Prevalence of neonatal lupus in a small group of antibody-carrying mothers and frequency of complete atrioventricular block
CONCLUSIONS: CCAB is rare and frequently associated with a maternal autoimmune disease, practically all of them will require a definitive pacemaker at some point in their lives.PMID:38507328 | DOI:10.24875/ACM.22000233 (Source: Archivos de Cardiologia de Mexico)
Source: Archivos de Cardiologia de Mexico - March 20, 2024 Category: Cardiology Authors: H éctor González-Zambrano Gerardo Orozco-Barocio Mar ía C Franco-Ramos Source Type: research

Low recurrent thrombosis rates in single positive antiphospholipid syndrome regardless of type of anticoagulation
Thrombotic antiphospholipid syndrome (TAPS) is characterized by thrombosis and persistently positive tests for antiphospholipid antibodies or lupus anticoagulant (LAC). Triple-positive APS has the highest risk of recurrent thrombosis, but no studies have focused on recurrent thrombosis in patients with single-positive TAPS. We conducted a retrospective cohort study of patients with single-positive TAPS diagnosed at Lifespan Health System, Rhode Island, to determine the rates and risk factors for recurrent thrombosis. (Source: Thrombosis Research)
Source: Thrombosis Research - March 20, 2024 Category: Hematology Authors: Brianna R. Bakow, Lisa Yanek, Mark A. Crowther, Shruti Chaturvedi Source Type: research

Aeromonas veronii-associated endogenous endophthalmitis: a case report
ConclusionsAeromonas veronii can cause infection in the human eye, which can manifest as acute endophthalmitis. Early diagnosis and targeted therapy are important for successful treatment. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - March 20, 2024 Category: General Medicine Source Type: research

Interferon Upregulation Associates with Insulin Resistance in Humans
Curr Diabetes Rev. 2024 Mar 18. doi: 10.2174/0115733998294022240309105112. Online ahead of print.ABSTRACTIn humans, insulin resistance is a physiological response to infections developed to supply sufficient energy to the activated immune system. This metabolic adaptation facilitates the immune response but usually persists after the recovery period of the infection and predisposes the hosts to type 2 diabetes and vascular injury. In patients with diabetes, superimposed insulin resistance worsens metabolic control and promotes diabetic ketoacidosis. Pathogenic mechanisms underlying insulin resistance during microbial invas...
Source: Current Diabetes Reviews - March 19, 2024 Category: Endocrinology Authors: Maria M Adeva-Andany Natalia Carneiro-Freire Elvira Castro-Quintela Eva Ameneiros-Rodriguez Lucia Adeva-Contreras Carlos Fernandez-Fernandez Source Type: research

Interferon Upregulation Associates with Insulin Resistance in Humans
Curr Diabetes Rev. 2024 Mar 18. doi: 10.2174/0115733998294022240309105112. Online ahead of print.ABSTRACTIn humans, insulin resistance is a physiological response to infections developed to supply sufficient energy to the activated immune system. This metabolic adaptation facilitates the immune response but usually persists after the recovery period of the infection and predisposes the hosts to type 2 diabetes and vascular injury. In patients with diabetes, superimposed insulin resistance worsens metabolic control and promotes diabetic ketoacidosis. Pathogenic mechanisms underlying insulin resistance during microbial invas...
Source: Current Diabetes Reviews - March 19, 2024 Category: Endocrinology Authors: Maria M Adeva-Andany Natalia Carneiro-Freire Elvira Castro-Quintela Eva Ameneiros-Rodriguez Lucia Adeva-Contreras Carlos Fernandez-Fernandez Source Type: research

Interferon Upregulation Associates with Insulin Resistance in Humans
Curr Diabetes Rev. 2024 Mar 18. doi: 10.2174/0115733998294022240309105112. Online ahead of print.ABSTRACTIn humans, insulin resistance is a physiological response to infections developed to supply sufficient energy to the activated immune system. This metabolic adaptation facilitates the immune response but usually persists after the recovery period of the infection and predisposes the hosts to type 2 diabetes and vascular injury. In patients with diabetes, superimposed insulin resistance worsens metabolic control and promotes diabetic ketoacidosis. Pathogenic mechanisms underlying insulin resistance during microbial invas...
Source: Current Diabetes Reviews - March 19, 2024 Category: Endocrinology Authors: Maria M Adeva-Andany Natalia Carneiro-Freire Elvira Castro-Quintela Eva Ameneiros-Rodriguez Lucia Adeva-Contreras Carlos Fernandez-Fernandez Source Type: research

Interferon Upregulation Associates with Insulin Resistance in Humans
Curr Diabetes Rev. 2024 Mar 18. doi: 10.2174/0115733998294022240309105112. Online ahead of print.ABSTRACTIn humans, insulin resistance is a physiological response to infections developed to supply sufficient energy to the activated immune system. This metabolic adaptation facilitates the immune response but usually persists after the recovery period of the infection and predisposes the hosts to type 2 diabetes and vascular injury. In patients with diabetes, superimposed insulin resistance worsens metabolic control and promotes diabetic ketoacidosis. Pathogenic mechanisms underlying insulin resistance during microbial invas...
Source: Current Diabetes Reviews - March 19, 2024 Category: Endocrinology Authors: Maria M Adeva-Andany Natalia Carneiro-Freire Elvira Castro-Quintela Eva Ameneiros-Rodriguez Lucia Adeva-Contreras Carlos Fernandez-Fernandez Source Type: research

Interferon Upregulation Associates with Insulin Resistance in Humans
Curr Diabetes Rev. 2024 Mar 18. doi: 10.2174/0115733998294022240309105112. Online ahead of print.ABSTRACTIn humans, insulin resistance is a physiological response to infections developed to supply sufficient energy to the activated immune system. This metabolic adaptation facilitates the immune response but usually persists after the recovery period of the infection and predisposes the hosts to type 2 diabetes and vascular injury. In patients with diabetes, superimposed insulin resistance worsens metabolic control and promotes diabetic ketoacidosis. Pathogenic mechanisms underlying insulin resistance during microbial invas...
Source: Current Diabetes Reviews - March 19, 2024 Category: Endocrinology Authors: Maria M Adeva-Andany Natalia Carneiro-Freire Elvira Castro-Quintela Eva Ameneiros-Rodriguez Lucia Adeva-Contreras Carlos Fernandez-Fernandez Source Type: research

Interferon Upregulation Associates with Insulin Resistance in Humans
Curr Diabetes Rev. 2024 Mar 18. doi: 10.2174/0115733998294022240309105112. Online ahead of print.ABSTRACTIn humans, insulin resistance is a physiological response to infections developed to supply sufficient energy to the activated immune system. This metabolic adaptation facilitates the immune response but usually persists after the recovery period of the infection and predisposes the hosts to type 2 diabetes and vascular injury. In patients with diabetes, superimposed insulin resistance worsens metabolic control and promotes diabetic ketoacidosis. Pathogenic mechanisms underlying insulin resistance during microbial invas...
Source: Current Diabetes Reviews - March 19, 2024 Category: Endocrinology Authors: Maria M Adeva-Andany Natalia Carneiro-Freire Elvira Castro-Quintela Eva Ameneiros-Rodriguez Lucia Adeva-Contreras Carlos Fernandez-Fernandez Source Type: research

Standing on Shoulders: Interferon Research, from Viral Interference to Lupus Pathogenesis and Treatment
The discovery of interferon in the 1950s represents much more than the identification of the first cytokine and the key mediator of anti-viral host defense. Defining the molecular nature and complexity of the type I interferon family, as well as its inducers and molecular mechanisms of action, was the work of investigators working at the highest level and producing insights of great consequence. Current knowledge of receptor-ligand interactions, cell signaling, and transcriptional regulation derive from studies of type I interferon. It is on the shoulders of the giants who produced that knowledge that others stand and have...
Source: Arthritis and Rheumatology - March 19, 2024 Category: Rheumatology Authors: Mary K. Crow, Mikhail Olferiev, Kyriakos A. Kirou Tags: Review Source Type: research

An updated advancement of bifunctional IL-27 in inflammatory autoimmune diseases
Interleukin-27 (IL-27) is a member of the IL-12 family. The gene encoding IL-27 is located at chromosome 16p11. IL-27 is considered as a heterodimeric cytokine, which consists of Epstein–Barr virus (EBV)-induced gene 3 (Ebi3) and IL-27p28. Based on the function of IL-27, it binds to receptor IL-27rα or gp130 and then regulates downstream cascade. To date, findings show that the expression of IL-27 is abnormal in different inflammatory autoimmune diseases (including systemic lupus erythematosus, rheumatoid arthritis, Sjogren syndrome, Behcet’s disease, inflammatory bowel disease, multiple sclerosis, systemic sclerosis,...
Source: Frontiers in Immunology - March 19, 2024 Category: Allergy & Immunology Source Type: research

Antimicrobial resistance in wildlife: detection of antimicrobial resistance genes in Apennine wolves (Canis lupus italicus Altobello, 1921) from Central Italy
AbstractThe aim of this study was to molecularly investigate the presence of antimicrobial resistance genes (ARGs) in organ samples from 11 Apennine wolves (Canis lupus italicus) collected in Central Italy. Samples from lung, liver, spleen, kidney, tongue and intestine were investigated by PCRs targeting the following genes:tet(A),tet(B),tet(C),tet(D),tet(E),tet(G),tet(K),tet(L),tet(M),tet(O),tetA(P),tet(Q),tet(S),tet(X),sul1,sul2,sul3,blaCTX −M,blaSHV,blaTEM andmcr-1. A PCR positivity was highlighted for 13 out of the 21 tested genes; no positive results were obtained fortet(C),tet(D),tet(E),tet(G),sul3,blaCTX,blaSHV an...
Source: Veterinary Research Communications - March 19, 2024 Category: Veterinary Research Source Type: research

Progressive multifocal leukoencephalopathy associated with systemic lupus erythematosus: longitudinal observation of lymphocytes, JC virus in cerebrospinal fluid, and brain magnetic resonance imaging
This report presents the case of a patient who developed PML due to SLE-associated multiple factors. A 60-year-old woman diagnosed with SLE undergoing multiple immunosuppressive therapies, including azathioprine, presented with cerebral cortical symptoms, lymphocytopenia, and vitamin B12 deficiency and was subsequently diagnosed with SLE-associated PML. We evaluated the cause and disease activity of PML, focusing on the longitudinal assessment of lymphocytopenia, JC virus (JCV) DNA copy number in the cerebrospinal fluid, and magnetic resonance imaging (MRI) findings. Discontinuing azathioprine and initiating alternative im...
Source: Journal of NeuroVirology - March 19, 2024 Category: Neurology Source Type: research

Regarding the association between innate immune function with disease activity in systemic lupus erythematosus patients
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - March 18, 2024 Category: Rheumatology Source Type: research

Evaluation of Type 2 SLE symptoms in patients with a range of lupus nephritis activity
ConclusionsWhile Type 2 SLE symptoms are common in SLE, our findings suggest that patients with active nephritis experience significant Type 2 SLE symptoms that may be ameliorated as nephritis improves. We also observed that non-nephritis patients had a similar burden of Type 2 SLE symptoms as patients with active nephritis, despite having on average lower Type 1 SLE activity. Therefore, the etiology of Type 2 SLE symptoms is likely multifactorial and may be driven by inflammatory and non-inflammatory biopsychosocial factors.Key Points• Patients with active nephritis experienced significant Type 2 symptoms that may be am...
Source: Clinical Rheumatology - March 18, 2024 Category: Rheumatology Source Type: research