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Fight Aging! Newsletter, June 21st 2021
This study showed that the leakage of this mitochondrial nucleic material may occur as a result of mitochondrial dysfunction, which may involve genetic mutations in genes encoding mitochondrial proteins or incomplete degradation of mitochondrial dsDNA in the lysosome - which is a 'degradation factory' of the cell. Upon the leakage into the cytoplasm, this undegraded dsDNA is detected by a 'foreign' DNA sensor of the cytoplasm (IFI16) which then triggers the upregulation of mRNAs encoding for inflammatory proteins." Using a PD zebrafish model (gba mutant), the researchers demonstrated that a combination of PD-like ph...
Source: Fight Aging! - June 20, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Explain yourself, machine. Producing simple text descriptions for AI interpretability
We describe a feature, give a location, and then synthesise a conclusion. For example: There is an irregular mass with microcalcification in the upper outer quadrant of the breast. Findings are consistent with malignancy. You don’t need to understand the words I used here, but the point is that the features (irregular mass, microcalcification) are consistent with the diagnosis (breast cancer, malignancy). A doctor reading this report already sees internal consistency, and that reassures them that the report isn’t wrong. An common example of a wrong report could be: Irregular mass or microcalcification. No ...
Source: The Health Care Blog - December 12, 2019 Category: Consumer Health News Authors: Christina Liu Tags: Artificial Intelligence Health Tech AI Luke Oakden-Rayner machine learning Radiology Source Type: blogs

Funtabulously Frivolous Friday Five 229
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog Just when you thought your brain could unwind on a Friday, you realise that it would rather be challenged with some good old fashioned medical trivia FFFF…introducing Funtabulously Frivolous Friday Five 229 – musical medial conditions from http://www.songfacts.com. Question 1 “I stare into Some great abyss And calculate The things I’d miss If I could only Make some sense of this.” Sheryl Crow is singing about her experience undergoing treatmen...
Source: Life in the Fast Lane - March 9, 2018 Category: Emergency Medicine Authors: Neil Long Tags: Frivolous Friday Five ACDC breast cancer cardiac arrest gonorrhoea heart attack heroin Leonard Cohen Madness radiation song Sheryl Crow Spiderbite The Flaming Lips The Jack Source Type: blogs