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Prevalence and Burden of Coconut Allergy in the United States
CONCLUSION: Roughly 1 in 260 Americans report symptoms consistent with an IgE-mediated allergy to coconut, although fewer than half of these individuals report receiving a physician diagnosis. Our data indicate that most individuals with reported coconut allergy meeting symptom-based criteria for convincingly IgE-mediated disease have comorbid food allergies, and for many patients, clinical management appears to be suboptimal.PMID:37625503 | DOI:10.1016/j.anai.2023.08.017
Source: Annals of Allergy, Asthma and Immunology - August 25, 2023 Category: Allergy & Immunology Authors: Christopher M Warren Shruti Sehgal Sai R Nimmagadda Ruchi Gupta Source Type: research

Impact of SARS-CoV-2 mRNA vaccine on arthritis condition in rheumatoid arthritis
ConclusionRA patients had more frequent and longer-lasting arthralgia after vaccination than healthy subjects, and one-third of patients with post-vaccination arthralgia required additional DMARDs. Although the SARS-CoV-2 mRNA vaccine was administered safely in most RA patients, in some patients RA symptoms may worsen after vaccination.
Source: Frontiers in Immunology - August 25, 2023 Category: Allergy & Immunology Source Type: research

Tezepelumab reduces exacerbations across all seasons in patients with severe, uncontrolled asthma (NAVIGATOR)
CONCLUSION: Tezepelumab reduced exacerbations across all seasons versus placebo in patients with severe, uncontrolled asthma, including patients with seasonal and perennial allergies. These data further support the efficacy of tezepelumab in a broad population of patients with severe, uncontrolled asthma.PMID:37619779 | DOI:10.1016/j.anai.2023.08.015
Source: Annals of Allergy, Asthma and Immunology - August 24, 2023 Category: Allergy & Immunology Authors: Ian D Pavord Flavia C L Hoyte Andrew W Lindsley Christopher S Ambrose Joseph D Spahn Stephanie L Roseti Bill Cook Janet M Griffiths Åsa Hellqvist Nicole Martin Jean-Pierre Llanos Neil Martin Gene Colice Jonathan Corren Source Type: research

How Does Global Warming Contribute to Disorders Originating from an Impaired Epithelial Barrier?
Ann Allergy Asthma Immunol. 2023 Aug 22:S1081-1206(23)00588-4. doi: 10.1016/j.anai.2023.08.010. Online ahead of print.ABSTRACTThe epithelial barrier represents the point of contact between the host and the external environment. It is the first line of defense against external insults in the skin, gastrointestinal and upper and lower respiratory tracts. The steep increase in chronic disorders in recent decades, including allergies and autoimmune disorders, has prompted studies to investigate the immune mechanisms of their underlying pathogeneses, all of which point to a thought-provoking shared finding: disrupted epithelial...
Source: Annals of Allergy, Asthma and Immunology - August 24, 2023 Category: Allergy & Immunology Authors: Cevdet Ozdemir Umut Can Kucuksezer Ismail Ogulur Yagiz Pat Duygu Yazici Ioana Agache Marek Jutel Kari C Nadeau M übeccel Akdis Cezmi A Akdis Source Type: research

When Nutrition Trends and Food Allergies Collide
Ann Allergy Asthma Immunol. 2023 Aug 22:S1081-1206(23)00592-6. doi: 10.1016/j.anai.2023.08.014. Online ahead of print.NO ABSTRACTPMID:37619775 | DOI:10.1016/j.anai.2023.08.014
Source: Annals of Allergy, Asthma and Immunology - August 24, 2023 Category: Allergy & Immunology Authors: Marion Groetch Isabel Skypala Source Type: research

Tezepelumab reduces exacerbations across all seasons in patients with severe, uncontrolled asthma (NAVIGATOR)
CONCLUSION: Tezepelumab reduced exacerbations across all seasons versus placebo in patients with severe, uncontrolled asthma, including patients with seasonal and perennial allergies. These data further support the efficacy of tezepelumab in a broad population of patients with severe, uncontrolled asthma.PMID:37619779 | DOI:10.1016/j.anai.2023.08.015
Source: Annals of Allergy, Asthma and Immunology - August 24, 2023 Category: Allergy & Immunology Authors: Ian D Pavord Flavia C L Hoyte Andrew W Lindsley Christopher S Ambrose Joseph D Spahn Stephanie L Roseti Bill Cook Janet M Griffiths Åsa Hellqvist Nicole Martin Jean-Pierre Llanos Neil Martin Gene Colice Jonathan Corren Source Type: research

How Does Global Warming Contribute to Disorders Originating from an Impaired Epithelial Barrier?
Ann Allergy Asthma Immunol. 2023 Aug 22:S1081-1206(23)00588-4. doi: 10.1016/j.anai.2023.08.010. Online ahead of print.ABSTRACTThe epithelial barrier represents the point of contact between the host and the external environment. It is the first line of defense against external insults in the skin, gastrointestinal and upper and lower respiratory tracts. The steep increase in chronic disorders in recent decades, including allergies and autoimmune disorders, has prompted studies to investigate the immune mechanisms of their underlying pathogeneses, all of which point to a thought-provoking shared finding: disrupted epithelial...
Source: Annals of Allergy, Asthma and Immunology - August 24, 2023 Category: Allergy & Immunology Authors: Cevdet Ozdemir Umut Can Kucuksezer Ismail Ogulur Yagiz Pat Duygu Yazici Ioana Agache Marek Jutel Kari C Nadeau M übeccel Akdis Cezmi A Akdis Source Type: research

When Nutrition Trends and Food Allergies Collide
Ann Allergy Asthma Immunol. 2023 Aug 22:S1081-1206(23)00592-6. doi: 10.1016/j.anai.2023.08.014. Online ahead of print.NO ABSTRACTPMID:37619775 | DOI:10.1016/j.anai.2023.08.014
Source: Annals of Allergy, Asthma and Immunology - August 24, 2023 Category: Allergy & Immunology Authors: Marion Groetch Isabel Skypala Source Type: research

The Role of IgA in the Manifestation and Prevention of Allergic Immune Responses
AbstractPurpose of ReviewImmunoglobulin A (IgA) mediates immune exclusion of antigens in the gut. Notably, IgA plays also a role in the prevention of IgE-mediated allergies and induction of immune tolerance. The present review addresses the role of IgA in the manifestation of IgE-mediated allergies, including allergen-specific immunotherapy (AIT), the regulation of IgA production, and the mechanism of IgA in immune cell activation.Recent FindingsThe majority of studies report an association of IgA with the induction of immune tolerance in IgE-mediated allergies. However, reports on the involvement of humoral and mucosal Ig...
Source: Current Allergy and Asthma Reports - August 23, 2023 Category: Allergy & Immunology Source Type: research

Lycopene alleviates food allergy by modulating the PI3K/AKT pathway in peanut-sensitized BALB/c mice
Immunobiology. 2023 Aug 15;228(6):152731. doi: 10.1016/j.imbio.2023.152731. Online ahead of print.ABSTRACTFood allergies, which lead to life-threatening acute symptoms, are considered an important public health problem. Therefore, it is essential to develop efficient preventive and treatment measures. We developed a crude peanut protein extract (PPE)-induced allergy mouse model to investigate the effects of lycopene on peanut allergy. Mice were divided into four groups: 5 mg/kg lycopene, 20 mg/kg lycopene, no treatment, and control groups. Serum inflammatory factors were detected using enzyme-linked immunosorbent assay. In...
Source: Immunobiology - August 22, 2023 Category: Allergy & Immunology Authors: Hongjuan He Xiaoyan Ji Lihua Cao Zhenzhen Wang Xiaoyu Wang Xiu-Min Li Mingsan Miao Source Type: research

Infant gut microbiota colonization: influence of prenatal and postnatal factors, focusing on diet
Maternal microbiota forms the first infant gut microbial inoculum, and perinatal factors (diet and use of antibiotics during pregnancy) and/or neonatal factors, like intra partum antibiotics, gestational age and mode of delivery, may influence microbial colonization. After birth, when the principal colonization occurs, the microbial diversity increases and converges toward a stable adult-like microbiota by the end of the first 3–5 years of life. However, during the early life, gut microbiota can be disrupted by other postnatal factors like mode of infant feeding, antibiotic usage, and various environmental factors genera...
Source: Frontiers in Microbiology - August 22, 2023 Category: Microbiology Source Type: research