Comprehensive autoantibody profiling in systemic autoimmunity by a highly-sensitive multiplex protein array
Comprehensive autoantibody evaluation is essential for the management of autoimmune disorders. However, conventional methods suffer from poor sensitivity, low throughput, or limited availability. Here, using a proteome-wide human cDNA library, we developed a novel multiplex protein assay (autoantibody array assay; A-Cube) covering 65 antigens of 43 autoantibodies that are associated with systemic sclerosis (SSc) and polymyositis/dermatomyositis (PM/DM). The performance of A-Cube was validated against immunoprecipitation and established enzyme-linked immunosorbent assay. Further, through an evaluation of serum samples from ...
Source: Frontiers in Immunology - August 28, 2023 Category: Allergy & Immunology Source Type: research
Clinical implications and mechanism of complement C1q in polymyositis
Appl Biochem Biotechnol. 2023 Aug 25. doi: 10.1007/s12010-023-04692-7. Online ahead of print.ABSTRACTPolymyositis (PM) is the most common autoimmune disease in neurology and among muscle disorders; it is of great significance to thoroughly understand the mechanism of PM to find new diagnosis and treatment methods. This research intends to elucidate the clinical implications and mechanisms of complement C1q in polymyositis (PM). One hundred fifteen PM patients (research group, RG) and 120 healthy subjects (control group, CG) who visited our hospital between March 2017 and March 2020 were selected. Peripheral blood C1q and c...
Source: Applied Biochemistry and Biotechnology - August 25, 2023 Category: Biochemistry Authors: Di Wu Yan Cui Yujia Cao Yanjuan Wang Jinhua Zhang Yijing Guo Baoyu Yuan Source Type: research
Clinical implications and mechanism of complement C1q in polymyositis
Appl Biochem Biotechnol. 2023 Aug 25. doi: 10.1007/s12010-023-04692-7. Online ahead of print.ABSTRACTPolymyositis (PM) is the most common autoimmune disease in neurology and among muscle disorders; it is of great significance to thoroughly understand the mechanism of PM to find new diagnosis and treatment methods. This research intends to elucidate the clinical implications and mechanisms of complement C1q in polymyositis (PM). One hundred fifteen PM patients (research group, RG) and 120 healthy subjects (control group, CG) who visited our hospital between March 2017 and March 2020 were selected. Peripheral blood C1q and c...
Source: Applied Biochemistry and Biotechnology - August 25, 2023 Category: Biochemistry Authors: Di Wu Yan Cui Yujia Cao Yanjuan Wang Jinhua Zhang Yijing Guo Baoyu Yuan Source Type: research
Pyomyositis Secondary to Localized Cellulitis in a Dermatomyositis Patient: A Case Report and Review of Infectious Complications in Dermatomyositis
Clin Cosmet Investig Dermatol. 2023 Aug 11;16:2201-2209. doi: 10.2147/CCID.S417772. eCollection 2023.ABSTRACTDermatomyositis (DM) is an autoimmune disorder characterized by proximal muscle weakness and distinct cutaneous features. Unfortunately, infection is a frequent and potentially life-threatening complication in patients with DM. Here, we present a case of pyomyositis in a patient with DM resulting from localized cellulitis. The patient also presented with subcutaneous calcification nodules and dermatomyositis-associated lipodermatosclerosis nodules. To our knowledge, there have been no reports of pyomyositis in patie...
Source: Clinical, Cosmetic and Investigational Dermatology - August 17, 2023 Category: Dermatology Authors: Xingwei Zhang Xiaoyan Lyu Source Type: research
A case report of polymyositis accompanied by Raynaud's phenomenon
Asian J Surg. 2023 Aug 1:S1015-9584(23)01004-7. doi: 10.1016/j.asjsur.2023.07.020. Online ahead of print.NO ABSTRACTPMID:37537038 | DOI:10.1016/j.asjsur.2023.07.020 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - August 3, 2023 Category: Surgery Authors: Xiaokai Duan Shuhan Yang Limin Zhao Source Type: research
Subcutaneous Edema in Polymyositis and Dermatomyositis
Intern Med. 2023;62(15):2161-2162. doi: 10.2169/internalmedicine.1199-22. Epub 2023 Aug 1.NO ABSTRACTPMID:37532512 | DOI:10.2169/internalmedicine.1199-22 (Source: Internal Medicine)
Source: Internal Medicine - August 2, 2023 Category: Internal Medicine Authors: Ryusuke Yoshimi Hideaki Nakajima Source Type: research
Differences in muscle magnetic resonance imaging findings between anti-signal recognition particle antibody-positive myopathy and anti-aminoacyl-tRNA synthetase antibody-positive myositis
CONCLUSIONS: A comparison of thigh MRI between anti-SRP myopathy and anti-ARS myositis showed different findings and lesion sites reflecting the different pathophysiology that may contribute to their diagnosis.PMID:37497714 | DOI:10.55563/clinexprheumatol/fjfkfs (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - July 27, 2023 Category: Rheumatology Authors: Masatoshi Kimura Ayako Aizawa Risa Kudou Yuki Rikitake Chihiro Iwao Mao Rikitake Kousho Iwao Yumi Kariya Takeshi Kawaguchi Motohiro Matsuda Shunichi Miyauchi Ichiro Takajo Kunihiko Umekita Source Type: research
