Treatment of < em > Helicobacter pylori < /em > with potassium competitive acid blockers: A systematic review and meta-analysis
CONCLUSION: VPZ-based triple therapy outperformed conventional PPI-based triple therapy in eradicating H. pylori, positioning it as a highly effective first-line regimen. Additionally, TPZ-based triple therapy was non-inferior to classical PPI triple therapy.PMID:38577188 | PMC:PMC10989498 | DOI:10.3748/wjg.v30.i9.1213 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 5, 2024 Category: Gastroenterology Authors: Joseph Edwin Kanu Jonathan Soldera Source Type: research

Early prediction and prevention of infected pancreatic necrosis
World J Gastroenterol. 2024 Mar 7;30(9):1005-1010. doi: 10.3748/wjg.v30.i9.1005.ABSTRACTApproximately 20%-30% of patients with acute necrotizing pancreatitis develop infected pancreatic necrosis (IPN), a highly morbid and potentially lethal complication. Early identification of patients at high risk of IPN may facilitate appropriate preventive measures to improve clinical outcomes. In the past two decades, several markers and predictive tools have been proposed and evaluated for this purpose. Conventional biomarkers like C-reactive protein, procalcitonin, lymphocyte count, interleukin-6, and interleukin-8, and newly develo...
Source: World Journal of Gastroenterology : WJG - April 5, 2024 Category: Gastroenterology Authors: Cheng Lv Zi-Xiong Zhang Lu Ke Source Type: research

Telomerase-related advances in hepatocellular carcinoma: A bibliometric and visual analysis
CONCLUSION: Our bibliometric analysis provides a comprehensive overview of HCC/telomerase research and insights into promising upcoming research.PMID:38577190 | PMC:PMC10989492 | DOI:10.3748/wjg.v30.i9.1224 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 5, 2024 Category: Gastroenterology Authors: Hai-Yang Li Lin-Lin Zheng Nan Hu Zhi-Hao Wang Chang-Cheng Tao Ya-Ru Wang Yue Liu Zulihumaer Aizimuaji Hong-Wei Wang Rui-Qi Zheng Ting Xiao Wei-Qi Rong Source Type: research

From liver to hormones: The endocrine consequences of cirrhosis
This article provides a comprehensive review of the epidemiology, pathophysiology, diagnosis, and treatment of endocrine disturbances in liver cirrhosis. The review was conducted using the PubMed/Medline, EMBASE, and Scielo databases, encompassing 172 articles. Liver cirrhosis is associated with endocrine disturbances, including diabetes, hypoglycemia, sarcopenia, thyroid dysfunction, hypogonadotropic hypogonadism, bone disease, adrenal insufficiency, growth hormone dysfunction, and secondary hyperaldosteronism. The optimal tools for diagnosing diabetes and detecting hypoglycemia are the oral glucose tolerance test and con...
Source: World Journal of Gastroenterology : WJG - April 5, 2024 Category: Gastroenterology Authors: Juan Eduardo Quiroz-Aldave Elman Rolando Gamarra-Osorio Mar ía Del Carmen Durand-Vásquez Luciana Del Pilar Rafael-Robles Jhean Gabriel Gonz áles-Yovera Mar ía Alejandra Quispe-Flores Luis Alberto Concepci ón-Urteaga Alejandro Rom án-González Jos é Source Type: research

Risk of hepatitis B virus reactivation in oncological patients treated with tyrosine kinase inhibitors: A case report and literature analysis
World J Gastroenterol. 2024 Mar 7;30(9):1253-1256. doi: 10.3748/wjg.v30.i9.1253.ABSTRACTHepatitis B virus (HBV) reactivation (HBVr) represents a severe and potentially life-threatening condition, and preventive measures are available through blood test screening or prophylactic therapy administration. The assessment of HBVr traditionally considers factors such as HBV profile, including hepatitis B surface antigen (HBsAg) and antibody to hepatitis B core antigen, along with type of medication (chemotherapy; immunomodulants). Nevertheless, consideration of possible patient's underlying tumor and the specific malignancy type ...
Source: World Journal of Gastroenterology : WJG - April 5, 2024 Category: Gastroenterology Authors: Francesca Colapietro Nicola Pugliese Antonio Voza Alessio Aghemo Stella De Nicola Source Type: research

sTREM-1 as promising prognostic biomarker for acute-on-chronic liver failure and mortality in patients with acute decompensation of cirrhosis
CONCLUSION: Serum sTREM-1 is a promising prognostic biomarker for ACLF development and mortality in patients with AD of cirrhosis.PMID:38577193 | PMC:PMC10989495 | DOI:10.3748/wjg.v30.i9.1177 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 5, 2024 Category: Gastroenterology Authors: Song-Man Yu Hai Li Guo-Hong Deng Xian-Bo Wang Xin Zheng Jin-Jun Chen Zhong-Ji Meng Yu-Bao Zheng Yan-Hang Gao Zhi-Ping Qian Feng Liu Xiao-Bo Lu Yu Shi Jia Shang Ruo-Chan Chen Yan Huang Source Type: research

Detachable string magnetically controlled capsule endoscopy for the noninvasive diagnosis of esophageal diseases: A prospective, blind clinical study
CONCLUSION: This study revealed that ds-MCE has the same diagnostic effects as traditional EGD for esophageal diseases and is more comfortable and convenient than EGD, providing a novel noninvasive method for treating esophageal diseases.PMID:38577194 | PMC:PMC10989486 | DOI:10.3748/wjg.v30.i9.1121 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 5, 2024 Category: Gastroenterology Authors: Yan-Ling Yang Huang-Wen Qin Zhao-Yu Chen Hui-Ning Fan Yi Yu Wei Da Jin-Shui Zhu Jing Zhang Source Type: research

Uridine diphosphate glucuronosyltransferase 1A1 prevents the progression of liver injury
CONCLUSION: UGT1A1 is upregulated as a compensatory response during liver injury, and interference with this upregulation process may worsen liver injury. UGT1A1 reduces ER stress, oxidative stress, and lipid metabolism disorder, thereby mitigating hepatocyte apoptosis and necroptosis.PMID:38577195 | PMC:PMC10989491 | DOI:10.3748/wjg.v30.i9.1189 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 5, 2024 Category: Gastroenterology Authors: Jin-Lian Jiang Yi-Yang Zhou Wei-Wei Zhong Lin-Yan Luo Si-Ying Liu Xiao-Yu Xie Mao-Yuan Mu Zhi-Gang Jiang Yuan Xue Jian Zhang Yi-Huai He Source Type: research

PRaG 3.0 therapy for human epidermal growth factor receptor 2-positive metastatic pancreatic ductal adenocarcinoma: A case report
CONCLUSION: PRaG 3.0 might be a novel strategy for HER2-positive metastatic PDAC patients who failed from previous first-line approach and even PD-1 immunotherapy but needs more data in prospective trials.PMID:38577174 | PMC:PMC10989490 | DOI:10.3748/wjg.v30.i9.1237 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 5, 2024 Category: Gastroenterology Authors: Yue-Hong Kong Mei-Ling Xu Jun-Jun Zhang Guang-Qiang Chen Zhi-Hui Hong Hong Zhang Xiao-Xiao Dai Yi-Fu Ma Xiang-Rong Zhao Chen-Yang Zhang Rong-Zheng Chen Peng-Fei Xing Li-Yuan Zhang Source Type: research

Genetic risk stratification of inflammatory bowel disease-associated venous thromboembolism: An Asian perspective
World J Gastroenterol. 2024 Mar 7;30(9):1250-1252. doi: 10.3748/wjg.v30.i9.1250.ABSTRACTThe utilisation of polygenic scoring models may enhance the clinician's ability to risk stratify an inflammatory bowel disease patient's individual risk for venous thromboembolism (VTE) and guide the appropriate usage of VTE thromboprophylaxis, yet there is a need to validate such models in ethnically diverse populations.PMID:38577175 | PMC:PMC10989499 | DOI:10.3748/wjg.v30.i9.1250 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 5, 2024 Category: Gastroenterology Authors: James Guoxian Huang Source Type: research

Melanocortin 3,5 receptors immunohistochemical expression in colonic mucosa of inflammatory bowel disease patients: A matter of disease activity?
CONCLUSION: MC3R and MC5R are expressed in the colon of IBD patients. Furthermore, expression may differ according to disease endoscopic activity, with a higher degree of expression in the traits affected by disease activity in both CD and UC, suggesting a potential use of these receptors in IBD pharmacology.PMID:38577176 | PMC:PMC10989484 | DOI:10.3748/wjg.v30.i9.1132 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 5, 2024 Category: Gastroenterology Authors: Antonietta Gerarda Gravina Iacopo Panarese Maria Consiglia Trotta Michele D'Amico Raffaele Pellegrino Franca Ferraraccio Marilena Galdiero Roberto Alfano Paolo Grieco Alessandro Federico Source Type: research

Staging liver fibrosis with various diffusion-weighted magnetic resonance imaging models
CONCLUSION: The DWI models were similarly valuable in distinguishing SF in patients with liver disease. The combined index of CTRW parameters had the highest AUC.PMID:38577177 | PMC:PMC10989501 | DOI:10.3748/wjg.v30.i9.1164 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 5, 2024 Category: Gastroenterology Authors: Yan-Li Jiang Juan Li Peng-Fei Zhang Feng-Xian Fan Jie Zou Pin Yang Peng-Fei Wang Shao-Yu Wang Jing Zhang Source Type: research

Exploring non-curative endoscopic submucosal dissection: Current treatment optimization and future indication expansion
This article emphasizes the significance of evaluating ESD quality, not only for curative cases but also for non-curative ones. Postoperative assessment relies on the endoscopic curability (eCura) classification, but management strategies for eCuraC-1 tumour with a positive horizontal margin are unclear. Current research primarily focuses on comparing additional surgical procedures in high-risk patients, while studies specifically targeting eCuraC-1 patients are limited. Exploring management strategies and follow-up outcomes for such cases could provide valuable insights. Furthermore, the application of molecular imaging u...
Source: World Journal of Gastroenterology : WJG - April 5, 2024 Category: Gastroenterology Authors: Yi-Nong Zhu Xiang-Lei Yuan Wei Liu Yu-Hang Zhang Yi Mou Bing Hu Lian-Song Ye Source Type: research

Clinical manifestation, lifestyle, and treatment patterns of chronic erosive gastritis: A multicenter real-world study in China
CONCLUSION: CEG is a multifactorial disease which is common in Asian patients and has non-specific symptoms. Gastroscopy may play a major role in its detection and diagnosis. Treatment should be individualized based on symptom profile.PMID:38577179 | PMC:PMC10989489 | DOI:10.3748/wjg.v30.i9.1108 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 5, 2024 Category: Gastroenterology Authors: Ying-Yun Yang Ke-Min Li Gui-Fang Xu Cheng-Dang Wang Hua Xiong Xiao-Zhong Wang Chun-Hui Wang Bing-Yong Zhang Hai-Xing Jiang Jing Sun Yan Xu Li-Juan Zhang Hao-Xuan Zheng Xiang-Bin Xing Liang-Jing Wang Xiu-Li Zuo Shi-Gang Ding Rong Lin Chun-Xiao Chen Xing-We Source Type: research

Diseases of bile duct in children
This article provides a concise review of bile duct diseases, with interesting cases.PMID:38577180 | PMC:PMC10989494 | DOI:10.3748/wjg.v30.i9.1043 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 5, 2024 Category: Gastroenterology Authors: Sutha Eiamkulbutr Chomchanat Tubjareon Anapat Sanpavat Teerasak Phewplung Nimmita Srisan Palittiya Sintusek Source Type: research