Fully human anti-CD19 CAR T cells derived from systemic lupus erythematosus patients exhibit cytotoxicity with reduced inflammatory cytokine production
CONCLUSION: Hu19-CD828Z CAR T cells generated from SLE patient lymphocytes demonstrate CAR-mediated and CD19-dependent activity against autologous primary B cells with reduced inflammatory cytokine production supporting KYV-101 as a novel potential therapy for the depletion of pathogenic B cells in SLE patients.PMID:38548226 | DOI:10.1016/j.jtct.2024.03.023 (Source: Cancer Control)
Source: Cancer Control - March 28, 2024 Category: Cancer & Oncology Authors: Janin Dingfelder Michael Aigner Jule Taubmann Ioanna Minopoulou Soo Park Charles D Kaplan Joseph K Cheng Tom Van Blarcom Georg Schett Andreas Mackensen Gloria Lutzny-Geier Source Type: research
Factors associated with non-adherence to medications in systemic lupus erythematosus: Results from a Swedish survey
CONCLUSIONS: Beliefs about medications were a major determinant of medication non-adherence. Patient education may help alleviate the negative impact of misinformation/unawareness on adherence.PMID:38545763 | DOI:10.1177/09612033241242692 (Source: Lupus)
Source: Lupus - March 28, 2024 Category: Rheumatology Authors: Sharzad Emamikia Alvaro Gomez Theodor Ådahl Gunilla von Perner Yvonne Enman Katerina Chatzidionysiou Elizabeth V Arkema Ioannis Parodis Source Type: research
Systemic Lupus Erythematosus-related Lung Disease
Semin Respir Crit Care Med. 2024 Mar 28. doi: 10.1055/s-0044-1782653. Online ahead of print.ABSTRACTSystemic Lupus Erythematosus (SLE) is a multifaceted, multisystem autoimmune disorder with diverse clinical expressions. While prevalence reports vary widely, pulmonary involvement accounts for significant morbidity and mortality in SLE. This comprehensive review explores the spectrum of pulmonary disease in SLE, including upper airway manifestations (e.g., laryngeal affection), lower airway conditions (e.g., bronchitis, bronchiolitis, bronchiectasis), parenchymal diseases (e.g., interstitial lung disease, acute lupus pneumo...
Source: Respiratory Care - March 28, 2024 Category: Respiratory Medicine Authors: Elisabeth Bendstrup Evelyn Lynn Anne Troldborg Source Type: research
Systemic lupus erythematosus: one year in review 2024
Clin Exp Rheumatol. 2024 Mar;42(3):583-592. doi: 10.55563/clinexprheumatol/mnvmvo. Epub 2024 Mar 27.ABSTRACTSystemic lupus erythematosus (SLE) is classically regarded as the landmark of systemic autoimmune diseases, characterised by protean, multi-systemic manifestations and a highly variable clinical course.Over the last years, both clinical and translational clinical research efforts led to significant steps forward in management and treatment of SLE. However, numerous aspects of SLE, from pathogenesis to treatment, still remain challenging, and several unmet needs persist for both patients and physicians. Following the ...
Source: Clinical and Experimental Rheumatology - March 28, 2024 Category: Rheumatology Authors: Davide Schilir ò Ettore Silvagni Benedetta Cirib è Federico Fattorini Vincenzo Maccarrone Elena Elefante Viola Signorini Dina Zucchi Chiara Cardelli Alessandra Bortoluzzi Chiara Tani Source Type: research
Assessment of Arterial Stiffness and Biochemical Markers in Systemic Lupus Erythematosus in the Diagnosis of Subclinical Atherosclerosis
J Pers Med. 2024 Mar 8;14(3):289. doi: 10.3390/jpm14030289.ABSTRACTPatients with systemic lupus erythematosus (SLE) are 2-10 times more likely to develop cardiovascular disease (CVD) than the general population. The assessment of the risk of developing CVD is an important direction for further clinical management. The study was conducted retrospectively and included patients with SLE. The aim of the study was to assess the measurements of pulse wave velocity (PWV), carotid intima-media thickness (CIMT), ankle-brachial index (ABI) and biochemical parameters. Subclinical atherosclerosis was also assessed. The study included ...
Source: Atherosclerosis - March 28, 2024 Category: Cardiology Authors: Dominika Blachut Brygida Przywara-Chowaniec Michalina Mazurkiewicz Andrzej Tomasik Source Type: research
Factors associated with non-adherence to medications in systemic lupus erythematosus: Results from a Swedish survey
CONCLUSIONS: Beliefs about medications were a major determinant of medication non-adherence. Patient education may help alleviate the negative impact of misinformation/unawareness on adherence.PMID:38545763 | DOI:10.1177/09612033241242692 (Source: Lupus)
Source: Lupus - March 28, 2024 Category: Rheumatology Authors: Sharzad Emamikia Alvaro Gomez Theodor Ådahl Gunilla von Perner Yvonne Enman Katerina Chatzidionysiou Elizabeth V Arkema Ioannis Parodis Source Type: research
Systemic Lupus Erythematosus-related Lung Disease
Semin Respir Crit Care Med. 2024 Mar 28. doi: 10.1055/s-0044-1782653. Online ahead of print.ABSTRACTSystemic Lupus Erythematosus (SLE) is a multifaceted, multisystem autoimmune disorder with diverse clinical expressions. While prevalence reports vary widely, pulmonary involvement accounts for significant morbidity and mortality in SLE. This comprehensive review explores the spectrum of pulmonary disease in SLE, including upper airway manifestations (e.g., laryngeal affection), lower airway conditions (e.g., bronchitis, bronchiolitis, bronchiectasis), parenchymal diseases (e.g., interstitial lung disease, acute lupus pneumo...
Source: Respiratory Care - March 28, 2024 Category: Respiratory Medicine Authors: Elisabeth Bendstrup Evelyn Lynn Anne Troldborg Source Type: research
Systemic lupus erythematosus: one year in review 2024
Clin Exp Rheumatol. 2024 Mar;42(3):583-592. doi: 10.55563/clinexprheumatol/mnvmvo. Epub 2024 Mar 27.ABSTRACTSystemic lupus erythematosus (SLE) is classically regarded as the landmark of systemic autoimmune diseases, characterised by protean, multi-systemic manifestations and a highly variable clinical course.Over the last years, both clinical and translational clinical research efforts led to significant steps forward in management and treatment of SLE. However, numerous aspects of SLE, from pathogenesis to treatment, still remain challenging, and several unmet needs persist for both patients and physicians. Following the ...
Source: Clinical and Experimental Rheumatology - March 28, 2024 Category: Rheumatology Authors: Davide Schilir ò Ettore Silvagni Benedetta Cirib è Federico Fattorini Vincenzo Maccarrone Elena Elefante Viola Signorini Dina Zucchi Chiara Cardelli Alessandra Bortoluzzi Chiara Tani Source Type: research
Factors associated with non-adherence to medications in systemic lupus erythematosus: Results from a Swedish survey
CONCLUSIONS: Beliefs about medications were a major determinant of medication non-adherence. Patient education may help alleviate the negative impact of misinformation/unawareness on adherence.PMID:38545763 | DOI:10.1177/09612033241242692 (Source: Lupus)
Source: Lupus - March 28, 2024 Category: Rheumatology Authors: Sharzad Emamikia Alvaro Gomez Theodor Ådahl Gunilla von Perner Yvonne Enman Katerina Chatzidionysiou Elizabeth V Arkema Ioannis Parodis Source Type: research
Systemic lupus erythematosus: one year in review 2024
Clin Exp Rheumatol. 2024 Mar;42(3):583-592. doi: 10.55563/clinexprheumatol/mnvmvo. Epub 2024 Mar 27.ABSTRACTSystemic lupus erythematosus (SLE) is classically regarded as the landmark of systemic autoimmune diseases, characterised by protean, multi-systemic manifestations and a highly variable clinical course.Over the last years, both clinical and translational clinical research efforts led to significant steps forward in management and treatment of SLE. However, numerous aspects of SLE, from pathogenesis to treatment, still remain challenging, and several unmet needs persist for both patients and physicians. Following the ...
Source: Clinical and Experimental Rheumatology - March 28, 2024 Category: Rheumatology Authors: Davide Schilir ò Ettore Silvagni Benedetta Cirib è Federico Fattorini Vincenzo Maccarrone Elena Elefante Viola Signorini Dina Zucchi Chiara Cardelli Alessandra Bortoluzzi Chiara Tani Source Type: research
Factors associated with non-adherence to medications in systemic lupus erythematosus: Results from a Swedish survey
CONCLUSIONS: Beliefs about medications were a major determinant of medication non-adherence. Patient education may help alleviate the negative impact of misinformation/unawareness on adherence.PMID:38545763 | DOI:10.1177/09612033241242692 (Source: Lupus)
Source: Lupus - March 28, 2024 Category: Rheumatology Authors: Sharzad Emamikia Alvaro Gomez Theodor Ådahl Gunilla von Perner Yvonne Enman Katerina Chatzidionysiou Elizabeth V Arkema Ioannis Parodis Source Type: research
Systemic lupus erythematosus: one year in review 2024
Clin Exp Rheumatol. 2024 Mar;42(3):583-592. doi: 10.55563/clinexprheumatol/mnvmvo. Epub 2024 Mar 27.ABSTRACTSystemic lupus erythematosus (SLE) is classically regarded as the landmark of systemic autoimmune diseases, characterised by protean, multi-systemic manifestations and a highly variable clinical course.Over the last years, both clinical and translational clinical research efforts led to significant steps forward in management and treatment of SLE. However, numerous aspects of SLE, from pathogenesis to treatment, still remain challenging, and several unmet needs persist for both patients and physicians. Following the ...
Source: Clinical and Experimental Rheumatology - March 28, 2024 Category: Rheumatology Authors: Davide Schilir ò Ettore Silvagni Benedetta Cirib è Federico Fattorini Vincenzo Maccarrone Elena Elefante Viola Signorini Dina Zucchi Chiara Cardelli Alessandra Bortoluzzi Chiara Tani Source Type: research
GSE252470 Single-cell RNA sequencing reveals the cellular and molecular heterogeneity of treatment-na ïve primary osteosarcoma in dogs
Contributors : Dylan T Ammons ; Steven DowSeries Type : Expression profiling by high throughput sequencingOrganism : Canis lupus familiarisWe used single-cell RNA sequencing to characterize the heterogeneity of canine osteosarcoma (OS) tumors. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - March 28, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Canis lupus familiaris Source Type: research
GSE251693 Spatial-transcriptomic analysis reveals lupus-associated features DNASE1L3 and double-negative B cells interacting in intestinal lymphoid tissue
Contributors : Jo Spencer ; Lucia Montorsi ; Michael PitcherSeries Type : OtherOrganism : Homo sapiensIntestinal homeostasis is maintained by the response of gut-associated lymphoid tissue to bacteria transported across the follicle associated epithelium into the subepithelial dome. The initial response to antigens and how bacteria are handled is incompletely understood. By iterative application of spatial transcriptomics and multiplexed single-cell technologies, we identify that the double negative 2 subset of B cells, previously associated with autoimmune diseases, is present in the subepithelial dome in health. We sh...
Source: GEO: Gene Expression Omnibus - March 28, 2024 Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research
