Horizon Pharma begins Actimmune’s Phase III trial for Friedreich's Ataxia
Ireland-based Horizon Pharma has started the Phase III study of Actimmune (interferon gamma-1b) to treat patients with Friedreich's Ataxia (FA), a degenerative neuro-muscular disorder. (Source: Drug Development Technology)
Source: Drug Development Technology - June 7, 2015 Category: Pharmaceuticals Source Type: news

Minor trauma causing stroke in a young athlete - Gupta V, Dhawan N, Bahl J.
A 17-year-old Caucasian male presented with sudden dizziness, ataxia, vertigo, and clumsiness lasting for a couple of hours. He had a subtle trauma during a wrestling match 2 days prior to the presentation. A CT Angiogram (CTA) and MRI showed left vertebra... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - April 24, 2015 Category: Global & Universal Tags: Age: Adolescents Source Type: news

Gene editing technique could prevent inherited diseases
ConclusionThis early research has developed a new technique to reduce the amount of mutation-carrying DNA within mitochondria. The hope is that this technique might be used in the eggs of women carrying disease-causing mitochondrial mutations.The government has recently given the go ahead for a technique that allows a woman who carries such a disease from passing it on to her child – making the UK the first country to do so. This technique has raised some ethical and safety concerns, as it places the woman’s chromosomes into a donor egg with healthy mitochondria. This means that once this egg is fertilised it contains...
Source: NHS News Feed - April 24, 2015 Category: Consumer Health News Tags: Genetics/stem cells Pregnancy/child Source Type: news

Horizon Pharma's Friedreich's Ataxia Drug Gets Fast-Track Designation
Horizon Pharma PLC said Friday that its experimental Friedreich’s ataxia treatment has received fast-track designation from the U.S. Food and Drug Administration, a move that could speed approval. (Source: WSJ.com: Health)
Source: WSJ.com: Health - April 10, 2015 Category: Pharmaceuticals Tags: PAID Source Type: news

Horizon Pharma plc Receives FDA Fast Track Designation for ACTIMMUNE(R) in the Treatment of Friedreich's Ataxia
DUBLIN, IRELAND--(Healthcare Sales & Marketing Network) - Horizon Pharma plc (NASDAQ: HZNP), a specialty biopharmaceutical company focused on improving patients' lives by identifying, developing, acquiring and commercializing differentiated products that a... Biopharmaceuticals, Neurology, FDAHorizon Pharma, ACTIMMUNE, Friedreich's Ataxia (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - April 10, 2015 Category: Pharmaceuticals Source Type: news

[Editors' Choice] GABA receptors as oxytocin targets
Oxytocin limits the ataxia and sedation effects of ethanol by reducing its potentiation of the GABAA family of Cl- channels. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - March 19, 2015 Category: Science Authors: Nancy Gough (mailto:ngough at aaas.org) Source Type: news

Ataxia: Types, Causes & Symptoms
The word, ‘ataxia,’ describes a lack of muscle control during voluntary movements such as picking up objects or walking. A sign of an underlying condition, ataxia may affect a person’s speech, eye movement, physical movements and swallowing. ‘Persistent ataxia,’ often times results from damage to a person’s cerebellum, the portion of the brain that controls coordination. Many conditions can cause ataxia to include: (Source: Disabled World)
Source: Disabled World - March 5, 2015 Category: Disability Tags: Health and Disability Source Type: news

Ataxia: Types, Causes, Symptoms, Treatments
Information regarding ataxia, a neurological sign consisting of lack of voluntary coordination of muscle movements (Source: Disabled World)
Source: Disabled World - March 5, 2015 Category: Disability Tags: Health and Disability Source Type: news

Horizon Pharma plc Submits Investigational New Drug Application for ACTIMMUNE(R) in the Treatment of Friedreich's Ataxia
Phase 3 Study Expected to Begin in Q2 2015 DUBLIN, IRELAND--(Healthcare Sales & Marketing Network) - Horizon Pharma plc (HZNP), a specialty biopharmaceutical company focused on improving patients' lives by identifying, developing, acquiring and commerci... Biopharmaceuticals, Neurology, FDAHorizon Pharma, ACTIMMUNE, Friedreich's Ataxia (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - February 13, 2015 Category: Pharmaceuticals Source Type: news

Gait and balance in adults with Friedreich's ataxia - Stephenson J, Zesiewicz T, Gooch C, Wecker L, Sullivan K, Jahan I, Kim SH.
Friedreich's ataxia (FA) is an autosomal recessive, neurodegenerative disease characterized by progressive muscle weakness and sensory loss, balance deficits, and gait ataxia. Gait and balance impairments become worse as the disease progresses, but limited... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - February 13, 2015 Category: Global & Universal Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

New study links neurological disorders in captive felids to improper diet
A new research study confirms the connection between high incidence of spinal cord issues in cheetahs and lions kept as exotic pets in the United Arab Emirates with dietary deficiencies. The study compared blood and tissue samples among captive felids, including cheetahs, lions and snow leopards, that were fed different diets. Thirty percent of the animals that did not receive supplements and existed primarily on a poultry muscle meat diet displayed clinical neurological signs such as ataxia, lack of coordination, swaying gait and moderate to severe hind limb weakness. Despite having normal appetites, these animals develop...
Source: ScienceDaily Headlines - December 30, 2014 Category: Science Source Type: news

Nicotine poisoning from an asparagus look-alike
This report, from the University of Wisconsin in Madison, describes two patients who developed symptoms consistent with nicotinic poisoning after ingesting foraged B australis. Patient 1 was an 85-year-old woman developed nausea, vomiting, diarrhea, abdominal distress, and dizziness within 15 minutes of ingesting what she took to be “wild asparagus.” Patient 2, her 48-year-old daughter, developed similar symptoms plus vertigo within a similar time frame after ingestion. Each patient was described as having severe truncal ataxia and was not able to stand unassisted. The patients were treated with fluids, anti...
Source: The Poison Review - December 30, 2014 Category: Toxicology Authors: Leon Tags: Medical asparagus baptisia look alike nicotine toxicity Source Type: news

Ataxia - Akbar U, Ashizawa T.
Ataxia is a disorder of balance and coordination resulted from dysfunctions involving cerebellum and its afferent and efferent connections. While a variety of disorders can cause secondary ataxias, the list of genetic causes of ataxias is growing longer. G... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - December 4, 2014 Category: Global & Universal Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

Converting Skin Cells into Sensory Neurons that Detect Body Sensations
A team led by scientists from The Scripps Research Institute (TSRI) has found a simple method to convert human skin cells into the specialized neurons that detect pain, itch, touch and other bodily sensations. These neurons are also affected by spinal cord injury and involved in Friedreich's ataxia, a devastating and currently incurable neurodegenerative disease that largely strikes children. (Source: Disabled World)
Source: Disabled World - November 24, 2014 Category: Disability Tags: Medical Research Source Type: news

Pain and itch in a dish
(Scripps Research Institute) A team led by scientists from The Scripps Research Institute has found a simple method to convert human skin cells into the specialized neurons that detect pain, itch, touch and other bodily sensations. These neurons are also affected by spinal cord injury and involved in Friedreich's ataxia, a devastating and currently incurable neurodegenerative disease that largely strikes children. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 24, 2014 Category: Global & Universal Source Type: news