The Effect of Metformin Treatment on Disease Control in Patients with Acromegaly
CONCLUSION: Due to the effect of metformin treatment on insulin-like growth factor-1 values in patients with acromegaly, it can be used in disease control, as well as diabetes treatment.PMID:38379171 | DOI:10.2174/0118715303260084231102105149 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - February 21, 2024 Category: Endocrinology Authors: Humeyra Rekali Sahin Serdar Sahin Betul Sarac Cem Sulu Pinar Kadioglu Hande Mefkure Ozkaya Source Type: research

The Effect of Metformin Treatment on Disease Control in Patients with Acromegaly
CONCLUSION: Due to the effect of metformin treatment on insulin-like growth factor-1 values in patients with acromegaly, it can be used in disease control, as well as diabetes treatment.PMID:38379171 | DOI:10.2174/0118715303260084231102105149 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - February 21, 2024 Category: Drugs & Pharmacology Authors: Humeyra Rekali Sahin Serdar Sahin Betul Sarac Cem Sulu Pinar Kadioglu Hande Mefkure Ozkaya Source Type: research

The Effect of Metformin Treatment on Disease Control in Patients with Acromegaly
CONCLUSION: Due to the effect of metformin treatment on insulin-like growth factor-1 values in patients with acromegaly, it can be used in disease control, as well as diabetes treatment.PMID:38379171 | DOI:10.2174/0118715303260084231102105149 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - February 21, 2024 Category: Endocrinology Authors: Humeyra Rekali Sahin Serdar Sahin Betul Sarac Cem Sulu Pinar Kadioglu Hande Mefkure Ozkaya Source Type: research

The Effect of Metformin Treatment on Disease Control in Patients with Acromegaly
CONCLUSION: Due to the effect of metformin treatment on insulin-like growth factor-1 values in patients with acromegaly, it can be used in disease control, as well as diabetes treatment.PMID:38379171 | DOI:10.2174/0118715303260084231102105149 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - February 21, 2024 Category: Drugs & Pharmacology Authors: Humeyra Rekali Sahin Serdar Sahin Betul Sarac Cem Sulu Pinar Kadioglu Hande Mefkure Ozkaya Source Type: research

The Effect of Metformin Treatment on Disease Control in Patients with Acromegaly
CONCLUSION: Due to the effect of metformin treatment on insulin-like growth factor-1 values in patients with acromegaly, it can be used in disease control, as well as diabetes treatment.PMID:38379171 | DOI:10.2174/0118715303260084231102105149 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - February 21, 2024 Category: Endocrinology Authors: Humeyra Rekali Sahin Serdar Sahin Betul Sarac Cem Sulu Pinar Kadioglu Hande Mefkure Ozkaya Source Type: research

High mortality risk among women with acromegaly still persists
ConclusionPatients diagnosed with acromegaly in the last 15 years had lower mortality rates than those diagnosed before 2008, due to the availability of new medications, primarily somatostatin receptor analogs and to a higher proportion of patients undergoing surgery. Females still have a high mortality ratio owing to older age at diagnosis and higher risk of metabolic complications. Therefore, efforts should be made for early diagnosis of acromegaly in women. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - February 21, 2024 Category: Endocrinology Source Type: research

Glucose intolerance in acromegaly is driven by low insulin secretion; results from an intravenous glucose tolerance test
ConclusionWe demonstrated that low insulin secretion is the main driver behind glucose intolerance in acromegaly. Compared to NGT and IGT controls with obesity, patients with NGT or IGT acromegaly had higher Si. Together, these findings suggest that impaired insulin secretion might be a specific mechanism for glucose intolerance in acromegaly. (Source: Pituitary)
Source: Pituitary - February 21, 2024 Category: Endocrinology Source Type: research

The changing landscape of acromegaly  - an epidemiological perspective
We present updated epidemiological data from the population-based Danish cohort of patients with acromegaly (AcroDEN), along with meta-analyses of existing estimates from around the world.Based on this, we conclude that the incidence, prevalence and age at acromegaly diagnosis are all steadily increasing, but with considerable variation between studies. An increased number of incidental cases may contribute to the increase in incidence and age at diagnosis, respectively. The clinical features at presentation are trending toward a milder disease phenotype at diagnosis, and advances in therapeutic options have reduced the mo...
Source: ENDOCR REV - February 10, 2024 Category: Endocrinology Authors: Christian Rosendal Mai Christiansen Arlien-S øborg Eigil Husted Nielsen Marianne Skovsager Andersen Claus Larsen Feltoft Caroline Kistorp Olaf M Dekkers Jens Otto Lunde J ørgensen Jakob Dal Source Type: research

The changing landscape of acromegaly  - an epidemiological perspective
We present updated epidemiological data from the population-based Danish cohort of patients with acromegaly (AcroDEN), along with meta-analyses of existing estimates from around the world.Based on this, we conclude that the incidence, prevalence and age at acromegaly diagnosis are all steadily increasing, but with considerable variation between studies. An increased number of incidental cases may contribute to the increase in incidence and age at diagnosis, respectively. The clinical features at presentation are trending toward a milder disease phenotype at diagnosis, and advances in therapeutic options have reduced the mo...
Source: ENDOCR REV - February 10, 2024 Category: Endocrinology Authors: Christian Rosendal Mai Christiansen Arlien-S øborg Eigil Husted Nielsen Marianne Skovsager Andersen Claus Larsen Feltoft Caroline Kistorp Olaf M Dekkers Jens Otto Lunde J ørgensen Jakob Dal Source Type: research

The changing landscape of acromegaly  - an epidemiological perspective
We present updated epidemiological data from the population-based Danish cohort of patients with acromegaly (AcroDEN), along with meta-analyses of existing estimates from around the world.Based on this, we conclude that the incidence, prevalence and age at acromegaly diagnosis are all steadily increasing, but with considerable variation between studies. An increased number of incidental cases may contribute to the increase in incidence and age at diagnosis, respectively. The clinical features at presentation are trending toward a milder disease phenotype at diagnosis, and advances in therapeutic options have reduced the mo...
Source: ENDOCR REV - February 10, 2024 Category: Endocrinology Authors: Christian Rosendal Mai Christiansen Arlien-S øborg Eigil Husted Nielsen Marianne Skovsager Andersen Claus Larsen Feltoft Caroline Kistorp Olaf M Dekkers Jens Otto Lunde J ørgensen Jakob Dal Source Type: research

The changing landscape of acromegaly  – an epidemiological perspective
We present updated epidemiological data from the population-based Danish cohort of patients with acromegaly (AcroDEN), along with meta-analyses of existing estimates from around the world.Based on this, we conclude that the incidence, prevalence and age at acromegaly diagnosis are all steadily increasing, but with considerable variation between studies. An increased number of incidental cases may contribute to the increase in incidence and age at diagnosis, respectively. The clinical features at presentation are trending toward a milder disease phenotype at diagnosis, and advances in therapeutic options have reduced the mo...
Source: Reviews in Endocrine and Metabolic Disorders - February 10, 2024 Category: Endocrinology Source Type: research

Cancers, Vol. 16, Pages 726: Alternations of Blood Pressure Following Surgical or Drug Therapy for Prolactinomas
bing Shang Zhe Bao Wu Several subtypes of pituitary neuroendocrine tumors (PitNETs), such as acromegaly and Cushing’s disease, can result in hypertension. However, whether prolactinoma is associated with this complication remains unknown. Moreover, the effect of treatment with surgery or drugs on blood pressure (BP) is unknown. Herein, a retrospective study reviewed 162 patients with prolactinoma who underwent transsphenoidal surgery between January 2005 and December 2022. BP measurements were performed 1 day before and 5 days after surgery. Accordingly, patients’ medical characteristics w...
Source: Cancers - February 9, 2024 Category: Cancer & Oncology Authors: Yijun Cheng Dapeng Wang Hao Tang Debing Tong Weiguo Zhao Shaojian Lin Hong Yao Wenwen Lv Xun Zhang Li Xue Hanbing Shang Zhe Bao Wu Tags: Article Source Type: research

Management of pasireotide-induced hyperglycemia in patients with acromegaly: An experts ’ consensus statement
Pasireotide is a somatostatin analogue for the treatment of acromegaly, a chronic condition caused by excess growth hormone. Despite the therapeutic benefits of pasireotide as a second-line treatment for inadequately controlled acromegaly, a major concern is its hyperglycemic side-effect. Here, we provide guidance on how to select appropriate patients with acromegaly for treatment with pasireotide. We summarize baseline characteristics of patients at high risk for pasireotide-associated hyperglycemia and recommend a monitoring strategy based on the risk profile. Self-monitoring of blood glucose levels (SMBG), measurements ...
Source: Frontiers in Endocrinology - February 9, 2024 Category: Endocrinology Source Type: research