Response to lorlatinib rechallenge in a case of ALK-rearranged metastatic NSCLC with a resistance mutation to second generation TKIs
CONCLUSION: In this case, the first ALK resistance mutation detected after progression on first line TKI, the I1171N, is a common resistance mutation after alectinib and confers sensitivity to brigatinib, that the patient received afterwards with a long-term disease stability. The second ALK resistance mutation detected after a chemotherapy interval, the G1202R, is the most common resistance mutation after second generation ALK TKIs and has been associated with sensitivity to third generation TKIs, such as lorlatinib. This case of a patient with EML4-ALK-rearranged NSCLC shows that sequential treatment with next-generation...
Source: Tumori - April 16, 2024 Category: Cancer & Oncology Authors: Rita Leporati Daniela Miliziano Teresa Beninato Laura Mazzeo Sara Manglaviti Marta Brambilla Mario Occhipinti Arsela Prelaj Claudia Proto Giuseppe Lo Russo Source Type: research
The digital revolution in pathology: Towards a smarter approach to research and treatment
Tumori. 2024 Apr 12:3008916241231035. doi: 10.1177/03008916241231035. Online ahead of print.ABSTRACTArtificial intelligence (AI) applications in oncology are at the forefront of transforming healthcare during the Fourth Industrial Revolution, driven by the digital data explosion. This review provides an accessible introduction to the field of AI, presenting a concise yet structured overview of the foundations of AI, including expert systems, classical machine learning, and deep learning, along with their contextual application in clinical research and healthcare. We delve into the current applications of AI in oncology, wi...
Source: Tumori - April 12, 2024 Category: Cancer & Oncology Authors: Francesco Tucci Arvydas Laurinavicius Jakob Nikolas Kather Catarina Eloy Source Type: research
The power of art and the powers of adolescents with cancer: Age-specific projects at Italian pediatric oncology centers
This article describes the oncology programs developed in Italy for adolescents and young adults with cancer, with a specific focus on the local projects created in pediatric oncology centers. A common feature of such projects is the emphasis on creative and artistic activities and laboratories (involving music, photography, novel writing, fashion design, and so on) designed to give young patients innovative means of expression.This article highlights the amazing powers of adolescents involved in these projects: the power to produce beautiful things in a place that is not normally associated with the idea of beauty; the po...
Source: Tumori - April 9, 2024 Category: Cancer & Oncology Authors: Andrea Ferrari Teresa Perillo Giuseppe Maria Milano Matteo Silva Chiara Rutigliano Andrea Salvo Virginia Livellara Massimo Conte Luca Coccoli Elena Amore Marta Pierobon Francesco Vietina Elena Pagani Bagliacca Marco Spinelli Maria Speranza Massei Valentin Source Type: research
A five-year review of chemoradiotherapy practice in anal cancer: Radiotherapy audit results from a cancer centre in Wales, UK
CONCLUSION: Audit results matched with the standards in six domains. Overall treatment time of 37.9 days, colostomy rates of 1.2%, and the 30-day mortality rate of 1.2% were commendable. Overall time interval between consent and CRT delivery can be achieved by time-constrained measures.PMID:38553430 | DOI:10.1177/03008916241241424 (Source: Tumori)
Source: Tumori - March 30, 2024 Category: Cancer & Oncology Authors: Mutahar A Tunio Nicki Davies Elliot Caparros Janis Davies Stuart Foyle Source Type: research
