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Total 221853 results found since Jan 2013.

Predictors of Health Service Utilizations Among Key Population in Washington DC
Conditions:   Pre-exposure Prophylaxis;   HIV;   Health Behavior Intervention:   Sponsor:   Us Helping Us, People Into Living, Inc. Not yet recruiting
Source: ClinicalTrials.gov - September 21, 2023 Category: Research Source Type: clinical trials

Virologic and Immunologic Characteristics of Severe Mpox in Persons With Advanced HIV
Conditions:   Monkeypox;   HIV Infections;   AIDS Intervention:   Sponsor:   Centers for Disease Control and Prevention Recruiting
Source: ClinicalTrials.gov - September 21, 2023 Category: Research Source Type: clinical trials

Safety and Pharmacokinetic Study of Oral MK-8527 QM in Participants at Low-Risk for HIV-1 Infection (MK-8527-007)
Conditions:   HIV;   HIV Pre-exposure Prophylaxis Interventions:   Drug: MK-8527;   Drug: Placebo to MK-8527 Sponsor:   Merck Sharp & Dohme LLC Not yet recruiting
Source: ClinicalTrials.gov - September 21, 2023 Category: Research Source Type: clinical trials

The Influence of Primary HIV-1 Drug Resistance Mutations on Immune Reconstruction in PLWH
Conditions:   Hiv;   AIDS;   CD4 Deficiency;   ART;   Treatment Resistant Disorders;   Treatment-Sensitive HIV Infection Intervention:   Other: differences in CD4 reconstruction Sponsor:   Medical University of Warsaw Not yet recruiting
Source: ClinicalTrials.gov - September 21, 2023 Category: Research Source Type: clinical trials

Atorvastatin vs Aspirin in People With HIV Atorvastatin vs Aspirin in People With HIV
Which of these two drugs are better at reducing HIV-associated inflammation, and in turn, the risk for cardiovascular disease?AIDS
Source: Medscape Hiv-Aids Headlines - September 21, 2023 Category: Infectious Diseases Tags: HIV/AIDS Journal Article Source Type: news

Assessment of the performance regarding confirmatory diagnosis and initiation of antiretroviral therapy under a modified national HIV testing algorithm and pay-for-performance program in Taiwan
CONCLUSION: A significant decrease in the time to ART initiation was observed after initiation of the pay-for-performance program and optimized testing algorithm in Taiwan.PMID:37735047 | DOI:10.1016/j.jmii.2023.08.015
Source: Journal of Microbiology, Immunology, and Infection - September 21, 2023 Category: Microbiology Authors: Yen-Fang Huang Li-Chern Pan Jyh-Yuan Yang Yu-Hsin Liao Hsin-Jou Su Nai-Hwa Mei Shiou-Pin Lin Jen-Hsiu Shen Yi-Chen Tsai Source Type: research

The role of Pannexin-1 channels, ATP, and purinergic receptors in the pathogenesis of HIV and SARS-CoV-2
Curr Opin Pharmacol. 2023 Sep 19;73:102404. doi: 10.1016/j.coph.2023.102404. Online ahead of print.ABSTRACTInfectious agents such as human immune deficiency virus-1 (HIV) and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) use host proteins to infect, replicate, and induce inflammation within the host. A critical component of these diseases is the axis between pannexin-1 channels, extracellular ATP, and purinergic receptors. Here, we describe the potential therapeutic role of Pannexin-1/purinergic approaches to prevent or reduce the devastating consequences of these pathogens.PMID:37734241 | DOI:10.1016/j.coph.2023.102404
Source: Current Opinion in Pharmacology - September 21, 2023 Category: Drugs & Pharmacology Authors: Cristian A Hernandez Eliseo A Eugenin Source Type: research

Selected biochemical parameters in the urine of HIV-infected patients in monitoring of kidney function
CONCLUSIONS: This research shows that the analyzed LMWP parameters are useful in the assessment of kidney damage in HIV patients during cART, especially NPT, NGAL and GST-π. However, future studies should be conducted on larger groups.PMID:37732028 | PMC:PMC10507753 | DOI:10.5114/aoms/114635
Source: Archives of Medical Science - September 21, 2023 Category: Biomedical Science Authors: Beata Szyma ńska Zofia Marchewka Brygida Knysz Agnieszka Piwowar Source Type: research

The New Era of Long-Acting Antiretroviral Therapy: When and Why to Make the Switch
AbstractPurpose of ReviewDespite the availability of safe and effective oral combination antiretroviral therapy, barriers to maintaining viral suppression remain a challenge to ending the HIV epidemic. Long-acting injectable antiretroviral therapy was developed as an alternative to daily oral therapy. This review summarizes the current literature on the efficacy of long-acting cabotegravir plus rilpivirine for the treatment of HIV-1, reasons to switch to injectable therapy, and barriers to switching.Recent FindingsLong-acting cabotegravir plus rilpivirine is safe and effective in maintaining HIV-1 virologic suppression. Id...
Source: Current HIV/AIDS Reports - September 21, 2023 Category: Infectious Diseases Source Type: research

Incident Kaposi sarcoma during the expansion of antiretroviral therapy eligibility in Nigeria: a retrospective cohort study
The expansion of antiretroviral therapy (ART) eligibility could lead to earlier initiation of Human Immunodeficiency Virus (HIV) treatment and consequently reduce the risk of HIV-associated Kaposi Sarcoma (KS)...
Source: BMC Cancer - September 21, 2023 Category: Cancer & Oncology Authors: Maxwell. O. Akanbi, Lucy. A. Bilaver, Chad Achenbach, Lisa. R. Hirschhorn, Adovich. S. Rivera, Orimisan. S. Adekolujo, Kehinde. U. A. Adekola, Olugbenga. A. Silas, Patricia. A. Agaba, Oche Agbaji, Nathan. Y. Shehu, Solomon. A. Sagay, Lifang Hou and Robert Tags: Research Source Type: research

Norovirus infection among HIV-infected patients in Abuja, Nigeria: impact of combination antiretroviral therapy status
This study aimed to determine the prevalence of Norovirus ...
Source: BMC Infectious Diseases - September 21, 2023 Category: Infectious Diseases Authors: Favour Osazuwa, William Olayemi Johnson and Hailey Seth Grobler Tags: Research Source Type: research

The role of DC-SIGN as a trans-receptor in infection by MERS-CoV
DC-SIGN is a C-type lectin expressed in myeloid cells such as immature dendritic cells and macrophages. Through glycan recognition in viral envelope glycoproteins, DC-SIGN has been shown to act as a receptor for a number of viral agents such as HIV, Ebola virus, SARS-CoV, and SARS-CoV-2. Using a system of Vesicular Stomatitis Virus pseudotyped with MERS-CoV spike protein, here, we show that DC-SIGN is partially responsible for MERS-CoV infection of dendritic cells and that DC-SIGN efficiently mediates trans-infection of MERS-CoV from dendritic cells to susceptible cells, indicating a potential role of DC-SIGN in MERS-CoV d...
Source: Frontiers in cellular and infection microbiology - September 21, 2023 Category: Microbiology Source Type: research

Derivation of a high-resolution CT-based, semi-automated radiographic score in tuberculosis and its relationship to bacillary load and antitubercular therapy
Extract Efforts to curb the tuberculosis (TB) pandemic remain hindered by a lack of objective measures to quantify disease severity and track treatment success that are valid in both HIV-1-infected and -uninfected TB patients. Ralph et al. [1] developed a promising radiographic scoring system, with baseline scores being predictive of sputum smear conversion at 2 months, but it is reliant on skilled readers and has not been systematically validated in predominantly HIV-infected study populations with varying CD4 counts. Superior to conventional chest radiography, high-resolution computed tomography (HRCT) is a highly sensit...
Source: European Respiratory Journal - September 21, 2023 Category: Respiratory Medicine Authors: Riou, C., du Bruyn, E., Kim, G. H. J., da Costa, I., Lee, J., Sher, A., Wilkinson, R. J., Allwood, B. W., Goldin, J. Tags: Respiratory infections and tuberculosis Research Letters Source Type: research

Viruses, Vol. 15, Pages 1969: Transcriptional Stochasticity as a Key Aspect of HIV-1 Latency
ia Basyuk This review summarizes current advances in the role of transcriptional stochasticity in HIV-1 latency, which were possible in a large part due to the development of single-cell approaches. HIV-1 transcription proceeds in bursts of RNA production, which stem from the stochastic switching of the viral promoter between ON and OFF states. This switching is caused by random binding dynamics of transcription factors and nucleosomes to the viral promoter and occurs at several time scales from minutes to hours. Transcriptional bursts are mainly controlled by the core transcription factors TBP, SP1 and NF-&kap...
Source: Viruses - September 21, 2023 Category: Virology Authors: Alexia Damour Vera Slaninova Ovidiu Radulescu Edouard Bertrand Eugenia Basyuk Tags: Review Source Type: research

Risk of  COVID-19 in-hospital mortality in people living with HIV compared to general population according to age and CD4 strata: data from the Icona network
Since the early phase of SARS-CoV-2 pandemic it has been questioned which groups of subjects were at higher risk of worse COVID-19 outcomes. This would have allowed firstly to implement specific preventing interventions, allocate therapeutic resources, and in the later phases of the pandemic prioritize COVID-19 vaccination. Demographic factors shortly appeared to be the main determinants of COVID-19 outcomes, with older age, male sex and social deprivation as strongly associated with hospitalization and death [1].
Source: International Journal of Infectious Diseases - September 21, 2023 Category: Infectious Diseases Authors: Andrea Giacomelli, Roberta Gagliardini, Alessandro Tavelli, Sara De Benedittis, Valentina Mazzotta, Giuliano Rizzardini, Annalisa Mondi, Matteo Augello, Spinello Antinori, Alessandra Vergori, Andrea Gori, Marianna Menozzi, Lucia Taramasso, Francesco Maria Source Type: research