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Which psychological and psychosocial constructs are important to measure in future tendinopathy clinical trials? A modified international Delphi study with expert clinician/researchers and people with tendinopathy
J Orthop Sports Phys Ther. 2023 Sep 20:1-29. doi: 10.2519/jospt.2023.11903. Online ahead of print.ABSTRACTOBJECTIVE: to identify which psychological and psychosocial constructs to include in a core outcome set to guide future clinical trials in the tendinopathy field. DESIGN: modified International Delphi study. METHODS: In three online Delphi rounds, we presented 35 psychological and psychosocial constructs to an international panel of 38 clinician/researchers and people with tendinopathy. Using a 9-point Likert scale (1 - not important to include, 9 -critical to include), consensus for construct inclusion required ≥70%...
Source: Physical Therapy - September 20, 2023 Category: Physiotherapy Authors: Carl Stubbs Sean Mc Auliffe Ruth L Chimenti Brooke K Coombes Terry Haines Luke Heales Robert-Jan de Vos Greg Lehman Adrian Mallows Lori A Michner Neal B W Millar Seth O'Neill Kieran O'Sullivan Melanie Plinsinga Michael Rathleff Ebonie Rio Megan Ross Jean- Source Type: research

Relevance of complementary treatment options in pain therapy
Schmerz. 2023 Oct;37(5):314-318. doi: 10.1007/s00482-023-00750-5. Epub 2023 Sep 20.NO ABSTRACTPMID:37728708 | DOI:10.1007/s00482-023-00750-5
Source: Schmerz - September 20, 2023 Category: Anesthesiology Authors: Stefanie Liv Jahn Marc Werner Jens Broscheit Source Type: research

The composition, pharmacological effects, related mechanisms and drug delivery of alkaloids from Corydalis yanhusuo
Biomed Pharmacother. 2023 Sep 18;167:115511. doi: 10.1016/j.biopha.2023.115511. Online ahead of print.ABSTRACTCorydalis yanhusuo W. T. Wang, also known as yanhusuo, yuanhu, yanhu and xuanhu, is one of the herb components of many Chinese Traditional Medicine prescriptions such as Jin Ling Zi San and Yuanhu-Zhitong priscription. C. yanhusuo was traditionally used to relieve pain and motivate blood and Qi circulation. Now there has been growing interest in pharmacological effects of alkaloids, the main bioactive components of C. yanhusuo. Eighty-four alkaloids isolated from C. yanhusuo are its important bioactive components a...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 20, 2023 Category: Drugs & Pharmacology Authors: Jia-Hua Feng Kang Chen Si-Yu Shen Yun-Feng Luo Xi-Hong Liu Xin Chen Wei Gao Yu-Ru Tong Source Type: research

Pain management for liver transplant recipients
We present current evidence-based literature that reviews optimal pain management strategies for this challenging patient demographic.RECENT FINDINGS: Multiple studies have shown that thoracic epidurals provide superior pain control in open hepatic resections. Recent data suggests thoracic epidurals may be safely considered in select liver transplant recipients with normal preoperative coagulation status; however, this evidence is limited, and further studies are needed. When the risks of coagulopathy prohibit epidural placement, truncal blocks such as transversus abdominis plane blocks or quadratus lumborum blocks and abd...
Source: Current Opinion in Organ Transplantation - September 20, 2023 Category: Transplant Surgery Authors: Simrat Kaur Patrick Henthorn Adrian Hendrickse Source Type: research

Sigma-1 receptor agonism exacerbates immune-driven nociception: Role of TRPV1  + nociceptors
Biomed Pharmacother. 2023 Sep 18;167:115534. doi: 10.1016/j.biopha.2023.115534. Online ahead of print.ABSTRACTThe analgesic effects of sigma-1 antagonists are undisputed, but the effects of sigma-1 agonists on pain are not well studied. Here, we used a mouse model to show that the administration of the sigma-1 agonists dextromethorphan (a widely used antitussive drug), PRE-084 (a standard sigma-1 ligand), and pridopidine (a selective drug being investigated in clinical trials for the treatment of neurodegenerative diseases) enhances PGE2-induced mechanical hyperalgesia. Superficial plantar incision induced transient weight...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 20, 2023 Category: Drugs & Pharmacology Authors: M Carmen Ruiz-Cantero Miguel Á Huerta Miguel Á Tejada Miriam Santos-Caballero Eduardo Fern ández-Segura Francisco J Ca ñizares Jos é M Entrena Jos é M Baeyens Enrique J Cobos Source Type: research

Effect of transversus abdominis plane block on postoperative outcomes in gynecologic oncology patients managed on an Enhanced Recovery After Surgery pathway
CONCLUSIONS: Surgeon-administered TAP blocks were associated with decreased length of stay and post-operative opioid use in patients not receiving scheduled NSAIDs. This decrease in opioid use was not associated with any increase in average or maximum pain scores.PMID:37729808 | DOI:10.1016/j.ygyno.2023.09.003
Source: Gynecologic Oncology - September 20, 2023 Category: Cancer & Oncology Authors: Kristin A Black Gregg Nelson Natalie Goucher Joshua Foley Sophia Pin Michael Chong Sunita Ghosh Steven P Bisch Source Type: research

miRNA contributes to neuropathic pains
Int J Biol Macromol. 2023 Sep 18:126893. doi: 10.1016/j.ijbiomac.2023.126893. Online ahead of print.ABSTRACTNeuropathic pain (NP) is a kind of chronic pain caused by direct injury to the peripheral or central nervous system (CNS). microRNAs (miRNAs) are small noncoding RNAs that mostly interact with the 3 untranslated region of messenger RNAs (mRNAs) to regulate the expression of multiple genes. NP is characterized by changes in the expression of receptors and mediators, and there is evidence that miRNAs may contribute to some of these alterations. In this review, we aimed to fully comprehend the connection between NP and ...
Source: International Journal of Biological Macromolecules - September 20, 2023 Category: Biochemistry Authors: Reyhaneh Vali Ali Azadi Ashkan Tizno Tahereh Farkhondeh Fariborz Samini Saeed Samarghandian Source Type: research

VEIN STEP: A Prospective, Observational, International Study to Assess Effectiveness of Conservative Treatments in Chronic Venous Disease
CONCLUSION: In this prospective study conducted in the real-world setting, treatment with conservative therapy, in particular MPFF, was associated with meaningful improvements in the clinical signs and symptoms of disease as well as in quality of life in patients with CVD.TRIAL REGISTRATION: ClinicalTrials.gov identifier NCT04574375.PMID:37728696 | DOI:10.1007/s12325-023-02643-6
Source: Adv Data - September 20, 2023 Category: Epidemiology Authors: Zoubida Tazi Mezalek Toni Feodor Larisa Chernukha Zhong Chen Ana Rueda Ignacio Escotto S ánchez Alejandro Jos é González Ochoa Joanna Chirol Vanessa Blanc-Guillemaud Caroline Lohier-Durel Jorge Hernando Ulloa Source Type: research

Synchronous rectal adenocarcinoma and intestinal mantle cell lymphoma: A case report
CONCLUSION: Synchronous rectal adenocarcinoma and intestinal MCL presenting as multiple lymphomatous polyposis are extremely rare. MCL is often discovered fortuitously when rectal cancer is diagnosed. The coexistence of these tumors poses treatment challenges.PMID:37727717 | PMC:PMC10506007 | DOI:10.12998/wjcc.v11.i24.5772
Source: Clinical Colorectal Cancer - September 20, 2023 Category: Cancer & Oncology Authors: Kim-Van Vu Nguyen-Van Trong Nguyen-Thi Khuyen Do Huyen Nga Hoang Anh Nguyen Tien Trung Pham Trung Thong Nguyen Minh Duc Source Type: research

Microfragmented adipose tissue in the treatment of a full-thickness supraspinatus tear: a case report
Regen Med. 2023 Sep 20. doi: 10.2217/rme-2023-0086. Online ahead of print.ABSTRACTA 70-year-old female presented with an 8-month history of right anterior shoulder pain and weakness, unresolved with conservative management. Among other shoulder pathology, the patient was diagnosed with a full-thickness supraspinatus tear and elected to proceed with the microfragmented adipose tissue procedure to treat the injured tendon and nearby relevant structures. Improvements in pain and function were documented along with progressive healing of the supraspinatus on ultrasound and MRI following the procedure. This case demonstrates th...
Source: Regenerative Medicine - September 20, 2023 Category: Genetics & Stem Cells Authors: John L Ferrell Alanna Dodson Joshua Martin Source Type: research

Neural mechanisms of priming effects of spicy food pictures induced analgesia
In this study, the effects of the priming of spicy food pictures on pain perception were evaluated in female participants using standardized methods of pain. Results from behavior tests revealed that the priming of spicy food pictures significantly reduced pain perception, particularly at high-pain intensities. Electrophysiological analysis showed that the analgesic effects of spicy food pictures were linked to decreased pain-related event-related potentials, such as N2 and P2 amplitudes, and suppressed θ-oscillations in the sensorimotor cortex. Both N2 amplitudes and θ-oscillations activities were found to be correlated...
Source: Biological Psychology - September 20, 2023 Category: Psychiatry & Psychology Authors: Di Yang Jin Jiang Wanchen Li Runjie Zhang Luzhuang Sun Jing Meng Source Type: research

Asylum seekers' self-reported health conditions in Rio de Janeiro, Brazil, from 2010 to 2017
This study aimed to analyze the self-reported health conditions of asylum seekers in the municipality of Rio de Janeiro from 2010 to 2017. This is a cross-sectional study with secondary data. Data were collected from asylum application forms at the Brazilian National Committee for Refugees (Conare) from 2010 to 2017 and from social interviews in the Archdiocesan Caritas of Rio de Janeiro (Cáritas/RJ). The prevalence rates of health conditions, their respective 95% confidence intervals (95%CI) and odds ratio (OR) were calculated in a simple logistic regression model according to sociodemographic and migration variables. Th...
Source: Cadernos de Saude Publica - September 20, 2023 Category: International Medicine & Public Health Authors: Raquel Proen ça Jo ão Roberto Cavalcante Anete Trajman Eduardo Faerstein Source Type: research

Moderately severe acute pancreatitis after snake bite: a case report from Southern China
In this report, we presented a rare case of moderately severe acute pancreatitis caused by snake venom even after prompt antivenom treatment. The patient was relieved, obviously, with effective treatment of acute pancreatitis and was discharged without severe complications. Although acute pancreatitis after snake bite is a rarity, its serious complications and lethality still deserve our utmost attention, and timely and standardized treatment of acute pancreatitis is needed in addition to antivenom treatment.PMID:37729941 | DOI:10.1055/a-2150-2291
Source: Zeitschrift fur Gastroenterologie - September 20, 2023 Category: Gastroenterology Authors: Ronglai Cao Jinli He Zhengping Yu Youxiang Chen Liang Zhu Source Type: research

Discharge prescribing and subsequent opioid use after traumatic musculoskeletal injury
CONCLUSIONS: After surgery for musculoskeletal injury, patients discharged by residents who prescribe greater supplies of opioid pain medications received higher supplies of opioids 7 to 8 months after surgery than patients discharged by residents who tend to prescribe less. Thus, limiting postoperative supplies of opioid pain medication may help reduce chronic opioid use.PMID:37729527 | DOI:10.37765/ajmc.2023.89424
Source: The American Journal of Managed Care - September 20, 2023 Category: Health Management Authors: Matthew F Basilico Abhiram R Bhashyam Emma K Harrington Monica Bharel J Michael McWilliams Marilyn Heng Source Type: research

Which psychological and psychosocial constructs are important to measure in future tendinopathy clinical trials? A modified international Delphi study with expert clinician/researchers and people with tendinopathy
J Orthop Sports Phys Ther. 2023 Sep 20:1-29. doi: 10.2519/jospt.2023.11903. Online ahead of print.ABSTRACTOBJECTIVE: to identify which psychological and psychosocial constructs to include in a core outcome set to guide future clinical trials in the tendinopathy field. DESIGN: modified International Delphi study. METHODS: In three online Delphi rounds, we presented 35 psychological and psychosocial constructs to an international panel of 38 clinician/researchers and people with tendinopathy. Using a 9-point Likert scale (1 - not important to include, 9 -critical to include), consensus for construct inclusion required ≥70%...
Source: Health Physics - September 20, 2023 Category: Physics Authors: Carl Stubbs Sean Mc Auliffe Ruth L Chimenti Brooke K Coombes Terry Haines Luke Heales Robert Jan Vos Greg Lehman Adrian Mallows Lori A Michner Neal B W Millar Seth O'Neill Kieran O'Sullivan Melanie Plinsinga Michael Rathleff Ebonie Rio Megan Ross Jean-Seb Source Type: research