Genomics, Transcriptomics, and Epigenetics of Sporadic Pituitary Tumors
Arch Med Res. 2023 Nov 17:102915. doi: 10.1016/j.arcmed.2023.102915. Online ahead of print.ABSTRACTPituitary tumors (PT) are highly heterogeneous neoplasms, comprising functioning and nonfunctioning lesions. Functioning PT include prolactinomas, causing amenorrhea-galactorrhea in women and sexual dysfunction in men; GH-secreting adenomas causing acromegaly-gigantism; ACTH-secreting corticotrophinomas causing Cushing disease (CD); and the rare TSH-secreting thyrotrophinomas that result in central hyperthyroidism. Nonfunctioning PT do not result in a hormonal hypersecretion syndrome and most of them are of gonadotrope differ...
Source: Cell Research - November 19, 2023 Category: Cytology Authors: Daniel Marrero-Rodr íguez Sandra Vela-Pati ño Florencia Martinez-Mendoza Alejandra Valenzuela-Perez Eduardo Pe ña-Martínez Amayrani Cano-Zaragoza Jacobo Kerbel Sergio Andonegui-Elguera Shimon S Glick-Betech Karla X Hermoso-Mier Sophia Mercado-Medrez A Source Type: research
Assessment of osteoprotegerin and RANKL levels and several cardiovascular risk scoring systems in acromegaly
CONCLUSION: OPG and RANKL may serve as potential markers for assessment of cardiovascular calcification and prediction of the cardiovascular risk status in acromegalic patients.PMID:37981618 | DOI:10.1007/s42000-023-00509-8 (Source: Hormones)
Source: Hormones - November 19, 2023 Category: Endocrinology Authors: Gokcen Unal Kocabas Banu Sarer Yurekli Ilgin Yildirim Simsir Su Ozgur Murat Aksit Giray Bozkaya Source Type: research
Osteosarcopenia in acromegaly: reduced muscle quality and increased vertebral fat deposition
ConclusionAcromegalic patients had reduced SMQ and pelvic BMD, but greater vertebral MRI-PDFF. Although lean tissue increases in AA, this does not affect SMQ. Therefore, increased vertebral MRI-PDFF in controlled acromegalic patients may be due to ectopic adiposity. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 17, 2023 Category: Endocrinology Source Type: research
The multi-biomarker acro-TIME score predicts fg-SRLs response: preliminary results of a retrospective acromegaly cohort
CONCLUSION: Although our predictive model should be validated in prospective studies, our data suggest that this nomogram may represent an easy-to-use tool, for early predicting the fg-SRLs outcome.PMID:37975821 | DOI:10.1210/clinem/dgad673 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - November 17, 2023 Category: Endocrinology Authors: Sabrina Chiloiro Rossana Moroni Antonella Giampietro Flavia Angelini Marco Gessi Liverana Lauretti Pier Paolo Mattogno Rosalinda Calandrelli Tommaso Tartaglione Angela Carlino Simona Gaudino Alessandro Olivi Guido Rindi Laura De Marinis Alfredo Pontecorvi Source Type: research
The multi-biomarker acro-TIME score predicts fg-SRLs response: preliminary results of a retrospective acromegaly cohort
CONCLUSION: Although our predictive model should be validated in prospective studies, our data suggest that this nomogram may represent an easy-to-use tool, for early predicting the fg-SRLs outcome.PMID:37975821 | DOI:10.1210/clinem/dgad673 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - November 17, 2023 Category: Endocrinology Authors: Sabrina Chiloiro Rossana Moroni Antonella Giampietro Flavia Angelini Marco Gessi Liverana Lauretti Pier Paolo Mattogno Rosalinda Calandrelli Tommaso Tartaglione Angela Carlino Simona Gaudino Alessandro Olivi Guido Rindi Laura De Marinis Alfredo Pontecorvi Source Type: research
Growth Hormone, Atherosclerosis and Peripheral Arterial Disease: Exploring the Spectrum from Acromegaly to Growth Hormone Deficiency
Curr Vasc Pharmacol. 2023 Nov 13. doi: 10.2174/0115701611269162231106042956. Online ahead of print.ABSTRACTGrowth hormone (GH) and insulin-like growth factor 1 (IGF-1) are increasingly recognised for their role in cardiovascular (CV) physiology. The GH-IGF-1 axis plays an essential role in the development of the CV system as well as in the complex molecular network that regulates cardiac and endothelial structure and function. A considerable correlation between GH levels and CV mortality exists even among individuals in the general population without a notable deviation in the GHIGF- 1 axis functioning. In addition, over t...
Source: Atherosclerosis - November 14, 2023 Category: Cardiology Authors: Herman R Janez A Mikhailidis Dp Poredos P Blinc A Sabovic M Bajuk Studen K Schernthaner Gh Anagnostis P Antignani Pl Jensterle M Source Type: research
Growth Hormone, Atherosclerosis and Peripheral Arterial Disease: Exploring the Spectrum from Acromegaly to Growth Hormone Deficiency
Curr Vasc Pharmacol. 2023 Nov 13. doi: 10.2174/0115701611269162231106042956. Online ahead of print.ABSTRACTGrowth hormone (GH) and insulin-like growth factor 1 (IGF-1) are increasingly recognised for their role in cardiovascular (CV) physiology. The GH-IGF-1 axis plays an essential role in the development of the CV system as well as in the complex molecular network that regulates cardiac and endothelial structure and function. A considerable correlation between GH levels and CV mortality exists even among individuals in the general population without a notable deviation in the GHIGF- 1 axis functioning. In addition, over t...
Source: Current Vascular Pharmacology - November 14, 2023 Category: Drugs & Pharmacology Authors: Herman R Janez A Mikhailidis Dp Poredos P Blinc A Sabovic M Bajuk Studen K Schernthaner Gh Anagnostis P Antignani Pl Jensterle M Source Type: research
Growth Hormone, Atherosclerosis and Peripheral Arterial Disease: Exploring the Spectrum from Acromegaly to Growth Hormone Deficiency
Curr Vasc Pharmacol. 2023 Nov 13. doi: 10.2174/0115701611269162231106042956. Online ahead of print.ABSTRACTGrowth hormone (GH) and insulin-like growth factor 1 (IGF-1) are increasingly recognised for their role in cardiovascular (CV) physiology. The GH-IGF-1 axis plays an essential role in the development of the CV system as well as in the complex molecular network that regulates cardiac and endothelial structure and function. A considerable correlation between GH levels and CV mortality exists even among individuals in the general population without a notable deviation in the GHIGF- 1 axis functioning. In addition, over t...
Source: Atherosclerosis - November 14, 2023 Category: Cardiology Authors: Herman R Janez A Mikhailidis Dp Poredos P Blinc A Sabovic M Bajuk Studen K Schernthaner Gh Anagnostis P Antignani Pl Jensterle M Source Type: research
Growth Hormone, Atherosclerosis and Peripheral Arterial Disease: Exploring the Spectrum from Acromegaly to Growth Hormone Deficiency
Curr Vasc Pharmacol. 2023 Nov 13. doi: 10.2174/0115701611269162231106042956. Online ahead of print.ABSTRACTGrowth hormone (GH) and insulin-like growth factor 1 (IGF-1) are increasingly recognised for their role in cardiovascular (CV) physiology. The GH-IGF-1 axis plays an essential role in the development of the CV system as well as in the complex molecular network that regulates cardiac and endothelial structure and function. A considerable correlation between GH levels and CV mortality exists even among individuals in the general population without a notable deviation in the GHIGF- 1 axis functioning. In addition, over t...
Source: Current Vascular Pharmacology - November 14, 2023 Category: Drugs & Pharmacology Authors: Herman R Janez A Mikhailidis Dp Poredos P Blinc A Sabovic M Bajuk Studen K Schernthaner Gh Anagnostis P Antignani Pl Jensterle M Source Type: research
Growth Hormone, Atherosclerosis and Peripheral Arterial Disease: Exploring the Spectrum from Acromegaly to Growth Hormone Deficiency
Curr Vasc Pharmacol. 2023 Nov 13. doi: 10.2174/0115701611269162231106042956. Online ahead of print.ABSTRACTGrowth hormone (GH) and insulin-like growth factor 1 (IGF-1) are increasingly recognised for their role in cardiovascular (CV) physiology. The GH-IGF-1 axis plays an essential role in the development of the CV system as well as in the complex molecular network that regulates cardiac and endothelial structure and function. A considerable correlation between GH levels and CV mortality exists even among individuals in the general population without a notable deviation in the GHIGF- 1 axis functioning. In addition, over t...
Source: Current Vascular Pharmacology - November 14, 2023 Category: Drugs & Pharmacology Authors: Herman R Janez A Mikhailidis Dp Poredos P Blinc A Sabovic M Bajuk Studen K Schernthaner Gh Anagnostis P Antignani Pl Jensterle M Source Type: research
Growth Hormone, Atherosclerosis and Peripheral Arterial Disease: Exploring the Spectrum from Acromegaly to Growth Hormone Deficiency
Curr Vasc Pharmacol. 2023 Nov 13. doi: 10.2174/0115701611269162231106042956. Online ahead of print.ABSTRACTGrowth hormone (GH) and insulin-like growth factor 1 (IGF-1) are increasingly recognised for their role in cardiovascular (CV) physiology. The GH-IGF-1 axis plays an essential role in the development of the CV system as well as in the complex molecular network that regulates cardiac and endothelial structure and function. A considerable correlation between GH levels and CV mortality exists even among individuals in the general population without a notable deviation in the GHIGF- 1 axis functioning. In addition, over t...
Source: Current Vascular Pharmacology - November 14, 2023 Category: Drugs & Pharmacology Authors: Herman R Janez A Mikhailidis Dp Poredos P Blinc A Sabovic M Bajuk Studen K Schernthaner Gh Anagnostis P Antignani Pl Jensterle M Source Type: research
Growth Hormone, Atherosclerosis and Peripheral Arterial Disease: Exploring the Spectrum from Acromegaly to Growth Hormone Deficiency
Curr Vasc Pharmacol. 2023 Nov 13. doi: 10.2174/0115701611269162231106042956. Online ahead of print.ABSTRACTGrowth hormone (GH) and insulin-like growth factor 1 (IGF-1) are increasingly recognised for their role in cardiovascular (CV) physiology. The GH-IGF-1 axis plays an essential role in the development of the CV system as well as in the complex molecular network that regulates cardiac and endothelial structure and function. A considerable correlation between GH levels and CV mortality exists even among individuals in the general population without a notable deviation in the GHIGF- 1 axis functioning. In addition, over t...
Source: Current Vascular Pharmacology - November 14, 2023 Category: Drugs & Pharmacology Authors: Herman R Janez A Mikhailidis Dp Poredos P Blinc A Sabovic M Bajuk Studen K Schernthaner Gh Anagnostis P Antignani Pl Jensterle M Source Type: research
