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This page shows you the latest news items in this category. This is page number 5.

Orencia: Try Again in Lupus? (CME/CE)
(MedPage Today) -- Benefits seen for articular symptoms (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - March 31, 2016 Category: Primary Care Source Type: news

Great American Smokeout Stands Out Among 'Awareness Days'
THURSDAY, March 31, 2016 -- Health-focused awareness days dot the calendar each year. There's World Health Day, World Dolphin Day, World Lupus Day and hundreds more. Whether they actually boost action on specific health issues isn't clear,... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - March 31, 2016 Category: Journals (General) Source Type: news

Kirsty Keep who begged to go to Dignitas told chemo may have been wrong
Kirsty Keep, 23, of Maidstone, Kent, was diagnosed with lupus and treated with chemotherapy. But doctors now say she may have a genetic skin and bone disorder instead. (Source: the Mail online | Health)
Source: the Mail online | Health - March 30, 2016 Category: Consumer Health News Source Type: news

An Open Letter to the Boston Globe About Lyme Disease
Today, the Boston Globe editorial board spoke out against a bill "that would require insurers in Massachusetts to cover Lyme disease treatments for as long as a doctor says they're needed." The Globe writes: Lawmakers may have good intentions, but they don't possess the expertise to decide whether it's beneficial, cost-efficient, or safe, to keep using strong medicines to treat a condition the medical establishment doubts is real. Such questions should be resolved by a consensus of doctors and researchers -- and buttressed by convincing clinical date [sic] -- not determined by legislative mandate. Who among the Boston Glob...
Source: Healthy Living - The Huffington Post - March 28, 2016 Category: Consumer Health News Source Type: news

Benlysta Found Steroid-Sparing in Lupus (CME/CE)
(MedPage Today) -- Modest effects in prednisone dose reduction seen in post-hoc analyses (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - March 26, 2016 Category: Primary Care Source Type: news

Targeting Interferon Shows Promise in Lupus (CME/CE)
(MedPage Today) -- Sifalimumab effective in a phase IIb trial, particularly for skin manifestations (Source: MedPage Today Rheumatology)
Source: MedPage Today Rheumatology - March 25, 2016 Category: Rheumatology Source Type: news

Lupus patients’ transition to adult care leaves gaps, delays in care
Patients with childhood-onset systemic lupus erythematosus (SLE) who transitioned to adult care without a formal transitioning process had long periods without care despite having moderate disease... (Source: Pediatric News)
Source: Pediatric News - March 25, 2016 Category: Journals (General) Source Type: news

Claims that man flu 'really exists' are unsupported
Conclusion This small laboratory study points to specific biological mechanisms that might explain why women are more likely to suffer autoimmune disorders, such as SLE, than men. It found the second silenced copy of the X chromosome in women can be partially reactivated and express immune-related genes, instead of staying completely silent. Though this is a plausible reason for the overactive immune system found in SLE, it does not explain why men can also have the condition. Also, only SLE was investigated in this study and with blood samples from just five children with the condition. It is not clear at this stage how...
Source: NHS News Feed - March 23, 2016 Category: Consumer Health News Tags: Lifestyle/exercise Medical practice Source Type: news

Regulatory B Cell Processes Appear Aberrant in LupusRegulatory B Cell Processes Appear Aberrant in Lupus
Disruption of the processes that govern the differentiation of immature B cells into regulatory B cells (Bregs) that restrain inflammation may contribute to the pathogenesis of systemic lupus erythematosus (SLE). Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - March 22, 2016 Category: Pathology Tags: Rheumatology News Source Type: news

Penn vet study identifies mechanism explaining female bias in autoimmunity
(University of Pennsylvania) Possessing two X chromosomes is a double-edged sword, immunologically speaking. Females are better at fighting off infection than males, but they are also more susceptible to many autoimmune conditions, such as lupus. A new study published in Proceedings of the National Academy of Sciences and led by researchers from the University of Pennsylvania now offers the first mechanistic explanation for why this is the case. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - March 21, 2016 Category: Global & Universal Source Type: news

Getting a leg up on bone comorbidities in lupus
MAUI, HAWAII – Patients with systemic lupus erythematosus (SLE) really need to be placed on bone protection therapy as soon as they start on corticosteroids because their risks of steroid-related... (Source: Clinical Endocrinology News)
Source: Clinical Endocrinology News - March 19, 2016 Category: Endocrinology Source Type: news

Precision medicine's potential to define the genetics of autoimmune disease
Demonstrating the potential of precision medicine, an international study used next-generation DNA sequencing technology to identify more than 1,000 gene variants that affect susceptibility to systemic lupus erythematosus (SLE). (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - March 18, 2016 Category: Science Source Type: news

Study shows precision medicine's potential to define the genetics of autoimmune disease
(UT Southwestern Medical Center) Demonstrating the potential of precision medicine, an international study based at UT Southwestern Medical Center used next-generation DNA sequencing technology to identify more than 1,000 gene variants that affect susceptibility to systemic lupus erythematosus (SLE). (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 18, 2016 Category: Global & Universal Source Type: news

Healthy IVF Egg Produces Offspring With LupusHealthy IVF Egg Produces Offspring With Lupus
Neonatal lupus can develop even when the newborn has not inherited a genetic susceptibility to autoimmunity from the mother, California-based researchers report. Reuters Health Information (Source: Medscape Dermatology Headlines)
Source: Medscape Dermatology Headlines - March 17, 2016 Category: Dermatology Tags: Dermatology News Source Type: news

Lupus study highlights importance of B cells
A new study has been published that could shed additional light on the factors that come into play for individuals who go on to develop lupus.   Carried out by senior researcher Claudia Mauri, professor of immunology at University College London in the UK, the study showed that some of the body's own anti-inflammatory B cells may be maturing in the wrong way in individuals with lupus - meaning they are actively creating inflammation, rather than fighting it.   These cells play an important part in the body's immune response system, managing the number of antibodies that are produced to fight infection. Ho...
Source: Arthritis Research UK - March 17, 2016 Category: Rheumatology Source Type: news

Pneumovax Falls Short in Lupus (CME/CE)
(MedPage Today) -- Fewer than a third of patients had a four-fold increase in anti-pneumococcal IgG (Source: MedPage Today Infectious Disease)
Source: MedPage Today Infectious Disease - March 13, 2016 Category: Infectious Diseases Source Type: news

Lupus Lipids Improve With Combo Tx (CME/CE)
(MedPage Today) -- Treatment with pravastatin and ezetimibe also benefited endothelial function (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - March 12, 2016 Category: Primary Care Source Type: news

Study Suggests Causes for Lupus' Impact on Immune System
Title: Study Suggests Causes for Lupus' Impact on Immune SystemCategory: Health NewsCreated: 3/8/2016 12:00:00 AMLast Editorial Review: 3/9/2016 12:00:00 AM (Source: MedicineNet Arthritis General)
Source: MedicineNet Arthritis General - March 9, 2016 Category: Rheumatology Source Type: news

Xencor begins Phase II trials of XmAb5871 for IgG4-related disease and SLE
US-based Xencor has started a Phase II trial of its drug candidate XmAb5871 in patients with IgG4-related disease (IgG4-RD), as well as patients with systemic lupus erythematosus (SLE). (Source: Drug Development Technology)
Source: Drug Development Technology - March 9, 2016 Category: Pharmaceuticals Source Type: news

What Causes Lupus' Impact on Immune System?
Certain cells seem to malfunction and create inflammation instead of fighting the disease, research say (Source: WebMD Health)
Source: WebMD Health - March 8, 2016 Category: Consumer Health News Source Type: news

Study Suggests Causes for Lupus' Impact on Immune System
Certain cells seem to malfunction and create inflammation instead of fighting the disease, research say Source: HealthDay Related MedlinePlus Page: Lupus (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - March 8, 2016 Category: Consumer Health News Source Type: news

Study Suggests Causes for Lupus' Impact on Immune System
Certain cells seem to malfunction and create inflammation instead of fighting the disease, research say (Source: U.S. News - Health)
Source: U.S. News - Health - March 8, 2016 Category: Consumer Health News Source Type: news

Study Suggests Causes for Lupus' Impact on Immune System
TUESDAY, March 8, 2016 -- Scientists have found new clues that help explain what's going wrong in the immune systems of people with lupus -- insight they hope will lead to new therapies, or help guide current treatment choices. Lupus has several... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - March 8, 2016 Category: Journals (General) Source Type: news

Casting a 'NET' to Find New Therapies for LupusCasting a 'NET' to Find New Therapies for Lupus
Dr Deane discusses a study that first examined the role of neutrophil extracellular traps in lupus pathophysiology, and then evaluated metformin to reduce disease flares in a proof-of-concept trial. Medscape Rheumatology (Source: Medscape Rheumatology Headlines)
Source: Medscape Rheumatology Headlines - March 3, 2016 Category: Rheumatology Tags: Rheumatology Viewpoint Source Type: news

Nick Cannon Looks Back On His 'Super Scary' Lupus Diagnosis
Nick Cannon didn't know anything about lupus nephritis when he was first diagnosed in 2012, so hearing that some of his other health complications were the result of the autoimmune disease came as a surprise. It was only after Cannon did some research on the condition, which had resulted in kidney failure and blood clots in his lungs, that he began to understand and take care of his well-being. Now he hopes his story encourages others to do the same. "[Y]ou realize that this is something that you can live with and actually overcome with the proper research and with the proper support system," he told HuffPost Live. In...
Source: Healthy Living - The Huffington Post - February 24, 2016 Category: Consumer Health News Source Type: news

Kirsty Keep left in agony for a decade is desperate to find a cure for her symptoms
Kirsty Keep, 23, of Maidstone, Kent, has been diagnosed with the autoimmune condition lupus, where her immune system attacks healthy cells, tissue and organs. (Source: the Mail online | Health)
Source: the Mail online | Health - February 23, 2016 Category: Consumer Health News Source Type: news

Response to Belimumab Among Patients With SLEResponse to Belimumab Among Patients With SLE
Does belimumab reduce SLE disease activity in real-world clinical practice? Lupus Science & Medicine (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - February 23, 2016 Category: Pathology Tags: Rheumatology Journal Article Source Type: news

Researchers uncover potential target for treating autoimmune disease
A molecule that appears to be a cause of autoimmune diseases such as lupus has been identified by a group of researchers. Elevated levels of the molecule allow self-reactive immune cells to escape into the blood stream and attack the body's own tissues. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - February 22, 2016 Category: Science Source Type: news

Lyme: The Infectious Disease Equivalent of Cancer, Says Top Duke Oncologist
Last week, I mentioned the case of Dr. Neil Spector, whose long-undiagnosed Lyme Disease resulted in irreversible heart failure and ultimately, a heart transplant. Dr. Spector, author of Gone in a Heartbeat: A Physician's Search for True Healing, is the Sandra Coates Associate Professor of Medicine and Associate Professor of Pharmacology and Cancer Biology at Duke University School of Medicine. As the Director of Developmental Therapeutics at the Duke Cancer Institute, he's a leader in applying translational research to the clinical development of molecularly targeted personalized cancer therapies. Here, Dr. Spector share...
Source: Science - The Huffington Post - February 19, 2016 Category: Science Source Type: news

Lupus Affects Pregnancy Outcome Even Before Diagnosis Lupus Affects Pregnancy Outcome Even Before Diagnosis
Pregnancy-related complications and poor infant outcomes were higher in women with lupus and in women with preclinical SLE. Medscape Medical News (Source: Medscape ObGyn and Womens Health Headlines)
Source: Medscape ObGyn and Womens Health Headlines - February 16, 2016 Category: OBGYN Tags: Rheumatology News Source Type: news

Lupus and Pregnancy: When Is the Highest Risk? (CME/CE)
(MedPage Today) -- Study suggests preclinical disease has worse pregnancy outcome, but an expert disagrees (Source: MedPage Today OB/GYN)
Source: MedPage Today OB/GYN - February 4, 2016 Category: OBGYN Source Type: news

ESRD in Lupus: A Work in Progress? (CME/CE)
(MedPage Today) -- Declines in disease risk seen since the 1970s, but recent stats have leveled off (Source: MedPage Today Rheumatology)
Source: MedPage Today Rheumatology - February 3, 2016 Category: Rheumatology Source Type: news

Highlights from 2015
Your achievements A massive thank you to everyone who ran, hosted coffee mornings and bake sales, jumped out of planes and trekked across the country and indeed the world to fundraise for us. More than 1,300 of you took on a challenge or donated your time and fundraising skills in 2015. Together, you raised over £780,000! If you’d like to join Team A in 2016 and help raise money for our work, have a look at our events or contact localfundraising@arthritisresearchuk.org Improving care for people with arthritis In 2015 we continued to support healthcare professionals to provide the best care to people with art...
Source: Arthritis Research UK - February 3, 2016 Category: Rheumatology Source Type: news

Lupus Raises Mortality by 67%; Young Adults at Highest Risk Lupus Raises Mortality by 67%; Young Adults at Highest Risk
Patients with systemic lupus erythematosus frequently die of circulatory system disease or cancer, just like patients without lupus, but at younger ages, according to a new analysis. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - February 2, 2016 Category: Consumer Health News Tags: Rheumatology News Source Type: news

Axis I psychiatric disorders high in skin-restricted lupus patients
The prevalence of psychiatric disorders is high among people with skin-restricted lupus (SRL), compared with the general population, yet most do not receive specialist mental health care or appropriate psychotropic treatment, researchers report. Investigators led by psychiatrist Isabelle... (Source: Skin and Allergy News)
Source: Skin and Allergy News - January 31, 2016 Category: Dermatology Source Type: news

Skin Less Affected in Late-Onset Lupus (CME/CE)
(MedPage Today) -- Dermal symptoms less common with SLE onset past age 50 (Source: MedPage Today Dermatology)
Source: MedPage Today Dermatology - January 30, 2016 Category: Dermatology Source Type: news

Researchers discover ten new lupus genes in Asian population study
10 new genes associated with the autoimmune disease lupus have been identified by researchers. One gene in particular, known as GTF2I, showed a high likelihood of being involved in the development of lupus, say scientists. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - January 25, 2016 Category: Science Source Type: news

The Real Reason You Get Sick After A Stressful Period Has Ended
Have you ever wondered how you manage to get through a particularly stressful period – whether it's an intense deadline at work, final exams in school or a spate of holiday houseguests – only to get sick after the stress has lifted? It's not a fluke. It's a phenomenon that's often referred to as "the let-down effect," a pattern in which people come down with an illness or develop flare-ups of a chronic condition not during a concentrated period of stress but after it dissipates, explains psychologist Marc Schoen, an assistant clinical professor of medicine at the Universi...
Source: Healthy Living - The Huffington Post - January 24, 2016 Category: Consumer Health News Source Type: news

Antibody Signals Adverse Pregnancy Outcome (CME/CE)
(MedPage Today) -- Lupus anticoagulant was the only antiphospholipid antibody linked with poor birth outcome (Source: MedPage Today OB/GYN)
Source: MedPage Today OB/GYN - January 22, 2016 Category: OBGYN Source Type: news

Mitochondrial troublemakers unmasked in lupus
Mitochondria could provoke the inflammation characteristic of lupus, an autoimmune disorder affecting the joints, skin, heart and brain. Byproducts of cells' power stations goad certain white blood cells into making mesh traps as a precursor to cell death. Mitochondrial DNA is spewed out, triggering a warning and a response that can damage various organ tissues. Mouse studies suggest this disease mechanism might respond to potential drug therapies. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - January 21, 2016 Category: Science Source Type: news

Assessing the Inhibitory Activity of Oligonucleotides on TLR7 Sensing
Aberrant sensing of self-nucleic acids by Toll-like receptor (TLR) 7, 8, or 9 is associated with several autoimmune disorders, including systemic lupus erythematosus (SLE), rheumatoid arthritis, psoriasis, or systemic sclerosis. In recent years, several classes of synthetic oligonucleotides have been shown to antagonize sensing of immunostimulatory nucleic acids by TLR7/8/9, indicating that these molecules could have therapeutic applications in such autoimmune diseases. Conversely, synthetic oligonucleotides used in therapeutic technologies such as antisense and microRNA inhibitors also have the potential to inhibit TLR7/8...
Source: Springer protocols feed by Immunology - January 7, 2016 Category: Allergy & Immunology Source Type: news

Toll-Like Receptor-Dependent Immune Complex Activation of B Cells and Dendritic Cells
High titers of autoantibodies reactive with DNA/RNA molecular complexes are characteristic of autoimmune disorders such as systemic lupus erythematosus (SLE). In vitro and in vivo studies have implicated the endosomal Toll-like receptor 9 (TLR9) and Toll-like receptor 7 (TLR7) in the activation of the corresponding autoantibody producing B cells. Importantly, TLR9/TLR7-deficiency results in the inability of autoreactive B cells to proliferate in response to DNA/RNA-associated autoantigens in vitro, and in marked changes in the autoantibody repertoire of autoimmune-prone mice. Uptake of DNA/RNA-associated autoantigen immune...
Source: Springer protocols feed by Immunology - January 7, 2016 Category: Allergy & Immunology Source Type: news

Insider’s guide to care: Doctors and dogs
Olivia and Dayton Olivia Burgess knows every nook and cranny of Boston Children’s Hospital. The 13-year-old and her parents have traveled from their home in Bermuda to Boston since Olivia was three years old for ongoing treatments for systemic onset juvenile rheumatoid (idiopathic) arthritis and pediatric lupus. “The unpredictable and severe nature of Olivia’s condition and the frequent travel required for medical treatment can be stressful at times,” says her mother Traci. Olivia sees providers in multiple departments: cardiology, nephrology, pulmonology, dermatology, neurology, gastroenterology and orthopedic sur...
Source: Thrive, Children's Hospital Boston - January 4, 2016 Category: Pediatrics Authors: Lisa Fratt Tags: Our Patients’ Stories Fatma Dedeoglu juvenile rheumatoid arthritis Marybeth Son Pawprints Program pediatric lupus rheumatology program Robert Geggel Sitaram Emani Source Type: news

ACR: Actual-weight hydroxychloroquine dosing works in SLE, up to a point
SAN FRANCISCO – Hydroxychloroquine (Plaquenil) dosing based on actual body weight – instead of ideal weight – is appropriate for patients with systemic lupus erythematosus (SLE), according to a review of... (Source: Skin and Allergy News)
Source: Skin and Allergy News - December 30, 2015 Category: Dermatology Source Type: news

Definition of remission for lupus patients 'may need refining'
A new international study has highlighted the need for the clinical definition of remission for lupus (SLE) patients to be further refined. The study, led by Germany's Heinrich-Heine University and involving the UK's Royal Blackburn Hospital, suggested that many systemic lupus erythematosus (SLE) patients deemed to be in remission still experience a range of debilitating symptoms. Data for 1,227 patients was drawn from a multinational real-world survey of patients with SLE, consulting rheumatologists and nephrologists in France, Germany, Italy, Spain and the UK. The team compared the reported symptom burden as recorded by...
Source: Arthritis Research UK - December 18, 2015 Category: Rheumatology Source Type: news

Dog DNA study reveals the incredible journey of man's best friend
Descended from the grey wolf, domesticated dogs have been companions to humans for about 33,000 years, a genetic study has shownMan’s proverbial first best friend was probably a grey wolf that may have made contact with the first human companions about 33,000 years ago, somewhere in south-east Asia.About 15,000 years ago, a small pack of domesticated dogs began trotting towards the Middle East and Africa. Canis lupus familiaris made it to Europe about 10,000 years ago, and when civilisation began in the Fertile Crescent, and humans began to build farmsteads and villages with walls, dogs were already there to help keep gu...
Source: Guardian Unlimited Science - December 15, 2015 Category: Science Authors: Tim Radford Tags: Genetics Science Animals Biology World news Evolution Source Type: news

Dog DNA study reveals the incredible journey of man's best friend
Descended from the grey wolf, domesticated dogs have been companions to humans for about 33,000 years, a genetic study has shownMan ’s proverbial first best friend was probably a grey wolf that may have made contact with the first human companions about 33,000 years ago, somewhere in south-east Asia.About 15,000 years ago, a small pack of domesticated dogs began trotting towards the Middle East and Africa.Canis lupus familiaris made it to Europe about 10,000 years ago, and when civilisation began in theFertile Crescent, and humans began to build farmsteads and villages with walls, dogs were already there to help keep gua...
Source: Guardian Unlimited Science - December 15, 2015 Category: Science Authors: Tim Radford Tags: Genetics Science Animals Biology World news Evolution Source Type: news

Treatment of lupus
LupuzorTM may become the first specific and non-immunosuppressant therapy for lupus, a disabling autoimmune disease that is currently incurable. This peptide is the subject of a patent (granted in 2009) and has already successfully completed phases I and II of its regulatory clinical trials. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - December 15, 2015 Category: Science Source Type: news

Diseases that cause skin problems also can trigger serious neurological conditions
(Loyola University Health System) Diseases such as lupus that cause rashes and other skin problems also can trigger migraine headaches, strokes and other serious neurological conditions, according to an article in a new volume of the Handbook of Clinical Neurology. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 15, 2015 Category: Global & Universal Source Type: news

Why Is It Called Christmas Disease?
Discussion Too much or too little causes the important homeostatic balance of life to be upset. This is true of the interactions between the circulatory and hematology systems of the body and their important function in ensuring that the circulatory system plumbing is not leaking (i.e. bleeding) and also not getting plugged up (i.e. thrombosis). A healthy system has adequate numbers of functional platelets, and protein synthesis of the factors needed for a balanced hemostasis system. An adequate amount of Vitamin K is needed for some factors activity. Additionally the absence of any drugs that interfere with platelets or t...
Source: PediatricEducation.org - December 14, 2015 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news