Fight Aging! Newsletter, February 26th 2024
In conclusion, mTORC1 signaling contributes to the ISC fate decision, enabling regional control of intestinal cell differentiation in response to nutrition. « Back to Top Reviewing the Development of Senotherapeutics to Treat Aging https://www.fightaging.org/archives/2024/02/reviewing-the-development-of-senotherapeutics-to-treat-aging/ Senescent cells accumulate with age and contribute meaningfully to chronic inflammation and degenerative aging. Destroying these cells produces rapid and sizable reversal of age-related diseases in mice, demonstrating that the presence of senescence cells ...
Source: Fight Aging! - February 25, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Circulating Claudin-5 Correlates with Age and Alzheimer's Disease
In this study, we developed a blood-based assay for CLDN-5 and investigated its diagnostic utility using 100 cognitively normal (control) subjects, 100 patients with MCI, and 100 patients with AD. Plasma CLDN-5 levels were increased in patients with AD (3.08 ng/mL) compared with controls (2.77 ng/mL). The BBB functions as a selective gate for the uptake of essential molecules from blood into the brain and the excretion of harmful molecules from the brain into blood via transporters and receptors on cellular membranes. In addition, the BBB prevents the influx of blood-borne neurotoxins, cells, and pathogens into the ...
Source: Fight Aging! - February 21, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Acute dyspnea in an older woman, is it OMI?
 Written by Willy FrickA woman in her 90s with a history of end stage renal disease and complete heart block status post dual chamber pacemaker presented from home with acute onset dyspnea. ECG is shown below.What do you think?The ST and T wave abnormalities jump off the page, but let ' s set that aside just for a moment to review the tracing systematically. The rate is 60 (and remember, slower heart rates are often seen in OMI). Close inspection revealsventricular pacing spikes, best seen in aVL. Many ECG readers will not comment any further on rhythm once ventricular pacing has been identified, but it...
Source: Dr. Smith's ECG Blog - February 18, 2024 Category: Cardiology Authors: Willy Frick Source Type: blogs

How Romantic Obsession Alters The Brain And Makes You Manic (M)
Find out why early love can mimic symptoms of obsessive-compulsive disorder in the brain. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - February 14, 2024 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Neuroscience Social psychology subscribers-only Source Type: blogs

From Bollywood dreams to bipolar reality: a doctor ’ s journey
“There is no greater agony than bearing an untold story inside you.” – Maya Angelou Since my teenage years, I have been watching Bollywood movies of all sorts. Maybe people from the subcontinent like them because no one can relate to these movies other than them. My favorite hero was Sushant Singh Rajput. I liked Read more… From Bollywood dreams to bipolar reality: a doctor’s journey originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - January 22, 2024 Category: General Medicine Authors: Tags: Conditions Psychiatry Source Type: blogs

The 5 Early Signs Of Bipolar Disorder (M)
Around 3 percent of people will develop bipolar disorder in their lifetime. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - December 15, 2023 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Bipolar Disorder subscribers-only Source Type: blogs

Talkiatry Finds Features and Flexibility in eClinicalWorks
Talkiatry is a telemedicine service connecting psychiatrists with patients suffering from depression, bipolar disorder, substance abuse, and other common mental health and behavioral problems. This market is an especially complex area of health care for many reasons. In this video, CEO Robert Krayn talks about how Talkiatry addresses the needs of patients by leveraging their eClinicalWorks EHR platform. Remote psychiatry is a crucial need, because psychiatrists are extremely unevenly distributed. If you’re in New York City or Boston, you can corral a psychiatrist by accosting people on the street. In a remote rural a...
Source: EMR and HIPAA - November 16, 2023 Category: Information Technology Authors: Colin Hung Tags: Ambulatory Clinical EMR-EHR Health IT Company Healthcare IT Telemedicine and Remote Monitoring Behavioral Telehealth eClinicalWorks eCW Healthcare IT Video Interviews Healthcare Scene Featured Psychiatry EHR Psychiatry EMR Robert Source Type: blogs

Dave Bradley ’ s Music
TL:DR – I have dozens of songs and instrumentals for you to download or stream through my BandCamp page right now. Although, I’m probably best known as a professional science writer and an amateur wildlife photographer, when I’m not involved in those you might catch me singing and playing live with my band, C5 Website/Facebook, or in our community a choir (TyrannoChorus). You can hear my latest solo and collaborative recorded music on BandCamp and SoundCloud. Some of my stuff is on Spotify and iTunes too, including a few cover songs. As of 30th July 2023, Mrs Sciencebase and myself are also now veterans ...
Source: David Bradley Sciencebase - Songs, Snaps, Science - August 14, 2023 Category: Science Authors: David Bradley Tags: Music Source Type: blogs

The Sweet Spot of Health Care Cost Containment
BY BEN WHEATLEY As health care continues to move in the direction of unaffordability, policy makers are considering a range of options to bring down health care costs. The Health Affairs Committee on Health Care Spending and Value has identified four broad areas for reform, including administrative savings, price regulation and supports for competition, spending growth targets, and value-based payment. These measures appropriately target health care’s supply side and the excesses that exist in the health care system. In this blog, I would like to highlight another avenue for savings: one that focuses on the demand ...
Source: The Health Care Blog - July 19, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Health Policy Ben Wheatley Health Care Cost Containment Health care spending Source Type: blogs

Inside the psychiatric unit: a PhD ’ s god-like status, ECT, and the harsh reality of mental illness treatment
PhD, the big man on the psych unit’s eighth floor, puffed on his pipe while listening to the dialogue of the broken, misfits, psychotics, schizophrenics, and bipolar patients. Many were beaten at birth, both physically and emotionally. In this land of serpents, he felt like a god. He’d select patients one by one for ECT, Read more… Inside the psychiatric unit: a PhD’s god-like status, ECT, and the harsh reality of mental illness treatment originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - May 18, 2023 Category: General Medicine Authors: Tags: Conditions Psychiatry Source Type: blogs

201 Monday Motivation Quotes (+ My 5 Favorite Tips for a Great Week)
Are you in need of some Monday motivation? If you’re perhaps tired, unmotivated and just reluctant to do anything and want a few more days of weekend right now then I have something that can help you. I’ve put together 201 of the best Monday motivation quotes I’ve ever come across to give you a boost of inspiration as you start your Monday and week and to maybe help you to find a change in perspective. That’s the first part of this post. In the second part I’ll share my own 5 favorite tips that I’ve used the most to overcome my own Monday blues and reluctance and to get my week off to a good and motivated star...
Source: Practical Happiness and Awesomeness Advice That Works | The Positivity Blog - May 4, 2023 Category: Consumer Health News Authors: Henrik Edberg Tags: Inspirational Quotes Personal Development Source Type: blogs

Bonus Features – March 5, 2023 – Two-thirds of patients connect with regular docs when they need medical care when traveling, half of clinical workflow automation users plan to expand their use, and more
This article will be a weekly roundup of interesting stories, product announcements, new hires, partnerships, research studies, awards, sales, and more. Because there’s so much happening out there in healthcare IT we aren’t able to cover in our full articles, we still want to make sure you’re informed of all the latest news, announcements, and stories happening to help you better do your job. News and Research With the COVID-19 Public Health Emergency due to end on May 11, the Drug Enforcement Administration has proposed restrictions on the remote prescription of controlled substances, with only buprenorphine and Sch...
Source: EMR and HIPAA - March 5, 2023 Category: Information Technology Authors: Brian Eastwood Tags: C-Suite Leadership Health IT Company Healthcare IT Hospital - Health System Abridge Alan Swenson ATA Biofourmis canon medical CareCloud Carequality Chugai Phmarceutical DEA Derek Shaw Dustin Spencer eClinicalWorks eCW emt Source Type: blogs

Bipolar Disorder Symptoms And Signs To Know
Bipolar disorder symptoms and signs include extreme mood swings from low to high and back again. It used to be called manic depression. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - February 2, 2023 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Bipolar Disorder Source Type: blogs

Epsilon Wave
Epsilon wave, the classical ECG finding in arrhythmogenic right ventricular dysplasia is seen at the end of the QRS complex. Epsilon wave is typically seen in right precordial leads though it has been noted in left precordial leads in those with left ventricular involvement. ARVD is better termed arrhythmogenic cardiomyopathy because of the possibility of left ventricular involvement. Epsilon wave represents the delayed activation of surviving islands of myocardium within the fibrofatty tissue in ARVD [1]. Some have called it as a ‘post excitation’ wave, as a corollary to the delta wave in pre excitation. It ...
Source: Cardiophile MD - January 20, 2023 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs

A 60 year old with chest pain
CONCLUSION:Take another LOOK at Figure-1. It was after Dr. Smith suggested repeating the initial ECG after repositioning the LL electrode — that ECG #2 was recorded.In your mind ' s eye — Wouldn ' t ECG #1 look like ECG #2 if we took away the artifactual deflections highlighted in RED, BLUE and GREEN?That said — there is nonspecific ST-T wave flattening in multiple leads of ECG #2, as well as T wave inversion in lead V2. There are also fairly large U waves in leads V3 and V4. Finally — significant baseline artifact persists in leads II and III of ECG #2, s...
Source: Dr. Smith's ECG Blog - January 17, 2023 Category: Cardiology Authors: Steve Smith Source Type: blogs