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Post-Partum Hemorrhage in Sub-Saharan Africa - A Prospective Study in Metropolitan Mozambique
CONCLUSIONS: PPH is a serious problem in Maputo province, a metropolitan area of SSA, portending high MM. Identification of correctable risk factors, including anemia, should catalyze the development of region-specific prevention protocols.PMID:37709148 | DOI:10.1016/j.jtha.2023.09.002
Source: Thrombosis and Haemostasis - September 14, 2023 Category: Hematology Authors: Michael M Glenzer Momade Correia Virgilio Nhantumbo Richard Fw Barnes Elvira Luis Ines Boaventura Nelia Manguele Patricia Silva Annette von Drygalski Source Type: research
Spontaneous HIV expression during suppressive ART is associated with the magnitude and function of HIV-specific CD4 < sup > + < /sup > and CD8 < sup > + < /sup > T cells
Cell Host Microbe. 2023 Sep 13;31(9):1507-1522.e5. doi: 10.1016/j.chom.2023.08.006.ABSTRACTSpontaneous transcription and translation of HIV can persist during suppressive antiretroviral therapy (ART). The quantity, phenotype, and biological relevance of this spontaneously "active" reservoir remain unclear. Using multiplexed single-cell RNAflow-fluorescence in situ hybridization (FISH), we detect active HIV transcription in 14/18 people with HIV on suppressive ART, with a median of 28/million CD4+ T cells. While these cells predominantly exhibit abortive transcription, p24-expressing cells are evident in 39% of participants...
Source: Cell Host and Microbe - September 14, 2023 Category: Microbiology Authors: Mathieu Dub é Olivier Tastet Caroline Dufour G érémy Sannier Nathalie Brassard Gloria-Gabrielle Delgado Am élie Pagliuzza Corentin Richard Manon Nayrac Jean-Pierre Routy Alexandre Prat Jacob D Estes R émi Fromentin Nicolas Chomont Daniel E Kaufmann Source Type: research
An active HIV reservoir during ART is associated with maintenance of HIV-specific CD8 < sup > + < /sup > T cell magnitude and short-lived differentiation status
Cell Host Microbe. 2023 Sep 13;31(9):1494-1506.e4. doi: 10.1016/j.chom.2023.08.012.ABSTRACTBefore initiation of antiretroviral therapy (ART), HIV-specific CD8+ T cells are dysfunctional and short lived. To better understand the relationship between the HIV reservoir in CD4+ T cells and the magnitude and differentiation status of HIV-specific CD8+ T cells, we investigated these cells from acute and chronic HIV-infected individuals after 2 years of ART. Although both the HIV reservoir and the CD8+ T cell responses declined significantly after 2 years of ART, sustained HIV-specific CD8+ T cell responses correlated with a grea...
Source: Cell Host and Microbe - September 14, 2023 Category: Microbiology Authors: Hiroshi Takata Julie L Mitchell Julian Pacheco Am élie Pagliuzza Suteeraporn Pinyakorn Supranee Buranapraditkun Carlo Sacdalan Louise Leyre Sam Nathanson Juyeon C Kakazu Jintana Intasan Peeriya Prueksakaew Nitiya Chomchey Nittaya Phanuphak Mark de Souza Source Type: research
Whack-a-virus: HIV-specific T cells play an exhausting game
Cell Host Microbe. 2023 Sep 13;31(9):1427-1430. doi: 10.1016/j.chom.2023.08.013.ABSTRACTT cell responses are important for the control of acute HIV infection but become progressively dysfunctional. In this issue of Cell Host & Microbe, Dubé et al. and Takata et al. provide insights into their ongoing interplay with persistent HIV reservoirs, with implications for harnessing functional, durable responses to eliminate HIV.PMID:37708850 | DOI:10.1016/j.chom.2023.08.013
Source: Cell Host and Microbe - September 14, 2023 Category: Microbiology Authors: Alberto Herrera R Brad Jones Source Type: research
Spontaneous HIV expression during suppressive ART is associated with the magnitude and function of HIV-specific CD4 < sup > + < /sup > and CD8 < sup > + < /sup > T cells
Cell Host Microbe. 2023 Sep 13;31(9):1507-1522.e5. doi: 10.1016/j.chom.2023.08.006.ABSTRACTSpontaneous transcription and translation of HIV can persist during suppressive antiretroviral therapy (ART). The quantity, phenotype, and biological relevance of this spontaneously "active" reservoir remain unclear. Using multiplexed single-cell RNAflow-fluorescence in situ hybridization (FISH), we detect active HIV transcription in 14/18 people with HIV on suppressive ART, with a median of 28/million CD4+ T cells. While these cells predominantly exhibit abortive transcription, p24-expressing cells are evident in 39% of participants...
Source: Cell Host and Microbe - September 14, 2023 Category: Microbiology Authors: Mathieu Dub é Olivier Tastet Caroline Dufour G érémy Sannier Nathalie Brassard Gloria-Gabrielle Delgado Am élie Pagliuzza Corentin Richard Manon Nayrac Jean-Pierre Routy Alexandre Prat Jacob D Estes R émi Fromentin Nicolas Chomont Daniel E Kaufmann Source Type: research
An active HIV reservoir during ART is associated with maintenance of HIV-specific CD8 < sup > + < /sup > T cell magnitude and short-lived differentiation status
Cell Host Microbe. 2023 Sep 13;31(9):1494-1506.e4. doi: 10.1016/j.chom.2023.08.012.ABSTRACTBefore initiation of antiretroviral therapy (ART), HIV-specific CD8+ T cells are dysfunctional and short lived. To better understand the relationship between the HIV reservoir in CD4+ T cells and the magnitude and differentiation status of HIV-specific CD8+ T cells, we investigated these cells from acute and chronic HIV-infected individuals after 2 years of ART. Although both the HIV reservoir and the CD8+ T cell responses declined significantly after 2 years of ART, sustained HIV-specific CD8+ T cell responses correlated with a grea...
Source: Cell Host and Microbe - September 14, 2023 Category: Microbiology Authors: Hiroshi Takata Julie L Mitchell Julian Pacheco Am élie Pagliuzza Suteeraporn Pinyakorn Supranee Buranapraditkun Carlo Sacdalan Louise Leyre Sam Nathanson Juyeon C Kakazu Jintana Intasan Peeriya Prueksakaew Nitiya Chomchey Nittaya Phanuphak Mark de Souza Source Type: research
Whack-a-virus: HIV-specific T cells play an exhausting game
Cell Host Microbe. 2023 Sep 13;31(9):1427-1430. doi: 10.1016/j.chom.2023.08.013.ABSTRACTT cell responses are important for the control of acute HIV infection but become progressively dysfunctional. In this issue of Cell Host & Microbe, Dubé et al. and Takata et al. provide insights into their ongoing interplay with persistent HIV reservoirs, with implications for harnessing functional, durable responses to eliminate HIV.PMID:37708850 | DOI:10.1016/j.chom.2023.08.013
Source: Cell Host and Microbe - September 14, 2023 Category: Microbiology Authors: Alberto Herrera R Brad Jones Source Type: research
Population prevalence of antiretroviral therapy sharing and its association with HIV viremia in rural Uganda: a cross-sectional population-based study
CONCLUSIONS: ART sharing is common among persons reporting ART use in rural Uganda, particularly among men. Sharing ART was associated with viremia, and receiving ART may facilitate viral suppression. HIV programmes may benefit from considering ART sharing in counselling messages.PMID:37705364 | PMC:PMC10500261 | DOI:10.1002/jia2.26135
Source: Journal of the International AIDS Society - September 14, 2023 Category: Infectious Diseases Authors: Caitlin E Kennedy Xinyi Feng Robert Ssekubugu Joseph G Rosen Joseph Ssekasanvu Godfrey Kigozi David Serwadda Ping Teresa Yeh Joseph Kagaayi Thomas C Quinn Aaron A R Tobian Maria J Wawer Steven J Reynolds Larry W Chang M Kate Grabowski Fred Nalugoda Source Type: research
Cross-sectional HIV and HCV cascades of care across the regions of Ukraine between 2019 and 2020: findings from the CARE cohort
CONCLUSIONS: Over 98% of PLHIV in care in both CARE sites in Ukraine were receiving ART, and the target of 90% virally suppressed was achieved in persons >6 months on ART. Only one of six HIV/HCV study sites tested over 50% anti-HCV-positive PLHIV for HCV-RNA and treated over 25% of eligible persons. While free HCV-RNA testing and DAA treatment are paramount to achieving HCV elimination targets, they remained a challenge in Ukraine in 2019-2020. The extent of the HIV and HCV care disruption during the war will be further assessed in the CARE cohort and compared with the pre-war findings.PMID:37705358 | PMC:PMC10500257 |...
Source: Journal of the International AIDS Society - September 14, 2023 Category: Infectious Diseases Authors: Olga Fursa Joanne Reekie Ihor Kuzin Larysa Hetman Alina Kryshchuk Olena Starychenko Nana Hrytsaiuk Inna Khodus Alla Nyzhnyk Viktoriia Rakhuba Maryna Kovalevska Tetiana Maistat Iryna Pryhoda Marianna Ahieieva Olena Varvarovska Olena Valdenmaiier Jens Lundg Source Type: research
Population prevalence of antiretroviral therapy sharing and its association with HIV viremia in rural Uganda: a cross-sectional population-based study
CONCLUSIONS: ART sharing is common among persons reporting ART use in rural Uganda, particularly among men. Sharing ART was associated with viremia, and receiving ART may facilitate viral suppression. HIV programmes may benefit from considering ART sharing in counselling messages.PMID:37705364 | PMC:PMC10500261 | DOI:10.1002/jia2.26135
Source: Journal of the International AIDS Society - September 14, 2023 Category: Infectious Diseases Authors: Caitlin E Kennedy Xinyi Feng Robert Ssekubugu Joseph G Rosen Joseph Ssekasanvu Godfrey Kigozi David Serwadda Ping Teresa Yeh Joseph Kagaayi Thomas C Quinn Aaron A R Tobian Maria J Wawer Steven J Reynolds Larry W Chang M Kate Grabowski Fred Nalugoda Source Type: research
Cross-sectional HIV and HCV cascades of care across the regions of Ukraine between 2019 and 2020: findings from the CARE cohort
CONCLUSIONS: Over 98% of PLHIV in care in both CARE sites in Ukraine were receiving ART, and the target of 90% virally suppressed was achieved in persons >6 months on ART. Only one of six HIV/HCV study sites tested over 50% anti-HCV-positive PLHIV for HCV-RNA and treated over 25% of eligible persons. While free HCV-RNA testing and DAA treatment are paramount to achieving HCV elimination targets, they remained a challenge in Ukraine in 2019-2020. The extent of the HIV and HCV care disruption during the war will be further assessed in the CARE cohort and compared with the pre-war findings.PMID:37705358 | PMC:PMC10500257 |...
Source: Journal of the International AIDS Society - September 14, 2023 Category: Infectious Diseases Authors: Olga Fursa Joanne Reekie Ihor Kuzin Larysa Hetman Alina Kryshchuk Olena Starychenko Nana Hrytsaiuk Inna Khodus Alla Nyzhnyk Viktoriia Rakhuba Maryna Kovalevska Tetiana Maistat Iryna Pryhoda Marianna Ahieieva Olena Varvarovska Olena Valdenmaiier Jens Lundg Source Type: research
Population prevalence of antiretroviral therapy sharing and its association with HIV viremia in rural Uganda: a cross-sectional population-based study
CONCLUSIONS: ART sharing is common among persons reporting ART use in rural Uganda, particularly among men. Sharing ART was associated with viremia, and receiving ART may facilitate viral suppression. HIV programmes may benefit from considering ART sharing in counselling messages.PMID:37705364 | DOI:10.1002/jia2.26135
Source: Journal of the International AIDS Society - September 14, 2023 Category: Infectious Diseases Authors: Caitlin E Kennedy Xinyi Feng Robert Ssekubugu Joseph G Rosen Joseph Ssekasanvu Godfrey Kigozi David Serwadda Ping Teresa Yeh Joseph Kagaayi Thomas C Quinn Aaron A R Tobian Maria J Wawer Steven J Reynolds Larry W Chang M Kate Grabowski Fred Nalugoda Source Type: research
Cross-sectional HIV and HCV cascades of care across the regions of Ukraine between 2019 and 2020: findings from the CARE cohort
CONCLUSIONS: Over 98% of PLHIV in care in both CARE sites in Ukraine were receiving ART, and the target of 90% virally suppressed was achieved in persons >6 months on ART. Only one of six HIV/HCV study sites tested over 50% anti-HCV-positive PLHIV for HCV-RNA and treated over 25% of eligible persons. While free HCV-RNA testing and DAA treatment are paramount to achieving HCV elimination targets, they remained a challenge in Ukraine in 2019-2020. The extent of the HIV and HCV care disruption during the war will be further assessed in the CARE cohort and compared with the pre-war findings.PMID:37705358 | DOI:10.1002/jia2.26166
Source: Journal of the International AIDS Society - September 14, 2023 Category: Infectious Diseases Authors: Olga Fursa Joanne Reekie Ihor Kuzin Larysa Hetman Alina Kryshchuk Olena Starychenko Nana Hrytsaiuk Inna Khodus Alla Nyzhnyk Viktoriia Rakhuba Maryna Kovalevska Tetiana Maistat Iryna Pryhoda Marianna Ahieieva Olena Varvarovska Olena Valdenmaiier Jens Lundg Source Type: research
Population prevalence of antiretroviral therapy sharing and its association with HIV viremia in rural Uganda: a cross-sectional population-based study
CONCLUSIONS: ART sharing is common among persons reporting ART use in rural Uganda, particularly among men. Sharing ART was associated with viremia, and receiving ART may facilitate viral suppression. HIV programmes may benefit from considering ART sharing in counselling messages.PMID:37705364 | PMC:PMC10500261 | DOI:10.1002/jia2.26135
Source: Journal of the International AIDS Society - September 14, 2023 Category: Infectious Diseases Authors: Caitlin E Kennedy Xinyi Feng Robert Ssekubugu Joseph G Rosen Joseph Ssekasanvu Godfrey Kigozi David Serwadda Ping Teresa Yeh Joseph Kagaayi Thomas C Quinn Aaron A R Tobian Maria J Wawer Steven J Reynolds Larry W Chang M Kate Grabowski Fred Nalugoda Source Type: research
Cross-sectional HIV and HCV cascades of care across the regions of Ukraine between 2019 and 2020: findings from the CARE cohort
CONCLUSIONS: Over 98% of PLHIV in care in both CARE sites in Ukraine were receiving ART, and the target of 90% virally suppressed was achieved in persons >6 months on ART. Only one of six HIV/HCV study sites tested over 50% anti-HCV-positive PLHIV for HCV-RNA and treated over 25% of eligible persons. While free HCV-RNA testing and DAA treatment are paramount to achieving HCV elimination targets, they remained a challenge in Ukraine in 2019-2020. The extent of the HIV and HCV care disruption during the war will be further assessed in the CARE cohort and compared with the pre-war findings.PMID:37705358 | PMC:PMC10500257 |...
Source: Journal of the International AIDS Society - September 14, 2023 Category: Infectious Diseases Authors: Olga Fursa Joanne Reekie Ihor Kuzin Larysa Hetman Alina Kryshchuk Olena Starychenko Nana Hrytsaiuk Inna Khodus Alla Nyzhnyk Viktoriia Rakhuba Maryna Kovalevska Tetiana Maistat Iryna Pryhoda Marianna Ahieieva Olena Varvarovska Olena Valdenmaiier Jens Lundg Source Type: research
