Impact of body composition on outcomes of immune checkpoint inhibitor combination therapy in patients with previously untreated advanced renal cell carcinoma
CONCLUSION: The SFI can be potentially utilized as an effective predictive and prognostic biomarker for first-line ICI combination therapy for advanced RCC.PMID:38653590 | DOI:10.1016/j.urolonc.2024.04.008 (Source: Urologic Oncology)
Source: Urologic Oncology - April 23, 2024 Category: Urology & Nephrology Authors: Hiroki Ishihara Koichi Nishimura Takashi Ikeda Hironori Fukuda Kazuhiko Yoshida Junpei Iizuka Tsunenori Kondo Toshio Takagi Source Type: research
Prognostic significance of lymph node count in surgically treated patients with T < sub > 2-4 < /sub > stage nonmetastatic adrenocortical carcinoma
CONCLUSIONS: Lymphadenectomy provides a prognostic benefit in nmACC patients and identifies pN1 patients with dismal prognosis. Conversely, in pN0 patients, a LNC cut-off ≥4 identifies those with particularly favorable prognosis.PMID:38653591 | DOI:10.1016/j.urolonc.2024.04.003 (Source: Urologic Oncology)
Source: Urologic Oncology - April 23, 2024 Category: Urology & Nephrology Authors: Anis Assad Francesco Barletta Reha-Baris Incesu Lukas Scheipner Simone Morra Andrea Baudo Cristina Cano Garcia Zhe Tian Sascha Ahyai Nicola Longo Felix K H Chun Shahrokh F Shariat Derya Tilki Alberto Briganti Fred Saad Pierre I Karakiewicz Source Type: research
HIVEC as an alternative option in non-muscle-invasive bladder cancer: Experiences from a high-volume center
CONCLUSION: Chemohyperthermia using HIVEC results in high recurrence-free survival and a 2-year progression-free survival rate of 98% with a bladder preservation rate of almost 80%. Comparing our data, HIVEC shows better oncological results together with better tolerability and safety making HIVEC a good alternative for patients who refuse radical cystectomy or who are ineligible for radical cystectomy.PMID:38653592 | DOI:10.1016/j.urolonc.2024.01.300 (Source: Urologic Oncology)
Source: Urologic Oncology - April 23, 2024 Category: Urology & Nephrology Authors: Lucas Kastner Constantin Rieger David Pfister Max Schmautz Enno Storz Axel Heidenreich Source Type: research
Network analysis of histopathological image features and genomics data improving prognosis performance in clear cell renal cell carcinoma
CONCLUSION: This study developed a histopathological-genetic-related nomogram by combining histopathological features and clinical predictors, providing a more comprehensive prognostic assessment for clear cell renal cell carcinoma patients.PMID:38653593 | DOI:10.1016/j.urolonc.2024.03.016 (Source: Urologic Oncology)
Source: Urologic Oncology - April 23, 2024 Category: Urology & Nephrology Authors: Jianrui Ji Yunsong Liu Yongxing Bao Yu Men Zhouguang Hui Source Type: research
Preoperative risk calculator for the probability of completing nephron sparing for kidney cancer
CONCLUSIONS: The probability of PN completion can be preoperatively assessed, with optimal accuracy relaying on routinely available clinical information. The proposed model might be useful in preoperative decision-making, patient consensus, or during preoperative counselling.PATIENT SUMMARY: In patients with a renal mass the probability of completing a partial nephrectomy varies considerably and without a predictive model is invariably inaccurate and subjective. In this study we build-up a risk calculator based on easily available preoperative variables that can predict with optimal accuracy the probability of not removing...
Source: Urologic Oncology - April 21, 2024 Category: Urology & Nephrology Authors: Francesco Cei Alessandro Larcher Giuseppe Rosiello Giuseppe Basile Giacomo Musso Chiara Re Giuseppe Fallara Federico Belladelli Giorgio Brembilla Giorgia Guazzarotti Francesco De Cobelli Laura Marandino Andrea Necchi Alberto Briganti Andrea Salonia Robert Source Type: research
Avoiding "Needless" nephrectomy: What is the role of small renal mass biopsy in 2024?
Urol Oncol. 2024 Apr 19:S1078-1439(24)00422-8. doi: 10.1016/j.urolonc.2024.04.002. Online ahead of print.ABSTRACTCurrent guidelines do not mandate routine preoperative renal mass biopsy (RMB) for small renal masses (SRMs), which results in a considerable rate (18%-26%) of needless nephrectomy/partial nephrectomy for benign renal tumors. In light of this ongoing practice, a narrative review was conducted to examine the role of routine RMB for SRM. First, arguments justifying the current non-biopsy approach to SRM are critically reviewed and contested. Second, as a standalone procedure, RMB is critically assessed; RMB was fo...
Source: Urologic Oncology - April 20, 2024 Category: Urology & Nephrology Authors: Bruce Gao Antonio R H Gorgen Rohit Bhatt Zachary E Tano Kalon L Morgan Kelvin Vo Sina Soltanzadeh Zarandi Sohrab N Ali Pengbo Jiang Roshan M Patel Ralph V Clayman Jaime Landman Source Type: research
Natural history and health care burden of non-curative treatment for muscle-invasive bladder cancer
CONCLUSIONS: Untreated muscle-invasive bladder cancer is associated with a limited lifespan and a high disease burden for the patient and health system. These data should be taken into consideration and portrayed to the patient when curative intent treatment is chosen to be avoided.PMID:38641474 | DOI:10.1016/j.urolonc.2024.03.009 (Source: Urologic Oncology)
Source: Urologic Oncology - April 19, 2024 Category: Urology & Nephrology Authors: Haim Herzberg Yossi Ventura Karin Lifshitz Ziv Savin Shay Golan Jack Baniel Ofer Yossepowitch Roy Mano Source Type: research
Open versus minimally invasive nephroureterectomy in octogenarians: An analysis of surgical approach trends, outcomes, and survival analysis with propensity matching
CONCLUSION: In octogenarians undergoing RNU, MIS is associated with improved median OS and 90-day mortality.PMID:38631967 | DOI:10.1016/j.urolonc.2024.02.005 (Source: Urologic Oncology)
Source: Urologic Oncology - April 17, 2024 Category: Urology & Nephrology Authors: Shaun Trecarten Mukund Bhandari Ahmad Abdelaziz Onika Noel Michael Liss Furkan Dursun Robert Svatek Ahmed M Mansour Source Type: research
Open versus minimally invasive nephroureterectomy in octogenarians: An analysis of surgical approach trends, outcomes, and survival analysis with propensity matching
CONCLUSION: In octogenarians undergoing RNU, MIS is associated with improved median OS and 90-day mortality.PMID:38631967 | DOI:10.1016/j.urolonc.2024.02.005 (Source: Urologic Oncology)
Source: Urologic Oncology - April 17, 2024 Category: Urology & Nephrology Authors: Shaun Trecarten Mukund Bhandari Ahmad Abdelaziz Onika Noel Michael Liss Furkan Dursun Robert Svatek Ahmed M Mansour Source Type: research
Use of inpatient palliative care in metastatic urethral cancer
CONCLUSION: IPC use in metastatic urethral cancer increased from a marginal rate of 5.8% to as high as 28%. Ideally, differences according to sex, metastatic site, and region should be addressed to improve IPC use rates.PMID:38627106 | DOI:10.1016/j.urolonc.2024.03.019 (Source: Urologic Oncology)
Source: Urologic Oncology - April 16, 2024 Category: Urology & Nephrology Authors: Carolin Siech Andrea Baudo Mario de Angelis Letizia Maria Ippolita Jannello Francesco Di Bello Jordan A Goyal Zhe Tian Fred Saad Shahrokh F Shariat Nicola Longo Luca Carmignani Ottavio de Cobelli Alberto Briganti S éverine Banek Philipp Mandel Luis A Klu Source Type: research
Estimation of the incidence of urachal cancer: A systematic review and meta-analysis of registry-based studies
CONCLUSIONS: Our study provides an up-to-date comparison of estimated incidence rates between 6 countries of 3 continents based on rigorously selected registry-based studies. The results suggest low incidence rates for UrC with considerable geographic differences. The present meta-analysis provides unbiased registry-based data on the incidence, clinicopathological parameters and survival of UrC.PMID:38627107 | DOI:10.1016/j.urolonc.2024.03.011 (Source: Urologic Oncology)
Source: Urologic Oncology - April 16, 2024 Category: Urology & Nephrology Authors: Csilla Olah Andr ás Kubik P éter Mátrai Marie Anne Engh Vikt ória Barna P éter Hegyi Henning Reis P éter Nyirády Tibor Szarvas Source Type: research
Use of inpatient palliative care in metastatic urethral cancer
CONCLUSION: IPC use in metastatic urethral cancer increased from a marginal rate of 5.8% to as high as 28%. Ideally, differences according to sex, metastatic site, and region should be addressed to improve IPC use rates.PMID:38627106 | DOI:10.1016/j.urolonc.2024.03.019 (Source: Urologic Oncology)
Source: Urologic Oncology - April 16, 2024 Category: Urology & Nephrology Authors: Carolin Siech Andrea Baudo Mario de Angelis Letizia Maria Ippolita Jannello Francesco Di Bello Jordan A Goyal Zhe Tian Fred Saad Shahrokh F Shariat Nicola Longo Luca Carmignani Ottavio de Cobelli Alberto Briganti S éverine Banek Philipp Mandel Luis A Klu Source Type: research
Estimation of the incidence of urachal cancer: A systematic review and meta-analysis of registry-based studies
CONCLUSIONS: Our study provides an up-to-date comparison of estimated incidence rates between 6 countries of 3 continents based on rigorously selected registry-based studies. The results suggest low incidence rates for UrC with considerable geographic differences. The present meta-analysis provides unbiased registry-based data on the incidence, clinicopathological parameters and survival of UrC.PMID:38627107 | DOI:10.1016/j.urolonc.2024.03.011 (Source: Urologic Oncology)
Source: Urologic Oncology - April 16, 2024 Category: Urology & Nephrology Authors: Csilla Olah Andr ás Kubik P éter Mátrai Marie Anne Engh Vikt ória Barna P éter Hegyi Henning Reis P éter Nyirády Tibor Szarvas Source Type: research
Precision medicine for prostate cancer: An international perspective
Urol Oncol. 2024 Apr 12:S1078-1439(24)00334-X. doi: 10.1016/j.urolonc.2024.02.004. Online ahead of print.ABSTRACTGreater personalization of cancer medicine continues to shape therapy development and patient selection accordingly. The treatment of prostate cancer has evolved considerably since the discovery of androgen deprivation therapy. The comprehensive profiling of the prostate cancer genome has mapped the targetable molecular landscape of the disease and identified opportunities for the implementation of novel and combination therapies. In this review, we provide an overview of the molecular biology of prostate cancer...
Source: Urologic Oncology - April 13, 2024 Category: Urology & Nephrology Authors: Anis A Hamid Christopher J Sweeney Christopher Hovens Niall Corcoran Arun A Azad Source Type: research
Timing, incidence and management of delayed bleeding after partial nephrectomy in patients at risk for recurrent, bilateral, multifocal renal tumors
CONCLUSIONS: Delayed bleeding after PN in a cohort of patients with multifocal tumors is an infrequent event, with similar rates to single tumor series. Patients should be counseled regarding timing and symptoms of delayed bleeding and multidisciplinary management with interventional radiology is critical for timely diagnosis and treatment.PMID:38614921 | DOI:10.1016/j.urolonc.2024.03.004 (Source: Urologic Oncology)
Source: Urologic Oncology - April 13, 2024 Category: Urology & Nephrology Authors: Patrick T Gomella Julie Solomon Michael Ahdoot Sandeep Gurram Amir H Lebastchi Elliot Levy Venkatesh Krishnasamy Michael T Kassin Richard Chang Bradford J Wood W Marston Linehan Mark W Ball Source Type: research
