Selection of a Suitable Animal Model to Evaluate Secretion of Drugs in the Human Milk: A Systematic Approach
Xenobiotica. 2024 Apr 18:1-23. doi: 10.1080/00498254.2024.2345283. Online ahead of print.ABSTRACTLack of data on drug secretion in human milk is a concern for safe use of drugs during postpartum.Clinical studies are often difficult to perform; despite substantial improvements in computational methodologies such as physiologically based pharmacokinetic modelling, there is limited clinical data to validate such models for many drugs.Various factors that are likely to impact milk to plasma ratio were identified. A literature search was performed to gather available data on milk composition, total volume of milk produced per d...
Source: Xenobiotica - April 18, 2024 Category: Research Authors: Riya Nilkant Chintha Kathiresan Namrata Kumar Steve Caritis Imam H Shaik Raman Venkataramanan Source Type: research
Developmental stage and infection status may affect drug distribution in the prostate of rats
Xenobiotica. 2024 Apr 18:1-13. doi: 10.1080/00498254.2024.2343892. Online ahead of print.ABSTRACTProstate inflammation is often treated with drugs which are ineffective. Antibacterial agents fail to reach the prostate epithelium, and the blood-prostate barrier (BPB) may affect the drug transport process. Factors affecting drug efficacy remain unclear.Rats were categorized into groups A and B, corresponding to adulthood and puberty, respectively. Group C included the model of chronic prostate infection. Dialysates of levofloxacin and cefradine were collected from the prostate gland and jugular vein and evaluated. Pharmacoki...
Source: Xenobiotica - April 18, 2024 Category: Research Authors: Ziyang Xu Lianzhan Sun Chang Yin Handa Wang Xue Wang Yunyun Yang Zhuo Wang Source Type: research
Exploring precision-cut liver slices for comparative xenobiotic metabolism profiling in swine and cattle
Xenobiotica. 2024 Apr 16:1-14. doi: 10.1080/00498254.2024.2343905. Online ahead of print.ABSTRACTIn vitro systems are useful tools for unravelling species differences in xenobiotic metabolism.The current work aimed to validate the technique of precision-cut liver slices (PCLS) for comparative studies on xenobiotic metabolism in swine and cattle.PCLS from swine (n = 3) and cattle (n = 3) were produced using a Brendel-VitronTM Tissue Slicer and cultured for 6 h. Tissue viability was preserved throughout the whole culture period.Metabolic viability was evaluated using the anthelmintics albendazole (ABZ) and fenbendazole (FBZ)...
Source: Xenobiotica - April 16, 2024 Category: Research Authors: Paula Ichinose Mar ía Victoria Miró Paula Viviani Juan Manuel Herrera Adri án Lifschitz Guillermo Virkel Source Type: research
Exploring precision-cut liver slices for comparative xenobiotic metabolism profiling in swine and cattle
Xenobiotica. 2024 Apr 16:1-14. doi: 10.1080/00498254.2024.2343905. Online ahead of print.ABSTRACTIn vitro systems are useful tools for unravelling species differences in xenobiotic metabolism.The current work aimed to validate the technique of precision-cut liver slices (PCLS) for comparative studies on xenobiotic metabolism in swine and cattle.PCLS from swine (n = 3) and cattle (n = 3) were produced using a Brendel-VitronTM Tissue Slicer and cultured for 6 h. Tissue viability was preserved throughout the whole culture period.Metabolic viability was evaluated using the anthelmintics albendazole (ABZ) and fenbendazole (FBZ)...
Source: Xenobiotica - April 16, 2024 Category: Research Authors: Paula Ichinose Mar ía Victoria Miró Paula Viviani Juan Manuel Herrera Adri án Lifschitz Guillermo Virkel Source Type: research
Academic foreign compound metabolism - 'Quo vadis'?
Xenobiotica. 2024 Apr 12:1-5. doi: 10.1080/00498254.2024.2340740. Online ahead of print.NO ABSTRACTPMID:38606913 | DOI:10.1080/00498254.2024.2340740 (Source: Xenobiotica)
Source: Xenobiotica - April 12, 2024 Category: Research Authors: S C Mitchell R H Waring Source Type: research
Bioanalytical Approaches to Support the Development of Antibody-Oligonucleotide Conjugate (AOC) Therapeutic Proteins
Xenobiotica. 2024 Apr 12:1-23. doi: 10.1080/00498254.2024.2339983. Online ahead of print.ABSTRACTRNA interference (RNAi) is a biological process that evolved to protect eukaryotic organisms from foreign genes delivered by viruses. This process has been adapted as a powerful tool to treat numerous diseases through the delivery of small-interfering RNAs (siRNAs) to target cells to alter aberrant gene expression.Antibody-oligonucleotide conjugates (AOCs) are monoclonal antibodies with complexed siRNA or antisense oligonucleotides (ASOs) that have emerged to address some of the challenges faced by naked or chemically conjugate...
Source: Xenobiotica - April 12, 2024 Category: Research Authors: Anthony Murphy Ryan Hill Michael Berna Source Type: research
Academic foreign compound metabolism - 'Quo vadis'?
Xenobiotica. 2024 Apr 12:1-5. doi: 10.1080/00498254.2024.2340740. Online ahead of print.NO ABSTRACTPMID:38606913 | DOI:10.1080/00498254.2024.2340740 (Source: Xenobiotica)
Source: Xenobiotica - April 12, 2024 Category: Research Authors: S C Mitchell R H Waring Source Type: research
Bioanalytical Approaches to Support the Development of Antibody-Oligonucleotide Conjugate (AOC) Therapeutic Proteins
Xenobiotica. 2024 Apr 12:1-23. doi: 10.1080/00498254.2024.2339983. Online ahead of print.ABSTRACTRNA interference (RNAi) is a biological process that evolved to protect eukaryotic organisms from foreign genes delivered by viruses. This process has been adapted as a powerful tool to treat numerous diseases through the delivery of small-interfering RNAs (siRNAs) to target cells to alter aberrant gene expression.Antibody-oligonucleotide conjugates (AOCs) are monoclonal antibodies with complexed siRNA or antisense oligonucleotides (ASOs) that have emerged to address some of the challenges faced by naked or chemically conjugate...
Source: Xenobiotica - April 12, 2024 Category: Research Authors: Anthony Murphy Ryan Hill Michael Berna Source Type: research
Academic foreign compound metabolism - 'Quo vadis'?
Xenobiotica. 2024 Apr 12:1-5. doi: 10.1080/00498254.2024.2340740. Online ahead of print.NO ABSTRACTPMID:38606913 | DOI:10.1080/00498254.2024.2340740 (Source: Xenobiotica)
Source: Xenobiotica - April 12, 2024 Category: Research Authors: S C Mitchell R H Waring Source Type: research
Bioanalytical Approaches to Support the Development of Antibody-Oligonucleotide Conjugate (AOC) Therapeutic Proteins
Xenobiotica. 2024 Apr 12:1-23. doi: 10.1080/00498254.2024.2339983. Online ahead of print.ABSTRACTRNA interference (RNAi) is a biological process that evolved to protect eukaryotic organisms from foreign genes delivered by viruses. This process has been adapted as a powerful tool to treat numerous diseases through the delivery of small-interfering RNAs (siRNAs) to target cells to alter aberrant gene expression.Antibody-oligonucleotide conjugates (AOCs) are monoclonal antibodies with complexed siRNA or antisense oligonucleotides (ASOs) that have emerged to address some of the challenges faced by naked or chemically conjugate...
Source: Xenobiotica - April 12, 2024 Category: Research Authors: Anthony Murphy Ryan Hill Michael Berna Source Type: research
Academic foreign compound metabolism - 'Quo vadis'?
Xenobiotica. 2024 Apr 12:1-5. doi: 10.1080/00498254.2024.2340740. Online ahead of print.NO ABSTRACTPMID:38606913 | DOI:10.1080/00498254.2024.2340740 (Source: Xenobiotica)
Source: Xenobiotica - April 12, 2024 Category: Research Authors: S C Mitchell R H Waring Source Type: research
Bioanalytical Approaches to Support the Development of Antibody-Oligonucleotide Conjugate (AOC) Therapeutic Proteins
Xenobiotica. 2024 Apr 12:1-23. doi: 10.1080/00498254.2024.2339983. Online ahead of print.ABSTRACTRNA interference (RNAi) is a biological process that evolved to protect eukaryotic organisms from foreign genes delivered by viruses. This process has been adapted as a powerful tool to treat numerous diseases through the delivery of small-interfering RNAs (siRNAs) to target cells to alter aberrant gene expression.Antibody-oligonucleotide conjugates (AOCs) are monoclonal antibodies with complexed siRNA or antisense oligonucleotides (ASOs) that have emerged to address some of the challenges faced by naked or chemically conjugate...
Source: Xenobiotica - April 12, 2024 Category: Research Authors: Anthony Murphy Ryan Hill Michael Berna Source Type: research
Drug-drug interaction between danshensu and irbesartan and its potential mechanism
Xenobiotica. 2024 Apr 9:1-9. doi: 10.1080/00498254.2024.2338183. Online ahead of print.ABSTRACT1. To uncover the effect of danshensu on irbesartan pharmacokinetics and its underlying mechanisms.2. To investigate the effect of danshensu on the pharmacokinetics of irbesartan, Sprague-Dawley rats (n = 6) were orally administered 30 mg/kg irbesartan alone (control group) or pretreated with 160 mg/kg danshensu (experimental group). The effect of danshensu on the metabolic stability of irbesartan in RLMs was examined by LC-MS/MS method. The effect of danshensu on CYP2C9 activity was also determined.3. Danshensu markedly increase...
Source: Xenobiotica - April 9, 2024 Category: Research Authors: Yuexia Li Liheng Liu Source Type: research
Drug-drug interaction between danshensu and irbesartan and its potential mechanism
Xenobiotica. 2024 Apr 9:1-9. doi: 10.1080/00498254.2024.2338183. Online ahead of print.ABSTRACT1. To uncover the effect of danshensu on irbesartan pharmacokinetics and its underlying mechanisms.2. To investigate the effect of danshensu on the pharmacokinetics of irbesartan, Sprague-Dawley rats (n = 6) were orally administered 30 mg/kg irbesartan alone (control group) or pretreated with 160 mg/kg danshensu (experimental group). The effect of danshensu on the metabolic stability of irbesartan in RLMs was examined by LC-MS/MS method. The effect of danshensu on CYP2C9 activity was also determined.3. Danshensu markedly increase...
Source: Xenobiotica - April 9, 2024 Category: Research Authors: Yuexia Li Liheng Liu Source Type: research
Drug-drug interaction between danshensu and irbesartan and its potential mechanism
Xenobiotica. 2024 Apr 9:1-9. doi: 10.1080/00498254.2024.2338183. Online ahead of print.ABSTRACT1. To uncover the effect of danshensu on irbesartan pharmacokinetics and its underlying mechanisms.2. To investigate the effect of danshensu on the pharmacokinetics of irbesartan, Sprague-Dawley rats (n = 6) were orally administered 30 mg/kg irbesartan alone (control group) or pretreated with 160 mg/kg danshensu (experimental group). The effect of danshensu on the metabolic stability of irbesartan in RLMs was examined by LC-MS/MS method. The effect of danshensu on CYP2C9 activity was also determined.3. Danshensu markedly increase...
Source: Xenobiotica - April 9, 2024 Category: Research Authors: Yuexia Li Liheng Liu Source Type: research
