poem
A List of Famous Hats -after James TateI knew a guy who believed hats evolved to fulfill a function,Purely utilitarian, nothing to do with fashion He further claimed that some hatsWere originally designed to fit the misshapenCranium of some poor soulWho needed to get out of the houseWithout a million wiseguys gawking At his unfortunate deformityThe first pope hat, in fact, was designed for a literal inbred coneheadNapoleon ' s tricorne monstrosity was originally crafted by a nun For a poor orphan girl with skull dominant acromegaly Fascinator hats were godsendsFor self conscious m...
Source: Buckeye Surgeon - January 26, 2023 Category: Surgery Authors: Jeffrey Parks MD FACS Source Type: blogs
Fight Aging! Newsletter, May 2nd 2022
In this study, we tested the therapeutic potential of VHHASC and a newly generated VHH against murine ASC (VHHmASC) to target ASC specks in vitro and in vivo. We show that pre-incubation of extracellular ASC specks with VHHASC abrogated their inflammatory functions in vitro. Recombinant VHHASC rapidly disassembled pre-formed ASC specks and thus inhibited their ability to seed the nucleation of soluble ASC. Notably, VHHASC required prior cytosolic access to prevent inflammasome activation within cells, but it was effective against extracellular ASC specks released following caspase-1-dependent loss of membrane integrity, an...
Source: Fight Aging! - May 1, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Merits of Late Life Suppression of Growth Hormone Signaling
The longest lived mice are those in which growth hormone or growth hormone receptor are knocked out, a gain of 70% or so in life span. They exhibit dwarfism, like the human population with the analogous inherited Laron syndrome, caused by a loss-of-function mutation in growth hormone receptor. The Laron syndrome population may be somewhat more resistant to some age-related diseases, that data still to be rigorously confirmed, but do not appear to live any longer than the rest of us. Studies on growth hormone metabolism and longevity conducted in mice should be read with that in mind, particularly when used to advocate ther...
Source: Fight Aging! - April 27, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, December 27th 2021
We report that whereas microglia are characterized by marked gene-level alterations related to negative regulation of protein phosphorylation and phagocytic vesicles, astrocytes show activation of enzyme- or peptidase-inhibitor signaling after detectable changes in BBB permeability. We also identify several genes enriched in these pathways that are notably altered after BBB breakdown. Our data reveal that microglia and astrocytes play an active role in maintaining BBB stabilization and corralling infiltrating cells, and thus might potentially function in ameliorating the lesions and neurologic disabilities in CNS diseases....
Source: Fight Aging! - December 26, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Self-Experimentation with Growth Hormone Releasing Hormone Gene Therapy
Growth hormone is not to be taken lightly; the side effects of tinkering with growth hormone metabolism can be highly problematic. Lowered levels of growth hormone or disruption of growth hormone metabolism via, say, growth hormone receptor knockout extends life in short lived mammals, and models show that it is beneficial even if started in adulthood. Nonetheless, most use of growth hormone involves adding more of it, which may not be a good idea. Here, a self-experimenter performs a quality self-experiment with growth hormone releasing hormone gene therapy, an approach to provoke upregulation of growth hormone. There was...
Source: Fight Aging! - December 20, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, March 22nd 2021
This article expresses sentiments regarding medical technology and human longevity that we'd all like to see more of in the mainstream media. At some point, it will come to be seen by the average person as basically sensible to work towards minimizing the tide of suffering and death caused aging and age-related disease. It has been, in hindsight, a strange thing to live in a world in which most people were reflexively opposed to that goal.
Death and aging constitute a mystery. Some of us die more quickly. We often ask about it as children, deny it in youth, and reluctantly come to accept it as adults. Aging is uni...
Source: Fight Aging! - March 21, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, April 6th 2020
This study delves into the mechanisms by which a short period of fasting can accelerate wound healing. Fasting triggers many of the same cellular stress responses, such as upregulated autophagy, as occur during the practice of calorie restriction. It isn't exactly the same, however, so it is always worth asking whether any specific biochemistry observed in either case does in fact occur in both situations. In particular, the period of refeeding following fasting appears to have beneficial effects that are distinct from those that occur while food is restricted.
Multiple forms of therapeutic fasting have been repor...
Source: Fight Aging! - April 5, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Age-Slowing Interventions in the Context of Lung Aging
Researchers here consider a very conservative set of interventions known to modestly slow the progression of aging in laboratory species, largely by altering metabolism to upregulate beneficial cellular stress responses. The researchers look through the lens of lung aging, specifically, reviewing the evidence for these therapies to slow the deterioration in lung function and onset of lung disease in older individuals, or to be the basis for treating established lung disease.
To date, the most reliable, best-researched way to extend life span is through the practice of calorie restriction (CR), which involves reduc...
Source: Fight Aging! - April 1, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Acromegaly : Case Discussion
Presenting an integrated case discussion on acromegaly in DAMS Unplugged series.Famous Radiology Blog http://www.sumerdoc.blogspot.com
TeleRad Providers at www.teleradproviders.com Mail us at sales@teleradproviders.com (Source: Sumer's Radiology Site)
Source: Sumer's Radiology Site - February 6, 2019 Category: Radiology Authors: Sumer Sethi Source Type: blogs
Seema Verma Hyperventilates About Tiny Differences Between ACOs Exposed to One-and Two-Sided Risk
By KIP SULLIVAN, JD
Kip Sullivan, JD
There is no meaningful difference between the performance of Medicare ACOs that accept only upside risk (the chance to make money) and ACOs that accept both up- and downside risk (the risk of losing money). But CMS’s administrator, Seema Verma, thinks otherwise. According to her, one-sided ACOs are raising Medicare’s costs while two-sided ACOs are saving “significant” amounts of money. She is so sure of this that she is altering the rules of the Medicare Shared Savings Program (MSSP). Currently only 18 percent of MSSP ACOs accept two-sided risk. That will change next year. Accor...
Source: The Health Care Blog - August 21, 2018 Category: Consumer Health News Authors: matthew holt Tags: Medicare ACOs Seema Verma Source Type: blogs
Clear your mind from all the distracting requirements clinicians face
After a Harvard endocrinology course several years ago, I walked out into the weak afternoon spring sunshine and crossed the street to the Boston Public Garden. Among the multitude of faces of the other flaneurs I was certain I saw scores of people suffering from endocrine diseases — probably undiagnosed, I thought to myself: I saw tall men with big jaws, typical of acromegaly; stout women with skinny extremities and flushed, puffy cheeks so typical of Cushing’s syndrome; hirsute, heavy set younger women sure to have polycystic ovary syndrome; long-legged beardless men, who seemed classic for Klinefelter’s; and o...
Source: Kevin, M.D. - Medical Weblog - May 29, 2018 Category: General Medicine Authors: < a href="https://www.kevinmd.com/blog/post-author/a-country-doctor" rel="tag" > A Country Doctor, MD < /a > Tags: Physician Mobile health Primary Care Source Type: blogs
Curb Your Enthusiasm
KIP SULLIVAN
Lawton Burns and Mark Pauly, economists at the Wharton School, just published an article that should be required reading for all policy makers and health services researchers. The article, entitled “Transformation of the health care industry: Curb your enthusiasm,” appears in the latest edition of the Milbank Quarterly.
Burns and Pauly undertook an enormous task and executed it well. They first sought to explain the assumptions underlying Managed Care (MC) 2.0 – the proposals promoted by the managed care movement in the wake of the HMO backlash of the late 1990s. Then they evaluated the probability t...
Source: The Health Care Blog - April 16, 2018 Category: Consumer Health News Authors: John Irvine Tags: Uncategorized Source Type: blogs
Cardiovascular disease in acromegaly
(Source: Notes from Dr. RW)
Source: Notes from Dr. RW - April 5, 2018 Category: Internal Medicine Tags: cardiovascular endocrinology Source Type: blogs
Best Post of December 2016: Fibrous Bodies Nicely Demonstrated in a Smear from a Somatotroph Pituitary Adenoma
The next in our " Best of the Month Series " is from December 2, 2016:Christian Davidson, MDDr. Christian Davidson, director of neuropathology at the Robert Wood Johnson University Hospitalin New Jersey, provides today ' s blog post:A 30-year-old man presented with bitemporal hemianopsia and a 3.0 cm pituitary mass was discovered upon MRI. His IGF-1 was elevated to 900, but he had no signs of acromegaly. A smear of tissue sent for frozen section evaluation (see below) revealed that most cells had round, eosinophilic, perinuclear inclusions suggestive of fibrous bodies (some examples are circled). Dot-like CAM5.2 ...
Source: neuropathology blog - April 25, 2017 Category: Radiology Tags: Best of the Month series neoplasms pituitary Source Type: blogs
Guest Post: Fibrous Bodies Nicely Demonstrated in a Smear from a Somatotroph Pituitary Adenoma
Christian Davidson, MDDr. Christian Davidson, director of neuropathology at theRobert Wood Johnson University Hospital in New Jersey, provides today ' s blog post:A 30-year-old man presented with bitemporal hemianopsia and a 3.0 cm pituitary mass was discovered upon MRI. His IGF-1 was elevated to 900, but he had no signs of acromegaly. A smear of tissue sent for frozen section evaluation (see above below) revealed that most cells had round, eosinophilic, perinuclear inclusions suggestive of fibrous bodies (some examples are circled). Dot-like CAM5.2 immunostain (not shown) confirmed my smear-based diagnostic suspicion...
Source: neuropathology blog - December 2, 2016 Category: Radiology Tags: neoplasms pituitary Source Type: blogs
