Systemic lupus erythematosus complicated with IgG4-related disease
Med Clin (Barc). 2024 Apr 2:S0025-7753(24)00018-6. doi: 10.1016/j.medcli.2023.11.037. Online ahead of print.NO ABSTRACTPMID:38570292 | DOI:10.1016/j.medcli.2023.11.037 (Source: Medicina Clinica)
Source: Medicina Clinica - April 3, 2024 Category: General Medicine Authors: Qian Wu Yuanhong Peng Source Type: research
Association of pulmonary hypertension with outcomes in patients with Systemic sclerosis and other connective tissue disorders: review and meta-analysis
CONCLUSIONS: Patients with SSc-PH are characterized by significantly lower survival function as compared to SSc patients without PH. Among the different entities of PH, SSc shows the worst survival, underlining prognostic significance of detection and evaluation of PH according to the currently established approach.PMID:38567564 | DOI:10.36141/svdld.v41i1.14570 (Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases)
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - April 3, 2024 Category: Respiratory Medicine Authors: Maka Gegenava Tea Gegenava Source Type: research
Systemic lupus erythematosus complicated with IgG4-related disease
Med Clin (Barc). 2024 Apr 2:S0025-7753(24)00018-6. doi: 10.1016/j.medcli.2023.11.037. Online ahead of print.NO ABSTRACTPMID:38570292 | DOI:10.1016/j.medcli.2023.11.037 (Source: Medicina Clinica)
Source: Medicina Clinica - April 3, 2024 Category: General Medicine Authors: Qian Wu Yuanhong Peng Source Type: research
Association of pulmonary hypertension with outcomes in patients with Systemic sclerosis and other connective tissue disorders: review and meta-analysis
CONCLUSIONS: Patients with SSc-PH are characterized by significantly lower survival function as compared to SSc patients without PH. Among the different entities of PH, SSc shows the worst survival, underlining prognostic significance of detection and evaluation of PH according to the currently established approach.PMID:38567564 | DOI:10.36141/svdld.v41i1.14570 (Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases)
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - April 3, 2024 Category: Respiratory Medicine Authors: Maka Gegenava Tea Gegenava Source Type: research
Association of pulmonary hypertension with outcomes in patients with Systemic sclerosis and other connective tissue disorders: review and meta-analysis
CONCLUSIONS: Patients with SSc-PH are characterized by significantly lower survival function as compared to SSc patients without PH. Among the different entities of PH, SSc shows the worst survival, underlining prognostic significance of detection and evaluation of PH according to the currently established approach.PMID:38567564 | PMC:PMC11008328 | DOI:10.36141/svdld.v41i1.14570 (Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases)
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - April 3, 2024 Category: Respiratory Medicine Authors: Maka Gegenava Tea Gegenava Source Type: research
A Novel Human Interleukin ‐23A Overexpressing Mouse Model of Systemic Lupus Erythematosus
ConclusionWe have generated and characterized a novel genetic mouse model of SLE, providing proof-of-concept for the etiopathogenic role of human IL-23A. This new model has a normal life span and integrates several characteristics of the human disease's complexity and chronicity, making it an attractive preclinical tool for studying IL-23 –dependent pathogenic mechanisms and assessing the efficacy of anti–human IL-23A or modeled disease-related therapeutics. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 3, 2024 Category: Rheumatology Authors: Eleni Christodoulou ‐Vafeiadou,
Christina Geka,
Lida Iliopoulou,
Lydia Ntari,
Maria C. Denis,
Niki Karagianni,
George Kollias Tags: Full Length Source Type: research
GSE247355 Targeting Osteosarcoma with Canine B7-H3 CAR T Cells and Impact of CXCR2 Co-Expression on Functional Activity
Contributors : Jennifer W Cao ; Jessica Lake ; Renata Impastato ; Lyndah Chow ; Luisanny Perez ; Laura Chubb ; Jade Kurihara ; Michael R Verneris ; Steven DowSeries Type : Expression profiling by high throughput sequencingOrganism : Canis lupus familiarisAbstract. The use of large animal spontaneous models of solid cancers, such as dogs with osteosarcoma (OS), can help develop new cancer immunotherapy approaches, including chimeric antigen receptor (CAR) T cells. Therefore, the goal of the present study was to generate canine CAR T cells targeting the B7-H3 (CD276) co-stimulatory molecule overexpressed by several so...
Source: GEO: Gene Expression Omnibus - April 3, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Canis lupus familiaris Source Type: research
GSE237690 Lupus dermal fibroblasts hyper-respond to inflammatory cytokines and exhibit a pro-fibrotic phenotype to TGF- β in patients with scarring skin disease
Contributors : J M Kahlenberg ; Suzanne K Shoffner-Beck ; Lisa Abernathy-Close ; Johann E Gudjonsson ; Lam C TsoiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapienswe examined responses to cytokines in dermal fibroblasts from the skin of SLE patients with CLE and healthy control volunteers to identify the inflammatory phenotype and gene expression profile associated with SLE and scarring CLE lesions. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 3, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Analysis of m6A-regulated genes and subtype classification in lupus nephritis
Lupus nephritis (LN) is the most common and severe clinical manifestation of systemic lupus erythematosus (SLE). N6-methyladenosine (m6A) is a reversible RNA modification and has been implicated in various bio... (Source: BMC Nephrology)
Source: BMC Nephrology - April 3, 2024 Category: Urology & Nephrology Authors: Diangeng Li, Yanchun Li, Kaiyi Zhu, Yuqing Yuan, Zheng He, Qianmei Sun and Meiling Jin Tags: Research Source Type: research
Risk factors for initial and recurrent severe infections in first hospitalized patients with systemic lupus erythematosus: A retrospective study of a Chinese cohort
ConclusionIn this cohort of SLE, patients with severe infection had a higher risk of reinfection, and low immunoglobulin, anti-dsDNA antibody positivity, and cyclophosphamide use were independent risk factors for recurrent severe infection. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - April 2, 2024 Category: Rheumatology Authors: Ying Zhu,
Kexin Zhu,
Xueyi Zhang,
Zhijie Qian,
Qingqing Guo,
Xuefeng Xu,
Genhong Yao,
Xiaojun Tang,
Dandan Wang,
Huayong Zhang,
Xuebing Feng,
Ziyi Jin,
Lingyun Sun Tags: ORIGINAL ARTICLE Source Type: research
