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Treatment of lupus nephritis: current paradigms and emerging strategies
Purpose of review: Lupus nephritis is the most common organ-threatening manifestation of lupus and continues to result in end-stage renal disease. This review describes the contemporary treatment of lupus nephritis as well as emerging therapeutic strategies. Recent findings: Lupus nephritis management consists of an initial (induction) phase and a maintenance (extended) phase in which steroids are used in combination with another immunosuppressive medication. Current treatments are incompletely effective and associated with substantial toxicity. Despite disappointing results of several recent trials, novel therapies targe...
Source: Current Opinion in Rheumatology - March 29, 2017 Category: Rheumatology Tags: CLINICAL THERAPEUTICS: Edited by W. Joseph McCune Source Type: research

Sirtuin 1 (Sirt1) Overexpression in BaF3 Cells Contributes to Cell Proliferation Promotion, Apoptosis Resistance and Pro-Inflammatory Cytokine Production.
CONCLUSIONS These results suggested that Sirt1 overexpression could promote BaF3 cell proliferation, inhibit apoptosis, and upregulate pro-inflammatory cytokines. The NF-κB pathway might be involved in these effects of Sirt1 on BaF3 cells, and Sirt1 might be a potential risk factor of SLE. PMID: 28346398 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 29, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Correlation between Epstein-Barr Virus Infection and Disease Activity of Systemic Lupus Erythematosus: a Cross-Sectional Study
Conclusion: The Epstein-Barr viral load in SLE patients with active disease was found to be markedly higher than in inactive cases. Thus, EBV may have an important role in the pathogenesis and activity of SLE. PMID: 28345840 [PubMed - as supplied by publisher] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - March 29, 2017 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Exploring the plasmatic platelet-activating factor acetylhydrolase activity in patients with anti-phospholipid antibodies.
CONCLUSIONS: PAF-AH plasmatic activity is particularly up-regulated in LAC+ and in aβ2GPI IgG+ patients, possibly representing an alternative prognostic biomarker for the therapeutic management of APS patients. PMID: 28341873 [PubMed] (Source: Atherosclerosis)
Source: Atherosclerosis - March 29, 2017 Category: Cardiology Authors: Fabris M, Cifù A, Pistis C, Siega-Ducaton M, Fontana DE, Giacomello R, Tonutti E, Curcio F Tags: Auto Immun Highlights Source Type: research

A second case of pericardial mesothelioma mimicking systemic lupus erythematosus in the literature in over 30 years: a case report
ConclusionsWe describe a rare case of pericardial mesothelioma in a patient with a clinical presentation compatible with lupus serositis. Clinicians should consider malignant mesothelioma in the differential diagnosis of pericardial effusion, especially when it is recurrent and not clearly explained by other causes. Cytological samples should always be obtained and, if imaging tools are suggestive for solid processes, histological confirmation is mandatory. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - March 29, 2017 Category: Journals (General) Source Type: research

Brief Report: Longitudinal Patterns of Response to Standard of Care Therapy for Systemic Lupus Erythematosus: Implications for Clinical Trial Design
ConclusionUse of sustained rather than landmark response may reduce high placebo response rates in SLE trials that continue aggressive standard of care. Further exploration to assess the power of this end point to improve discrimination between active and placebo arms is indicated. Lack of temporal stability in response highlights a potential weakness with shorter studies. Rates of response to standard of care are affected by the severity of the disease and the aggressiveness of background immunosuppressive treatments. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 29, 2017 Category: Rheumatology Authors: Mimi Kim, Joan Merrill, Kenneth Kalunian, Bevra Hahn, Anita Roach, Peter Izmirly, Tags: Systemic Lupus Erythematosus Source Type: research

Effects of Hydroxychloroquine in Patients With Cutaneous Lupus Erythematosus: A Multicenter, Double ‐Blind, Randomized, Parallel‐Group Trial
ConclusionThe results of this randomized clinical trial support the efficacy and tolerability of HCQ in patients with CLE. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 29, 2017 Category: Rheumatology Authors: N. Yokogawa, H. Eto, A. Tanikawa, T. Ikeda, K. Yamamoto, T. Takahashi, H. Mizukami, T. Sato, N. Yokota, F. Furukawa Tags: Systemic Lupus Erythematosus Source Type: research

Brief Report: CD4+ T Cells From Patients With Systemic Lupus Erythematosus Respond Poorly to Exogenous Interleukin ‐2
ConclusionThese data suggest that altered IL‐2 production, as well as impaired IL‐2–mediated signaling and proliferative responses, characterize SLE CD4+ T cells. Our data demonstrate the need for caution in designing IL‐2 treatment trials for patients with SLE. Approaches to restore CD4+ T cell sensitivity to IL‐2 should be considered. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 29, 2017 Category: Rheumatology Authors: Denis Comte, Maria P. Karampetsou, Katalin Kis ‐Toth, Nobuya Yoshida, Sean J. Bradley, Vasileios C. Kyttaris, George C. Tsokos Tags: Systemic Lupus Erythematosus Source Type: research

Ultraviolet B Irradiation Causes Stimulator of Interferon Genes –Dependent Production of Protective Type I Interferon in Mouse Skin by Recruited Inflammatory Monocytes
ConclusionIn wild‐type mice, repeated doses of UVB irradiation induce monocyte‐dependent and PDC‐independent expression of type I IFN together with expression of other proinflammatory cytokines. Induction is dependent on the adaptor protein STING. Surprisingly, studies using IFNAR‐deficient mice revealed that type I IFN protects against UVB irradiation–induced skin inflammation, in part by attenuating proinflammatory cytokine expression and limiting tissue damage. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 29, 2017 Category: Rheumatology Authors: Clayton Sontheimer, Denny Liggitt, Keith B. Elkon Tags: Systemic Lupus Erythematosus Source Type: research

Validation of Systemic Lupus Erythematosus Diagnosis as the Primary Cause of Renal Failure in the US Renal Data System
ConclusionThe diagnosis of SLE as the primary cause of ESRD in the USRDS has good sensitivity, and excellent specificity, PPV, and NPV. Nationwide access to medical records and biopsy reports may significantly improve sensitivity of SLE diagnosis. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - March 29, 2017 Category: Rheumatology Authors: Anna Broder, Wenzhu B. Mowrey, Peter Izmirly, Karen H. Costenbader Tags: Brief Report Source Type: research

Type I interferon as a biomarker in autoimmunity and viral infection: a leukocyte subset-specific analysis unveils hidden diagnostic options
AbstractInterferon alpha and its surrogates, including IP-10 and SIGLEC1, paralleled changes of disease activity in systemic lupus erythematosus (SLE). However, the whole blood interferon signature (WBIFNS) —the current standard for type I IFN assessment in SLE—does not correlate with SLE disease activity in individual patients over time. The underlying causes for this apparent contradiction have not been convincingly demonstrated. Using a multicenter dataset of gene expression data from leukocyte subsets in SLE, we identify distinctive subset-specific contributions to the WBIFNS. In a subsequent analysis, the effects ...
Source: Journal of Molecular Medicine - March 29, 2017 Category: Molecular Biology Source Type: research

Impact of disease activity on health-related quality of life in systemic lupus erythematosus – a cross-sectional analysis of the Swiss Systemic Lupus Erythematosus Cohort Study (SSCS)
To assess the impact of disease activity on health-related quality of life (HRQoL) in systemic lupus erythematosus (SLE). (Source: BMC Immunology)
Source: BMC Immunology - March 28, 2017 Category: Allergy & Immunology Authors: Benjamin Chaigne, Carlo Chizzolini, Thomas Perneger, Marten Trendelenburg, Uyen Huynh-Do, Eric Dayer, Thomas Stoll, Johannes von Kempis and Camillo Ribi Source Type: research

Subacute cutaneous lupus erythematosus
A 31-year-old female soldier developed subacute cutaneous lupus erythematosus, which remained undiagnosed for 4 years. Referral to dermatology and a punch biopsy confirmed the diagnosis and effective treatment was instituted. The presence of an unresolving annular rash in light-exposed areas, especially in a young woman, should prompt thorough investigation and referral if necessary. The prognosis for this condition is generally good, although a small proportion of patients will go on to develop systemic lupus erythematosus. The occupational implications of this condition require thoughtful management in the military ...
Source: Journal of the Royal Army Medical Corps - March 28, 2017 Category: Journals (General) Authors: Furzeland, J., Malcolm, P. Tags: Immunology (including allergy), Radiology, Connective tissue disease, Systemic lupus erythematosus, Dermatology, Surgical diagnostic tests, General surgery Case report Source Type: research

May you live in interesting times: Challenges and opportunities in Lupus research
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 28, 2017 Category: Rheumatology Authors: I ñaki Sanz Tags: Review Article Source Type: research

Cerebral venous thrombosis after spinal anesthesia: case report
We describe a case of a patient who underwent spinal anesthesia and had postoperative headache complicated with CVT. Case report Male patient, 30 years old, ASA 1, who underwent uneventful arthroscopic knee surgery under spinal anesthesia. Forty-eight hours after the procedure, the patient showed frontal, orthostatic headache that improved when positioned supine. Diagnosis of sinusitis was made in the general emergency room, and he received symptomatic medication. In subsequent days, the headache worsened with holocranial location and with little improvement in the supine position. The patient presented with left hemiplegi...
Source: Brazilian Journal of Anesthesiology - March 28, 2017 Category: Anesthesiology Source Type: research

Chilblain lupus erythematosus treated successfully with mycophenolate mofetil
(Source: International Journal of Dermatology)
Source: International Journal of Dermatology - March 27, 2017 Category: Dermatology Authors: Laurie Gouillon, Sebastien Debarbieux, Micheline Berruyer, Nicole Fabien, Jean ‐Christophe Lega, Luc Thomas Tags: Correspondence Source Type: research

Basophil Activation-Dependent Autoantibody and Interleukin-17 Production Exacerbate Systemic Lupus Erythematosus
Qingjun Pan, Li Gong, Haiyan Xiao, Yongmin Feng, Lu Li, Zhenzhen Deng, Ling Ye, Jian Zheng, Carol A. Dickerson, Lin Ye, Ning An, Chen Yang, Hua-feng Liu (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - March 27, 2017 Category: Allergy & Immunology Source Type: research

Ocular Manifestations in Children with Juvenile-Onset Systemic Lupus Erythematosus.
CONCLUSION: Serious sight-threatening complications were not detected in our study; dry eye was the most common ocular finding, and the detected retinopathy was related to systemic hypertension and could not be correlated to either disease activity or duration. PMID: 28340314 [PubMed - as supplied by publisher] (Source: Seminars in Ophthalmology)
Source: Seminars in Ophthalmology - March 27, 2017 Category: Opthalmology Tags: Semin Ophthalmol Source Type: research

Jaccoud's arthropathy in systemic lupus erythematosus: clinical, laboratory and ultrasonographic features.
CONCLUSIONS: JA should no longer be considered a non-erosive condition since bone damage can occur in more than half of patients. Moreover, the erosive damage seems to be associated with the presence of ACPA. PMID: 28339366 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - March 27, 2017 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Anti-N-methyl-D-aspartate receptor antibodies are associated with fibromyalgia in patients with systemic lupus erythematosus: a case-control study.
CONCLUSIONS: To our knowledge, this report is the first to suggest that anti-NMDAR antibodies are associated with the pathogenesis of FM with SLE. PMID: 28339361 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - March 27, 2017 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Autoantibodies to box A of high mobility group box 1 in systemic lupus erythematosus
Summary Autoantibodies to nuclear structures are a hallmark of systemic lupus erythematosus (SLE), including autoantibodies to nuclear protein high mobility group box 1 (HMGB1). HMGB1 consists of three separate domains: box A, box B and an acidic tail. Recombinant box A acts as a competitive antagonist for HMGB1 and might be an interesting treatment option in SLE. However, antibodies to box A might interfere. Therefore, levels of anti‐box A were examined in SLE patients in association with disease activity and clinical parameters. Serum anti‐box A was measured in 86 SLE patients and 44 age‐ and sex‐matched healthy ...
Source: Clinical and Experimental Immunology - March 27, 2017 Category: Allergy & Immunology Authors: F. Schaper, K. de Leeuw, G. Horst, F. Maas, H. Bootsma, P. Heeringa, P. C. Limburg, J. Westra Tags: Original Article Source Type: research

Research and therapeutics—traditional and emerging therapies in systemic lupus erythematosus
<span class="paragraphSection"><div class="boxTitle">Abstract</div>This review summarizes traditional and emerging therapies for SLE. Evidence suggests that the heterogeneity of SLE is a crucial aspect contributing to the failure of large clinical trials for new targeted therapies. A clearer understanding of the mechanisms driving disease pathogenesis combined with recent advances in medical science are predicted to enable accelerated progress towards improved SLE diagnosis and personalized approaches to treatment.</span> (Source: Rheumatology)
Source: Rheumatology - March 27, 2017 Category: Rheumatology Source Type: research

Paediatric systemic lupus erythematosus: insights from translational research
This article reviews unique features of paediatric SLE and details important developments in paediatric lupus research.</span> (Source: Rheumatology)
Source: Rheumatology - March 27, 2017 Category: Rheumatology Source Type: research

Pathways leading to an immunological disease: systemic lupus erythematosus
We describe the immunological changes that characterize this form of autoimmunity. The major leucocytes that are essential for disease progression are discussed, together with key mediators that propagate the immune response and drive the inflammatory response in SLE.</span> (Source: Rheumatology)
Source: Rheumatology - March 27, 2017 Category: Rheumatology Source Type: research

High prevalence of alcohol use disorders in patients with inflammatory skin diseases
ConclusionsPatients with eczema attending a single site hospital clinic have been shown to have high levels of alcohol use disorders of a similar level to patients with psoriasis and higher than patients with non‐inflammatory skin diseases. The role of alcohol in the exacerbation of eczema needs further investigation. Caution and a full alcohol history is recommended when treating eczema patients with potentially hepatotoxic medication. By identifying heavier drinking patients we may be able to support them with interventions to reduce alcohol intake and potentially improve their skin disease.This article is protected by...
Source: British Journal of Dermatology - March 27, 2017 Category: Dermatology Authors: K. Al ‐Jefri, D. Newbury‐Birch, C.R. Muirhead, E. Gilvarry, V. Araújo‐Soares, N.J. Reynolds, E. Kaner, P.J. Hampton Tags: Original Article Source Type: research

Case report: primary osteonecrosis associated with thrombophilia-hypofibrinolysis and worsened by testosterone therapy
ConclusionsIdiopathic ON, often caused by thrombophilia-hypofibrinolysis, is worsened by TT, and its progression may be slowed or stopped by discontinuation of TT and, thereafter, anticoagulation. Recognition of thrombophilia-hypofibrinolysis before joint collapse facilitates anticoagulation which may stop ON, preserving joints. (Source: BMC Hematology)
Source: BMC Hematology - March 27, 2017 Category: Hematology Source Type: research

High prevalence of alcohol use disorders in patients with inflammatory skin diseases.
CONCLUSIONS: Patients with eczema attending a single site hospital clinic have been shown to have high levels of alcohol use disorders of a similar level to patients with psoriasis and higher than patients with non-inflammatory skin diseases. The role of alcohol in the exacerbation of eczema needs further investigation. Caution and a full alcohol history is recommended when treating eczema patients with potentially hepatotoxic medication. By identifying heavier drinking patients we may be able to support them with interventions to reduce alcohol intake and potentially improve their skin disease. This article is protected b...
Source: The British Journal of Dermatology - March 27, 2017 Category: Dermatology Authors: Al-Jefri K, Newbury-Birch D, Muirhead CR, Gilvarry E, Araújo-Soares V, Reynolds NJ, Kaner E, Hampton PJ Tags: Br J Dermatol Source Type: research

The role of miR-146a in modulating TRAF6-induced inflammation during lupus nephritis.
CONCLUSIONS: The expression of miR-146a in renal tissues of LN patients was significantly depressed, while the transcriptional activity of TRAF6 and NF-κB was enhanced. MiR-146 thus inhibited NF-κB transcriptional activity and inflammatory factor synthesis, and alleviated chemotactic effect towards macrophage via the inhibition of TRAF6 activity. PMID: 28338190 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - March 26, 2017 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Exploring the plasmatic platelet-activating factor acetylhydrolase activity in patients with anti-phospholipid antibodies
ConclusionsPAF-AH plasmatic activity is particularly up-regulated in LAC+ and in a β2GPI IgG+ patients, possibly representing an alternative prognostic biomarker for the therapeutic management of APS patients. (Source: Autoimmunity Highlights)
Source: Autoimmunity Highlights - March 25, 2017 Category: Allergy & Immunology Source Type: research

TWEAK/Fn14 activation contributes to the pathogenesis of bullous pemphigoid
In this study, we found an elevated serum level of TWEAK and a positive correlation between serum TWEAK and anti-BP180 antibodies. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - March 25, 2017 Category: Dermatology Authors: Yale Liu, Lingling Peng, Liang Li, Chengfei Liu, Xiao Hu, Shengxiang Xiao, Yumin Xia Tags: Original Article Source Type: research

Immunostimulatory endogenous nucleic acids drive the lesional inflammation in cutaneous lupus erythematosus
Cutaneous lupus erythematosus (CLE) is a photosensitive autoimmune disease characterized by a strong type-I-interferon (IFN) associated inflammation. Keratinocytes are known to determine the interface-dermatitis-pattern in CLE by production of proinflammatory cytokines in the lower epidermis. These cytokines drive a cytotoxic anti-epithelial immune response resulting in keratinocytic cell death and release of endogenous nucleic acids (eNA). We hypothesized that these eNA (RNA- and DNA-motifs) have the capacity to activate innate immune pathways in keratinocytes via pathogen-recognition-receptors (PRR). (Source: Journal of ...
Source: Journal of Investigative Dermatology - March 25, 2017 Category: Dermatology Authors: Benedikt Scholtissek, Sabine Zahn, Judith Maier, Sophie Klaeschen, Christine Braegelmann, Michael Hoelzel, Thomas Bieber, Winfried Barchet, Joerg Wenzel Tags: Original Article Source Type: research

Effects of a spleen tyrosine kinase inhibitor on progression of the lupus nephritis in mice
Publication date: Available online 25 March 2017 Source:Journal of Pharmacological Sciences Author(s): Maki Kitai, Noboru Fukuda, Takahiro Ueno, Morito Endo, Takashi Maruyama, Masanori Abe, Kazuyoshi Okada, Masayoshi Soma, Koichi Matsumoto The Fc receptors (FcR) have pivotal roles in the pathogenesis of the autoimmune glomerulonephritis. We therefore investigated the effects of a Syk inhibitor on the progression of lupus nephritis and SH3 domain binding protein 2 and p38MAP kinase signalings in mice. NZB/W F1 mice, a model of lupus nephritis, received a Syk inhibitor R406. Western blotting and immunohistochemistry reveale...
Source: Journal of Pharmacological Sciences - March 25, 2017 Category: Drugs & Pharmacology Source Type: research

APRIL gene polymorphism and serum sAPRIL levels in children with systemic lupus erythematosus
AbstractSystemic lupus erythematosus (SLE) is a multi-factor autoimmune disorder with diverse clinical manifestations and unclear pathogenesis. Genetic components play important roles in the incidence and development of SLE. Among these, APRIL as a cytokine has roles in the stimulation and antibody production in B cells. APRIL was hypothesized to be associated with SLE. The aim of this study was to assess the involvement of the APRIL gene in SLE susceptibility in Iranian patients. A single-nucleotide polymorphism (SNP) for rs11552708 of APRIL gene was analyzed by real-time PCR in 60 SLE Iranian children and 64 healthy cont...
Source: Clinical Rheumatology - March 24, 2017 Category: Rheumatology Source Type: research

Platelet-Derived Interleukin-1 β Fuels the Fire in Blood Vessels in Systemic Lupus Erythematosus.
Platelet-Derived Interleukin-1β Fuels the Fire in Blood Vessels in Systemic Lupus Erythematosus. Arterioscler Thromb Vasc Biol. 2017 Apr;37(4):607-608 Authors: Boilard E PMID: 28330943 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 24, 2017 Category: Cardiology Authors: Boilard E Tags: Arterioscler Thromb Vasc Biol Source Type: research

Course of Neuropsychiatric Symptoms during Flares of Systemic Lupus Erythematosus (SLE).
We present the case of a seventeen-year-old girl who presents with an interesting course of neuropsychiatric symptoms during several flares of SLE. The patient was diagnosed at the age of thirteen and has had four flares in total. The latter two flares included cutaneous and neuropsychiatric symptoms. The most recent flare occurred when she was aged seventeen. She had cutaneous symptoms which coincided with an episode of hypomania. Her mental state further deteriorated following steroid treatment. She exhibited affective and psychotic symptoms. Treatment with cyclophosphamide and olanzapine was associated with an improveme...
Source: Case Reports in Psychiatry - March 24, 2017 Category: Psychiatry Tags: Case Rep Psychiatry Source Type: research

Complement regulation and kidney diseases: recent knowledge of the double-edged roles of complement activation in nephrology
AbstractThe complement activation system plays important roles to maintain homeostasis in the host and to fight foreign invaders to protect the host. Therefore, the complement system is considered a core part of innate immunity which also cross-talks to acquired immunity. In the history of nephrology, the complement system is familiar to us, because complement protein or fragment deposition, including C3, C4, C1q, and/or C4d, is routinely estimated by immunohistochemistry to diagnose renal pathologies. The relationships between pathological mechanisms and complement activation have been investigated for renal diseases such...
Source: Clinical and Experimental Nephrology - March 24, 2017 Category: Urology & Nephrology Source Type: research

MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and primary Sj ögren's syndrome
by Ji-Qing Chen, G ábor Papp, Szilárd Póliska, Krisztina Szabó, Tünde Tarr, Bálint László Bálint, Péter Szodoray, Margit Zeher The discovery of microRNAs (miRNAs) and their critical role in genetic control opened new avenues in understanding of various biological processes including immune cell lineage commitment, differentiation, proliferation and apoptosis. However, a given miRNA may have hundreds of different mRNA targ ets and a target might be regulated by multiple miRNAs, thus the characterisation of dysregulated miRNA expression profiles could give a better insight into the development of immunological dis...
Source: PLoS One - March 24, 2017 Category: Biomedical Science Authors: Ji-Qing Chen Source Type: research

Predictors of low quality of life in discoid lupus patients.
This article is protected by copyright. All rights reserved. PMID: 28338221 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 24, 2017 Category: Dermatology Authors: Teske NM, Cardon ZE, Ogunsanya ME, Li X, Adams-Huet B, Chong B Tags: Br J Dermatol Source Type: research

Helicobacter cinaedi Bacteremia Mimicking a Flare of Systemic Lupus Erythematosus.
Authors: Nishida R, Shimono N, Miyake N, Chong Y, Shimoda S, Tsukamoto H, Akashi K Abstract A 40-year-old woman with systemic lupus erythematosus (SLE) presented with high-grade fever and severe thrombocytopenia. Acalculous cholecystitis and thrombocytopenia were initially suspected to be complicated with SLE and vasculitis. Contrary to our expectation, however, the patient was finally diagnosed with Helicobacter cinaedi bacteremia. SLE patients show various symptoms, especially when their condition is complicated with vasculitis, which mimics H. cinaedi bacteremia. It is therefore difficult to provide a definite d...
Source: Internal Medicine - March 23, 2017 Category: Internal Medicine Tags: Intern Med Source Type: research

Effects of Denosumab on Bone Metabolic Markers and Bone Mineral Density in Patients Treated with Glucocorticoids.
Authors: Sawamura M, Komatsuda A, Togashi M, Wakui H, Takahashi N Abstract Objective We performed a prospective study to determine the efficacy and safety of denosumab on bone metabolic indices and bone mineral density (BMD) in 29 patients receiving long-term glucocorticoids (GCs) who had clinical risk factors for fracture. Methods Among these patients, 16 had systemic lupus erythematosus (SLE), 6 RA, 4 other autoimmune diseases, and 3 renal diseases. All patients received donosumab 60 mg at baseline and 6 months. Serum N-terminal cross-linked telopeptide of type I collagen (NTX) and bone-specific alkaline phosphat...
Source: Internal Medicine - March 23, 2017 Category: Internal Medicine Tags: Intern Med Source Type: research

Lupus Hepatitis and Autoimmune Hepatitis (Lupoid Hepatitis).
Abstract Liver dysfunction occurs in approximately 50% of patients with systemic lupus erythematosus (SLE), and patients with SLE and elevated liver enzymes can present a complicated and difficult differential diagnosis. Lupus hepatitis and autoimmune hepatitis are 2 immunologic conditions involving the liver, which can have similar clinical, laboratory and systemic presentations, leading to difficulties in diagnosis. Physicians need to be aware of these 2 hepatic diseases as diagnosis and appropriate therapy need to occur early in the disease course to prevent progression to advanced liver disease. We review the ...
Source: The American Journal of the Medical Sciences - March 23, 2017 Category: Journals (General) Authors: Adiga A, Nugent K Tags: Am J Med Sci Source Type: research

Systemic Lupus Erythematosus Is Associated With Increased Adverse Postoperative Renal Outcomes and Mortality: A Historical Cohort Study Using Administrative Health Data.
CONCLUSIONS: This is, by far, the largest clinical study for postoperative outcomes of SLE patients with adequately powered statistical analyses. We concluded that SLE was associated with a higher risk of renal complications and in-hospital mortality but not cardiac events after major surgery. In SLE patients, more aggressive measures should be taken to prevent renal injury in the perioperative period. PMID: 28319545 [PubMed - in process] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - March 23, 2017 Category: Anesthesiology Authors: Babazade R, Yilmaz HO, Leung SM, Zimmerman NM, Turan A Tags: Anesth Analg Source Type: research

Dissecting the relationships of IgG subclasses and complements in membranous lupus nephritis and idiopathic membranous nephropathy
by Woong Na, Kijong Yi, Young Soo Song, Moon Hyang Park Membranous lupus nephritis (MLN) and idiopathic membranous nephropathy (IMN) are kidney diseases with similar morphology, but distinct etiologies, both producing glomeruli with immune deposits. Immunoglobulins and complements, the main components of the deposits, can be detected by immunofluoresce nce (IF) microscopy. Previous researches characterized the immune deposits only individually, but not the interactions between them. To study these relationships we analyzed an IF profile of IgG subclasses and complements (IgG1, IgG2, IgG3, IgG4, C3, C1q, and C4) in 53 and ...
Source: PLoS One - March 23, 2017 Category: Biomedical Science Authors: Woong Na Source Type: research

IL-21 may promote Granzyme B-dependent NK/plasmacytoid dendritic cell functional interaction in cutaneous lupus erythematosus
Autoimmune skin lesions are characterized by a complex cytokine milieu and by the accumulation of plasmacytoid dendritic cells (pDCs). Granzyme B (GrB) transcript is abundant in activated pDCs, though its mechanisms of regulation and biological role are largely unknown. Here we report that IL-21 was the only Th1/Th17 cytokine able to induce the expression and secretion of GrB by pDCs and that this action was counteracted by the autocrine production of type I interferons (IFNs). In lupus erythematosus (LE) skin lesions, the percentage of GrB+ pDCs directly correlated with the IL-21/MxA ratio, indicating that the interplay b...
Source: Journal of Investigative Dermatology - March 23, 2017 Category: Dermatology Authors: Valentina Salvi, William Vermi, Andrea Cavani, Silvia Lonardi, Teresa Carbone, Fabio Facchetti, Daniela Bosisio, Silvano Sozzani Tags: Original Article Source Type: research

A new benzenediamine derivative modulates Toll-like receptors-induced myeloid dendritic cells activation and ameliorates lupus-like syndrome in MRLlpr/lpr mice.
This study was designed to evaluate the effects of FC-99, a novel benzenediamine derivative, on TLR-induced activation of mDCs, and to assess the efficacy of FC-99 in a murine model of SLE. In vitro, FC-99 inhibited the phenotypic (CD40 and MHC-II) and functional activation (IL-12 and CXCL10) of mDCs induced by TLR ligands. In vivo, MRLlpr/lpr mice displayed renal diseases associated with increased levels of proteinuria and immunoglobulin, which were ameliorated by FC-99. Enhanced accumulation and activation of mDCs in lymphoid organs was also impaired by FC-99. Additionally, FC-99 inhibited the activation of IκB-α and u...
Source: European Journal of Pharmacology - March 23, 2017 Category: Drugs & Pharmacology Authors: Gao S, Gong Y, Ji J, Yuan L, Han L, Guo Y, Fan X, Hou Y, Hua C Tags: Eur J Pharmacol Source Type: research

Reply to: Direct Immunofluorescence Findings in Discoid Lupus Erythematosus and Bullous Pemphigoid
No abstract available (Source: The American Journal of Dermatopathology)
Source: The American Journal of Dermatopathology - March 22, 2017 Category: Pathology Tags: Letters to the Editor Source Type: research

Association Between TNF ‐α Promoter −308 A/G Polymorphism and Systemic Lupus Erythematosus Susceptibility: A Case–Control Study and Meta‐Analysis
Abstract The tumour necrosis factor‐α (TNF‐α) promoter −308 A/G polymorphism plays an important role in the aetiology of systemic lupus erythematosus (SLE). Several studies have estimated the association between TNF‐α −308 A/G and SLE risk. However, results were inconsistent. A case–control study was carried out to explore the association between TNF‐α −308 A/G and the SLE risk in a Chinese Han population. Meta‐analysis combining present with previous studies was conducted to further explore the association. Our case–control study included 556 patients with SLE along with 570 matched healthy control...
Source: Scandinavian Journal of Immunology - March 22, 2017 Category: Allergy & Immunology Authors: Z. ‐C. Yang, F. Xu, M. Tang, X. Xiong Tags: Human Immunology Source Type: research

Clinical characteristics of multifocal osteonecrosis in Korean patients with rheumatic disease
ConclusionOur findings indicate that multifocal ON is common in young SLE patients who have been using corticosteroids and the most commonly involved site is the knee. (Source: APLAR Journal of Rheumatology)
Source: APLAR Journal of Rheumatology - March 22, 2017 Category: Rheumatology Authors: Hye ‐Jin Jeong, Dam Kim, Soo‐Kyung Cho, Yeesuk Kim, Sang‐Cheol Bae, Yoon‐Kyoung Sung Tags: Original Article Source Type: research

Monocentric experience of the rituximab therapy in systemic lupus erythematosus-associated antiphospholipid syndrome with warfarin therapy failure
Dear Editor, (Source: Seminars in Arthritis and Rheumatism)
Source: Seminars in Arthritis and Rheumatism - March 22, 2017 Category: Rheumatology Authors: Chrong-Reen Wang, Chia-Tse Weng, Ming-Fei Liu Source Type: research

[Laboratory diagnosis of antiphospholipid syndrome: From criteria to practice].
Authors: Joste V, Dragon-Durey MA, Darnige L Abstract The antiphospholipid syndrome is a bioclinical entity defined by thrombosis and/or obstetrical complications in the presence, at least 12 weeks apart, of antiphospholipid antibodies detected by coagulation test (lupus anticoagulant) or immunological assays (anticardiolipin, anti-β2-glycoprotein I antibodies). Biological markers' improvement such as anti-phosphatidylserine/prothrombin and biological score should allow better patients' management and preventive therapeutic for thrombosis and obstetrical complications. This review describes different types of an...
Source: Revue de Medecine Interne - March 21, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research