Progressive familial intrahepatic cholestasis-2 mimicking non-accidental injury - Reddy S, Fleishman N, Dempsey K, Ferren E, Kamionek M, Gopalareddy VV.
Progressive familial intrahepatic cholestasis (PFIC) is a heterogeneous group of disorders characterized by defective secretion of bile acids or transport defects resulting in progressive cholestasis. These disorders usually present during infancy or child... (Source: SafetyLit)
Source: SafetyLit - April 11, 2024 Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news
Mirum Pharmaceuticals ’ Livmarli Receives FDA Approval for Treatment of Cholestatic Pruritus in Patients with Progressive Familial Intrahepatic Cholestasis
FOSTER CITY, Calif.--(BUSINESS WIRE) March 13, 2024 -- Mirum Pharmaceuticals, Inc. (NASDAQ: MIRM) today announced that the U.S. Food and Drug Administration (FDA) has approved Livmarli® (maralixibat) oral solution for the treatment of... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - March 13, 2024 Category: Drugs & Pharmacology Source Type: news
Elafibranor Appears Effective, Safe for PBC Elafibranor Appears Effective, Safe for PBC
Treatment with elafibranor showed significantly greater improvements in relevant biochemical indicators of cholestasis than the placebo.Medscape Medical News (Source: Medscape Pharmacist Headlines)
Source: Medscape Pharmacist Headlines - December 28, 2023 Category: Drugs & Pharmacology Tags: Gastroenterology Source Type: news
Quiz: Can you identify these pregnancy symptoms?
The Nursing in Practice ‘picture quizzes’ aim to test your knowledge through photo presentations of symptoms. Work your way through them to understand the key clinical problems faced by patients, and how to correctly identify them. Press ‘start’ below to begin the quiz.
During the later stages of her pregnancy this lady presented with an inflamed red area on her outer side of her right thigh. She was otherwise well and the pregnancy was progressing normally. The area was tender and felt firmer than the surrounding tissue. There was no swelling of the distal limb, but she had had varicose veins for a number of ye...
Source: Nursing in Practice - December 14, 2023 Category: Nursing Authors: Mollie Fraser-Andrews Tags: Women's health Pregnancy Quiz Source Type: news
Drug Trials Snapshot: LIVMARLI
LIVMARLI is a drug for the treatment of itching (pruritus) due to blockage of bile flow out of the liver (cholestasis) in patients with Alagille syndrome (ALGS) one year of age and older. (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - October 4, 2023 Category: Drugs & Pharmacology Authors: FDA Source Type: news
Drug Trials Snapshot: BYLVAY
BYLVAY is a drug used to treat pruritus (itching) due to progressive familial intrahepatic cholestasis (PFIC) in patients 3 months of age or older. (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - October 4, 2023 Category: Drugs & Pharmacology Authors: FDA Source Type: news
Liver Function Tests Can ID Occult Disorders in Systemic Sclerosis
WEDNESDAY, May 31, 2023 -- Liver function test (LFT) screening can identify occult hepatitis, cholestasis, and cholestatic hepatitis in patients with systemic sclerosis (SSc), according to a study published online May 2 in Open Access Rheumatology:... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - May 31, 2023 Category: Pharmaceuticals Source Type: news
Maralixibat Takes Out the Itch of Rare Liver Disease
(MedPage Today) -- WASHINGTON -- Another ileal bile acid transporter inhibitor has demonstrated in a phase III trial the ability to reduce pruritus and serum bile acids for kids with progressive familial intrahepatic cholestasis (PFIC).
In children... (Source: MedPage Today Dermatology)
Source: MedPage Today Dermatology - November 9, 2022 Category: Dermatology Source Type: news
Odevixibat Scratches the Itch of Kids' Rare Liver Disease
(MedPage Today) -- Odevixibat (Bylvay) reduced intense itching and serum bile acids in children with progressive familial intrahepatic cholestasis (PFIC), as detailed in the publication of the PEDFIC 1 trial results that led to the drug's recent... (Source: MedPage Today Dermatology)
Source: MedPage Today Dermatology - July 8, 2022 Category: Dermatology Source Type: news
Severe COVID-19 in Chronic Liver Disease Linked With Cholestasis and Secondary Sclerosing Cholangitis Severe COVID-19 in Chronic Liver Disease Linked With Cholestasis and Secondary Sclerosing Cholangitis
Severe COVID-19 increases the risk for cholestasis and secondary sclerosing cholangitis in patients with chronic liver disease, researchers say.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 30, 2022 Category: Consumer Health News Tags: Infectious Diseases News Source Type: news
COVID-19 Tied to Progression of Chronic Liver Disease
TUESDAY, June 21, 2022 -- About one in five patients with chronic liver disease (CLD) develop progressive cholestasis after severe COVID-19, according to a study published online May 21 in Hepatology.
Lukas Hartl, M.D., from University of Vienna,... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - June 21, 2022 Category: Pharmaceuticals Source Type: news
Are These Stools Acholic?
Discussion
Color can be difficult to discern and communicate. Stooling is an important part of overall health and an important harbinger of potential illness. Stooling consistency and color changes with food, environment, medication, and health conditions.
For neonates and young infants, some hepatobiliary problems may not be seen at birth but in the next few days to weeks. This includes Alagille syndrome, biliary atresia and cystic fibrosis. It is not uncommon for these patients to have prolonged jaundice and therefore the diagnosis may be delayed with some presenting with increased jaundice, acholic stool and poor feedin...
Source: PediatricEducation.org - May 23, 2022 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news
Kate Mara: Actress was 'terrified' during pregnancy after cholestasis diagnosis - symptoms
ACTRESS Kate Mara starred in the first season of House of Cards and dozens of other shows and films such as Shooter, The Martian and Fantastic Four. But behind the screens, the star has had a difficult journey towards motherhood. (Source: Daily Express - Health)
Source: Daily Express - Health - March 28, 2022 Category: Consumer Health News Source Type: news
Neonatal Cholestasis: Updates on Diagnostics, Therapeutics, and Prevention
Cholestatic jaundice is a common presenting feature of hepatobiliary and/or metabolic dysfunction in the newborn and young infant. Timely detection of cholestasis, followed by rapid step-wise evaluation to determine the etiology, is crucial to identify those causes that are amenable to medical or surgical intervention and to optimize outcomes for all infants. In the past 2 decades, genetic etiologies have been elucidated for many cholestatic diseases, and next-generation sequencing, whole-exome sequencing, and whole-genome sequencing now allow for relatively rapid and cost-effective diagnosis of conditions not previously i...
Source: NeoReviews recent issues - December 1, 2021 Category: Pediatrics Source Type: news
FDA OKs Odevixibat for Pruritus Associated With Rare Liver Disease FDA OKs Odevixibat for Pruritus Associated With Rare Liver Disease
Odevixibat (Bylvay) is the first drug approved for the treatment of severe itching in children as young as 3 months with progressive familial intrahepatic cholestasis.FDA Approvals (Source: Medscape Pharmacist Headlines)
Source: Medscape Pharmacist Headlines - July 21, 2021 Category: Drugs & Pharmacology Tags: Gastroenterology News Source Type: news
