Rhabdomyosarcoma Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Primary Alveolar Rhabdomyosarcoma of the Thyroid: A Case Report
We present the case of an adolescent who presented with a neck mass and suffered rapid deterioration. Establishment of final diagnosis was possible only because of a skilfully performed pathological examination which revealed a thyroid gland rhabdomyosarcoma. An alveolar variety of rhabdomyosarcoma presenting in the thyroid gland is extremely rare. To the best of our knowledge, only two cases of the aforementioned are documented as yet. Through this report, we aim at highlighting the possibility of such an occurrence and vigilance on part of the treating surgeon so that timely intervention can be instituted. (Source: India...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - April 12, 2024 Category: ENT & OMF Source Type: research

NF1 -Driven Rhabdomyosarcoma Phenotypes: A Comparative Clinical and Molecular Study of NF1 -Mutant Rhabdomyosarcoma and NF1 -Associated Malignant Triton Tumor
CONCLUSION: Patients with NF1-mutant ERMS lacking TP53 alterations may benefit from dose-reduction chemotherapy. On the basis of the diagnostic challenges and significant treatment and prognostic differences, molecular profiling of challenging tumors with rhabdomyoblastic differentiation is recommended.PMID:38603649 | DOI:10.1200/PO.23.00597 (Source: Cancer Control)
Source: Cancer Control - April 11, 2024 Category: Cancer & Oncology Authors: Henry de Traux de Wardin Josephine K Dermawan Fabio Vanoli Samuel C Jiang Samuel Singer Ping Chi William Tap Leonard H Wexler Cristina R Antonescu Source Type: research

Paratesticular spindle cell rhabdomyosarcoma: A case report
Asian J Surg. 2024 Apr 10:S1015-9584(24)00607-9. doi: 10.1016/j.asjsur.2024.03.180. Online ahead of print.NO ABSTRACTPMID:38604842 | DOI:10.1016/j.asjsur.2024.03.180 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 11, 2024 Category: Surgery Authors: Yifei Hong Tongtong Wang Li Li Source Type: research

Brachytherapy for rhabdomyosarcoma: Survey of international clinical practice and development of guidelines
CONCLUSIONS: Consensus guidelines for the use of brachytherapy in pediatric rhabdomyosarcoma have been developed through multicenter collaboration establishing the basis for future work. These have been adopted for the open EpSSG overarching study for children and adults with Frontline and Relapsed RhabdoMyoSarcoma (FaR-RMS).PMID:38588921 | DOI:10.1016/j.radonc.2024.110273 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 8, 2024 Category: Radiology Authors: Raquel D ávila Fajardo Giovanni Scarzello Mark N Gaze Tom Boterberg Alison Cameron Joerg Fuchs Florent Gu érin Peter Hoskin Matthew J Krasin Petra Kroon Henriette Magelssen Claes Mercke Johannes H M Merks Frank Paulsen Pascal Pommier Monica Ramos Helen Source Type: research

Integration of pan-cancer cell line and single-cell transcriptomic profiles enables inference of therapeutic vulnerabilities in heterogeneous tumors
Cancer Res. 2024 Apr 6. doi: 10.1158/0008-5472.CAN-23-3005. Online ahead of print.ABSTRACTSingle-cell RNA-sequencing (scRNA-seq) greatly advanced the understanding of intratumoral heterogeneity by identifying distinct cancer cell subpopulations. However, translating biological differences into treatment strategies is challenging due to a lack of tools to facilitate efficient drug discovery that tackles heterogeneous tumors. Developing such approaches requires accurate prediction of drug response at the single-cell level to offer therapeutic options to specific cell subpopulations. Here, we developed a transparent computati...
Source: Cell Research - April 6, 2024 Category: Cytology Authors: Weijie Zhang Danielle Maeser Adam Lee Yingbo Huang Robert F Gruener Israa G Abdelbar Sampreeti Jena Anand G Patel R Stephanie Huang Source Type: research

Brachytherapy for rhabdomyosarcoma: Survey of international clinical practice and development of guidelines
Brachytherapy can be a highly effective treatment with very limited morbidity for some carefully selected children with rhabdomyosarcoma (RMS). However, access may be limited by the need for highly specialized experienced teams that are needed to deliver the service [1]. RMS is the most common soft tissue sarcoma of childhood, accounting for around 3.5  % of all malignant diseases in children [2,3]. RMS derives from embryonal mesenchyme and can arise at almost any anatomical site. Current multimodal treatment strategies including chemotherapy, surgery, and radiotherapy achieve an overall 5-year survival rate of 80 % [4...
Source: Radiotherapy and Oncology - April 6, 2024 Category: Radiology Authors: Raquel D ávila Fajardo, Giovanni Scarzello, Mark N Gaze, Tom Boterberg, Alison Cameron, Joerg Fuchs, Florent Guérin, Peter Hoskin, Matthew J Krasin, Petra Kroon, Henriette Magelssen, Claes Mercke, Johannes H.M. Merks, Frank Paulsen, Pascal Pommier, Moni Tags: Original Article Source Type: research

Rare Glottic Pleomorphic Rhabdomyosarcoma: A Case Report with Review of Literature
This report highlights a case of rare pleomorphic rhabdomyosarcoma of glottis in a 67-year-old male who presented with hoarseness and a description of its management. (Source: Indian Journal of Otolaryngology and Head and Neck Surgery)
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - April 6, 2024 Category: ENT & OMF Source Type: research

TRIB3 silencing promotes the downregulation of Akt pathway and PAX3-FOXO1 in high-risk rhabdomyosarcoma
In this study, the main aim was to address this challenge by investigating regulators of FOXO1. Specifically, we focused on TRIB3, a potential regulator of the fusion protein in RMS. Our findings revealed a prominent TRIB3 expression in RMS tumors, highlighting its correlation with the presence of fusion protein. By conducting TRIB3 genetic inhibition experiments, we observed an impairment on cell proliferation. Notably, the knockdown of TRIB3 led to a decrease in PAX3-FOXO1 and its target genes at protein level, accompanied by a reduction in the activity of the Akt signaling pathway. Additionally, inducible silencing of T...
Source: Experimental Hematology and Oncology - April 5, 2024 Category: Cancer & Oncology Source Type: research

134. When You Hear Hooves, Do Not Forget the Zebras
We present a case of uterine ERS. Although the diagnosis is rare, this case serves as a reminder to keep a wide differential and not forget the zebras. (Source: Journal of Pediatric and Adolescent Gynecology)
Source: Journal of Pediatric and Adolescent Gynecology - April 1, 2024 Category: OBGYN Authors: Claudette Shephard, Laura Kebert Himel Source Type: research

113. Rare mutant-type DICER 1 embryonal rhabdomyosarcoma following precocious puberty and voice deepening: associations or red herrings?
DICER 1 mutant-type embryonal rhabdomyosarcoma (ERMS) is rare. It has been recently proposed as a unique subset of DICER 1 rhabdomyosarcomas, which commonly present as soft tissue malignancies in children. These tumor mutations can be associated with germline DICER 1 syndrome. There is a known association with this syndrome and androgenizing ovarian tumors. (Source: Journal of Pediatric and Adolescent Gynecology)
Source: Journal of Pediatric and Adolescent Gynecology - April 1, 2024 Category: OBGYN Authors: Laura Rekedal, Amy Williamson Source Type: research

Clinical and histopathological spectrum of cranial small round cell tumors: An experience from a tertiary care center
CONCLUSIONS: SRCTs have a variable age of presentation. Their incidence in CNS is low as compared to other organ systems. On light microscopy, the histopathology of these lesions is overlapping, posing a great diagnostic dilemma for the pathologist. The use of ancillary techniques like immunohistochemistry helps in arriving at the correct diagnosis. Treatment strategy and tumor prognosis also vary along the entire spectrum of SRCT, thus making exact characterization essential for proper management.PMID:38554327 | DOI:10.4103/jcrt.jcrt_383_22 (Source: Cell Research)
Source: Cell Research - March 30, 2024 Category: Cytology Authors: Pooja Gupta Fouzia Siraj K B Shankar Manish Rawat Dipanker S Mankotia Vivek Yadav Amit Dagar Source Type: research