Interaction and Antiviral Treatment of Coinfection between SARS-CoV-2 and Influenza in Vitro
CONCLUSIONS: In coinfection, the replication of SARS-CoV-2 would be interfered by influenza H1N1. Compared with molnupiravir or baloxavir monotherapy, treatment with a combination of molnupiravir and baloxavir should be considered for early treatment in patients with SARS-CoV-2 and influenza coinfection.PMID:38621598 | DOI:10.1016/j.virusres.2024.199371 (Source: Virus Research)
Source: Virus Research - April 15, 2024 Category: Virology Authors: Danlei Liu Ka-Yi Leung Hoi-Yan Lam Ruiqi Zhang Yujing Fan Xiaochun Xie Kwok-Hung Chan Ivan Fan-Ngai Hung Source Type: research
Interaction and Antiviral Treatment of Coinfection between SARS-CoV-2 and Influenza in Vitro
CONCLUSIONS: In coinfection, the replication of SARS-CoV-2 would be interfered by influenza H1N1. Compared with molnupiravir or baloxavir monotherapy, treatment with a combination of molnupiravir and baloxavir should be considered for early treatment in patients with SARS-CoV-2 and influenza coinfection.PMID:38621598 | DOI:10.1016/j.virusres.2024.199371 (Source: Virus Research)
Source: Virus Research - April 15, 2024 Category: Virology Authors: Danlei Liu Ka-Yi Leung Hoi-Yan Lam Ruiqi Zhang Yujing Fan Xiaochun Xie Kwok-Hung Chan Ivan Fan-Ngai Hung Source Type: research
Interaction and Antiviral Treatment of Coinfection between SARS-CoV-2 and Influenza in Vitro
CONCLUSIONS: In coinfection, the replication of SARS-CoV-2 would be interfered by influenza H1N1. Compared with molnupiravir or baloxavir monotherapy, treatment with a combination of molnupiravir and baloxavir should be considered for early treatment in patients with SARS-CoV-2 and influenza coinfection.PMID:38621598 | DOI:10.1016/j.virusres.2024.199371 (Source: Virus Research)
Source: Virus Research - April 15, 2024 Category: Virology Authors: Danlei Liu Ka-Yi Leung Hoi-Yan Lam Ruiqi Zhang Yujing Fan Xiaochun Xie Kwok-Hung Chan Ivan Fan-Ngai Hung Source Type: research
Immunogenicity of Novel vB_EcoS_NBD2 Bacteriophage-Originated Nanotubes as a Carrier for Peptide-Based Vaccines
This study investigated, for the first time, the immunogenicity of long and flexible polytubes formed by yeast-expressed tail tube protein gp39 of bacteriophage vB_EcoS_NBD2 and evaluated their ability to elicit an immune response against the inserted protein fragments. Protein gp39-based polytubes induced humoral immune response in mice, even without the use of adjuvant. Bioinformatics analysis guided the selection of protein fragments from Acinetobacter baumannii for insertion into the C-terminus of gp39. Chimeric polytubes, displaying 28-amino acid long OmpA protein fragment, induced IgG response against OmpA protein fr...
Source: Virus Research - April 13, 2024 Category: Virology Authors: Aliona Avi žinienė Indr ė Dalgėdienė Julija Armalyt ė Rasa Petraityt ė-Burneikienė Source Type: research
Immunogenicity of Novel vB_EcoS_NBD2 Bacteriophage-Originated Nanotubes as a Carrier for Peptide-Based Vaccines
This study investigated, for the first time, the immunogenicity of long and flexible polytubes formed by yeast-expressed tail tube protein gp39 of bacteriophage vB_EcoS_NBD2 and evaluated their ability to elicit an immune response against the inserted protein fragments. Protein gp39-based polytubes induced humoral immune response in mice, even without the use of adjuvant. Bioinformatics analysis guided the selection of protein fragments from Acinetobacter baumannii for insertion into the C-terminus of gp39. Chimeric polytubes, displaying 28-amino acid long OmpA protein fragment, induced IgG response against OmpA protein fr...
Source: Virus Research - April 13, 2024 Category: Virology Authors: Aliona Avi žinienė Indr ė Dalgėdienė Julija Armalyt ė Rasa Petraityt ė-Burneikienė Source Type: research
Development of an attenuated potato virus Y mutant carrying multiple mutations in helper-component protease for cross-protection
This study showed that PVY-HCELR mutant was a promising mild mutant for cross-protection to control PVY.PMID:38608732 | DOI:10.1016/j.virusres.2024.199369 (Source: Virus Research)
Source: Virus Research - April 12, 2024 Category: Virology Authors: Xiao-Jie Xu Xu-Jie Sun Chun-Ju Liu Xiu-Zhai Chen Qing Zhu Yan-Ping Tian Xiang-Dong Li Source Type: research
Development of an attenuated potato virus Y mutant carrying multiple mutations in helper-component protease for cross-protection
This study showed that PVY-HCELR mutant was a promising mild mutant for cross-protection to control PVY.PMID:38608732 | DOI:10.1016/j.virusres.2024.199369 (Source: Virus Research)
Source: Virus Research - April 12, 2024 Category: Virology Authors: Xiao-Jie Xu Xu-Jie Sun Chun-Ju Liu Xiu-Zhai Chen Qing Zhu Yan-Ping Tian Xiang-Dong Li Source Type: research
Viral deubiquitinating proteases and the promising strategies of their inhibition
Virus Res. 2024 Apr 11;344:199368. doi: 10.1016/j.virusres.2024.199368. Online ahead of print.ABSTRACTSeveral viruses are now known to code for deubiquitinating proteases in their genomes. Ubiquitination is an essential post-translational modification of cellular substrates involved in many processes in the cell, including in innate immune signalling. This post-translational modification is regulated by the ubiquitin conjugation machinery, as well as various host deubiquitinating enzymes. The conjugation of ubiquitin chains to several innate immune related factors is often needed to induce downstream signalling, shaping th...
Source: Virus Research - April 8, 2024 Category: Virology Authors: Vera J E van Vliet Anuradha De Silva Brian L Mark Marjolein Kikkert Source Type: research
Viral deubiquitinating proteases and the promising strategies of their inhibition
Virus Res. 2024 Apr 6:199368. doi: 10.1016/j.virusres.2024.199368. Online ahead of print.ABSTRACTSeveral viruses are now known to code for deubiquitinating proteases in their genomes. Ubiquitination is an essential post-translational modification of cellular substrates involved in many processes in the cell, including in innate immune signalling. This post-translational modification is regulated by the ubiquitin conjugation machinery, as well as various host deubiquitinating enzymes. The conjugation of ubiquitin chains to several innate immune related factors is often needed to induce downstream signalling, shaping the ant...
Source: Virus Research - April 8, 2024 Category: Virology Authors: Vera J E van Vliet Anuradha De Silva Brian L Mark Marjolein Kikkert Source Type: research
Viral deubiquitinating proteases and the promising strategies of their inhibition
Virus Res. 2024 Apr 6:199368. doi: 10.1016/j.virusres.2024.199368. Online ahead of print.ABSTRACTSeveral viruses are now known to code for deubiquitinating proteases in their genomes. Ubiquitination is an essential post-translational modification of cellular substrates involved in many processes in the cell, including in innate immune signalling. This post-translational modification is regulated by the ubiquitin conjugation machinery, as well as various host deubiquitinating enzymes. The conjugation of ubiquitin chains to several innate immune related factors is often needed to induce downstream signalling, shaping the ant...
Source: Virus Research - April 8, 2024 Category: Virology Authors: Vera J E van Vliet Anuradha De Silva Brian L Mark Marjolein Kikkert Source Type: research
Viral deubiquitinating proteases and the promising strategies of their inhibition
Virus Res. 2024 Apr 6:199368. doi: 10.1016/j.virusres.2024.199368. Online ahead of print.ABSTRACTSeveral viruses are now known to code for deubiquitinating proteases in their genomes. Ubiquitination is an essential post-translational modification of cellular substrates involved in many processes in the cell, including in innate immune signalling. This post-translational modification is regulated by the ubiquitin conjugation machinery, as well as various host deubiquitinating enzymes. The conjugation of ubiquitin chains to several innate immune related factors is often needed to induce downstream signalling, shaping the ant...
Source: Virus Research - April 8, 2024 Category: Virology Authors: Vera J E van Vliet Anuradha De Silva Brian L Mark Marjolein Kikkert Source Type: research
Global landscape of coxsackieviruses in human health
Virus Res. 2024 Apr 6;344:199367. doi: 10.1016/j.virusres.2024.199367. Online ahead of print.ABSTRACTCoxsackieviruses-induced infections, particularly in infants and young children, are one of the most important public health issues in low- and middle-income countries, where the surveillance system varies substantially, and these manifestations have been disregarded. They are widespread throughout the world and are responsible for a broad spectrum of human diseases, from mildly symptomatic conditions to severe acute and chronic disorders. Coxsackieviruses (CV) have been found to have 27 identified genotypes, with overlaps ...
Source: Virus Research - April 1, 2024 Category: Virology Authors: Raiana S Machado Fernando N Tavares Ivanildo P Sousa Source Type: research
Global Landscape of Coxsackieviruses in Human Health
Virus Res. 2024 Mar 30:199367. doi: 10.1016/j.virusres.2024.199367. Online ahead of print.ABSTRACTCoxsackieviruses-induced infections, particularly in infants and young children, are one of the most important public health issues in low- and middle-income countries, where the surveillance system varies substantially, and these manifestations have been disregarded. They are widespread throughout the world and are responsible for a broad spectrum of human diseases, from mildly symptomatic conditions to severe acute and chronic disorders. Coxsackieviruses (CV) have been found to have 27 identified genotypes, with overlaps in ...
Source: Virus Research - April 1, 2024 Category: Virology Authors: Raiana S Machado Fernando N Tavares Ivanildo P Sousa Source Type: research
Global Landscape of Coxsackieviruses in Human Health
Virus Res. 2024 Mar 30:199367. doi: 10.1016/j.virusres.2024.199367. Online ahead of print.ABSTRACTCoxsackieviruses-induced infections, particularly in infants and young children, are one of the most important public health issues in low- and middle-income countries, where the surveillance system varies substantially, and these manifestations have been disregarded. They are widespread throughout the world and are responsible for a broad spectrum of human diseases, from mildly symptomatic conditions to severe acute and chronic disorders. Coxsackieviruses (CV) have been found to have 27 identified genotypes, with overlaps in ...
Source: Virus Research - April 1, 2024 Category: Virology Authors: Raiana S Machado Fernando N Tavares Ivanildo P Sousa Source Type: research
Global Landscape of Coxsackieviruses in Human Health
Virus Res. 2024 Mar 30:199367. doi: 10.1016/j.virusres.2024.199367. Online ahead of print.ABSTRACTCoxsackieviruses-induced infections, particularly in infants and young children, are one of the most important public health issues in low- and middle-income countries, where the surveillance system varies substantially, and these manifestations have been disregarded. They are widespread throughout the world and are responsible for a broad spectrum of human diseases, from mildly symptomatic conditions to severe acute and chronic disorders. Coxsackieviruses (CV) have been found to have 27 identified genotypes, with overlaps in ...
Source: Virus Research - April 1, 2024 Category: Virology Authors: Raiana S Machado Fernando N Tavares Ivanildo P Sousa Source Type: research
