Anti-DNA antibody-targeted D-peptide nanoparticles ameliorate lupus nephritis in MRL/lpr mice
J Autoimmun. 2024 Mar 16;145:103205. doi: 10.1016/j.jaut.2024.103205. Online ahead of print.ABSTRACTPeptide ALW (ALWPPNLHAWVP) targeting anti-dsDNA antibodies has shown promising therapeutic effects in alleviating lupus nephritis, but is potentially limited by poor stability and non-kidney targeting. We recently developed a D-form modified ALW, called D-ALW, which has the capacity to widely inhibit pathogenic polyclonal anti-dsDNA antibody reactions. Further modification of D-ALW using PEG-PLGA nanoparticles to enhance good kidney-targeting ability and extend half-life. Here, we demonstrate that the D-form modified ALW mai...
Source: Journal of Autoimmunity - March 17, 2024 Category: Allergy & Immunology Authors: Yaqi Wang Shuang Wang Wei Liu Hanjiang Gu Mai Luo Tong Xiao Mingzhu Zhou Yutong Ran Shengxiang Xiao Yumin Xia Huixia Wang Source Type: research

Anti-DNA antibody-targeted D-peptide nanoparticles ameliorate lupus nephritis in MRL/lpr mice
J Autoimmun. 2024 Mar 16;145:103205. doi: 10.1016/j.jaut.2024.103205. Online ahead of print.ABSTRACTPeptide ALW (ALWPPNLHAWVP) targeting anti-dsDNA antibodies has shown promising therapeutic effects in alleviating lupus nephritis, but is potentially limited by poor stability and non-kidney targeting. We recently developed a D-form modified ALW, called D-ALW, which has the capacity to widely inhibit pathogenic polyclonal anti-dsDNA antibody reactions. Further modification of D-ALW using PEG-PLGA nanoparticles to enhance good kidney-targeting ability and extend half-life. Here, we demonstrate that the D-form modified ALW mai...
Source: Journal of Autoimmunity - March 17, 2024 Category: Allergy & Immunology Authors: Yaqi Wang Shuang Wang Wei Liu Hanjiang Gu Mai Luo Tong Xiao Mingzhu Zhou Yutong Ran Shengxiang Xiao Yumin Xia Huixia Wang Source Type: research

Subclinical synovitis impact on the progression of lupus joint disease: A 10-year longitudinal multicenter study
CONCLUSIONS: The finding of subclinical synovitis in patients with systemic lupus erythematosus is associated with the development of joint disease progression both clinically and ultrasonographically.PMID:38491423 | DOI:10.1177/09612033241240584 (Source: Lupus)
Source: Lupus - March 16, 2024 Category: Rheumatology Authors: Carlos A Guill én-Astete Marcelino Revenga-Mart ínez Antonio C Zea-Mendoza Mar ía E Brito-Brito Pablo Zurita-Prada Claudia Urrego-Laur ín Lourdes Villalobos-S ánchez Nuria Garc ía-Montes M ónica Vázquez-Díaz Source Type: research

Subclinical synovitis impact on the progression of lupus joint disease: A 10-year longitudinal multicenter study
CONCLUSIONS: The finding of subclinical synovitis in patients with systemic lupus erythematosus is associated with the development of joint disease progression both clinically and ultrasonographically.PMID:38491423 | DOI:10.1177/09612033241240584 (Source: Lupus)
Source: Lupus - March 16, 2024 Category: Rheumatology Authors: Carlos A Guill én-Astete Marcelino Revenga-Mart ínez Antonio C Zea-Mendoza Mar ía E Brito-Brito Pablo Zurita-Prada Claudia Urrego-Laur ín Lourdes Villalobos-S ánchez Nuria Garc ía-Montes M ónica Vázquez-Díaz Source Type: research

Subclinical synovitis impact on the progression of lupus joint disease: A 10-year longitudinal multicenter study
CONCLUSIONS: The finding of subclinical synovitis in patients with systemic lupus erythematosus is associated with the development of joint disease progression both clinically and ultrasonographically.PMID:38491423 | DOI:10.1177/09612033241240584 (Source: Lupus)
Source: Lupus - March 16, 2024 Category: Rheumatology Authors: Carlos A Guill én-Astete Marcelino Revenga-Mart ínez Antonio C Zea-Mendoza Mar ía E Brito-Brito Pablo Zurita-Prada Claudia Urrego-Laur ín Lourdes Villalobos-S ánchez Nuria Garc ía-Montes M ónica Vázquez-Díaz Source Type: research

The Problem of Pain in Lupus: Epidemiological Profiles of Patients Attending Multidisciplinary Pain Clinics
Patients with systemic lupus erythematosus (SLE) bear a significant burden of pain. We aimed to identify factors that distinguish patients with SLE referred to comprehensive pain clinics and those who are not. Characterizing this patient population will identify unmet needs in SLE management and inform efforts to improve pain care in rheumatology. (Source: Pain Management Nursing)
Source: Pain Management Nursing - March 16, 2024 Category: Nursing Authors: Tiffany E. Jiang, Alissa P. Pascual, Nathan Le, Thy B. Nguyen, Sean Mackey, Beth D. Darnall, Julia F. Simard, Titilola Falasinnu Tags: Original Research Source Type: research

Case report: Dysgeusia in a senile male systemic lupus erythematosus patient with serious cytomegalovirus infection
(Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - March 15, 2024 Category: Rheumatology Authors: I ‐Ting Tsai, Hung‐Hsin Lin, Chia‐Hua Lin, Feng‐Cheng Liu, Hsiang‐Cheng Chen, Fu‐Chiang Yeh Tags: LETTER TO THE EDITOR Source Type: research

Comprehensive Pan-cancer Analysis of CMPK2 as Biomarker and Prognostic Indicator for Immunotherapy
CONCLUSION: Our analysis preliminarily describes the complex function of CMPK2 in cancer progression and immune microenvironment highlighting its potential as a diagnostic and therapeutic target for immunotherapy.PMID:38486392 | DOI:10.2174/0115680096281451240306062101 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - March 15, 2024 Category: Cancer & Oncology Authors: Jingyuan Luo Qianyue Zhang Shutong Wang Luojie Zheng Jie Liu Yuchen Zhang Yingchen Wang Ranran Wang Zhigang Xiao Zheng Li Source Type: research

Hearing loss in Takayasu's arteritis
CONCLUSIONS: Our study reveals an increased prevalence of hearing loss in TAK. Further research is crucial to uncover the underlying causes.PMID:38489315 | DOI:10.55563/clinexprheumatol/gtd2uv (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - March 15, 2024 Category: Rheumatology Authors: Ugur Kimyon Emine Deniz G özen Ebru Karaman Elif Emel G ünay Sinem Nihal Esatoglu Ahmet Atas Emin Karaman Emire Seyahi Source Type: research

Mental health in paediatric and adult myositis-related diseases: current state of research, interventions, and future steps from the MIHRA Psychological Impact Scientific Working Group
Clin Exp Rheumatol. 2024 Feb;42(2):413-424. doi: 10.55563/clinexprheumatol/cngdfn. Epub 2024 Mar 14.ABSTRACTPsychological and emotional well-being are critical aspects of overall health for individuals with chronic rheumatologic conditions. Mental health-related literature, however, predominantly focuses on systemic lupus erythematosus or rheumatoid arthritis, with limited emphasis on idiopathic inflammatory myopathies (IIMs). High proportions of those with juvenile myositis report psychological distress at levels warranting mental health referral. Adults with dermatomyositis diagnosed with depression or anxiety do not rec...
Source: Clinical and Experimental Rheumatology - March 15, 2024 Category: Rheumatology Authors: Aviya Lanis Helene Alexanderson Kaveh Ardalan Suzanne Edison Christopher D Graham Ingrid de Groot Latika Gupta Susan Kim Andrea M Knight Linda Kobert Polly Livermore Christian Lood Clarissa Pilkington Malin Regardt Tamar B Rubinstein Susan Shenoi Luke Tur Source Type: research

First validation of the childhood lupus low disease activity state (cLLDAS) definition in a real-life longitudinal cSLE cohort
CONCLUSION: Time to reach cLLDAS in cSLE differs from time to (a)LLDAS, which validates the new cLLDAS definition. Attaining cLLDAS-50 was difficult in real-life. This cohort shows the high risk for early damage in cSLE. T2T with earlier focus on steroid-tapering and starting steroid-sparing drugs seems important to prevent (steroid-related) damage in cSLE.PMID:38490344 | DOI:10.1016/j.clim.2024.110172 (Source: Clinical Immunology)
Source: Clinical Immunology - March 15, 2024 Category: Allergy & Immunology Authors: Sandy C Bergkamp Thipa Kanagasabapathy Mariken P Gruppen Taco W Kuijpers Amara Nassar-Sheikh Rashid J Merlijn van den Berg Dieneke Schonenberg-Meinema Source Type: research

Comparison Of Attainment And Protective Effects Of Lupus Low Disease Activity State In Patients With Newly Diagnosed Versus Established SLE
CONCLUSION: LLDAS attainment is protective from flare in recent onset SLE. Significant protection from damage accrual was not observed, due to low rates of damage accrual in the first years after SLE diagnosis.PMID:38490668 | DOI:10.3899/jrheum.2023-0900 (Source: J Rheumatol)
Source: J Rheumatol - March 15, 2024 Category: Rheumatology Authors: Vera Golder Rangi Kandane-Rathnayake Worawit Louthrenoo Yi-Hsing Chen Jiacai Cho Aisha Lateef Laniyati Hamijoyo Shue-Fen Luo Yeong-Jian J Wu Sandra V Navarra Leonid Zamora Zhanguo Li Sargunan Sockalingam Yasuhiro Katsumata Masayoshi Harigai Yanjie Hao Zhu Source Type: research

Global tuberculosis disease and infection in systemic lupus erythematosus patients: A systematic review and meta-analysis
CONCLUSION: TB prevalence in SLE was relatively high and associated with GC. Awareness of TB and lowering GC dose are warranted to alleviate the TB burden in SLE.PMID:38490946 | DOI:10.1177/09612033241239504 (Source: Lupus)
Source: Lupus - March 15, 2024 Category: Rheumatology Authors: Guntur Darmawan Lie Monica Sherine Liman Suryo Anggoro Kusumo Wibowo Laniyati Hamijoyo Lika Apriani Nur Atik Bachti Alisjahbana Edhyana Sahiratmadja Source Type: research

Comprehensive Pan-cancer Analysis of CMPK2 as Biomarker and Prognostic Indicator for Immunotherapy
CONCLUSION: Our analysis preliminarily describes the complex function of CMPK2 in cancer progression and immune microenvironment highlighting its potential as a diagnostic and therapeutic target for immunotherapy.PMID:38486392 | DOI:10.2174/0115680096281451240306062101 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - March 15, 2024 Category: Cancer & Oncology Authors: Jingyuan Luo Qianyue Zhang Shutong Wang Luojie Zheng Jie Liu Yuchen Zhang Yingchen Wang Ranran Wang Zhigang Xiao Zheng Li Source Type: research

Comparison Of Attainment And Protective Effects Of Lupus Low Disease Activity State In Patients With Newly Diagnosed Versus Established SLE
CONCLUSION: LLDAS attainment is protective from flare in recent onset SLE. Significant protection from damage accrual was not observed, due to low rates of damage accrual in the first years after SLE diagnosis.PMID:38490668 | DOI:10.3899/jrheum.2023-0900 (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - March 15, 2024 Category: Rheumatology Authors: Vera Golder Rangi Kandane-Rathnayake Worawit Louthrenoo Yi-Hsing Chen Jiacai Cho Aisha Lateef Laniyati Hamijoyo Shue-Fen Luo Yeong-Jian J Wu Sandra V Navarra Leonid Zamora Zhanguo Li Sargunan Sockalingam Yasuhiro Katsumata Masayoshi Harigai Yanjie Hao Zhu Source Type: research