Efficacy of risankizumab across subgroups in patients with active psoriatic arthritis: a post hoc integrated analysis of the phase 3 KEEPsAKE 1 and KEEPsAKE 2 randomized controlled trials
J Dermatolog Treat. 2024 Dec;35(1):2342383. doi: 10.1080/09546634.2024.2342383. Epub 2024 Apr 18.ABSTRACTIn the KEEPsAKE 1 (NCT03675308) and KEEPsAKE 2 (NCT03671148) phase 3 trials, risankizumab demonstrated greater efficacy compared with placebo in patients with active psoriatic arthritis (PsA). This post hoc integrated analysis evaluated achieving the following efficacy outcomes at weeks 24 and 52 by baseline demographics and clinical characteristics: ≥20%/50%/70% improvement in American College of Rheumatology response criteria (ACR20/50/70), ≥90% improvement in Psoriasis Area and Severity Index, minimal disease act...
Source: Journal of Dermatological Treatment - April 18, 2024 Category: Dermatology Authors: Joseph F Merola April Armstrong Saakshi Khattri So Yeon Paek Byron Padilla Cuiyong Yue Huzefa Photowala Blair Kaplan Lars Erik Kristensen Source Type: research
Real-world outcomes and drug survival of brodalumab: results from the German Psoriasis Registry PsoBest
J Dermatolog Treat. 2024 Dec;35(1):2340107. doi: 10.1080/09546634.2024.2340107. Epub 2024 Apr 18.ABSTRACTBrodalumab, a human monoclonal antibody that targets interleukin-17 receptor A (IL-17RA), is approved in the US and EU for treatment of adults with moderate-to-severe plaque psoriasis. Although brodalumab has demonstrated efficacy and safety vs placebo in clinical trials of patients with psoriasis and psoriatic arthritis (PsA), real-world evidence is needed to evaluate long-term effectiveness and safety of brodalumab in routine care. This interim analysis of the German Psoriasis Registry PsoBest examined patient profile...
Source: Journal of Dermatological Treatment - April 18, 2024 Category: Dermatology Authors: Lisa Schaeffer Nesrine Ben-Anaya Christina Sorbe Stephan Jeff Rustenbach Ulrich Mrowietz Matthias Augustin Source Type: research
The role of Epstein-Barr virus in autoimmune and autoinflammatory diseases
Crit Rev Microbiol. 2024 Apr 18:1-21. doi: 10.1080/1040841X.2024.2344114. Online ahead of print.ABSTRACTEpstein-Barr Virus (EBV), a dsDNA herpesvirus, is believed to play a significant role in exacerbating and potentially triggering autoimmune and autoinflammatory maladies. Around 90% of the world is infected with the virus, which establishes latency within lymphocytes. EBV is also known to cause infectious mononucleosis, a self-limited flu-like illness, in adolescents. EBV is often reactivated and it employs several mechanisms of evading the host immune system. It has also been implicated in inducing host immune dysfuncti...
Source: Critical Reviews in Microbiology - April 18, 2024 Category: Microbiology Authors: Abdul Hamid Borghol Elio R Bitar Aya Hanna Georges Naim Elias A Rahal Source Type: research
Gastrointestinal bleeding due to disseminated histoplasmosis in a patient under anti-TNF treatment
Rev Esp Enferm Dig. 2024 Apr 18. doi: 10.17235/reed.2024.10432/2024. Online ahead of print.ABSTRACTA 62-year-old woman, originally from Peru, with rheumatoid arthritis under treatment with anti-tumor necrosis factor (anti-TNF) therapy, was admitted due to constitutional syndrome and suspicion of neoplasia. Computed tomography (CT) scan revealed involvement of three segments of the colon, ascites, and likely peritoneal implants. Ascitic fluid analysis showed elevated adenosine deaminase (ADA) levels and lymphocytosis. The patient presented with hematemesis and hematochezia with hemodynamic instability. Upper gastrointestina...
Source: Revista Espanola de Enfermedades Digestivas - April 18, 2024 Category: Gastroenterology Authors: Irene Gonz ález Díaz Cristina Su árez Ferrer Clara Amiama Roig Carmen Amor Costa Source Type: research
Unusual presentation of disseminated gonococcal infection
A 30-year-old homosexual man living with HIV and receiving virologically suppressive antiretroviral treatment presented to the emergency department with a 3-day history of pain in his left wrist accompanied by fever and chills. On examination, the left wrist showed redness, swelling, tenderness and decreased range of movement. The patient had no history of trauma, insect bites or scratches. Four weeks earlier, he had engaged in unprotected oral sex with a casual partner. Nucleic acid amplification tests (NAATs) for Chlamydia trachomatis and Neisseria gonorrhoea (Ng) were performed from oropharyngeal, anal and urine samples...
Source: Sexually Transmitted Infections - April 18, 2024 Category: Sexual Medicine Authors: AlHammadi, M., Schembri, A., Calleja, L., Padovese, V. Tags: PostScript Source Type: research
Acute cervical epidural abscess with concurrent calcium pyrophosphate deposition after cervical spinal surgery: A case report
CONCLUSION: An acute onset of SEA complicated with CPPD after cervical surgery has rarely been reported. The suppurative inflammation fostered by the crystal-induced inflammation may account for the acute symptomatology.PMID:38628534 | PMC:PMC11021091 | DOI:10.25259/SNI_740_2023 (Source: Hand Surgery)
Source: Hand Surgery - April 17, 2024 Category: Surgery Authors: Koki Mitani Manabu Minami Toshiyuki Takahashi Mariko Toyoda Ryo Kanematsu Junya Hanakita Source Type: research
Population Pharmacokinetics of Adalimumab in Juvenile Idiopathic Arthritis Patients: A Retrospective Cohort Study Using Clinical Care Data
CONCLUSIONS: Five literature models effectively described adalimumab PK in this pediatric cohort, highlighting the potential for extrapolating existing models to the pediatric population. The new JIA model confirmed the effect of several known covariates and found a novel association for drug clearance with methotrexate use (lower) and uveitis (higher), which might have clinical relevance for personalized dosing in JIA.PMID:38630199 | DOI:10.1007/s40272-024-00629-7 (Source: Paediatric Drugs)
Source: Paediatric Drugs - April 17, 2024 Category: Pediatrics Authors: Amara Nassar-Sheikh Rashid Femke Hooijberg Sandy C Bergkamp Mariken P Gruppen Taco W Kuijpers Mike Nurmohamed Theo Rispens Gertjan Wolbink J Merlijn van den Berg Dieneke Schonenberg-Meinema Ron A A Math ôt Source Type: research
Septic arthritis due to Pasteurella multocida
Rev Esp Quimioter. 2024 Apr 17:pina17apr2024. doi: 10.37201/req/019.2024. Online ahead of print.NO ABSTRACTPMID:38627987 | DOI:10.37201/req/019.2024 (Source: Revista Espanola de Quimioterapia)
Source: Revista Espanola de Quimioterapia - April 17, 2024 Category: Drugs & Pharmacology Authors: C Pi ña Delgado M N Carmona Tello M Bola ños Rivero M C Lavilla Salgado I de Miguel Mart ínez Source Type: research
Acute cervical epidural abscess with concurrent calcium pyrophosphate deposition after cervical spinal surgery: A case report
CONCLUSION: An acute onset of SEA complicated with CPPD after cervical surgery has rarely been reported. The suppurative inflammation fostered by the crystal-induced inflammation may account for the acute symptomatology.PMID:38628534 | PMC:PMC11021091 | DOI:10.25259/SNI_740_2023 (Source: Surgical Neurology International)
Source: Surgical Neurology International - April 17, 2024 Category: Neurosurgery Authors: Koki Mitani Manabu Minami Toshiyuki Takahashi Mariko Toyoda Ryo Kanematsu Junya Hanakita Source Type: research
Angiogenesis-related immune response may be the prelude to the syndesmophyte formation in Ankylosing spondylitis
CONCLUSIONS: We explored the intimate relationship between local inflammation and bone formation in AS from the perspective of nascent vascularisation. Hence, our study lays the foundation for elucidating a unified AS pathogenesis through the immune-angiogenesis-osteogenesis axis.PMID:38631220 | DOI:10.1016/j.intimp.2024.112040 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 17, 2024 Category: Allergy & Immunology Authors: Chunmei Cai Yuye Huang Liyan Li Kai Kei Miu Zhangting Wang Yujie Deng Yanzhen Cai Jinxiu Li Liang Wu Hepeng Zhu Yang Gao Jun Chen Wende Xiao Li Lu Source Type: research
Use of risk chart algorithms for the identification of psoriatic arthritis patients at high risk for cardiovascular disease: findings derived from the project CARMA cohort after a 7.5-year follow-up period
CONCLUSIONS: Risk chart algorithms are very useful for discriminating PsA at low and high CV risk. An integrated model featuring QRISK3 and SCORE2 yielded the optimal synergy of QRISK3's discrimination ability and SCORE2's calibration accuracy.PMID:38631846 | DOI:10.1136/rmdopen-2024-004207 (Source: Atherosclerosis)
Source: Atherosclerosis - April 17, 2024 Category: Cardiology Authors: Jessica Polo Y La Borda Santos Casta ñeda Elena Heras-Recuero Fernando S ánchez-Alonso Zulema Plaza Carmen Garc ía Gómez Ivan Ferraz-Amaro Jes ús Tomás Sanchez-Costa Olga Carmen S ánchez-González Ana Isabel Turri ón-Nieves Ana Perez-Alcal á Caro Source Type: research
Detection of common pathogenesis of rheumatoid arthritis and atherosclerosis via microarray data analysis
This study underscores the shared pathogenic mechanisms, pivotal genes, and potential therapeutic interventions bridging RA and AS, offering valuable insights for future research and clinical management strategies.PMID:38628735 | PMC:PMC11019104 | DOI:10.1016/j.heliyon.2024.e28029 (Source: Atherosclerosis)
Source: Atherosclerosis - April 17, 2024 Category: Cardiology Authors: Fan Xu Linfeng Xie Jian He Qiuyu Huang Yanming Shen Liangwan Chen Xiaohong Zeng Source Type: research
β-Indole-3-acetic acid attenuated collagen-induced arthritis through reducing the ubiquitination of Foxp3 via the AhR-TAZ-Tip60 pathway
In this study, the collagen-induced arthritis (CIA) rat model was established. Based on metabolomics analysis, the contents of β-indole-3-acetic acid (IAA), indolylpropionic acid, and indole-3-β-acrylic acid in the sera of CIA rats were significantly less compared with those of the normal rats. Under the condition of Treg or Th17 cell differentiation, IAA significantly promoted the differentiation and activation of Treg cells instead of Th17 cells. Intestinal tryptophan metabolites are well-known endogenic ligands of aryl hydrocarbon receptor (AhR). Not surprisingly, IAA increased the level of Foxp3 through activating th...
Source: Cell Research - April 17, 2024 Category: Cytology Authors: Xiaoran Su Xinliu Wang Xin Zhang Yajie Sun Yugai Jia Source Type: research
Phosphatidic Acid Promoting the Generation of Interleukin ‐17A Producing Double‐Negative T Cells by Enhancing mTORC1 Signaling in Lupus
ConclusionThe accumulation of PA in T cells could activate the mTORC1 pathway, promoting DNT cell expansion and IL-17A secretion, resulting in GCB cell abnormalities in lupus. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 17, 2024 Category: Rheumatology Authors: Wenjing Li,
Xiaojun Tang,
Yuanyuan Zheng,
Xuefeng Xu,
Nan Zhao,
Betty P. Tsao,
Xuebing Feng,
Lingyun Sun Tags: Full Length Source Type: research
Long-term effects of abatacept on atherosclerosis and arthritis in older vs. younger patients with rheumatoid arthritis: 3-year results of a prospective, multicenter, observational study
We aimed to reveal the effect of abatacept (ABT) on atherosclerosis in rheumatoid arthritis (RA) patients, 3-year efficacy for arthritis, and safety in a population of older vs. younger patients. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - April 17, 2024 Category: Rheumatology Authors: Zento Yamada, Sei Muraoka, Mai Kawazoe, Wataru Hirose, Hajime Kono, Shinsuke Yasuda, Takahiko Sugihara and Toshihiro Nanki Tags: Research Source Type: research
