This page shows you the latest news items in this category.

Total 4725 results found since Jan 2013.

Sarcoidosis onset simulating a unique hepatic metastasis.
We present a clinical case of a female diagnosed with an isolated hepatic sarcoidosis that simulated a unique hepatic metastatic lesion. The hepatic biopsy was diagnostic. PMID: 29931995 [PubMed - as supplied by publisher]
Source: Revista Espanola de Enfermedades Digestivas - June 23, 2018 Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research

ASNC releases new guidelines for SPECT MPI
The American Society of Nuclear Cardiology (ASNC) has published its 2018 guidelines...Read more on AuntMinnie.comRelated Reading: SNMMI, ASNC offer guidelines for myocardial perfusion imaging with PET Radiologist wins ASNC's 1st clinical abstract award Medical societies expand collaboration on cardiac registry ASNC, SNMMI advise on cardiac sarcoidosis ASNC releases guidance on MPI in women
Source: AuntMinnie.com Headlines - June 21, 2018 Category: Radiology Source Type: news

Granulomatous Tumoral Melanosis Associated With Pembrolizumab Therapy: A Mimicker of Disease Progression in Metastatic Melanoma
We report a case of sarcoid-like granulomatous tumoral melanosis in a patient on the programmed cell death-1 (PD-1) receptor inhibitor pembrolizumab for metastatic melanoma. This is, to our knowledge, the first reported case of a sarcoidal form of tumoral melanosis in a patient on anti-PD-1 therapy. We postulate that this reflects tumor regression in response to pembrolizumab-induced immune activation, with concomitant therapy–triggered induction of a sarcoid-like reaction. These findings and the literature review presented herein should alert clinicians and pathologists to the possibility of regressed lesions with sarco...
Source: The American Journal of Dermatopathology - June 21, 2018 Category: Pathology Tags: Extraordinary Case Report Source Type: research

Clinical characteristics associated with pacing-induced cardiac dysfunction: a high incidence of undiagnosed cardiac sarcoidosis before permanent pacemaker implantation
AbstractPrevious studies suggested that right ventricular pacing was associated with pacing-induced cardiac dysfunction (PICD). The purpose of this study was to investigate the clinical characteristics including the incidence of undiagnosed cardiac sarcoidosis (CS) in patients with atrioventricular block (AVB) who manifest PICD. We retrospectively investigated consecutive patients with permanent pacemaker (PPM) undergoing a first-generator replacement surgery with a new PPM or an upgrade procedure to a cardiac resynchronization therapy (CRT) device between December 1, 2011 and June 30, 2017. Patients with AVB showing norma...
Source: Heart and Vessels - June 21, 2018 Category: Cardiology Source Type: research

Pulmonary haemodynamics and mortality in chronic hypersensitivity pneumonitis
Chronic hypersensitivity pneumonitis (CHP) is a common interstitial lung disease (ILD) frequently associated with lung fibrosis [1]. Among patients with CHP, the degree of pulmonary function impairment and the extent of fibrosis are known predictors of mortality [2, 3]. In other forms of ILD, such as idiopathic pulmonary fibrosis (IPF) and sarcoidosis, abnormal pulmonary haemodynamics measured during resting supine right heart catheterisation (RHC) are additionally associated with poor prognosis [4–7]. In CHP, however, the prognostic value of RHC is unknown.
Source: European Respiratory Journal - June 21, 2018 Category: Respiratory Medicine Authors: Oliveira, R. K. F., Ota-Arakaki, J. S., Gomes, P. S., Gimenez, A., Messina, C. M. S., Ramos, R. P., Ferreira, E. V. M., Systrom, D. M., Pereira, C. A. C. Tags: Original Articles: Research letters Source Type: research

Peptide receptor radionuclide therapy as a new tool in treatment-refractory sarcoidosis - initial experience in two patients
Conclusion: Peptide receptor radionuclide therapy in sarcoidosis is feasible and might be a new valuable tool in patients with otherwise treatment-refractory disease. Given the long experience with and good tolerability of PRRT, further evaluation of this new treatment option for otherwise treatment-refractory sarcoidosis in larger patient cohorts is warranted.
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Constantin Lapa, Malte Kircher, Heribert H ä nscheid, Andreas Schirbel, G ö tz Ulrich Grigoleit, Erdwine Klinker, Markus B ö ck, Samuel Samnick, Theo Pelzer, Andreas K Buck Tags: Research Paper Source Type: research

Diagnostic Potential of PET/MRI in Cardiac Sarcoidosis
Conditions:   Sarcoidosis;   Cardiomyopathies Interventions:   Diagnostic Test: 18F-FDG-PET/MRI;   Diagnostic Test: 18F-GE180-PET/MRI Sponsors:   St. Olavs Hospital;   Norwegian University of Science and Technology;   University Hospital, Essen Not yet recruiting
Source: ClinicalTrials.gov - June 19, 2018 Category: Research Source Type: clinical trials

Sarcoidosis of the central nervous system: clinical features, imaging, and CSF results
ConclusionsThis prospective study of neurosarcoidosis increases our understanding of the pathophysiology of the disease. A reclassification of the clinical and imaging features of the disease allows an understanding of its pathophysiology and correlation with CSF indices allows an early identification of those with a more destructive disease will help to define treatment and may thereby improve outcome.
Source: Journal of Neurology - June 19, 2018 Category: Neurology Source Type: research

Atypical Cutaneous Presentations of Sarcoidosis: Two Case Reports and Review of the Literature
AbstractPurpose of ReviewThe goal of this review is to provide the reader with an updated summary of the cutaneous manifestations of systemic sarcoidosis, with a particular emphasis on the predilection of sarcoidosis for scars, tattoos, and other areas of traumatized skin.Recent FindingsWhile the mechanism underlying the propensity for traumatized skin to develop sarcoidosis lesions remains unclear, several theories have been proposed including the idea that cutaneous sarcoidosis represents an exuberant, antigen-driven foreign-body response, as well as the theory that traumatized skin represents an immunocompromised distri...
Source: Current Allergy and Asthma Reports - June 14, 2018 Category: Allergy & Immunology Source Type: research

Thoracic and cutaneous sarcoid-like reaction associated with anti-PD-1 therapy: longitudinal monitoring of PD-1 and PD-L1 expression after stopping treatment
ConclusionThis case sheds the light on a complex regulation of PD-L1 expression in vivo on PBMC after nivolumab arrest and triggers the question of monitoring the expression of immune checkpoint on immune cells during and after treatment with ICI.
Source: Journal for Immunotherapy of Cancer - June 13, 2018 Category: Cancer & Oncology Source Type: research

Chapter 21 Immune-mediated ataxias
Publication date: 2018 Source:Handbook of Clinical Neurology, Volume 155 Author(s): Bastien Joubert, Kevin Rostásy, Jérôme Honnorat Immune-mediated cerebellar ataxia (CA) comprises a group of rare diseases that are still incompletely described, and are probably underdiagnosed. Both acute and progressive progressions are possible. Different syndromes have been identified, including CA associated with anti-GAD antibodies, the cerebellar type of Hashimoto encephalopathy, primary autoimmune CA, gluten ataxia, opsoclonus-myoclonus syndrome, and paraneoplastic cerebellar degenerations. Most of these syndromes are associated ...
Source: Handbook of Clinical Neurology - June 13, 2018 Category: Neurology Source Type: research

Assessment of posaconazole salvage therapy in chronic pulmonary aspergillosis by using predefined response criteria
Chronic pulmonary aspergillosis (CPA) is a slowly progressive infection mainly caused by Aspergillus fumigatus, characterized by inflammatory destruction of lung tissue with cavitation, pleural thickening and/or fibrosis, and associated with significant respiratory and constitutional symptoms [1 –3]. CPA usually affects patients with underlying structural airway disease with air-filled cavities or bullae, such as tuberculosis (TB), non-tuberculous mycobacterial infection, chronic obstructive pulmonary disease (COPD), allergic bronchopulmonary aspergillosis (ABPA), pneumothorax and sarcoid osis.
Source: International Journal of Antimicrobial Agents - June 12, 2018 Category: Drugs & Pharmacology Authors: Isabel Rodriguez-Goncer, Chris Harris, Chris Kosmidis, Eavan G. Muldoon, Pippa J. Newton, David W. Denning Source Type: research

Acute kidney injury as the presenting manifestation of sarcoidosis: A case series and review of literature
Nephrology,Volume 23, Issue 6, Page 597-600, June 2018.
Source: Nephrology - June 11, 2018 Category: Urology & Nephrology Authors: Theepika Rajkumar , Tom Lea ‐Henry , Bobby Chacko Source Type: research

Treatment of Sarcoidosis: Grading the evidence.
Authors: James WE, Baughman R Abstract INTRODUCTION: Treatment of sarcoidosis recommendations are often based on clinical experience and expert opinion. However, there are an increasing number of studies which are providing evidence to support decisions regarding treatment. Areas Covered: Several studies have identified factors associated with increased risk for organ failure or death ("danger"). There have been several studies focused on the role of treatment to improve quality of life for the patient. Sarcoidosis treatment often follows a progression, based on response. Corticosteroids remain the initial treatmen...
Source: Expert Review of Clinical Pharmacology - June 9, 2018 Category: Drugs & Pharmacology Tags: Expert Rev Clin Pharmacol Source Type: research

d68Ga-DOTATATE PET/CT Assessment of Cardiac Sarcoidosis
Condition:   Cardiac Sarcoidosis Interventions:   Drug: 68Ga-DOTATATE PET/CT;   Drug: 18FDG PET/CT scan;   Drug: 13NH3 PET/CT scan Sponsor:   Mayo Clinic Not yet recruiting
Source: ClinicalTrials.gov - June 8, 2018 Category: Research Source Type: clinical trials

Chapter 20 Differential diagnosis with other rapid progressive dementias in human prion diseases
Publication date: 2018 Source:Handbook of Clinical Neurology, Volume 153 Author(s): Michael D. Geschwind, Katy Murray Prion diseases are unique in medicine as in humans they occur in sporadic, genetic, and acquired forms. The most common human prion disease is sporadic Creutzfeldt–Jakob disease (CJD), which commonly presents as a rapidly progressive dementia (RPD) with behavioral, cerebellar, extrapyramidal, and some pyramidal features, with the median survival from symptom onset to death of just a few months. Because human prion diseases, as well as other RPDs, are relatively rare, they can be difficult to diagnose, as...
Source: Handbook of Clinical Neurology - June 8, 2018 Category: Neurology Source Type: research

Urinary N-terminal fragment of titin is a marker to diagnose muscular dystrophy in patients with cardiomyopathy
Publication date: September 2018 Source:Clinica Chimica Acta, Volume 484 Author(s): Akiomi Yoshihisa, Takatoyo Kiko, Takamasa Sato, Masayoshi Oikawa, Atsushi Kobayashi, Yasuchika Takeishi The differential diagnosis of cardiomyopathy is important. It has been recently reported that urinary titin N (U-TN) is increased in patients with muscular dystrophy (MD), and is associated with muscular damage. We aimed to clarify whether U-TN is useful as a diagnostic tool for distinguishing MD from various cardiomyopathies [e.g. dilated cardiomyopathy (DCM), hypertrophic cardiomyopathy (HCM)]. We measured and compared the U-TN/creatin...
Source: Clinica Chimica Acta - June 7, 2018 Category: Laboratory Medicine Source Type: research

What rheumatologists can learn from ophthalmologists.
Abstract Intraocular inflammation with the imprecise and broad umbrella term "uveitis" is a diagnostic and therapeutic challenge in ophthalmology. Uveitis is one of the most common causes of blindness worldwide and due to the associated costs is comparable to diabetic retinopathy. Patients can be affected by uveitis at any age. Any part of the eye may be affected. The symptoms range from complete absence of symptoms, through all types of vision deterioration up to a red and even very painful eye. Uveitis can be strictly unilateral (also alternating from the left to the right eye) or bilateral with a relapsing o...
Source: Zeitschrift fur Rheumatologie - June 7, 2018 Category: Rheumatology Authors: Becker MD, Max R, Dimitriou A, Saurenmann T, Lorenz HM, Jansen A, Lortz S, Grulich-Henn J, Weber M Tags: Z Rheumatol Source Type: research

Muscular sarcoidosis under anti-TNF treatment in ankylosing spondylitis
Publication date: Available online 19 May 2018 Source:Joint Bone Spine Author(s): Daniel Wendling, Jean-Philippe Nueffer
Source: Joint Bone Spine - June 6, 2018 Category: Orthopaedics Source Type: research

Thyroid Gland < sup > 18 < /sup > F-FDG Uptake in Neurofibromatosis Type 1
Conclusion: Even though NF1 patients did not show an increased risk of thyroid incidentaloma on PET/CT compared to previous studies on non-thyroid cancer patients, the incidence shows that awareness of possible thyroid disease is important.Eur Thyroid J
Source: European Thyroid Journal - June 5, 2018 Category: Endocrinology Source Type: research

The Etiology of Intraocular Inflammation in HIV Positive and HIV Negative Adults at a Tertiary Hospital in Cape Town, South Africa.
CONCLUSION: Infectious uveitis is common in South Africa, especially amongst HIV+ patients. Causes of anterior and panuveitis differ between HIV+ and HIV- patients. PMID: 29847196 [PubMed - as supplied by publisher]
Source: Ocular Immunology and Inflammation - June 4, 2018 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

The Odd Gallbladder —a Rare Case of Gallbladder and Lymph Node Sarcoidosis: a Case Report and Review of the Literature
Source: Journal of Gastrointestinal Cancer - June 2, 2018 Category: Cancer & Oncology Source Type: research

Urinary N-terminal fragment of titin is a marker to diagnose muscular dystrophy in patients with cardiomyopathy.
Abstract The differential diagnosis of cardiomyopathy is important. It has been recently reported that urinary titin N (U-TN) is increased in patients with muscular dystrophy (MD), and is associated with muscular damage. We aimed to clarify whether U-TN is useful as a diagnostic tool for distinguishing MD from various cardiomyopathies [e.g. dilated cardiomyopathy (DCM), hypertrophic cardiomyopathy (HCM)]. We measured and compared the U-TN/creatinine ratio (U-TN/Cr; pmol/mg/dl) in 278 control subjects and 331 patients with various cardiomyopathies (DCM, n = 199; sarcoidosis, n = 18; HCM, n = 86; amyloid...
Source: International Journal of Clinical Chemistry - June 2, 2018 Category: Chemistry Authors: Yoshihisa A, Kiko T, Sato T, Oikawa M, Kobayashi A, Takeishi Y Tags: Clin Chim Acta Source Type: research

Respiratory muscle involvement in sarcoidosis.
Authors: Schreiber T, Windisch W Abstract INTRODUCTION: In sarcoidosis, muscle involvement is common, but mostly asymptomatic. Currently, little is known about respiratory muscle and diaphragm involvement and function in patients with sarcoidosis. Reduced inspiratory muscle strength and/or a reduced diaphragm function may contribute to exertional dyspnea, fatigue and reduced health-related quality of life. Previous studies using volitional and non-volitional tests demonstrated a reduced inspiratory muscle strength in sarcoidosis compared to control subjects, and also showed that respiratory muscle function may even...
Source: Expert Review of Respiratory Medicine - June 1, 2018 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Bilateral Cicatrizing Conjunctivitis in a Middle-aged Man
A 53-year-old man with multiorgan sarcoid presented with chronic ocular irritation and bilateral trichiasis of the lower eyelids with scarring of the inferior fornices and symplepharon, but no evidence of intraocular involvement of sarcoid. What would you do next?
Source: JAMA Ophthalmology - June 1, 2018 Category: Opthalmology Source Type: research

Importance of Early Diagnosis of Cardiac Sarcoidosis in Patients with Complete Atrioventricular Block.
Authors: Kaida T, Inomata T, Minami Y, Yazaki M, Fujita T, Iida Y, Ikeda Y, Nabeta T, Ishii S, Naruke T, Maekawa E, Koitabashi T, Ako J Abstract Our aim is to clarify the factors for early diagnosis of cardiac sarcoidosis (CS) in patients with complete atrioventricular block (CAVB) and its impact on cardiac function after corticosteroid therapy.A total of 15 CS patients with CAVB who underwent corticosteroid therapy were retrospectively analyzed. Patients were divided into two groups according to the time from the first CAVB onset to the diagnosis of CS. Clinical characteristics and outcomes were compared between t...
Source: International Heart Journal - May 30, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

A Sarcoidosis Clinician's Perspective of MHC Functional Elements Outside the Antigen Binding Site.
Abstract Sarcoidosis is a multisystem granulomatous disease of unknown cause. Evidence supports an integral role for interactions at the MHC binding site in the development of sarcoidosis. However, despite this evidence, there are clinical data that suggest that additional mechanisms are involved in the immunopathogenesis of this disease. This manuscript provides a brief clinical description of sarcoidosis, and a clinician's perspective of the immunopathogenesis of sarcoidosis in terms of the MHC binding site, MHC functional elements beyond the binding site, and other possible alternative mechanisms. Input from cl...
Source: Human Immunology - May 30, 2018 Category: Allergy & Immunology Authors: Judson MA Tags: Hum Immunol Source Type: research

Prognostic significance of ventricular late potentials in patients with pulmonary sarcoidosis
Early detection of cardiac involvement in sarcoidosis is difficult but essential to achieve optimal treatment. Signal-averaged electrocardiography (SAECG) can detect subtle cardiac electrical abnormalities termed late potentials (LPs) and would be useful for the early diagnosis of cardiac involvement.
Source: Heart Rhythm - May 29, 2018 Category: Cardiology Authors: Kenji Yodogawa, Yoshihiko Seino, Toshihiko Ohara, Yu-ki Iwasaki, Meiso Hayashi, Yasushi Miyauchi, Arata Azuma, Wataru Shimizu Tags: Featured Article Source Type: research

Tattoo ‐associated uveitis with or without systemic sarcoidosis: a comparative review of the literature
Journal of the European Academy of Dermatology and Venereology, EarlyView.
Source: Journal of the European Academy of Dermatology and Venereology - May 29, 2018 Category: Dermatology Authors: N. Kluger Source Type: research

Sarcoidosis with multiple organ involvement
Clinical Case Reports, EarlyView.
Source: Clinical Case Reports - May 29, 2018 Category: General Medicine Authors: Yve Mendes Rodrigues , Gl áucia Zanetti , Edson Marchiori Source Type: research

Tattoo ‐associated uveitis with or without systemic sarcoidosis: a comparative review of the literature
Journal of the European Academy of Dermatology and Venereology, EarlyView.
Source: Journal of the European Academy of Dermatology and Venereology - May 29, 2018 Category: Dermatology Authors: N. Kluger Source Type: research

Three Cases of Scalp Sarcoidosis with Alopecia.
PMID: 29857946 [PubMed - as supplied by publisher]
Source: Actas Dermo-Sifiliograficas - May 29, 2018 Category: Dermatology Authors: Ishikawa M, Ohtsuka M, Yamamoto T Tags: Actas Dermosifiliogr Source Type: research

Unusual presentation of a skull base mass lesion in sarcoidosis mimicking malignant neoplasm: a case report
Sarcoidosis is a multi-organ disease of unknown etiology characterised by the presence of epithelioid granulomas, without caseous necrosis. Systemic sarcoidosis is rare among children, while neurosarcoidosis i...
Source: BMC Neurology - May 29, 2018 Category: Neurology Authors: Katsunori Shijo, Nobuhiro Moro, Mari Sasano, Mitsuru Watanabe, Hiroshi Yagasaki, Shori Takahashi, Taku Homma and Atsuo Yoshino Tags: Case report Source Type: research

Sarcoidosis: when the initial manifestations are musculoskeletal symptoms
Abstract The recent association between the increase in the number of neonates with microcephaly in northeastern Brazil and the outbreak of infection with the Zika virus, which has been occurring in the Americas, has been declared a public health emergency of international concern. The evidence that implicates the virus as the cause of this public health emergency has been demonstrated ever more consistently. This pictorial essay illustrates the imaging characteristics seen on computed tomography and magnetic resonance imaging scans of infants admitted to a rehabilitation hospital with a diagnosis of microcephaly and a mat...
Source: Radiologia Brasileira - May 28, 2018 Category: Radiology Source Type: research

IJERPH, Vol. 15, Pages 1077: Short-Term Particulate Air Pollution Exposure is Associated with Increased Severity of Respiratory and Quality of Life Symptoms in Patients with Fibrotic Sarcoidosis
This study aimed to determine if short-term exposure to particulate matter (PM2.5) and ozone (O3) is associated with increased symptoms or lung function decline in fibrotic sarcoidosis. Sixteen patients with fibrotic sarcoidosis complicated by frequent exacerbations completed pulmonary function testing and questionnaires every three months for one year. We compared 7-, 10-, and 14-day average levels of PM2.5 and O3 estimated at patient residences to spirometry (forced expiratory volume in 1 s (FEV1), to forced vital capacity (FVC), episodes of FEV1 decline &amp;gt; 10%) and questionnaire outcomes (Leicester cough quest...
Source: International Journal of Environmental Research and Public Health - May 26, 2018 Category: Environmental Health Authors: Cheryl S. Pirozzi Daniel L. Mendoza Yizhe Xu Yue Zhang Mary Beth Scholand Robert P. Baughman Tags: Article Source Type: research