Comment on: Impact of prior bariatric surgery on outcomes of hospitalized patients with systemic lupus erythematosus: a propensity score-matched analysis of the U.S. Nationwide Inpatient Sample
The myriad of benefits from metabolic and bariatric surgery (MBS) include long-term mitigation of obesity-associated medical comorbidities, improved quality of life, and increased life expectancy. The 1991 NIH consensus development conference panel published MBS patient selection guidelines over 30 years ago with limited studies and general clinical knowledge about obesity-related health issues. Since the 1980s, there has been an explosion in research studies looking at the positive impact of MBS on obesity-related medical problems. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - April 1, 2024 Category: Surgery Authors: Elizabeth M. Hechenbleikner Tags: Editorial Source Type: research
74. Labial Adhesion Mimicking a Persistent Urogenital Sinus in a Reproductive-Aged Woman: a Case Report
Labial adhesion is a condition generally associated with hypoestrogenic status of prepubertal girls but can also occur during reproductive years related to vulvar trauma (mutilation, delivery, sexual abuse) or inflammatory diseases (herpes, lichen, lupus). In severe and long-standing cases, it can mimic congenital anomalies, such as persistent urogenital sinus (PUS), when is difficult to distinguish the characteristic midline raphe of a fusion. The purpose of this case it to portray the difficulties of the differential diagnosis of persistent labial adhesions and congenital malformations. (Source: Journal of Pediatric and ...
Source: Journal of Pediatric and Adolescent Gynecology - April 1, 2024 Category: OBGYN Authors: Maria Canessa, Alvaro Cerda, Andrea Huneeus, Mariane von M ühlenbrock Source Type: research
From Prescription to Predicament: Hydroxychloroquine (HCQ)-Induced Cardiogenic Shock (CS)
We present a case of biopsy-proven HCQ-induced CS successfully managed with tMCS as a bridge to recovery. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , A. Al-Busaidi, R. Gilead, D.H. Brahmbhatt, Y. Xie, N. Aleksova, A. Luk, J. Duero Posada, Y. Moayedi, M.A. Seidman, M. Laflamme, R.J. Cusimano, J. Alvarez, E. Fan, H. Faghfoury, F. Billia Source Type: research
Cardiogenic Shock Due to Culture Negative Mitral Valve Endocarditis
We present a case of culture negative endocarditis in a young patient who presented in cardiogenic shock (CS) and was bridged with temporary mechanical circulatory support (MCS) including veno-arterial extra corporeal membrane oxygenation (VA-ECMO) to mitral valve replacement (MVR) which was complicated by paravalvular abscess. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , I. Vavilin, E. Sarin, Q. Zhao, K. Kumaran, S. Sinha Source Type: research
Animal models of neuropsychiatric systemic lupus erythematosus: deciphering the complexity and guiding therapeutic development
Autoimmunity. 2024 Dec;57(1):2330387. doi: 10.1080/08916934.2024.2330387. Epub 2024 Mar 31.ABSTRACTSystemic lupus erythematosus (SLE) poses formidable challenges due to its multifaceted etiology while impacting multiple tissues and organs and displaying diverse clinical manifestations. Genetic and environmental factors contribute to SLE complexity, with relatively limited approved therapeutic options. Murine models offer insights into SLE pathogenesis but do not always replicate the nuances of human disease. This review critically evaluates spontaneous and induced animal models, emphasizing their validity and relevance to ...
Source: Autoimmunity - March 31, 2024 Category: Allergy & Immunology Authors: Baruh Polis Carla M Cuda Chaim Putterman Source Type: research
GSE255441 Microbiota-derived Inosine Suppresses Systemic Autoimmunity via Restriction of B Cell Differentiation and Migration
Contributors : Qianjin Lu ; Lingyu Gao ; Yuhan Zhang ; Shengwen ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe role of gut microbiota dysbiosis in systemic lupus erythematosus (SLE) pathogenesis remains elusive. Here, we show that fecal microbiota transplantation (FMT) from healthy mice to lupus mice ameliorated lupus-like symptoms. Microbiota reconstitution effectively reduced systemic class switch recombination and elevated IGH na ïve isotype. Microbiota profiling revealed an enrichment of Lactobacillus johnsonii post-FMT, with a significant correlation to purine metab...
Source: GEO: Gene Expression Omnibus - March 31, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Obesity and tobacco smoking are independently associated with poor patient-reported outcomes in SLE: a cross-sectional study
AbstractWe investigated associations of obesity and tobacco smoking with health-related quality of life (HRQoL), pain, fatigue, and functional impairment in systemic lupus erythematosus (SLE). Furthermore, we explored whether there was an effect modification between these two factors. We included adult SLE patients from the Link öping University Hospital (n = 325) in the present cross-sectional analysis. We further included population-based controls and performed cardinality matching to balance age and sex distributions with cases (n = 224). HRQoL was assessed with the EQ-5D index score; pain, fatigue, and overall...
Source: Rheumatology International - March 30, 2024 Category: Rheumatology Source Type: research
The prevalence of neutropenia and association with infections in patients with systemic lupus erythematosus: a Swedish single-center study conducted over 14 years
AbstractHematologic abnormalities are common manifestations of SLE, although neutropenia is observed less frequently and is not included in the classification criteria. Nonetheless, neutropenia is a risk factor for infections, especially those caused by bacteria or fungi. We aimed to evaluate the impact of neutropenia in SLE through a systematic investigation of all infections in a large cohort of well-characterized patients, focusing on neutropenia, lymphopenia, and hypocomplementemia. Longitudinal clinical and laboratory parameters obtained at visits to the Rheumatology Unit, Link öping University Hospital, and linked d...
Source: Rheumatology International - March 30, 2024 Category: Rheumatology Source Type: research
Pancytopenia with aplastic anemia in systemic lupus erythematosus: case series and literature review
We report two cases of SLE patients who presented with pancytopenia, with bone marrow biopsy confirmed AA. One case was treated with cyclophosphamide but unfortunately succumbed to Acute Respiratory Distress Syndrome (ARDS), while the other case was managed with rituximab with a good response. Interestingly, both patients were on azathioprine before the diagnosis of AA. A comprehensive search for reported cases of AA in PubMed, Scopus, and the Directory of Open Access Journals databases was performed to enhance the understanding of the diagnostic and management challenges associated with AA in SLE, facilitating ongoing exp...
Source: Rheumatology International - March 30, 2024 Category: Rheumatology Source Type: research
Quality indicators and satisfaction with care in patients with systemic lupus erythematosus
AbstractGrading the quality of care in patients with systemic lupus erythematosus and determining its relationship with care satisfaction may recognize gaps that could lead to better clinical practice. Eighteen quality indicators (QIs) were recently developed and validated for patients with SLE based on the 2019 EULAR management recommendations. Few studies have analyzed the relationship between quality of care and care satisfaction in patients with lupus. This was a cross-sectional study. We included patients at least 18 years old who met the EULAR/ACR 2019 classification criteria for SLE. We interviewed patients and re...
Source: Rheumatology International - March 30, 2024 Category: Rheumatology Source Type: research
Efficacy of lifestyle interventions in the management of systemic lupus erythematosus: a systematic review of the literature
In conclusion, psychosocial interventions are viable for managing depressive symptoms, and exercise appears essential for reducing fatigue and improving aerobic capacity and physical function. Photoprotection should be recommended to all patients. Lifestyle interventions should be considered a complement, not a substitute, to pharmacotherapy. (Source: Rheumatology International)
Source: Rheumatology International - March 30, 2024 Category: Rheumatology Source Type: research
Rutin alleviates lupus nephritis by inhibiting T cell oxidative stress through PPAR γ
Chem Biol Interact. 2024 Mar 28:110972. doi: 10.1016/j.cbi.2024.110972. Online ahead of print.ABSTRACTSystemic lupus erythematosus (SLE) is an autoimmune disorder characterized by complex clinical symptoms and multi-organ damage. One of the most prevalent complications of SLE is lupus nephritis (LN). Rutin, a natural flavonoid compound found in various plants used in traditional Chinese medicine, has shown promising anti-inflammatory, antioxidant, and renal protective effects. In our study, we treated MRL/lpr mice, a model known for spontaneously developing LN, with Rutin. Our findings reveal that Rutin markedly reduced se...
Source: Chemico-Biological Interactions - March 30, 2024 Category: Molecular Biology Authors: Tongtong Yi Wei Zhang Ying Hua Xingpan Xin Zhenyu Wu Ying Li Chengping Wen Yongsheng Fan Jinjun Ji Li Xu Source Type: research
Rutin alleviates lupus nephritis by inhibiting T cell oxidative stress through PPAR γ
Chem Biol Interact. 2024 Mar 28:110972. doi: 10.1016/j.cbi.2024.110972. Online ahead of print.ABSTRACTSystemic lupus erythematosus (SLE) is an autoimmune disorder characterized by complex clinical symptoms and multi-organ damage. One of the most prevalent complications of SLE is lupus nephritis (LN). Rutin, a natural flavonoid compound found in various plants used in traditional Chinese medicine, has shown promising anti-inflammatory, antioxidant, and renal protective effects. In our study, we treated MRL/lpr mice, a model known for spontaneously developing LN, with Rutin. Our findings reveal that Rutin markedly reduced se...
Source: Chemico-Biological Interactions - March 30, 2024 Category: Molecular Biology Authors: Tongtong Yi Wei Zhang Ying Hua Xingpan Xin Zhenyu Wu Ying Li Chengping Wen Yongsheng Fan Jinjun Ji Li Xu Source Type: research
Rutin alleviates lupus nephritis by inhibiting T cell oxidative stress through PPAR γ
Chem Biol Interact. 2024 Mar 28;394:110972. doi: 10.1016/j.cbi.2024.110972. Online ahead of print.ABSTRACTSystemic lupus erythematosus (SLE) is an autoimmune disorder characterized by complex clinical symptoms and multi-organ damage. One of the most prevalent complications of SLE is lupus nephritis (LN). Rutin, a natural flavonoid compound found in various plants used in traditional Chinese medicine, has shown promising anti-inflammatory, antioxidant, and renal protective effects. In our study, we treated MRL/lpr mice, a model known for spontaneously developing LN, with Rutin. Our findings reveal that Rutin markedly reduce...
Source: Chemico-Biological Interactions - March 30, 2024 Category: Molecular Biology Authors: Tongtong Yi Wei Zhang Ying Hua Xingpan Xin Zhenyu Wu Ying Li Chengping Wen Yongsheng Fan Jinjun Ji Li Xu Source Type: research
Rutin alleviates lupus nephritis by inhibiting T cell oxidative stress through PPAR γ
Chem Biol Interact. 2024 Mar 28;394:110972. doi: 10.1016/j.cbi.2024.110972. Online ahead of print.ABSTRACTSystemic lupus erythematosus (SLE) is an autoimmune disorder characterized by complex clinical symptoms and multi-organ damage. One of the most prevalent complications of SLE is lupus nephritis (LN). Rutin, a natural flavonoid compound found in various plants used in traditional Chinese medicine, has shown promising anti-inflammatory, antioxidant, and renal protective effects. In our study, we treated MRL/lpr mice, a model known for spontaneously developing LN, with Rutin. Our findings reveal that Rutin markedly reduce...
Source: Chemico-Biological Interactions - March 30, 2024 Category: Molecular Biology Authors: Tongtong Yi Wei Zhang Ying Hua Xingpan Xin Zhenyu Wu Ying Li Chengping Wen Yongsheng Fan Jinjun Ji Li Xu Source Type: research
