rapid visceral and social behavior responses. We aimed to describe the morphology of the neurons that compose the human CeA (N = 8 adult men). Cells within CeA coronal borders were identified using the thionine staining and were further analyzed using the "single-...
Source: Cell Research - April 17, 2024 Category: Cytology Authors: Carlos E V ásquez K étlyn T Knak Guerra Josu é Renner Alberto A Rasia-Filho Source Type: research
Simultaneous EEG-fMRI Investigation of Rhythm-Dependent Thalamo-Cortical Circuits Alteration in Schizophrenia
This study aims to provide new insight into network communication in schizophrenia by integrating FC and EEG rhythm information. After collecting simultaneous resting-state EEG-functional magnetic resonance imaging data, the effect of rhythm modulations on FC was explored using what we term "dynamic rhythm information." We also investigated the synergistic relationships among three networks under rhythm modulation conditions, where this relationship presents the coupling between two brain networks with other networks as the center by the rhythm modulation. This study found FC between the thalamus and cortical network regio...
Source: International Journal of Neural Systems - April 16, 2024 Category: Neurology Authors: Haonan Pei Sisi Jiang Mei Liu Guofeng Ye Yun Qin Yayun Liu Mingjun Duan Dezhong Yao Cheng Luo Source Type: research
Multimorbidity and the Etiology of Schizophrenia
Curr Psychiatry Rep. 2024 Apr 16. doi: 10.1007/s11920-024-01500-9. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: A global study of multimorbidity in schizophrenia, especially of the association with physical conditions, might offer much needed etiological insights.RECENT FINDINGS: Our review suggests that life-style factors and medication related to schizophrenia are only part of the explanation of the increase in risk for cardiovascular, metabolic, pulmonary disorders, and some cancers. Positive associations with autoimmune disorders (with the exception of rheumatoid arthritis) and epilepsy are promising avenues of res...
Source: Epilepsy Curr - April 16, 2024 Category: Neurology Authors: A Szoke B Pignon O Godin A Ferchiou R Tamouza M Leboyer F Sch ürhoff Source Type: research
Simultaneous EEG-fMRI Investigation of Rhythm-Dependent Thalamo-Cortical Circuits Alteration in Schizophrenia
This study aims to provide new insight into network communication in schizophrenia by integrating FC and EEG rhythm information. After collecting simultaneous resting-state EEG-functional magnetic resonance imaging data, the effect of rhythm modulations on FC was explored using what we term "dynamic rhythm information." We also investigated the synergistic relationships among three networks under rhythm modulation conditions, where this relationship presents the coupling between two brain networks with other networks as the center by the rhythm modulation. This study found FC between the thalamus and cortical network regio...
Source: International Journal of Neural Systems - April 16, 2024 Category: Neurology Authors: Haonan Pei Sisi Jiang Mei Liu Guofeng Ye Yun Qin Yayun Liu Mingjun Duan Dezhong Yao Cheng Luo Source Type: research
Multimorbidity and the Etiology of Schizophrenia
Curr Psychiatry Rep. 2024 Apr 16. doi: 10.1007/s11920-024-01500-9. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: A global study of multimorbidity in schizophrenia, especially of the association with physical conditions, might offer much needed etiological insights.RECENT FINDINGS: Our review suggests that life-style factors and medication related to schizophrenia are only part of the explanation of the increase in risk for cardiovascular, metabolic, pulmonary disorders, and some cancers. Positive associations with autoimmune disorders (with the exception of rheumatoid arthritis) and epilepsy are promising avenues of res...
Source: Epilepsy Curr - April 16, 2024 Category: Neurology Authors: A Szoke B Pignon O Godin A Ferchiou R Tamouza M Leboyer F Sch ürhoff Source Type: research
Multimorbidity and the Etiology of Schizophrenia
AbstractPurpose of ReviewA global study of multimorbidity in schizophrenia, especially of the association with physical conditions, might offer much needed etiological insights.Recent FindingsOur review suggests that life-style factors and medication related to schizophrenia are only part of the explanation of the increase in risk for cardiovascular, metabolic, pulmonary disorders, and some cancers. Positive associations with autoimmune disorders (with the exception of rheumatoid arthritis) and epilepsy are promising avenues of research but to date have not been fully exploited. The same holds for the negative comorbidit...
Source: Current Psychiatry Reports - April 16, 2024 Category: Psychiatry Source Type: research
The impact of familial involvement on dropout in a culturally informed group therapy for people diagnosed with 'schizophrenia'
We examined whether familial involvement and other demographic variables predicted dropout among 101 patients enrolled in culturally informed group therapy for schizophrenia (CIGT-S), which incorporates collectivistic principles and spiritual coping into treatment. We reviewed records and conducted follow-up calls to identify reasons for dropout, and performed survival analyses to identify when dropout was likely.RESULTS: Familial involvement was linked to greater engagement with treatment and lower dropout, signifying a mechanism for improving treatment attendance in this group. Ethnic minorities and patients with higher ...
Source: Psychosis - April 15, 2024 Category: Psychiatry Authors: Jessica Maura Salman Shaheen Ahmad Amy Weisman de Mamani Source Type: research
Robert Rosenthal (1933-2024)
Am Psychol. 2024 Apr 15. doi: 10.1037/amp0001356. Online ahead of print.ABSTRACTRobert Rosenthal died on January 5, 2024, in Riverside, California, at the age of 90. Born March 2, 1933, in Giessen, Germany, just as the Nazis came to power, the young Bob-he always insisted that everyone call him "Bob"-and his family fled in 1939 to Rhodesia (a British African protectorate) before making it to New York and then Los Angeles. Bob's dissertation derived from the Thematic Apperception Test (TAT). It compared projection in paranoid schizophrenic patients versus a normal control group after an experimental manipulation. Bob analyz...
Source: The American Psychologist - April 15, 2024 Category: Psychiatry & Psychology Authors: Howard S Friedman Source Type: research
Discovery and in vitro Evaluation of Novel Serotonin 5-HT2A Receptor Ligands Identified Through Virtual Screening
ChemMedChem. 2024 Apr 15:e202400080. doi: 10.1002/cmdc.202400080. Online ahead of print.ABSTRACTThe 5-HT2A receptor is a molecular target of high pharmacological importance. Ligands of this protein, particularly atypical antipsychotics, are useful in the treatment of numerous mental disorders, including schizophrenia and major depressive disorder. Structure-based virtual screening using a 5-HT2A receptor complex was performed to identify novel ligands for the 5-HT2A receptor, serving as potential antidepressants. From the Enamine screening library, containing over 4 million compounds, 48 molecules were selected for subsequ...
Source: ChemMedChem - April 15, 2024 Category: Chemistry Authors: Agata Zi ęba Damian Bartuzi Piotr St ępnicki Dariusz Matosiuk Tomasz M Wr óbel Tuomo Laitinen Mari án Castro Agnieszka Anna Kaczor Source Type: research
A longitudinal study on the effects of social support on self-stigma, psychiatric symptoms, and personal and social functioning in community patients with severe mental illnesses in China
CONCLUSION: It is necessary to provide comprehensive social support services and stigma reduction interventions at the community level to improve the prognosis of SMI.PMID:38616508 | DOI:10.1177/00207640241245932 (Source: The International Journal of Social Psychiatry)
Source: The International Journal of Social Psychiatry - April 15, 2024 Category: Psychiatry Authors: Ning Ma Runzi Chen Yu Bai Wufang Zhang Zecong Chen Jun Zhou Yajie Cao Liping Wen Xiaobing Chen Xuhui Zhan Yunge Fan Source Type: research
Systematic Review on the Relationship between Toxoplasmosis and Mental Disorders
CONCLUSIONS: Due to the limits of the study, no conclusions can be drawn in childhood and adolescence. However, the results of this systematic review show a possible association of schizophrenia, bipolar disorder and compulsive disorder with T. gondii infection in adults. There is a need to improve control, integrated surveillance and extend prevention measures to the entire population.PMID:38622004 | DOI:10.62641/aep.v52i2.1658 (Source: Actas Espanolas de Psiquiatria)
Source: Actas Espanolas de Psiquiatria - April 15, 2024 Category: Psychiatry Authors: Leticia E Bartolom é Del Pino Vicente Zan ón-Moreno Source Type: research
The impact of familial involvement on dropout in a culturally informed group therapy for people diagnosed with 'schizophrenia'
We examined whether familial involvement and other demographic variables predicted dropout among 101 patients enrolled in culturally informed group therapy for schizophrenia (CIGT-S), which incorporates collectivistic principles and spiritual coping into treatment. We reviewed records and conducted follow-up calls to identify reasons for dropout, and performed survival analyses to identify when dropout was likely.RESULTS: Familial involvement was linked to greater engagement with treatment and lower dropout, signifying a mechanism for improving treatment attendance in this group. Ethnic minorities and patients with higher ...
Source: Psychosis - April 15, 2024 Category: Psychiatry Authors: Jessica Maura Salman Shaheen Ahmad Amy Weisman de Mamani Source Type: research
Schizophrenic poetry, queerness, and the limits of self-expression
CMAJ. 2024 Apr 14;196(14):E489-E490. doi: 10.1503/cmaj.231440.NO ABSTRACTPMID:38621776 | DOI:10.1503/cmaj.231440 (Source: cmaj)
Source: cmaj - April 15, 2024 Category: General Medicine Authors: Nam S Hoang Source Type: research
