Long Lost Medieval Graveyard With Over 1,300 Bodies Reveals Mutation Mystery
An ancient graveyard holding over 1,300 medieval bodies has revealed a bone mutation mystery. Scientists from Queen's University Belfast and Trinity College Dublin discovered that two men, hidden within the graveyard at Ballyhanna, suffered from a condition called multiple osteochondromas, which…#iseultjackson #irish #europeanjournalofhumangenetics #trinitycollegedublin #discovery #ireland #viasciencenewsweekcom #danbradley #queensuniversity #countydonegal (Source: Reuters: Health)
Source: Reuters: Health - December 6, 2022 Category: Consumer Health News Source Type: news

Radiological Case: Rib Osteochondromas Mimicking Lung Nodules Radiological Case: Rib Osteochondromas Mimicking Lung Nodules
What was the cause of intermittent right-sided chest pain in this 12-year-old with known hereditary exostoses?Applied Radiology (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - March 30, 2021 Category: Intensive Care Tags: Radiology Journal Article Source Type: news

How Common Are Bone Spurs in Young Athletes?
Discussion The terminology of abnormal calcification of soft tissues and uses of the terms is often muddied. Especially as the causes may be similar and multiple adjacent tissues may be involved. An exostosis is an abnormal proliferation of bone from the joint. They can appear in various forms and in many locations. An osteophyte is also known as a bone spur and is type of exostosis. Osteophytes are thought to be periosteal or synovial mesenchymal stems cells that become calcified. They usually have a more narrow or pointed projection from the joint. Osteophytes are a very common feature of osteoarthritis. Enthesophytes a...
Source: PediatricEducation.org - November 30, 2020 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Osteochondroma of the Distal Volar Thumb Osteochondroma of the Distal Volar Thumb
A patient presents with a boney mass on her right thumb. What did radiographic imaging reveal about this mass and how was it treated?ePlasty, Open Access Journal of Plastic Surgery (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 28, 2019 Category: Consumer Health News Tags: Plastic Surgery & Aesthetic Medicine Journal Article Source Type: news

Medical News Today: What to know about bone spurs
Exostosis is a bone spur or outgrowth from the surface of a bone. Exostosis can affect any bone, including the knee and heel of the foot. The spur can occur inside the skull, for example, in the mouth, sinuses, or ear canal where it is called surfer ’s ear. Hereditary exostoses can increase the risk of osteochondroma. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 16, 2018 Category: Consumer Health News Tags: Bones / Orthopedics Source Type: news

Preclinical study demonstrates promising treatment for rare bone disease
(Sanford-Burnham Prebys Medical Discovery Institute) Researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) have led a preclinical study demonstrating that the drug palovarotene suppresses the formation of bony tumors (osteochondromas) in models of multiple hereditary exostoses (MHE). The research, published in the Journal of Bone and Mineral Research, is an important step toward an effective pharmacological treatment for MHE, a rare genetic condition that affects about 1 in 50,000 people worldwide. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - November 20, 2017 Category: Biology Source Type: news

Snapping Scapula Syndrome
What is snapping scapula syndrome? Snapping scapula syndrome is a condition causing painful grinding, clicking or snapping of the shoulder blade (Figure 1). The shoulder joint itself is called the glenohumeral joint. The acromioclavicular joint is associated with shoulder separation. Snapping scapula occurs at the scapulothoracic joint and is different from other shoulder related problems (Figure 2). Over 1/3 of the shoulder movement occurs between the scapula and the thoracic cage. The shoulder blade serves as an anchor for the subscapularis and serratus anterior muscles (Figure 3). These muscles as well as the...
Source: Healthy Living - The Huffington Post - November 10, 2016 Category: Consumer Health News Source Type: news

Study identifies mechanisms underlying osteochondroma formation
(Journal of Clinical Investigation) In this issue of JCI Insight, Antonios Aliprantis and colleagues at Brigham and Women's Hospital and Harvard Medical School in Boston demonstrate that loss of the genes encoding nuclear factor of activated T cells c1 and c2 (known as NFATs) induce osteochondroma formation in mice. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 7, 2016 Category: Cancer & Oncology Source Type: news

Absence of specific enzyme in cartilage can lead to benign tumors in mice
Rhode Island Hospital researchers have found that the absence of the Shp-2 enzyme near specialized cartilage cells can lead to the development of multiple benign cartilage tumors in mice, a model that recapitulates the rare human tumor syndrome metachondromatosis. Shp2 is an enzyme in the cell that regulates the activity of other proteins and signaling pathways. Mice lacking Shp2 formed two types of tumors: enchondromas and osteochondromas, and also developed deformed joints. The study is published online in advance of print in the journal Nature... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - July 23, 2013 Category: Consumer Health News Tags: Bones / Orthopedics Source Type: news

RI Hospital: Absence of specific enzyme in cartilage can lead to benign tumors in mice
(Lifespan) Rhode Island Hospital researchers have found that the absence of the Shp-2 enzyme near specialized cartilage cells can lead to the development of multiple benign cartilage tumors in mice, a model that recapitulates the rare human tumor syndrome metachondromatosis. Shp2 is an enzyme in the cell that regulates the activity of other proteins and signaling pathways. Mice lacking Shp2 formed two types of tumors: enchondromas and osteochondromas, and also developed deformed joints. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 18, 2013 Category: Global & Universal Source Type: news