Histological and neuroimaging comparison of SMART syndrome versus focal neuronal gigantism
In this study, we contrast histological and neuroimaging features of 3 FNG vs. 4 SMART cases, the latter diagnosed by a neuroradiologist, neurooncologist, and/or neurosurgeon. We confirm the cortical thickening, dyslamination, neuronal cytomegaly, and gliosis in FNG vs. cortical architectural preservation and normal neuronal cytology in SMART, although both showed gliosis, scattered neurons with cytoplasmic accumulation of tau and neurofibrillary protein and variable co-existence of other radiation-induced lesions. Both conditions lacked significant inflammation or consistent small vessel hyalinization throughout the entir...
Source: Clinical Neuropathology - December 12, 2023 Category: Pathology Authors: Ahmed Gilani Bette K Kleinschmidt-DeMasters Source Type: research
Histological and neuroimaging comparison of SMART syndrome versus focal neuronal gigantism
In this study, we contrast histological and neuroimaging features of 3 FNG vs. 4 SMART cases, the latter diagnosed by a neuroradiologist, neurooncologist, and/or neurosurgeon. We confirm the cortical thickening, dyslamination, neuronal cytomegaly, and gliosis in FNG vs. cortical architectural preservation and normal neuronal cytology in SMART, although both showed gliosis, scattered neurons with cytoplasmic accumulation of tau and neurofibrillary protein and variable co-existence of other radiation-induced lesions. Both conditions lacked significant inflammation or consistent small vessel hyalinization throughout the entir...
Source: Clinical Neuropathology - December 12, 2023 Category: Pathology Authors: Ahmed Gilani Bette K Kleinschmidt-DeMasters Source Type: research
Histological and neuroimaging comparison of SMART syndrome versus focal neuronal gigantism
In this study, we contrast histological and neuroimaging features of 3 FNG vs. 4 SMART cases, the latter diagnosed by a neuroradiologist, neurooncologist, and/or neurosurgeon. We confirm the cortical thickening, dyslamination, neuronal cytomegaly, and gliosis in FNG vs. cortical architectural preservation and normal neuronal cytology in SMART, although both showed gliosis, scattered neurons with cytoplasmic accumulation of tau and neurofibrillary protein and variable co-existence of other radiation-induced lesions. Both conditions lacked significant inflammation or consistent small vessel hyalinization throughout the entir...
Source: Clinical Neuropathology - December 12, 2023 Category: Pathology Authors: Ahmed Gilani Bette K Kleinschmidt-DeMasters Source Type: research
Histological and neuroimaging comparison of SMART syndrome versus focal neuronal gigantism
In this study, we contrast histological and neuroimaging features of 3 FNG vs. 4 SMART cases, the latter diagnosed by a neuroradiologist, neurooncologist, and/or neurosurgeon. We confirm the cortical thickening, dyslamination, neuronal cytomegaly, and gliosis in FNG vs. cortical architectural preservation and normal neuronal cytology in SMART, although both showed gliosis, scattered neurons with cytoplasmic accumulation of tau and neurofibrillary protein and variable co-existence of other radiation-induced lesions. Both conditions lacked significant inflammation or consistent small vessel hyalinization throughout the entir...
Source: Clinical Neuropathology - December 12, 2023 Category: Pathology Authors: Ahmed Gilani Bette K Kleinschmidt-DeMasters Source Type: research
Histological and neuroimaging comparison of SMART syndrome versus focal neuronal gigantism
In this study, we contrast histological and neuroimaging features of 3 FNG vs. 4 SMART cases, the latter diagnosed by a neuroradiologist, neurooncologist, and/or neurosurgeon. We confirm the cortical thickening, dyslamination, neuronal cytomegaly, and gliosis in FNG vs. cortical architectural preservation and normal neuronal cytology in SMART, although both showed gliosis, scattered neurons with cytoplasmic accumulation of tau and neurofibrillary protein and variable co-existence of other radiation-induced lesions. Both conditions lacked significant inflammation or consistent small vessel hyalinization throughout the entir...
Source: Clinical Neuropathology - December 12, 2023 Category: Pathology Authors: Ahmed Gilani Bette K Kleinschmidt-DeMasters Source Type: research
Histological and neuroimaging comparison of SMART syndrome versus focal neuronal gigantism
In this study, we contrast histological and neuroimaging features of 3 FNG vs. 4 SMART cases, the latter diagnosed by a neuroradiologist, neurooncologist, and/or neurosurgeon. We confirm the cortical thickening, dyslamination, neuronal cytomegaly, and gliosis in FNG vs. cortical architectural preservation and normal neuronal cytology in SMART, although both showed gliosis, scattered neurons with cytoplasmic accumulation of tau and neurofibrillary protein and variable co-existence of other radiation-induced lesions. Both conditions lacked significant inflammation or consistent small vessel hyalinization throughout the entir...
Source: Clinical Neuropathology - December 12, 2023 Category: Pathology Authors: Ahmed Gilani Bette K Kleinschmidt-DeMasters Source Type: research
Histological and neuroimaging comparison of SMART syndrome versus focal neuronal gigantism
In this study, we contrast histological and neuroimaging features of 3 FNG vs. 4 SMART cases, the latter diagnosed by a neuroradiologist, neurooncologist, and/or neurosurgeon. We confirm the cortical thickening, dyslamination, neuronal cytomegaly, and gliosis in FNG vs. cortical architectural preservation and normal neuronal cytology in SMART, although both showed gliosis, scattered neurons with cytoplasmic accumulation of tau and neurofibrillary protein and variable co-existence of other radiation-induced lesions. Both conditions lacked significant inflammation or consistent small vessel hyalinization throughout the entir...
Source: Clinical Neuropathology - December 12, 2023 Category: Pathology Authors: Ahmed Gilani Bette K Kleinschmidt-DeMasters Source Type: research
Aneurysmal dilation of sinus of Valsalva in a patient with undiagnosed acromegaly
Coronal oblique CT angiography reconstruction shows dilation of sinus of Valsalva with effacement in Sinu-tubular ridge. Key Clinical MessageIn patients presenting with aortic ectasia and myxomatous valve diseases at young ages, possible underlying acromegaly should be in mind.AbstractAcromegaly is a chronic systemic disease mainly caused by the benign pituitary adenoma secreting growth hormone (GH) in excess. Acromegaly is associated with various complications such as cardiovascular diseases. In this regard, timely diagnosis, and management of these patients could be life-saving. Herein, a case of aneurysmal dilation of t...
Source: Clinical Case Reports - December 12, 2023 Category: General Medicine Authors: Hoda Gharoy,
Sepideh Taghavi,
Zahra Ghaemmaghami,
Parham Rabiei,
Azadeh Afzalnia Tags: CASE REPORT Source Type: research
Biomarkers of response to treatment in acromegaly
Expert Rev Endocrinol Metab. 2023 Dec 11:1-11. doi: 10.1080/17446651.2023.2293107. Online ahead of print.ABSTRACTINTRODUCTION: Medical treatment of acromegaly is based in a `trial and error` approach. First-generation somatostatin receptor ligands (fg-SRL) are prescribed as first-line medical therapy to the vast majority of patients, despite lack of disease control in approximately 60% of patients. However, other drugs used in acromegaly treatment are available (cabergoline, pasireotide and pegvisomant).AREAS COVERED: In this article, we review and discuss the biomarkers of response to medical treatment in acromegaly.EXPER...
Source: Expert Review of Endocrinology and Metabolism - December 11, 2023 Category: Endocrinology Authors: Leandro Kasuki Elisa Lamback Ximene Antunes M ônica R Gadelha Source Type: research
The prevalence and associated risk factors of detectable renal morphological abnormalities in acromegaly
ConclusionThe results of this study showed that acromegaly disease significantly increased the prevalence of SRCs and kidney length compared to the age-sex matched healthy population, while the prevalence of KSD was similar. Advanced age and male gender were seen to be independent risk factors for SRC formation in patients with acromegaly. (Source: Pituitary)
Source: Pituitary - December 8, 2023 Category: Endocrinology Source Type: research
Correction: consensus on criteria for acromegaly diagnosis and remission
(Source: Pituitary)
Source: Pituitary - December 6, 2023 Category: Endocrinology Source Type: research
