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Total 5691 results found since Jan 2013.

Differences between patients with sarcoidosis with and without joint involvement treated for fifteen years in a third level hospital
ConclusionsPatients with sarcoidosis who have joint involvement have a much higher frequency of concomitant skin involvement. The absence of cutaneous findings in a patient with joint symptoms decreases the likelihood of sarcoidosis.ResumenIntroducciónLa sarcoidosis es una enfermedad compleja, de etiología desconocida, de curso variable y con formas de presentación diversas. Nuestro objetivo fue caracterizar a todos nuestros pacientes con sarcoidosis con énfasis en su forma de presentación clínica y establecer diferencias entre los pacientes con sarcoidosis con y sin compromiso articular.MétodosSe revisaron las hist...
Source: Reumatologia Clinica - May 19, 2019 Category: Rheumatology Source Type: research

Synthetic pharmacotherapy for pulmonary sarcoidosis.
Authors: Llabres M, Brito-Zerón P, Ramos-Casals M, Sellares J Abstract INTRODUCTION: Sarcoidosis is a granulomatous systemic disease of unknown cause where the lungs are the most frequently affected. Therapeutic management of the disease is challenging as clinical presentation and prognosis are very heterogeneous. Areas covered: This review summarizes the current knowledge of synthetic therapies for pulmonary sarcoidosis. The most commonly used medication for the treatment of sarcoidosis with lung involvement are glucocorticoids. Nevertheless, not all patients reach an acceptable response or tolerate them and the ...
Source: Expert Opinion on Pharmacotherapy - May 17, 2019 Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research

Screening sarcoidosis patients for cardiac sarcoidosis: What the data really show
Cardiac sarcoidosis is a major cause of death in sarcoidosis patients. In most series, cardiac sarcoidosis is second only to pulmonary sarcoidosis in causes of death related to sarcoidosis [1], although cardiac sarcoidosis has been found to be the leading cause of death in some reports [2,3]. More importantly, the deaths from cardiac sarcoidosis may occur suddenly and early after diagnosis, relating to the development of a small focus of granulomatous inflammation in a strategically vulnerable portion of the cardiac conduction system.
Source: Respiratory Medicine - May 16, 2019 Category: Respiratory Medicine Authors: Marc A. Judson Tags: Editorial Source Type: research

VEGF-A from Granuloma Macrophages Regulates Granulomatous Inflammation by a Non-angiogenic Pathway during Mycobacterial Infection
Publication date: 14 May 2019Source: Cell Reports, Volume 27, Issue 7Author(s): Jeffrey S. Harding, Melinda Herbath, Yuli Chen, Aditya Rayasam, Anna Ritter, Balazs Csoka, George Hasko, Iacovos P. Michael, Zsuzsanna Fabry, Andras Nagy, Matyas SandorSummaryMany autoimmune and infectious diseases are characterized by the formation of granulomas which are inflammatory lesions that consist of spatially organized immune cells. These sites protect the host and control pathogens like Mycobacterium tuberculosis (Mtb), but are highly inflammatory and cause pathology. Using bacille Calmette-Guerin (BCG) and Mtb infection in mice that...
Source: Cell Reports - May 15, 2019 Category: Cytology Source Type: research

Infectious versus non-infectious causes of oligoarticular inflammatory arthritis: A prospective study from a tertiary care hospital in north India.
Authors: Gupta N, Chaudhry R, Soneja M, Valappil VE, Malla S, Razik A, Vyas S, Ray A, Khan MA, Kumar U, Wig N Abstract Oligoarticular arthritis (inflammation of upto 4 joints) has a wide range of infectious and non-infectious etiologies. The aim of our study was to identify the features which could help in the differentiation of infectious from non-infectious arthritis. The study was prospective and observational, and included 100 patients with oligoarticular inflammatory arthritis. The final diagnosis was made using standard diagnostic criteria and the patients were categorized into infectious and non-infectious g...
Source: Drug Discoveries and Therapeutics - May 14, 2019 Category: Drugs & Pharmacology Tags: Drug Discov Ther Source Type: research

Cutaneous periocular sarcoidosis.
PMID: 31084397 [PubMed - as supplied by publisher]
Source: Orbit - May 14, 2019 Category: Opthalmology Authors: DeMaria L, Shinder R Tags: Orbit Source Type: research

Correspondence for “Clinical epidemiology of familial sarcoidosis: A systematic literature review”
It is with great interest that we read the article titled “Clinical epidemiology of familial sarcoidosis: A systematic literature review” by Drs. Terwiel and van Moorsel published recently in Respiratory Medicine [1]. Their systematic review on familial sarcoidosis highlights the great heterogeneity in familial disease prevalence and in familial relati ve risks among published studies. They also emphasize the high heritability (>60%) of sarcoidosis.
Source: Respiratory Medicine - May 13, 2019 Category: Respiratory Medicine Authors: Marios Rossides, Johan Grunewald, Anders Eklund, Susanna Kullberg, Johan Askling, Elizabeth V. Arkema Tags: Correspondence Source Type: research

The Equine Sarcoid
This article discusses the main treatments for sarcoid and the specific difficulties of these. It explains to some extent why the frustrations of a condition for which there is no single treatment option have led to the burgeoning of an industry of irrational treatments. The factors that need to be considered before selecting an option for treatment are wider than is the case in most other disease entities as a result of the complexity of the condition, its variable phenotypes, and the individual perceptions and experiences of both veterinarians and owners.
Source: Veterinary Clinics of North America: Equine Practice - May 13, 2019 Category: Veterinary Research Authors: Derek C. Knottenbelt Source Type: research

Abatacept induced granulomatous hepatitis with a sarcoidosis- like reaction: a blinded trial in mice.
CONCLUSION: Abatacept may play a role in inducing granulomatous hepatitis with a sarcoidosis-like reaction. Additional data including transaminases, antinuclear antibodies (ANA), Antimitochondrial antibodies (AMA) and other auto antibodies should be tested. PMID: 31064410 [PubMed - in process]
Source: BMC Pharmacology and Toxicology - May 9, 2019 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

A Study in Subjects With Sarcoidosis-associated Pulmonary Hypertension (SAPH) to Assess the Efficacy and Safety of Oral Selexipag
Condition:   Sarcoidosis-associated Pulmonary Hypertension Interventions:   Drug: Selexipag;   Drug: Placebo Sponsor:   Actelion Not yet recruiting
Source: ClinicalTrials.gov - May 8, 2019 Category: Research Source Type: clinical trials

Is This Sarcoidosis?
Discussion Sarcoidosis is rare and is even rarer in the pediatric age group. Sarcoidosis is seen in all ages with an estimated prevalence is 10-40/100,000 in the U.S. population. Pediatric sarcoidosis has an estimated incidence of 0.2/100,000 per year. For the pediatric age range it is more likely from 9-15 years of age. In adults it commonly presents between 20-39 years but bimodal distribution is also reported. Women are more likely to have sarcoidosis than men. African American females have the highest risk, and usually present slightly older, especially in the 4th decade of life. African American women are also more li...
Source: PediatricEducation.org - May 6, 2019 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Comparison of the chemokine profiles in the bronchoalveolar lavage fluid between IgG4-related respiratory disease and sarcoidosis: CC-chemokine ligand 1 might be involved in the pathogenesis of sarcoidosis.
CONCLUSIONS: CCL1 might reflect disease activity and its involvement in the pathogenesis of sarcoidosis might be more closely related to Th1 than to Th2. PMID: 31063909 [PubMed - as supplied by publisher]
Source: Cytokine - May 4, 2019 Category: Molecular Biology Authors: Yamamoto H, Yasuo M, Komatsu M, Ushiki A, Hamano H, Hori A, Nakajima T, Uehara T, Fujinaga Y, Matsui S, Hanaoka M Tags: Cytokine Source Type: research

Sarcoidosis in the periocular scar as the first finding of systemic sarcoidosis: Clinical-radiological characteristics.
Authors: Díaz-Cabanas L, Belani-Raju M, González-Márquez PI, Artioli-Schellini S, Guereñu-Panero I, Galindo-Ferreiro A Abstract An unusual case is presented of a 29 year-old Caucasian woman with a granuloma in an old scar in the right periocular region as a first clinical sign of a systemic sarcoidosis. An excisional biopsy was performed, for which the histological diagnosis was a chronic non-necrotising granulomatous inflammation, suggestive of scar sarcoidosis. The lesion re-appeared one year after initial treatment, and was treated with intralesional depot steroids, showing adequate progression. This disease...
Source: Archivos de la Sociedad Espanola de Oftalmologia - May 2, 2019 Category: Opthalmology Tags: Arch Soc Esp Oftalmol Source Type: research

GSE121500 Genetic characterization of bronchoalveolar lavage fluid cells from patients with IPF and sarcoidosis
Conclusions: Analysis of BALf from sarcoidosis and IPF showed highly different mRNA profile of cells present in bronchoalveolar compartment and provided new data on the pathobiology of these ILDs. The changes of most important biological processes observed at the molecular level in BALf cells were associated with ribosome biogenesis and proteasome apparatus in sarcoidosis and neutrophilic dysfunction in IPF.
Source: GEO: Gene Expression Omnibus - May 2, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

Periocular cutaneous sarcoid: case series and review of the literature
Periocular cutaneous sarcoid: case series and review of the literature, Published online: 02 May 2019; doi:10.1038/s41433-019-0448-5Periocular cutaneous sarcoid: case series and review of the literature
Source: Eye - May 2, 2019 Category: Opthalmology Authors: Rehan Rajput Priscilla Mathewson Hardeep Singh Mudhar Paul Hiley Soupramanien Sandramouli Rina Bhatt Source Type: research

Nasal and Lacrimal Sac Histopathology in Patients With Systemic Sarcoidosis Undergoing External Lacrimal Drainage Surgery
Conclusions: In patients with sarcoidosis undergoing external dacryocystorhinostomy, the characteristic histological feature—noncaseating granulomas—is present in most patients’ lacrimal sac mucosa and in almost all of their nasal mucosae. The lacrimal sac and nasal mucosa often appears abnormal—thickened or friable—during surgery.
Source: Ophthalmic Plastic and Reconstructive Surgery - May 1, 2019 Category: Opthalmology Tags: Original Investigations Source Type: research

Foreign-Body Granulomata Caused by Injected Permanent Filler Masquerading as Cutaneous Sarcoidosis
Foreign-body granuloma formation following filler injections is most commonly seen with permanent fillers; these reactions can occur years following the injections and often require either an intralesional steroid injection or surgical excision. The authors present a case of a 75-year-old woman with a history of systemic sarcoidosis previously treated with numerous immunosuppressive medications who was examined for bilateral infraorbital nodules and swelling that were unresponsive to treatment. She underwent a bilateral anterior orbitotomy through a transconjunctival approach with mass excision. The histologic analysis was...
Source: Ophthalmic Plastic and Reconstructive Surgery - May 1, 2019 Category: Opthalmology Tags: Case Reports Source Type: research

Oral sarcoid in a cat.
Abstract A 10-month-old, domestic shorthaired, spayed female cat was presented to the Veterinary Medical Centre, Western College of Veterinary Medicine, for evaluation of an oral mucosal mass. Histopathology and polymerase chain reaction with sequencing allowed for a definitive diagnosis of bovine papillomavirus type-14-associated oral sarcoid. The mass resolved spontaneously following incisional biopsy and was still grossly absent 10 months later. PMID: 31080260 [PubMed - in process]
Source: The Canadian Veterinary Journal - May 1, 2019 Category: Veterinary Research Authors: Greenwood S, Campbell O, Movasseghi AR Tags: Can Vet J Source Type: research

Nodosum erythema and sarcoidosis: Case report.
PMID: 31056102 [PubMed - in process]
Source: Atencion Primaria - May 1, 2019 Category: Primary Care Authors: González Peredo R, Amado Fernández C, Fombellida Gutiérrez P Tags: Aten Primaria Source Type: research

Noncaseating granulomatous diseases in germ cell cancer patients-A single-center experience.
CONCLUSIONS: In GCT patients, the coexistence of noncaseating granulomatous disease is common. Minimal invasive bronchoscopic techniques can serve for the cytopathologic exclusion of malignant thoracic manifestations. In our monocenter patient group the coexistence of SLL did not have any prognostic impact on overall survival. PMID: 31053525 [PubMed - as supplied by publisher]
Source: Urologic Oncology - April 30, 2019 Category: Urology & Nephrology Authors: Schmidt LH, Huss S, Schuelke C, Schulze A, Evers G, Schliemann C, Hansmeier A, Schilling B, Lauterbach B, Barth P, Wiebe K, Goerlich D, Berdel WE, Puehse G, Mohr M Tags: Urol Oncol Source Type: research

Natalizumab induced cutaneous sarcoidosis-like reaction
We present a case of a drug-induced sarcoidosis -like reaction (DISR) occurring following initiation of Natalizumab for multiple sclerosis. The reaction was purely cutaneous, and disappeared following drug withdrawal. We highlight this case to the practicing neurologists, with warning to be wary of a new rash on immunomodulatory therapies.
Source: Journal of Neuroimmunology - April 30, 2019 Category: Allergy & Immunology Authors: R. Durcan, C. Heffron, B. Sweeney Tags: Short Communication Source Type: research

Disparities in Sarcoidosis Mortality by Region, Urbanization and Race in the United States: A Multiple Cause of Death Analysis
Gender, race/ethnicity and geographic disparities in sarcoidosis-associated mortality were assessed for the most recent period.
Source: The American Journal of Medicine - April 29, 2019 Category: General Medicine Authors: Funmilola Ogundipe, Alem Mehari, Richard Gillum Tags: Clinical Research Study Source Type: research

Use of 18 F-FDG PET/CT texture analysis to diagnose cardiac sarcoidosis
ConclusionsThe texture analysis had high inter-operator and high inter-scan reproducibility. Some of texture features showed higher diagnostic value than SUVmax for CS diagnosis. Therefore, texture analysis may have a role in semi-automated systems for diagnosing CS.
Source: European Journal of Nuclear Medicine and Molecular Imaging - April 27, 2019 Category: Nuclear Medicine Source Type: research

Prevalence of Obstructive Sleep Apnea Syndrome in Sarcoidosis and Impact of CPAP Treatment on Associated Fatigue Status
Conditions:   Sarcoidosis;   Sleep Apnea, Obstructive;   Fatigue Intervention:   Device: Continuous Positive Airway Pressure (CPAP) Sponsor:   Policlinico Universitario Agostino Gemelli Recruiting
Source: ClinicalTrials.gov - April 25, 2019 Category: Research Source Type: clinical trials

Feasibility and Accuracy of Hybrid Magnetic Resonance and Positron Emission Tomography With 18F-Fluorodeoxyglucose in Diagnosing Cardiac Sarcoidosis
Condition:   Cardiac Sarcoidosis Intervention:   Diagnostic Test: hybrid PET/MRI Sponsor:   University of Alabama at Birmingham Not yet recruiting
Source: ClinicalTrials.gov - April 22, 2019 Category: Research Source Type: clinical trials