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Total 5363 results found since Jan 2013.

18F-fluorodeoxyglucose positron emission tomography is useful for the diagnosis of intraocular sarcoidosis in patients with a normal CT scan.
CONCLUSION: 18F-FDG PET/CT enabled the diagnosis of intraocular sarcoidosis even in patients with a normal CT scan. Older age at diagnosis, presence of synechiae and elevated ACE are associated with positive findings on 18F-FDG PET/CT consistent with sarcoidosis. PMID: 30658987 [PubMed - as supplied by publisher]
Source: The British Journal of Ophthalmology - January 18, 2019 Category: Opthalmology Authors: Chauvelot P, Skanjeti A, Jamilloux Y, de Parisot A, Broussolle C, Denis P, Ramackers JM, Giammarile F, Kodjikian L, Seve P Tags: Br J Ophthalmol Source Type: research

Simultaneous amplification and testing method for Mycobacterium Tuberculosis rRNA (SAT-TB) to differentiate sputum negative tuberculosis from sarcoidosis.
CONCLUSION: The SAT-TB may be an effective method for using biopsy specimens to differentiate sputum negative tuberculosis from sarcoidosis. PMID: 30652492 [PubMed - as supplied by publisher]
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - January 17, 2019 Category: Cytology Authors: Li QH, Zhang Y, Zhao MM, Gu Y, Hu Y, Su YL, Zhang F, Shen L, Zhou Y, Li HP Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

A Suspected Association Between Sarcoidosis and Development of Diabetes Mellitus
Conditions:   Sarcoidosis;   Diabetes Mellitus Interventions:   Diagnostic Test: Venous blood sample;   Diagnostic Test: Ultrasound of pancreas Sponsor:   University of Alabama at Birmingham Recruiting
Source: ClinicalTrials.gov - January 16, 2019 Category: Research Source Type: clinical trials

Total 12-Lead QRS Voltage in Patients Having Orthotopic Heart Transplantation for Heart Failure Caused by Adriamycin-Induced Cardiomyopathy
Conclusion: These low voltages are like those found in patients with carcinoid syndrome, severe cardiac adiposity, cardiac amyloidosis, and cardiac sarcoidosis.Cardiology 2018;141:172 –175
Source: Cardiology - January 16, 2019 Category: Cardiology Source Type: research

Clinically-useful serum biomarkers for diagnosis and prognosis of sarcoidosis.
Authors: Ramos-Casals M, Retamozo S, Sisó-Almirall A, Pérez-Alvarez R, Pallarés L, Brito-Zerón P Abstract INTRODUCTION: Sarcoidosis is a complex systemic disease with a silent, long-term evolution, and a heterogeneous clinical presentation. The diagnostic approach is complex with no single diagnostic test that may confirm the disease. Areas Covered: A large list of serum biomarkers has been tested during the last 40 years. In this review, we analyse the potential usefulness in the diagnosis and prognosis of sarcoidosis of serum biomarkers classified according to their corresponding cellular source. Expert comme...
Source: Expert Review of Clinical Immunology - January 12, 2019 Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research

Development of Propionibacterium acnes-associated Sarcoidosis During Etanercept Therapy: A Case Report.
Authors: Isshiki T, Matsuyama H, Sakamoto S, Honma N, Mikami T, Shibuya K, Eishi Y, Homma S Abstract Although numerous recent studies have reported the development of sarcoidosis in patients treated with TNF-α inhibitors, it is unclear whether the pathogenesis of drug-induced sarcoidosis is identical to that of spontaneous sarcoidosis. We herein present the case of a patient who developed sarcoidosis 6 months after the introduction of etanercept as treatment for rheumatoid arthritis. Typical clinical symptoms with noncaseating epithelioid granulomas detected in a mediastinal lymph node specimen were consistent wit...
Source: Internal Medicine - January 12, 2019 Category: Internal Medicine Tags: Intern Med Source Type: research

Tiger man sign in sarcoid myopathy
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 12, 2019 Category: Nuclear Medicine Source Type: research

The association of other autoimmune diseases in patients with Graves' disease (with or without ophthalmopathy): Review of the literature and report of a large series
In conclusion, we suggest GD patients who are still sick, or who develop new unspecific symptoms (even if during an appropriate treatment of hyperthyroidism) should be appropriately screened for the presence of other autoimmune disorders.
Source: Autoimmunity Reviews - January 11, 2019 Category: Allergy & Immunology Source Type: research

Can the Sarcoidosis Health Questionnaire predict the long-term outcomes in Japanese sarcoidosis patients?
The Sarcoidosis Health Questionnaire (SHQ) is the first sarcoidosis-specific health status questionnaire ever developed. Worse health status, as evaluated by the SHQ, indicates higher risk for deterioration in the following 5 years.
Source: Respiratory Medicine - January 11, 2019 Category: Respiratory Medicine Authors: Kiminobu Tanizawa, Tomohiro Handa, Sonoko Nagai, Toru Oga, Takeshi Kubo, Yutaka Ito, Kensaku Aihara, Kohei Ikezoe, Akihiko Sokai, Yoshinari Nakatsuka, Toyohiro Hirai, Kazuo Chin, Michiaki Mishima, Takateru Izumi Source Type: research

A web-based registry for patients with sarcoidosis.
Conclusions: A web-based registry is an effective method for establishing a cohort of patients with sarcoidosis invested in clinical research with DNA specimens. Despite limitations, opportunities for research in patient-oriented outcomes and broad internet-based research methodology are possible. Our results demonstrate that web-based approaches to recruit study subjects need to be focused to match different target populations. PMID: 30613131 [PubMed]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - January 10, 2019 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

FDG PET/CT Course of Pembrolizumab-Associated Multiorgan Sarcoidosis
An 80-year-old man with metastatic melanoma had been receiving treatment with pembrolizumab from September 2015 until June 2017. Series FDG PET/CT scans from March 7, 2017, to June 14, 2018, showed the course of biopsy-proven pembrolizumab-induced sarcoidosis. Reported here is the first case of multiorgan sarcoidosis induced by pembrolizumab and its self-resolving course on FDG PET/CT.
Source: Clinical Nuclear Medicine - January 9, 2019 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Non-infectious Granulomatous Lesions of the Orofacial Region
AbstractGranulomatous lesions of the orofacial region are a heterogeneous group of disorders characterized by a granulomatous reaction to a variety of stimuli. Infectious agents, foreign material, systemic inflammation and metabolic disorders can all be associated with granulomatous inflammation. In the orofacial region primary causes of granulomatosis include foreign body reaction, delayed hypersensitivity to topical agents and idiopathic orofacial granulomatosis. Secondary causes of granulomas include infectious agents, sarcoid, and Crohn disease. For this review, infectious causes of orofacial granulomatosis (OFG) inclu...
Source: Head and Neck Pathology - January 9, 2019 Category: Pathology Source Type: research

Cardiac FDG/PET imaging mimicking sarcoidosis
Source: Journal of Nuclear Cardiology - January 9, 2019 Category: Nuclear Medicine Source Type: research

Sarcoidosis associated with Interferon beta treatment.
Authors: García Ródenas MDM, Gayá García-Manso I, García Sevila R PMID: 30611535 [PubMed - as supplied by publisher]
Source: Medicina Clinica - January 8, 2019 Category: General Medicine Tags: Med Clin (Barc) Source Type: research

Heerfordt syndrome developing in a patient with cutaneous sarcoidosis.
PMID: 30623412 [PubMed - as supplied by publisher]
Source: The Australasian Journal of Dermatology - January 8, 2019 Category: Dermatology Authors: Shiraishi K, Sadamoto Y, Sayama K Tags: Australas J Dermatol Source Type: research

Pulmonary Sarcoidosis: A Pictorial Review
Publication date: Available online 4 January 2019Source: Seminars in Ultrasound, CT and MRIAuthor(s): Arya M. Iranmanesh, Lacey WashingtonAbstractSarcoidosis is a multisystem granulomatous process that most commonly involves the lungs. Radiographic findings consistent with sarcoidosis are important to the diagnosis of this disease, as no specific diagnostic test for sarcoidosis exists. The classic imaging manifestations of sarcoidosis are related to granulomatous involvement along the lymphatic pathways within the lungs, granulomatous involvement of lymph nodes, and fibrosis at the sites of previous inflammation. These fin...
Source: Seminars in Ultrasound, CT and MRI - January 5, 2019 Category: Radiology Source Type: research

Predictive value of platelet-to-lymphocyte ratio in patients with sarcoidosis.
CONCLUSION: Increase in PLR value can be used for guiding both the diagnosis of sarcoidosis and the involvement of parenchyma. PMID: 30604642 [PubMed - as supplied by publisher]
Source: Future Medicine: Biomarkers in Medicine - January 5, 2019 Category: Internal Medicine Tags: Biomark Med Source Type: research

Severe Cutaneous Sarcoid Responds to Tofacitinib
(MedPage Today) -- Case study reveals benefits of this novel approach
Source: MedPage Today Primary Care - January 5, 2019 Category: Primary Care Source Type: news

Tofacitinib Hypothesis-generating, Pilot Study for Corticosteroid-Dependent Sarcoidosis
Conditions:   Sarcoidosis, Pulmonary;   Sarcoidosis Lung;   Sarcoidosis Interventions:   Drug: Tofacitinib 5mg Oral Tablet [Xeljanz] 16 week trial;   Diagnostic Test: Spirometry;   Genetic: RNA Sequencing;   Diagnostic Test: Laboratory testing;   Drug: Corticosteroid;   Drug: Tofacitinib 5mg [Xeljanz] 1 year open-label extension Sponsors:   Oregon Health and Science University;   Pfizer Not yet recruiting
Source: ClinicalTrials.gov - January 4, 2019 Category: Research Source Type: clinical trials

Elevated Periostin Concentrations in the Bronchoalveolar Lavage Fluid of Patients with Eosinophilic Pneumonia
Conclusions: Although some blood leakage may be involved in the elevation of periostin in the BALF of EP, periostin can be induced locally, at least in part. Therefore, periostin may play a role in the development of EP.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - January 4, 2019 Category: Allergy & Immunology Source Type: research

18 F-FDG uptake of the right ventricle is an important predictor of histopathologic diagnosis by endomyocardial biopsy in patients with cardiac sarcoidosis
ConclusionsFDG uptake of the RV but no other heart segment was associated with positive EMB in CS patients. The presence of RV FDG uptake could improve the rate of positive EMB up to 42% in patients with CS.
Source: Journal of Nuclear Cardiology - January 4, 2019 Category: Nuclear Medicine Source Type: research

Pseudoachalasia as First Manifestation of a Malignancy
We describe a 16-year-old high school student referred for management of achalasia who turned out to have pseudoachalasia due to adenocarcinoma of the cardia. He was cured with preoperative chemotherapy followed by radical surgery. Therapy of pseudoachalasia secondary to neoplasia is directed against the tumor or may be palliative to keep the lumen open. Other causes of pseudoachalasia include esophageal motility disturbances as a paraneoplastic phenomenon (e.g., with small cell lung cancer), post fundoplication or post bariatric surgery, in association with a thoracic aortic aneurysm, or with sarcoidosis or amyloidosis. T...
Source: Digestive Diseases - January 2, 2019 Category: Gastroenterology Source Type: research

Diagnostic performance of F-18 FDG PET for detection of cardiac sarcoidosis; A systematic review and meta-analysis
ConclusionThe current meta-analysis showed the moderate sensitivity and specificity of F-18 FDG PET or PET/CT for diagnosis of CS. The presence of combined myocardial perfusion imaging could improve diagnostic accuracy of F-18 FDG PET or PET/CT for diagnosis of CS. At present, the literature regarding the use of F-18 FDG PET for detection of CS remains limited; thus, further large multicenter studies would be necessary to substantiate the diagnostic accuracy of F-18 FDG PET for diagnosis of CS.
Source: Journal of Nuclear Cardiology - January 2, 2019 Category: Nuclear Medicine Source Type: research

Same day comparison of PET/CT and PET/MR in patients with cardiac sarcoidosis
ConclusionIn this limited patient study, PET/CT and PET/MR provided similar diagnostic data for18F-FDG uptake, and the concurrent acquisition of MR images provided further insight into the disease process.
Source: Journal of Nuclear Cardiology - January 2, 2019 Category: Nuclear Medicine Source Type: research

Dacryocystitis and Rhinosinusitis Secondary to Sarcoidosis
Sarcoidosis rarely develops in the lacrimal sac. Lacrimal sac sarcoidosis may be associated with sarcoidosis-related rhinosinusitis. The anatomical and histological relationship between the lacrimal drainage system and nasal mucosa has been indicated as a predisposing factor for this concomitance. However, the characteristics of this condition are not fully understood. Herein, the authors report a case where dacryocystitis and rhinosinusitis developed secondary to sarcoidosis. Pathological examination of the lacrimal sac wall revealed noncaseating epithelioid granulomas in the subepithelial layer, which contains the lacrim...
Source: Journal of Craniofacial Surgery - January 1, 2019 Category: Surgery Tags: Brief Clinical Studies Source Type: research

Chylothorax due to sarcoidosis: A unique occurrence
Abhishek Gupta, Ketaki Utpat, Unnati Desai, Jyotsna M JoshiLung India 2019 36(1):87-89
Source: Lung India - December 31, 2018 Category: Respiratory Medicine Authors: Abhishek Gupta Ketaki Utpat Unnati Desai Jyotsna M Joshi Source Type: research

One Woman's Case Gives New Hope Against Disfiguring Sarcoidosis
Title: One Woman's Case Gives New Hope Against Disfiguring SarcoidosisCategory: Health NewsCreated: 12/26/2018 12:00:00 AMLast Editorial Review: 12/27/2018 12:00:00 AM
Source: MedicineNet Arthritis General - December 27, 2018 Category: Rheumatology Source Type: news

Woman's Case Gives Hope Against Sarcoidosis
Sarcoidosis is an inflammatory disease that affects multiple organs. While some patients recover without treatment, others suffer damage to lungs, heart, lymph nodes, skin and other organs. On the skin, it can cause disfiguring lesions.
Source: WebMD Health - December 26, 2018 Category: Consumer Health News Source Type: news

Yale experts treat severe, disfiguring sarcoidosis with novel therapy
A team of Yale researchers has found a promising new treatment for sarcoidosis, a disease that can affect multiple organs: tofacitinib, an arthritis medication.
Source: Yale Science and Health News - December 26, 2018 Category: Universities & Medical Training Source Type: news

One Woman ' s Case Gives New Hope Against Disfiguring Sarcoidosis
WEDNESDAY, Dec. 26, 2018 -- In very preliminary findings, an existing rheumatoid arthritis drug appeared to cure one woman of a rare but potentially life-threatening condition known as sarcoidosis. After 10 months of use, tofacitinib (Xeljanz)...
Source: Drugs.com - Daily MedNews - December 26, 2018 Category: General Medicine Source Type: news

Yale experts treat severe, disfiguring sarcoidosis with novel therapy
(Yale University) An all-Yale team of researchers successfully treated a patient with disfiguring sarcoidosis, a chronic disease that can affect multiple organs, with a drug approved for rheumatoid arthritis. Successful treatment of two other patients with similarly severe disease suggests an effective treatment for an incurable, sometimes life-threatening illness is within reach, the scientists said.
Source: EurekAlert! - Medicine and Health - December 26, 2018 Category: International Medicine & Public Health Source Type: news

Clinical features of hypertrophic pachymeningitis in a center survey
DiscussionIn the described series, a female predominance was identified, with symptoms ’ onset in the 5th decade. Although headache was the most common symptom, clinical presentation was varied, emphasizing the role of MRI in HP diagnosis. The underlying etiologies were diverse, with only a few cases remaining idiopathic, also reflecting the contribution of the recently described Ig G4-RD.
Source: Neurological Sciences - December 26, 2018 Category: Neurology Source Type: research