A Case of Palmoplantar Keratoderma in the Constellation of Connective Tissue Diseases
Cureus. 2024 Mar 20;16(3):e56531. doi: 10.7759/cureus.56531. eCollection 2024 Mar.ABSTRACTOverlap syndrome is a clinical challenge and brings together a wide range of treatment options for the treating physician. Addressing each and every complaint of the patient is crucial. A 50-year-old female patient presented with skin thickening, blackening, and hyperkeratosis; dysphagia; joint pain; features of myopathy; Raynaud's phenomenon; and dry mouth. Inflammatory markers were raised along with a positive antinuclear antibody (ANA) with Golgi apparatus pattern, anti-Sjögren's-syndrome-related antigen A (anti-SSA)/Ro60 3+, anti...
Source: Pain Physician - April 22, 2024 Category: Anesthesiology Authors: Ishan Verma Amol H Dube Sunita Kumbhalkar Keshao Nagpure Gitesh Sawatkar Sachin R Chuadhari Ashwini Umredkar Source Type: research
Elevated serum B-cell activator factor levels predict rapid progressive interstitial lung disease in anti-melanoma differentiation associated protein 5 antibody positive dermatomyositis
Rapid progressive interstitial lung disease (RP-ILD) is the leading cause of anti-melanoma differentiation associated protein 5 antibody positive dermatomyositis (anti-MDA5+DM) related death. Elevated serum B-cel... (Source: Orphanet Journal of Rare Diseases)
Source: Orphanet Journal of Rare Diseases - April 19, 2024 Category: Internal Medicine Authors: Yumeng Shi, Hanxiao You, Chang Liu, Yulu Qiu, Chengyin Lv, Yujing Zhu, Lingxiao Xu, Fang Wang, Miaojia Zhang and Wenfeng Tan Tags: Research Source Type: research
Hospitalization and Continuity of Care in Anti-MDA5 Dermatomyositis
This cohort study describes the clinical features, patient characteristics, and treatment of anti-melanoma differentiation –associated gene 5 (MDA5) dermatomyositis. (Source: JAMA Dermatology)
Source: JAMA Dermatology - April 17, 2024 Category: Dermatology Source Type: research
ACR Image Competition 2023 Results, Part 5
For the 2023 Image Competition, the ACR sought images representing a diverse range of patients with idiopathic inflammatory myopathies (IIMs) or IIM mimics. Pneumomediastinum & Ulcerative Cutaneous Dermatomyositis These images depict a 22-year-old woman with a recent diagnosis of anti-melanoma differentiation-associated gene 5 (MDA-5) antibody dermatomyositis who sought evaluation of worsening skin rashes and pleuritic... (Source: The Rheumatologist)
Source: The Rheumatologist - April 11, 2024 Category: Rheumatology Authors: David Mecham, DO Tags: Conditions Myositis anti-MDA-5 antibody dermatomyositis image case report Image Competition Source Type: research
Assessing Time of Onset for Interstitial Lung Disease in Anti-MDA5 Antibody-Positive Dermatomyositis
This cohort study seeks to describe the time interval between interstitial lung disease and anti –melanoma differentiation-associated gene 5 antibody-positive dermatomyositis diagnoses. (Source: JAMA Dermatology)
Source: JAMA Dermatology - April 10, 2024 Category: Dermatology Source Type: research
Value of radiomics-based automatic grading of muscle edema in polymyositis/dermatomyositis based on MRI fat-suppressed T2-weighted images
CONCLUSION: The Naive Bayes model, utilizing radiomics features extracted from thigh FS T2W images, accurately assesses the severity of muscle edema in cases of PM/DM.PMID:38591947 | DOI:10.1177/02841851241244507 (Source: Acta Radiologica)
Source: Acta Radiologica - April 9, 2024 Category: Radiology Authors: Yumei Zhang Yuefen Zou Wenfeng Tan Chengyin Lv Source Type: research
Value of radiomics-based automatic grading of muscle edema in polymyositis/dermatomyositis based on MRI fat-suppressed T2-weighted images
CONCLUSION: The Naive Bayes model, utilizing radiomics features extracted from thigh FS T2W images, accurately assesses the severity of muscle edema in cases of PM/DM.PMID:38591947 | DOI:10.1177/02841851241244507 (Source: Acta Radiologica)
Source: Acta Radiologica - April 9, 2024 Category: Radiology Authors: Yumei Zhang Yuefen Zou Wenfeng Tan Chengyin Lv Source Type: research
Value of radiomics-based automatic grading of muscle edema in polymyositis/dermatomyositis based on MRI fat-suppressed T2-weighted images
CONCLUSION: The Naive Bayes model, utilizing radiomics features extracted from thigh FS T2W images, accurately assesses the severity of muscle edema in cases of PM/DM.PMID:38591947 | DOI:10.1177/02841851241244507 (Source: Acta Radiologica)
Source: Acta Radiologica - April 9, 2024 Category: Radiology Authors: Yumei Zhang Yuefen Zou Wenfeng Tan Chengyin Lv Source Type: research
Value of radiomics-based automatic grading of muscle edema in polymyositis/dermatomyositis based on MRI fat-suppressed T2-weighted images
CONCLUSION: The Naive Bayes model, utilizing radiomics features extracted from thigh FS T2W images, accurately assesses the severity of muscle edema in cases of PM/DM.PMID:38591947 | DOI:10.1177/02841851241244507 (Source: Acta Radiologica)
Source: Acta Radiologica - April 9, 2024 Category: Radiology Authors: Yumei Zhang Yuefen Zou Wenfeng Tan Chengyin Lv Source Type: research
A case of autoimmune pulmonary alveolar proteinosis during the course of treatment of rapidly progressive interstitial pneumonia associated with anti-MDA5 antibody-positive dermatomyositis
Autoimmune pulmonary alveolar proteinosis (APAP) is a diffuse lung disease that causes abnormal accumulation of lipoproteins in the alveoli; however, its pathogenesis remains unclear. Recently, APAP cases have... (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - April 8, 2024 Category: Respiratory Medicine Authors: Masakiyo Yatomi, Keiichi Akasaka, Shintaro Sato, Mizuki Chida, Mio Kanbe, Hiru Sawada, Itaru Yokota, Ikuo Wakamatsu, Sohei Muto, Mari Sato, Kochi Yamaguchi, Yosuke Miura, Hiroaki Tsurumaki, Reiko Sakurai, Kenichiro Hara, Yasuhiko Koga & hellip; Tags: Case Report Source Type: research
A 30-year-old female with dermatomyositis without high elevation of muscle enzymes: a rare case report from Syria
CONCLUSION: Even if test findings are not conclusive, dermatomyositis should always be considered when muscular weakness manifests. It's important to distinguish the disorder from connective tissue diseases like lupus erythematosus. In fact, to correctly diagnose DM, if there are any doubts, a muscle biopsy is required.PMID:38576947 | PMC:PMC10990297 | DOI:10.1097/MS9.0000000000001682 (Source: Annals of Medicine)
Source: Annals of Medicine - April 5, 2024 Category: Internal Medicine Authors: Suaad Hamsho Bilal Sleiay Mouhammed Sleiay Obeda Batrash Hadi Alabdullah Majed Aboud Source Type: research
A 30-year-old female with dermatomyositis without high elevation of muscle enzymes: a rare case report from Syria
CONCLUSION: Even if test findings are not conclusive, dermatomyositis should always be considered when muscular weakness manifests. It's important to distinguish the disorder from connective tissue diseases like lupus erythematosus. In fact, to correctly diagnose DM, if there are any doubts, a muscle biopsy is required.PMID:38576947 | PMC:PMC10990297 | DOI:10.1097/MS9.0000000000001682 (Source: Hand Surgery)
Source: Hand Surgery - April 5, 2024 Category: Surgery Authors: Suaad Hamsho Bilal Sleiay Mouhammed Sleiay Obeda Batrash Hadi Alabdullah Majed Aboud Source Type: research
A 30-year-old female with dermatomyositis without high elevation of muscle enzymes: a rare case report from Syria
CONCLUSION: Even if test findings are not conclusive, dermatomyositis should always be considered when muscular weakness manifests. It's important to distinguish the disorder from connective tissue diseases like lupus erythematosus. In fact, to correctly diagnose DM, if there are any doubts, a muscle biopsy is required.PMID:38576947 | PMC:PMC10990297 | DOI:10.1097/MS9.0000000000001682 (Source: Annals of Medicine)
Source: Annals of Medicine - April 5, 2024 Category: Internal Medicine Authors: Suaad Hamsho Bilal Sleiay Mouhammed Sleiay Obeda Batrash Hadi Alabdullah Majed Aboud Source Type: research
Pembrolizumab-associated anti-MDA5 dermatomyositis in a patient with lung cancer: a first case report
We report the first case of anti-melanoma differentiation-associated gene 5 (MDA5)-positive dermatomyositis as a systemic immune-related adverse event in a 64-year-old man receiving pembrolizumab to treat advanced lung cancer. The patient experienced hypothyroidism, myalgia, skin involvement, dyspnoea and diarrhoea. Laboratory tests revealed raised inflammatory markers, hypercreatinekinasemia and anti-MDA5 autoantibodies. Electroneuromyography and pathognomonic signs on physical examination confirmed the diagnosis of pauci-myopathic dermatomyositis. Pembrolizumab was discontinued and immunosuppressive therapy led to rapid ...
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Antonino Marcello Pilia Lorenzo Salvati Alessia Guidolin Francesca Mazzoni Lorenzo Antonuzzo Paola Parronchi Francesco Liotta Source Type: research
A 30-year-old female with dermatomyositis without high elevation of muscle enzymes: a rare case report from Syria
CONCLUSION: Even if test findings are not conclusive, dermatomyositis should always be considered when muscular weakness manifests. It's important to distinguish the disorder from connective tissue diseases like lupus erythematosus. In fact, to correctly diagnose DM, if there are any doubts, a muscle biopsy is required.PMID:38576947 | PMC:PMC10990297 | DOI:10.1097/MS9.0000000000001682 (Source: Hand Surgery)
Source: Hand Surgery - April 5, 2024 Category: Surgery Authors: Suaad Hamsho Bilal Sleiay Mouhammed Sleiay Obeda Batrash Hadi Alabdullah Majed Aboud Source Type: research
