Brain border-associated macrophages: common denominators in infection, aging, and Alzheimer's disease?
Trends Immunol. 2024 Apr 16:S1471-4906(24)00065-6. doi: 10.1016/j.it.2024.03.007. Online ahead of print.ABSTRACTMammalian brain border-associated macrophages (BAMs) are strategically positioned to support vital properties and processes: for example, the composition of the brain's perivascular extracellular matrix and cerebrospinal fluid flow via the glymphatic pathway. BAMs also effectively restrict the spread of infectious microbes into the brain. However, while fighting infections, BAMs sustain long-term transcriptomic changes and can be replaced by inflammatory monocytes, potentially leading to a gradual loss of their b...
Source: Trends in Immunology - April 17, 2024 Category: Allergy & Immunology Authors: Sandro Da Mesquita Rejane Rua Source Type: research
Astrocytes ACLYmate to chronic neuroinflammation
Trends Immunol. 2024 Apr 16:S1471-4906(24)00072-3. doi: 10.1016/j.it.2024.04.003. Online ahead of print.ABSTRACTAstrocytes are essential cells of the mammalian central nervous system (CNS), with key roles in development, homeostasis, and disease. Lee and colleagues recently showed that astrocytes can develop epigenetic memory, which enhances proinflammatory responses to subsequent stimulation, potentially driving sustained neurological disease pathology, such as in multiple sclerosis (MS).PMID:38632002 | DOI:10.1016/j.it.2024.04.003 (Source: Trends in Immunology)
Source: Trends in Immunology - April 17, 2024 Category: Allergy & Immunology Authors: Kevin Champagne-Jorgensen Jennifer Gommerman Source Type: research
Microglia pack a toolbox for life
Trends Immunol. 2024 Apr 13:S1471-4906(24)00068-1. doi: 10.1016/j.it.2024.03.010. Online ahead of print.ABSTRACTAfter decades of being overlooked, a recent wave of studies have explored the roles of microglia in brain health and disease. Microglia perform important physiological functions to set up and maintain proper neural network functions, as well as orchestrate responses to toxic stimuli to limit harm. Many microglial transcriptional programs, extracellular sensing molecules, and functional outputs are seen throughout life. A stark example is the similarity of microglial responses to stressors during neurodevelopment ...
Source: Trends in Immunology - April 14, 2024 Category: Allergy & Immunology Authors: Kristine E Zengeler John R Lukens Source Type: research
Microglia pack a toolbox for life
Trends Immunol. 2024 Apr 13:S1471-4906(24)00068-1. doi: 10.1016/j.it.2024.03.010. Online ahead of print.ABSTRACTAfter decades of being overlooked, a recent wave of studies have explored the roles of microglia in brain health and disease. Microglia perform important physiological functions to set up and maintain proper neural network functions, as well as orchestrate responses to toxic stimuli to limit harm. Many microglial transcriptional programs, extracellular sensing molecules, and functional outputs are seen throughout life. A stark example is the similarity of microglial responses to stressors during neurodevelopment ...
Source: Trends in Immunology - April 14, 2024 Category: Allergy & Immunology Authors: Kristine E Zengeler John R Lukens Source Type: research
Microglia pack a toolbox for life
Trends Immunol. 2024 Apr 13:S1471-4906(24)00068-1. doi: 10.1016/j.it.2024.03.010. Online ahead of print.ABSTRACTAfter decades of being overlooked, a recent wave of studies have explored the roles of microglia in brain health and disease. Microglia perform important physiological functions to set up and maintain proper neural network functions, as well as orchestrate responses to toxic stimuli to limit harm. Many microglial transcriptional programs, extracellular sensing molecules, and functional outputs are seen throughout life. A stark example is the similarity of microglial responses to stressors during neurodevelopment ...
Source: Trends in Immunology - April 14, 2024 Category: Allergy & Immunology Authors: Kristine E Zengeler John R Lukens Source Type: research
Will cellular immunotherapies end neurodegenerative diseases?
Trends Immunol. 2024 Apr 9:S1471-4906(24)00064-4. doi: 10.1016/j.it.2024.03.006. Online ahead of print.ABSTRACTNeurodegenerative disorders present major challenges to global health, exacerbated by an aging population and the absence of therapies. Despite diverse pathological manifestations, they share a common hallmark, loosely termed 'neuroinflammation'. The prevailing dogma is that the immune system is an active contributor to neurodegeneration; however, recent evidence challenges this. By analogy with road construction, which causes temporary closures and disruptions, the immune system's actions in the central nervous s...
Source: Trends in Immunology - April 10, 2024 Category: Allergy & Immunology Authors: Pavle Boskovic Wenqing Gao Jonathan Kipnis Source Type: research
Will cellular immunotherapies end neurodegenerative diseases?
Trends Immunol. 2024 Apr 9:S1471-4906(24)00064-4. doi: 10.1016/j.it.2024.03.006. Online ahead of print.ABSTRACTNeurodegenerative disorders present major challenges to global health, exacerbated by an aging population and the absence of therapies. Despite diverse pathological manifestations, they share a common hallmark, loosely termed 'neuroinflammation'. The prevailing dogma is that the immune system is an active contributor to neurodegeneration; however, recent evidence challenges this. By analogy with road construction, which causes temporary closures and disruptions, the immune system's actions in the central nervous s...
Source: Trends in Immunology - April 10, 2024 Category: Allergy & Immunology Authors: Pavle Boskovic Wenqing Gao Jonathan Kipnis Source Type: research
Will cellular immunotherapies end neurodegenerative diseases?
Trends Immunol. 2024 Apr 9:S1471-4906(24)00064-4. doi: 10.1016/j.it.2024.03.006. Online ahead of print.ABSTRACTNeurodegenerative disorders present major challenges to global health, exacerbated by an aging population and the absence of therapies. Despite diverse pathological manifestations, they share a common hallmark, loosely termed 'neuroinflammation'. The prevailing dogma is that the immune system is an active contributor to neurodegeneration; however, recent evidence challenges this. By analogy with road construction, which causes temporary closures and disruptions, the immune system's actions in the central nervous s...
Source: Trends in Immunology - April 10, 2024 Category: Allergy & Immunology Authors: Pavle Boskovic Wenqing Gao Jonathan Kipnis Source Type: research
Approaches for studying human macrophages
Trends Immunol. 2024 Apr 4:S1471-4906(24)00032-2. doi: 10.1016/j.it.2024.02.007. Online ahead of print.ABSTRACTMacrophages are vital tissue components involved in organogenesis, maintaining homeostasis, and responses to disease. Mouse models have significantly improved our understanding of macrophages. Further investigations into the characteristics and development of human macrophages are crucial, considering the substantial anatomical and physiological distinctions between mice and humans. Despite challenges in human macrophage research, recent studies are shedding light on the ontogeny and function of human macrophages....
Source: Trends in Immunology - April 5, 2024 Category: Allergy & Immunology Authors: Yuzhou Bao Guanlin Wang Hanjie Li Source Type: research
Approaches for studying human macrophages
Trends Immunol. 2024 Apr 4:S1471-4906(24)00032-2. doi: 10.1016/j.it.2024.02.007. Online ahead of print.ABSTRACTMacrophages are vital tissue components involved in organogenesis, maintaining homeostasis, and responses to disease. Mouse models have significantly improved our understanding of macrophages. Further investigations into the characteristics and development of human macrophages are crucial, considering the substantial anatomical and physiological distinctions between mice and humans. Despite challenges in human macrophage research, recent studies are shedding light on the ontogeny and function of human macrophages....
Source: Trends in Immunology - April 5, 2024 Category: Allergy & Immunology Authors: Yuzhou Bao Guanlin Wang Hanjie Li Source Type: research
Approaches for studying human macrophages
Trends Immunol. 2024 Apr 4:S1471-4906(24)00032-2. doi: 10.1016/j.it.2024.02.007. Online ahead of print.ABSTRACTMacrophages are vital tissue components involved in organogenesis, maintaining homeostasis, and responses to disease. Mouse models have significantly improved our understanding of macrophages. Further investigations into the characteristics and development of human macrophages are crucial, considering the substantial anatomical and physiological distinctions between mice and humans. Despite challenges in human macrophage research, recent studies are shedding light on the ontogeny and function of human macrophages....
Source: Trends in Immunology - April 5, 2024 Category: Allergy & Immunology Authors: Yuzhou Bao Guanlin Wang Hanjie Li Source Type: research
Approaches for studying human macrophages
Trends Immunol. 2024 Apr 4:S1471-4906(24)00032-2. doi: 10.1016/j.it.2024.02.007. Online ahead of print.ABSTRACTMacrophages are vital tissue components involved in organogenesis, maintaining homeostasis, and responses to disease. Mouse models have significantly improved our understanding of macrophages. Further investigations into the characteristics and development of human macrophages are crucial, considering the substantial anatomical and physiological distinctions between mice and humans. Despite challenges in human macrophage research, recent studies are shedding light on the ontogeny and function of human macrophages....
Source: Trends in Immunology - April 5, 2024 Category: Allergy & Immunology Authors: Yuzhou Bao Guanlin Wang Hanjie Li Source Type: research
Approaches for studying human macrophages
Trends Immunol. 2024 Apr 4:S1471-4906(24)00032-2. doi: 10.1016/j.it.2024.02.007. Online ahead of print.ABSTRACTMacrophages are vital tissue components involved in organogenesis, maintaining homeostasis, and responses to disease. Mouse models have significantly improved our understanding of macrophages. Further investigations into the characteristics and development of human macrophages are crucial, considering the substantial anatomical and physiological distinctions between mice and humans. Despite challenges in human macrophage research, recent studies are shedding light on the ontogeny and function of human macrophages....
Source: Trends in Immunology - April 5, 2024 Category: Allergy & Immunology Authors: Yuzhou Bao Guanlin Wang Hanjie Li Source Type: research
Lipocalin-2: a novel potential therapy for GVHD
Trends Immunol. 2024 Mar 27:S1471-4906(24)00049-8. doi: 10.1016/j.it.2024.03.004. Online ahead of print.ABSTRACTCzech et al. used mouse models of allogeneic hematopoietic stem cell transplantation (allo-HCT) to investigate the role of lipocalin-2 (LCN2) as a newfound regulator of intestinal graft-versus-host disease (GVHD). Administration of recombinant LCN2 protein after disease onset prevented GVHD progression, suggesting that it may play a role in reversing tissue damage that has already begun.PMID:38548552 | DOI:10.1016/j.it.2024.03.004 (Source: Trends in Immunology)
Source: Trends in Immunology - March 28, 2024 Category: Allergy & Immunology Authors: Kate A Markey Source Type: research
Lipocalin-2: a novel potential therapy for GVHD
Trends Immunol. 2024 Mar 27:S1471-4906(24)00049-8. doi: 10.1016/j.it.2024.03.004. Online ahead of print.ABSTRACTCzech et al. used mouse models of allogeneic hematopoietic stem cell transplantation (allo-HCT) to investigate the role of lipocalin-2 (LCN2) as a newfound regulator of intestinal graft-versus-host disease (GVHD). Administration of recombinant LCN2 protein after disease onset prevented GVHD progression, suggesting that it may play a role in reversing tissue damage that has already begun.PMID:38548552 | DOI:10.1016/j.it.2024.03.004 (Source: Trends in Immunology)
Source: Trends in Immunology - March 28, 2024 Category: Allergy & Immunology Authors: Kate A Markey Source Type: research
