The translocator protein 18kDa ligand etifoxine in the treatment of depressive disorders —a double-blind, randomized, placebo-controlled proof-of-concept study
This study will provide a first proof-of-concept on the potential of the TSPO ligand etifoxine in the treatment of depressive disorders.Trial registrationClinical Trials Register (EudraCT number:2021-006773-38, registration date: 14 September 2022) and German Register of Clinical Studies (DRKS number:DRKS00031099, registration date: 23 January 2023). (Source: Trials)
Source: Trials - April 22, 2024 Category: Research Source Type: clinical trials
Multicenter Study of Lumateperone for the Treatment of Bipolar Depression in Pediatric Patients
Conditions: Major Depressive Episode Associated With Bipolar I or Bipolar II Disorder Interventions: Drug: Lumateperone; Drug: Placebo Sponsors: Intra-Cellular Therapies, Inc. Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 18, 2024 Category: Research Source Type: clinical trials
Use of Ketosis in Modulating Metabolic Pathways in Bipolar Disorder
Conditions: Bipolar Disorder; Bipolar Disorder Type 1 Interventions: Dietary Supplement: Glucose; Dietary Supplement: Ketones Sponsors: Stony Brook University; Massachusetts General Hospital; Mclean Hospital Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 18, 2024 Category: Research Source Type: clinical trials
Prospective evaluation of blood biomarkers as an aid to diagnostic and treatment in drug-naive patients with depression
Conditions: Depressive Disorder; Bipolar Disorder; Bipolar Depression Sponsors: Les Toises - Psychiatry and Psychotherapy Center Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 17, 2024 Category: Research Source Type: clinical trials
A Trial to Assess a Wearable Patch's Functioning to Detect Medication Ingestion
Conditions: Mental Disorder; Schizophrenia; Major Depressive Disorder; Bipolar I Disorder Interventions: Drug: Placebo IEM tablet; Drug: Abilify MyCite ®; Device: D-Tect Patch Sponsors: Otsuka Pharmaceutical Development& Commercialization, Inc. Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 17, 2024 Category: Research Source Type: clinical trials
Effect of Intermittent and Continuous Theta Burst Stimulation on Sleep, Daytime Sleepiness, and Fatigue in Depression
Conditions: Unipolar Depression; Bipolar Disorder Interventions: Device: iTBS; Device: cTBS; Device: Sham Sponsors: Jakub Antczak; Institute of Psychiatry and Neurology, Warsaw Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 17, 2024 Category: Research Source Type: clinical trials
Evaluation of blood biomarker-based diagnostic aid in outpatients suffering from depression
Conditions: Depressive Disorder; Bipolar Disorder; Bipolar Depression Interventions: Other: there is no intervention Sponsors: Les Toises - Psychiatry and Psychotherapy Center Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 17, 2024 Category: Research Source Type: clinical trials
Theta-Burst Stimulation for Bipolar Depression
Conditions: Bipolar Depression; Bipolar Disorder; Treatment- Resistant Bipolar Disorder; Type 2 Bipolar Disorder Interventions: Device: iTBS Stimulation; Device: Sham iTBS Stimulation Sponsors: Centre for Addiction and Mental Health; University Health Network, Toronto Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 17, 2024 Category: Research Source Type: clinical trials
Ningbo Severe Mental Disorders Cohort
Conditions: Severe Mental Disorder; Schizophrenia; Bipolar Disorder; Schizo-Affective Psychosis; Paranoid Psychoses; Mental Retardation; Epileptic Psychosis Interventions: Other: Patient with severe mental disorder without intervention Sponsors: Ningbo University; The Affiliated Kangning Hospital of Ningbo University Active, not recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 17, 2024 Category: Research Source Type: clinical trials
ACT for Syndromic and Subsyndromic Depression in Bipolar Disorder
Conditions: Bipolar Disorder Interventions: Behavioral: Acceptance and Commitment Therapy; Other: Bipolar Disorder Psychoeducation Therapy Sponsors: Beny Lafer Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 15, 2024 Category: Research Source Type: clinical trials
Multisite rTMS for Mood, Cognitive Impairment and Other Symptoms of Depression
Conditions: Unipolar Depression; Bipolar Disorder Interventions: Device: Active rTMS over the left DLPFC and over the left DMPFC; Device: Active rTMS over the left DLPFC; Device: Sham rTMS Sponsors: Jakub Antczak; Andrzej Frycz Modrzewski Krakow University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 12, 2024 Category: Research Source Type: clinical trials
NRx Pharmaceuticals Announces Data-Lock of Phase 2b/3 Trial of NRX-101 in Suicidal Treatment Resistant Bipolar Depression
RADNOR, Pa., April 8, 2024. NRx Pharmaceuticals, Inc. ( " NRx Pharmaceuticals " , the " Company " ), a clinical-stage biopharmaceutical company, today announced that the Company has achieved data-lock in its Phase 2b/3 Suicidal Treatment Resistant Bipolar... (Source: Drugs.com - Clinical Trials)
Source: Drugs.com - Clinical Trials - April 9, 2024 Category: Pharmaceuticals Source Type: clinical trials
Getting Out of the House: Using Behavioral Activation to Increase Community Participation
Conditions: Major Depressive Disorder; Schizo Affective Disorder; Schizophrenia; Bipolar Disorder Interventions: Behavioral: Behavior Activation Sponsors: Temple University; National Institute on Disability, Independent Living, and Rehabilitation Research Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 29, 2024 Category: Research Source Type: clinical trials
Brain Small Chain Fatty Acid Metabolism in Bipolar Disorder: Ketones
Conditions: Bipolar Disorder Interventions: Dietary Supplement: Ketone Ester Beverage; Behavioral: Low Glycemic Index Diet Sponsors: University of Michigan Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 28, 2024 Category: Research Source Type: clinical trials
The Effect of Dulaglutide as an Adjuvant Therapy on Cognitive Function in Bipolar Disorder Patients With Obesity
Conditions: Bipolar Disorder; Obesity; Cognition Interventions: Drug: dulaglutide injection Sponsors: First Affiliated Hospital of Zhejiang University Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 26, 2024 Category: Research Source Type: clinical trials
