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Total 5152 results found since Jan 2013.

A Comparative Study of Characteristics and Outcomes of Patients with Proved and Suggested Sarcoid Uveitis Occurring after Ophthalmic Procedure.
Conclusions: Sarcoid uveitis has similar characteristics in patients with new onset sarcoid uveitis after or without ophthalmic procedure. As a consequence, ophthalmic intervention should be seen as a potential trigger of latent sarcoidosis. PMID: 30420915 [PubMed]
Source: Journal of Ophthalmology - November 15, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Lymphopaenia as a predictor of sarcoidosis in patients with a first episode of uveitis.
CONCLUSION: Lymphopaenia is a non-invasive and useful marker for diagnosing sarcoidosis-associated uveitis. PMID: 30442816 [PubMed - as supplied by publisher]
Source: The British Journal of Ophthalmology - November 15, 2018 Category: Opthalmology Authors: Groen-Hakan F, Eurelings L, Rothova A, van Laar J Tags: Br J Ophthalmol Source Type: research

Sarcoidosis deaths in the United States: 1999 –2016
It has been over a decade since a comprehensive study has been published that has examined sarcoidosis deaths at the national level. The purpose of this study was to analyze sarcoidosis as the underlying cause of death using current national death certificate data. Results from this project can be used to evaluate and compare trends of sarcoidosis reported deaths across the U.S.
Source: Respiratory Medicine - November 15, 2018 Category: Respiratory Medicine Authors: Gregory D. Kearney, Ogugua Ndili Obi, Veeranna Maddipati, Arjun Mohan, Anagha Malur, J. Christopher Carter, Mary Jane Thomassen Source Type: research

Examining the epidemiology of coincident psoriasis and sarcoidosis: An observational cross-sectional study
Source: Journal of the American Academy of Dermatology - November 14, 2018 Category: Dermatology Authors: Elizabeth B. Wallace, Hasan Khosravi, Cara J. Joyce, Frank R. Vleugels, Mital Patel Source Type: research

MicroRNA fingerprints in serum and whole blood of sarcoid ‐affected horses as potential non‐invasive diagnostic biomarkers
In this study, we compared equine sarcoid (ES) disease‐specific serum and whole blood miRNA fingerprints and correlated them to miRNA expression in sarcoid tissue. After high throughput sequencing, miRNA differential expression analysis between six ES‐affecte d and five control horses was carried out in serum and whole blood using a DESeq algorithm, accounting for the influence of hemolysis and the white blood cell count. Target gene, pathway prediction and enrichment analyses were conducted using TarBase, mirPath and GeneCodis. After exclusion of four h emolyzed out of a total of 11 serum samples, nine miRNAs were fou...
Source: Veterinary and Comparative Oncology - November 14, 2018 Category: Veterinary Research Authors: Lucia Unger, Vinzenz Gerber, Alicja Pacholewska, Tosso Leeb, Vidhya Jagannathan Tags: ORIGINAL ARTICLE Source Type: research

What Causes Post-Inflammatory Hypopigmentation?
Discussion Hypopigmentation can be worrisome for many families because of cosmesis and the worry that “something is wrong.” The normal natural changes in skin-tone over the year due to different light exposure and wide variations within individuals is not something that many people are aware of. Post-inflammatory hypopigmentation is a common cause of hypopigmentation. Vitiligo is the most common cause of depigmentation. Vitiligo is an acquired, depigmenting disorder with typical lesions appearing as milky white macules with distinct margins that are not scaly. Hair (including eyebrows and eyelashes) can be dep...
Source: - November 12, 2018 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

The prognostic value of quantitating and localizing F-18 FDG uptake in cardiac sarcoidosis
ConclusionsSUV at time of CS diagnosis has significant associations with future cardiac events. Patients with higher SUV, particularly in basal segments, are at increased risk of events. Further studies are needed to identify treatment methods utilizing risk stratification of CS.
Source: Journal of Nuclear Cardiology - November 12, 2018 Category: Nuclear Medicine Source Type: research

Periocular scar sarcoidosis
No abstract is available for this article.
Source: Clinical and Experimental Ophthalmology - November 11, 2018 Category: Opthalmology Authors: Tess G Ryan, David S Curragh, Dinesh Selva Tags: Letter to the Editor Source Type: research

Pulmonary manifestations of large, medium, and variable vessel vasculitis
The hallmark of vasculitis is autoimmune inflammation of blood vessels and surrounding tissues, resulting in an array of constitutional symptoms and organ damage. The lung is commonly targeted in the more familiar ANCA-associated small vessel vasculitidies, but large and medium vessel vasculitides, including Takayasu arteritis, giant cell arteritis, polyarteritis nodosa, Behcet's disease, and necrotizing sarcoid granulomatosis, may also feature prominent pulmonary involvement. Pulmonary manifestations of these conditions include pulmonary arterial aneurysms, pulmonary hypertension, diffuse alveolar hemorrhage, pulmonary no...
Source: Respiratory Medicine - November 10, 2018 Category: Respiratory Medicine Authors: Traci N. Adams, Da Zhang, Kiran Batra, John E. Fitzgerald Tags: Review article Source Type: research

Acute kidney injury as a rare manifestation of pediatric sarcoidosis: A case report and systematic literature review
ConclusionsSarcoidosis should be considered in children with acute kidney injury of an unknown etiology. A final diagnosis is established through a combination of the clinical and laboratory characteristics, radiological presentation, and histological features of noncaseating granulomas. A therapeutic schedule should be decided after a systemic assessment.
Source: Clinica Chimica Acta - November 8, 2018 Category: Laboratory Medicine Source Type: research

Myopathies Featuring Non-caseating Granulomas: Sarcoidosis, Inclusion body myositis and an unfolding overlap
Granulomatous myopathy is a clinically and etiologically heterogeneous group of uncommon inflammatory myopathies, pathologically characterized by the presence of granulomas in skeletal muscle. Granulomas may contain necrosis as typically seen in infectious disorders (fungal, tuberculosis, or brucellosis) [1-3] or may occur without necrosis, so-called non-necrotizing or non-caseating granulomas. Various disorders were reported in association with non-caseating granulomatous myopathy, including sarcoidosis and less commonly other autoimmune diseases (Crohn's disease, anti-mitochondrial autoimmunity with or without primary bi...
Source: Neuromuscular Disorders - November 8, 2018 Category: Neurology Authors: Reem M. Alhammad, Teerin Liewluck Source Type: research

Cutaneous sarcoidosis after Hodgkin lymphoma
International Journal of Dermatology, EarlyView.
Source: International Journal of Dermatology - November 8, 2018 Category: Dermatology Authors: Sanna Impivaara, Lauri M äkelä, Micaela Hernberg, Leila Jeskanen, Nicolas Kluger Tags: Correspondence Source Type: research

Serum 1,25(OH)2 Vitamin D and 25(OH) Vitamin D Ratio for the Diagnosis of Sarcoidosis-Related Uveitis.
CONCLUSION: The measurement of serum 25(OH)D and 1,25(OH)2D levels is a useful tool in the etiological workup of patients with unexplained uveitis, since a high 1,25(OH)2D/25(OH)D ratio is suggestive of ocular sarcoidosis. PMID: 30395752 [PubMed - as supplied by publisher]
Source: Ocular Immunology and Inflammation - November 7, 2018 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Acute kidney injury as a rare manifestation of pediatric sarcoidosis: A case report and systematic literature review.
CONCLUSIONS: Sarcoidosis should be considered in children with acute kidney injury of an unknown etiology. A final diagnosis is established through a combination of the clinical and laboratory characteristics, radiological presentation, and histological features of noncaseating granulomas. A therapeutic schedule should be decided after a systemic assessment. PMID: 30414436 [PubMed - as supplied by publisher]
Source: International Journal of Clinical Chemistry - November 7, 2018 Category: Chemistry Authors: Wang C, Liu H, Zhang T, Xu H, Shen J, Feng J, Sun L Tags: Clin Chim Acta Source Type: research

Cardiac Sarcoidosis
Clinical and subclinical cardiac sarcoidosis (CS) remain diagnostically challenging as the sensitivity and specificity of the diagnostic modalities are limited. The Japanese Ministry of Health and Welfare criteria and the Heart Rhythm Society expert consensus statement on CS are the most common guidelines used to diagnose CS. However, they are mostly based on expert opinions and lack clinical trial validation. The emergence and increase use of newer imaging modalities such as cardiac magnetic resonance and positron emission tomography may give valuable information for accurate diagnosis and assessment of treatment response in CS patient.
Source: The American Journal of Cardiology - November 5, 2018 Category: Cardiology Authors: Jian Liang Tan, Hee Kong Fong, Edo Y. Birati, Yuchi Han Source Type: research

Three Cases of Scalp Sarcoidosis with Alopecia
Publication date: Available online 3 November 2018Source: Actas Dermo-Sifiliográficas (English Edition)Author(s): M. Ishikawa, M. Ohtsuka, T. Yamamoto
Source: Actas Dermo-Sifiliograficas - November 4, 2018 Category: Dermatology Source Type: research

Circumferential extent of thinning of the basal muscular ventricular septum in a case of cardiac sarcoidosis
Echocardiography, EarlyView.
Source: Echocardiography - November 2, 2018 Category: Cardiology Authors: Atsusuke Yatomi, Shumpei Mori, Ayu Shono, Tsubasa Kamio, Shinsuke Shimoyama, Yu Izawa, Ken ‐ichi Hirata Source Type: research

Neuroimaging Findings in Intracranial Sarcoid Phlebitis: A Case Report
Venous phlebitis in Neurosarcoidosis (NS) is rare but is often associated with intracranial hemorrhage (ICH). Imaging findings in such cases have been recently described on susceptibility weighted imaging (SWI).
Source: Journal of Stroke and Cerebrovascular Diseases - November 2, 2018 Category: Neurology Authors: Girish Bathla, Sudeepta Dandapat, Neetu Soni, Ravishankar P. Maheshwarappa Source Type: research

Advanced cardiovascular imaging for the evaluation of cardiac sarcoidosis
AbstractCardiac sarcoidosis (CS) remains an intriguing infiltrating disorder and one of the most important forms of inflammatory cardiomyopathy. Identification of patients with CS is of extreme importance because they are at higher risk of sudden death, and heart-failure progression. And while it remains a diagnostic conundrum, a great amount of experience has been accumulated over the last decade with the advent of fluorine-18 fluorodeoxyglucose positron emission tomography and cardiac magnetic resonance with late gadolinium enhancement imaging. They have both proven to be advanced imaging techniques that provide importan...
Source: Journal of Nuclear Cardiology - November 2, 2018 Category: Nuclear Medicine Source Type: research

A Dose Escalation Study to Assess the Safety and Efficacy of Pulsed Inhaled Nitric Oxide in Subjects With Pulmonary Fibrosis or Sarcoidosis
Conditions:   Pulmonary Hypertension;   Pulmonary Fibrosis;   Sarcoidosis, Pulmonary Intervention:   Combination Product: iNO Sponsor:   Bellerophon Not yet recruiting
Source: - November 1, 2018 Category: Research Source Type: clinical trials

Life-threatening hypercalcemia and acute kidney injury induced by etanercept.
We report a case of sarcoid-like granulomatosis manifesting as life-threatening hypercalcemia and acute kidney injury in a woman treated with etanercept for a rheumatoid arthritis. Seven days after admission, she developed hypoxemic interstitial pneumonia with negative mycobacterial and fungal analysis. This picture suggested sarcoid-like disease induced by tumor necrosis factor blockers and prompted etanercept cessation. Kidney biopsy performed 30 days after admission revealed significant acute interstitial nephritis and intratubular calcium crystals. Staining for acid-fast bacilli and fungi was negative. Clinical pictur...
Source: Nephrologie and Therapeutique - November 1, 2018 Category: Urology & Nephrology Authors: Tsevi YM, Aydin S, Durez P, Labriola L Tags: Nephrol Ther Source Type: research

Pulmonary Sarcoidosis Considerations in Primary Care
The current literature shows that pharmacologic treatment of pulmonary sarcoidosis should depend on patient-specific symptomology and be individually customized. Approaching this multifaceted disease process that has poorly understood etiology and disease predictability is further complicated by a lack of standardized guidelines for this condition, specifically detailing the appropriateness of observation for possible spontaneous resolution and when to initiate pharmacotherapy in the primary care setting.
Source: The Journal for Nurse Practitioners - November 1, 2018 Category: Nursing Authors: Kaitlin Denson, Melissa Herbein, Felicia Stewart Tags: Feature Article Source Type: research

Pathology of endomyocardial biopsy
Endomyocardial biopsy (EMB) is routinely performed for cardiac transplant monitoring. Moreover, it can be a useful tool in the diagnostic work-up of myocarditis, cardiomyopathies, drug toxicity, unexplained arrhythmias, heart involvement in systemic disease, and to diagnose cardiac masses. Pathologic evaluation of EMB represents the gold standard in specific disorders, including myocarditis and cardiac involvement by amyloidosis and sarcoidosis. To increase the diagnostic yield of the procedure, multiple myocardial samples should be obtained, and processed in a fully-equipped laboratory, with access to immunohistochemical/...
Source: Diagnostic Histopathology - November 1, 2018 Category: Pathology Authors: Giulia d ’Amati, Bruna Cerbelli, Carla Giordano Tags: Mini-symposium: Cardiovascular pathology Source Type: research

Corrigendum to ‘DNA methylation patterns of the S100A14, POU2F3 and SFN genes in equine sarcoid tissues’ Research in Veterinary Science 119 (2018) 302–307
Publication date: December 2018Source: Research in Veterinary Science, Volume 121Author(s): E. Semik-Gurgul, T. Ząbek, A. Fornal, M. Wnuk, K. Pawlina-Tyszko, A. Gurgul, J. Klukowska-Rötzler, C. Koch, K. Mählmann, M. Bugno-Poniewierska
Source: Research in Veterinary Science - October 31, 2018 Category: Veterinary Research Source Type: research

Cardiac Sarcoidosis Mimicking Septal Tumor with Intermittent Complete Atrioventricular Block.
Authors: Fujimoto R, Asano T, Maezawa H, Shimojima H, Tsujiuchi M, Hori Y, Ebato M, Suzuki H Abstract A 52-year-old woman with intermittent complete atrioventricular (AV) block detected on exercise was admitted to the hospital. Echocardiography revealed lesions on the right ventricular side of the interventricular septum and free wall of the basal inferolateral area. Gadolinium-enhanced cardiovascular magnetic resonance (CMR) imaging revealed the mass and wall thickening at the same locations with late gadolinium enhancement (LGE). Focal uptake at the septal lesion was detected using 67Ga scintigraphy. Focal on dif...
Source: International Heart Journal - October 31, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Management and outcomes of cardiac sarcoidosis: a 20 ‐year experience in two tertiary care centres
European Journal of Heart Failure, EarlyView.
Source: European Journal of Heart Failure - October 31, 2018 Category: Cardiology Authors: Lynn A. Fussner, Erin Karlstedt, David O. Hodge, Nowell M. Fine, Sanjay Kalra, Eva M. Carmona, James P. Utz, Debra L. Isaac, Leslie T. Cooper Source Type: research

Cardiac sarcoidosis with complete metabolic response and resolution of left ventricular dysfunction complicated by subsequent VT storm
We present a case of cardiac sarcoidosis with significantly impaired ejection fraction that was diagnosed late in the course of disease with complete metabolic response to therapy and an improvement of LV function, but with a subsequent complication of ventricular tachycardia storm.
Source: Journal of Nuclear Cardiology - October 30, 2018 Category: Nuclear Medicine Source Type: research

Cryoprobe transbronchial lung biopsy: How we do it ?
We describe our technique of performing cryoprobe-TBLB.
Source: Lung India - October 30, 2018 Category: Respiratory Medicine Authors: Karan Madan Saurabh Mittal Nishkarsh Gupta Vijay Hadda Anant Mohan Randeep Guleria Source Type: research

Bronchial purging: Atypical pulmonary sarcoidosis presenting with bronchorrhea
Shweta Mahapatra, Loveleen Mangla, Deepak TalwarLung India 2018 35(6):533-535
Source: Lung India - October 30, 2018 Category: Respiratory Medicine Authors: Shweta Mahapatra Loveleen Mangla Deepak Talwar Source Type: research

Granulomatous Reaction in a Patient With Metastatic Melanoma Treated With Ipilimumab: First Case Reported With Isolated Cutaneous Findings.
We present the first case of a 67-year-old man with isolated cutaneous granulomatous reaction involving the trunk, extremities, and face after eighteen months of treatment with ipilimumab for metastatic melanoma. This case documents the eruption of isolated cutaneous granulomatous reaction as a late treatment-related adverse effect of ipilimumab, highlighting the importance of adequate, prolonged follow-up. PMID: 30389125 [PubMed - as supplied by publisher]
Source: Actas Dermo-Sifiliograficas - October 30, 2018 Category: Dermatology Authors: Cervantes J, Rosen A, Dehesa L, Dickinson G, Alonso-Llamazares J Tags: Actas Dermosifiliogr Source Type: research

Detection of mitochondrial transfer RNA (mt-tRNA) gene mutations in patients with idiopathic pulmonary fibrosis and sarcoidosis
Publication date: Available online 26 October 2018Source: MitochondrionAuthor(s): Zoe Daniil, Ourania S. Kotsiou, Alexandros Grammatikopoulos, Sotiria Peletidou, Helen Gkika, Foteini Malli, Katerina Antoniou, Eirini Vasarmidi, Zissis Mamuris, Konstantinos Gourgoulianis, Emily ZifaAbstractMitochondrial reactive oxygen species production may lead to tissue injury associated with two respiratory disorders of unknown origin which are shared by common tissue fibrosis, IPF and sarcoidosis. Sequence analysis of 22 mt-tRNA genes and parts of their flanking genes revealed 32 and 45 mutations in 38/40 IPF and 69/85 sarcoidosis patie...
Source: Mitochondrion - October 27, 2018 Category: Biochemistry Source Type: research

Response to Letter to Editor regarding "Sarcoidosis and IPF in the same patient-a coincidence, an association or a phenotype?"
We thank Drs. Valentin, Hyde, Gomez and Patel for commenting on our recently published article “Sarcoidosis and IPF in the same patient-a coincidence, an association or a phenotype?” [1]. Indeed, one of our objectives in reporting our observations was to provoke further interest in the scientific community regarding such patients and conduct of clinical studies in such cohorts.
Source: Respiratory Medicine - October 26, 2018 Category: Respiratory Medicine Authors: Bridget F. Collins, Ganesh Raghu Tags: Correspondence Source Type: research

Evaluation of FDG PET combined with cardiac MRI for the diagnosis and therapeutic monitoring of cardiac sarcoidosis
To compare combined 2-[18F]-fluoro-2-deoxy-d-glucose (FDG)-positron-emission tomography (PET) and cardiac magnetic resonance imaging (CMR) for the diagnosis and therapy monitoring of cardiac sarcoidosis (CS).
Source: Clinical Radiology - October 25, 2018 Category: Radiology Authors: B. Sgard, P.-Y. Brillet, D. Bouvry, S. Djelbani, H. Nunes, C. Meune, D. Valeyre, M. Soussan Source Type: research

Sarcoid uveitis in a patient with multiple neurological lesions: a case report and review of the literature
ConclusionsAccording to the literature, patients with multiple cranial nerve palsies associated with sarcoidosis respond well to orally administered steroid therapy. However, our findings suggest that careful follow-up is necessary for patients with neurosarcoidosis due to potential aggravation of neuropathy.
Source: Journal of Medical Case Reports - October 23, 2018 Category: General Medicine Source Type: research

Bosentan for patients with steroid-resistant pulmonary sarcoidosis: a randomised controlled trial.
CONCLUSIONS: There is no evidence to support efficacy of bosentan as an antifibrotic treatment for patients with steroid-resistant pulmonary sarcoidosis. Bosentan was well tolerated and no drug-related adverse effects were observed within the study population. TRIAL REGISTRATION: ISRCTN registry, ISRCTN73579020. PMID: 30378090 [PubMed - in process]
Source: Swiss Medical Weekly - October 22, 2018 Category: General Medicine Authors: Hostettler K, Baty F, Kleiner R, Junker L, Tamm M, Brutsche M Tags: Swiss Med Wkly Source Type: research