Tailor-made molecular imprints for biological event intervention
Trends Biotechnol. 2024 Apr 10:S0167-7799(24)00063-5. doi: 10.1016/j.tibtech.2024.02.015. Online ahead of print.ABSTRACTMolecular imprints, which are crosslinked architectures containing specific molecular recognition cavities for targeting compounds, have recently transitioned from in vitro diagnosis to in vivo treatment. In current application scenarios, it has become an important topic to create new biomolecular recognition pathways through molecular imprinting, thereby inhibiting the pathogenesis and regulating the development of diseases. This review starts with a pathological analysis, mainly focusing on the correspo...
Source: Trends in Biotechnology - April 11, 2024 Category: Biotechnology Authors: Fan Ding Yue Ma Wensi Fan Jingjing Xu Guoqing Pan Source Type: research
Harnessing oleaginous yeast to produce omega fatty acids
Trends Biotechnol. 2024 Apr 9:S0167-7799(24)00084-2. doi: 10.1016/j.tibtech.2024.03.005. Online ahead of print.ABSTRACTOmega fatty acids are important for human health. They are traditionally extracted from animals or plants but can be alternatively produced using oleaginous yeast. Current efforts are producing yeast strains with similar fatty acid distributions and powerful lipogenesis capacity. The next step is to further make the process more competitive.PMID:38594144 | DOI:10.1016/j.tibtech.2024.03.005 (Source: Trends in Biotechnology)
Source: Trends in Biotechnology - April 9, 2024 Category: Biotechnology Authors: Lu Lin Rodrigo Ledesma-Amaro Xiao-Jun Ji He Huang Source Type: research
Harnessing oleaginous yeast to produce omega fatty acids
Trends Biotechnol. 2024 Apr 9:S0167-7799(24)00084-2. doi: 10.1016/j.tibtech.2024.03.005. Online ahead of print.ABSTRACTOmega fatty acids are important for human health. They are traditionally extracted from animals or plants but can be alternatively produced using oleaginous yeast. Current efforts are producing yeast strains with similar fatty acid distributions and powerful lipogenesis capacity. The next step is to further make the process more competitive.PMID:38594144 | DOI:10.1016/j.tibtech.2024.03.005 (Source: Trends in Biotechnology)
Source: Trends in Biotechnology - April 9, 2024 Category: Biotechnology Authors: Lu Lin Rodrigo Ledesma-Amaro Xiao-Jun Ji He Huang Source Type: research
Harnessing oleaginous yeast to produce omega fatty acids
Trends Biotechnol. 2024 Apr 9:S0167-7799(24)00084-2. doi: 10.1016/j.tibtech.2024.03.005. Online ahead of print.ABSTRACTOmega fatty acids are important for human health. They are traditionally extracted from animals or plants but can be alternatively produced using oleaginous yeast. Current efforts are producing yeast strains with similar fatty acid distributions and powerful lipogenesis capacity. The next step is to further make the process more competitive.PMID:38594144 | DOI:10.1016/j.tibtech.2024.03.005 (Source: Trends in Biotechnology)
Source: Trends in Biotechnology - April 9, 2024 Category: Biotechnology Authors: Lu Lin Rodrigo Ledesma-Amaro Xiao-Jun Ji He Huang Source Type: research
The green revolution of food waste upcycling to produce polyhydroxyalkanoates
Trends Biotechnol. 2024 Apr 5:S0167-7799(24)00066-0. doi: 10.1016/j.tibtech.2024.03.002. Online ahead of print.ABSTRACTThis review emphasizes the urgent need for food waste upcycling as a response to the mounting global food waste crisis. Focusing on polyhydroxyalkanoates (PHAs) as an alternative to traditional plastics, it examines the potential of various food wastes as feedstock for microbial fermentation and PHA production. The upcycling of food waste including cheese whey, waste cooking oil, coffee waste, and animal fat is an innovative practice for food waste management. This approach not only mitigates environmental...
Source: Trends in Biotechnology - April 6, 2024 Category: Biotechnology Authors: Shashi Kant Bhatia Anil Kumar Patel Yung-Hun Yang Source Type: research
The green revolution of food waste upcycling to produce polyhydroxyalkanoates
Trends Biotechnol. 2024 Apr 5:S0167-7799(24)00066-0. doi: 10.1016/j.tibtech.2024.03.002. Online ahead of print.ABSTRACTThis review emphasizes the urgent need for food waste upcycling as a response to the mounting global food waste crisis. Focusing on polyhydroxyalkanoates (PHAs) as an alternative to traditional plastics, it examines the potential of various food wastes as feedstock for microbial fermentation and PHA production. The upcycling of food waste including cheese whey, waste cooking oil, coffee waste, and animal fat is an innovative practice for food waste management. This approach not only mitigates environmental...
Source: Trends in Biotechnology - April 6, 2024 Category: Biotechnology Authors: Shashi Kant Bhatia Anil Kumar Patel Yung-Hun Yang Source Type: research
The green revolution of food waste upcycling to produce polyhydroxyalkanoates
Trends Biotechnol. 2024 Apr 5:S0167-7799(24)00066-0. doi: 10.1016/j.tibtech.2024.03.002. Online ahead of print.ABSTRACTThis review emphasizes the urgent need for food waste upcycling as a response to the mounting global food waste crisis. Focusing on polyhydroxyalkanoates (PHAs) as an alternative to traditional plastics, it examines the potential of various food wastes as feedstock for microbial fermentation and PHA production. The upcycling of food waste including cheese whey, waste cooking oil, coffee waste, and animal fat is an innovative practice for food waste management. This approach not only mitigates environmental...
Source: Trends in Biotechnology - April 6, 2024 Category: Biotechnology Authors: Shashi Kant Bhatia Anil Kumar Patel Yung-Hun Yang Source Type: research
Killer yeasts: expanding frontiers in the age of synthetic biology
Trends Biotechnol. 2024 Apr 3:S0167-7799(24)00067-2. doi: 10.1016/j.tibtech.2024.03.003. Online ahead of print.ABSTRACTKiller yeasts secrete protein toxins that are selectively lethal to other yeast and filamentous fungi. These exhibit exceptional genetic and functional diversity, and have several biotechnological applications. However, despite decades of research, several limitations hinder their widespread adoption. In this perspective we contend that technical advances in synthetic biology present an unprecedented opportunity to unlock the full potential of yeast killer systems across a spectrum of applications. By leve...
Source: Trends in Biotechnology - April 4, 2024 Category: Biotechnology Authors: Sonja Billerbeck Roy S K Walker Isak S Pretorius Source Type: research
Killer yeasts: expanding frontiers in the age of synthetic biology
Trends Biotechnol. 2024 Apr 3:S0167-7799(24)00067-2. doi: 10.1016/j.tibtech.2024.03.003. Online ahead of print.ABSTRACTKiller yeasts secrete protein toxins that are selectively lethal to other yeast and filamentous fungi. These exhibit exceptional genetic and functional diversity, and have several biotechnological applications. However, despite decades of research, several limitations hinder their widespread adoption. In this perspective we contend that technical advances in synthetic biology present an unprecedented opportunity to unlock the full potential of yeast killer systems across a spectrum of applications. By leve...
Source: Trends in Biotechnology - April 4, 2024 Category: Biotechnology Authors: Sonja Billerbeck Roy S K Walker Isak S Pretorius Source Type: research
Driving towards digital biomanufacturing by CHO genome-scale models
Trends Biotechnol. 2024 Mar 27:S0167-7799(24)00065-9. doi: 10.1016/j.tibtech.2024.03.001. Online ahead of print.ABSTRACTGenome-scale metabolic models (GEMs) of Chinese hamster ovary (CHO) cells are valuable for gaining mechanistic understanding of mammalian cell metabolism and cultures. We provide a comprehensive overview of past and present developments of CHO-GEMs and in silico methods within the flux balance analysis (FBA) framework, focusing on their practical utility in rational cell line development and bioprocess improvements. There are many opportunities for further augmenting the model coverage and establishing in...
Source: Trends in Biotechnology - March 28, 2024 Category: Biotechnology Authors: Seo-Young Park Dong-Hyuk Choi Jinsung Song Meiyappan Lakshmanan Anne Richelle Seongkyu Yoon Cleo Kontoravdi Nathan E Lewis Dong-Yup Lee Source Type: research
Driving towards digital biomanufacturing by CHO genome-scale models
Trends Biotechnol. 2024 Mar 27:S0167-7799(24)00065-9. doi: 10.1016/j.tibtech.2024.03.001. Online ahead of print.ABSTRACTGenome-scale metabolic models (GEMs) of Chinese hamster ovary (CHO) cells are valuable for gaining mechanistic understanding of mammalian cell metabolism and cultures. We provide a comprehensive overview of past and present developments of CHO-GEMs and in silico methods within the flux balance analysis (FBA) framework, focusing on their practical utility in rational cell line development and bioprocess improvements. There are many opportunities for further augmenting the model coverage and establishing in...
Source: Trends in Biotechnology - March 28, 2024 Category: Biotechnology Authors: Seo-Young Park Dong-Hyuk Choi Jinsung Song Meiyappan Lakshmanan Anne Richelle Seongkyu Yoon Cleo Kontoravdi Nathan E Lewis Dong-Yup Lee Source Type: research
Driving towards digital biomanufacturing by CHO genome-scale models
Trends Biotechnol. 2024 Mar 27:S0167-7799(24)00065-9. doi: 10.1016/j.tibtech.2024.03.001. Online ahead of print.ABSTRACTGenome-scale metabolic models (GEMs) of Chinese hamster ovary (CHO) cells are valuable for gaining mechanistic understanding of mammalian cell metabolism and cultures. We provide a comprehensive overview of past and present developments of CHO-GEMs and in silico methods within the flux balance analysis (FBA) framework, focusing on their practical utility in rational cell line development and bioprocess improvements. There are many opportunities for further augmenting the model coverage and establishing in...
Source: Trends in Biotechnology - March 28, 2024 Category: Biotechnology Authors: Seo-Young Park Dong-Hyuk Choi Jinsung Song Meiyappan Lakshmanan Anne Richelle Seongkyu Yoon Cleo Kontoravdi Nathan E Lewis Dong-Yup Lee Source Type: research
Driving towards digital biomanufacturing by CHO genome-scale models
Trends Biotechnol. 2024 Mar 27:S0167-7799(24)00065-9. doi: 10.1016/j.tibtech.2024.03.001. Online ahead of print.ABSTRACTGenome-scale metabolic models (GEMs) of Chinese hamster ovary (CHO) cells are valuable for gaining mechanistic understanding of mammalian cell metabolism and cultures. We provide a comprehensive overview of past and present developments of CHO-GEMs and in silico methods within the flux balance analysis (FBA) framework, focusing on their practical utility in rational cell line development and bioprocess improvements. There are many opportunities for further augmenting the model coverage and establishing in...
Source: Trends in Biotechnology - March 28, 2024 Category: Biotechnology Authors: Seo-Young Park Dong-Hyuk Choi Jinsung Song Meiyappan Lakshmanan Anne Richelle Seongkyu Yoon Cleo Kontoravdi Nathan E Lewis Dong-Yup Lee Source Type: research
Driving towards digital biomanufacturing by CHO genome-scale models
Trends Biotechnol. 2024 Mar 27:S0167-7799(24)00065-9. doi: 10.1016/j.tibtech.2024.03.001. Online ahead of print.ABSTRACTGenome-scale metabolic models (GEMs) of Chinese hamster ovary (CHO) cells are valuable for gaining mechanistic understanding of mammalian cell metabolism and cultures. We provide a comprehensive overview of past and present developments of CHO-GEMs and in silico methods within the flux balance analysis (FBA) framework, focusing on their practical utility in rational cell line development and bioprocess improvements. There are many opportunities for further augmenting the model coverage and establishing in...
Source: Trends in Biotechnology - March 28, 2024 Category: Biotechnology Authors: Seo-Young Park Dong-Hyuk Choi Jinsung Song Meiyappan Lakshmanan Anne Richelle Seongkyu Yoon Cleo Kontoravdi Nathan E Lewis Dong-Yup Lee Source Type: research
Driving towards digital biomanufacturing by CHO genome-scale models
Trends Biotechnol. 2024 Mar 27:S0167-7799(24)00065-9. doi: 10.1016/j.tibtech.2024.03.001. Online ahead of print.ABSTRACTGenome-scale metabolic models (GEMs) of Chinese hamster ovary (CHO) cells are valuable for gaining mechanistic understanding of mammalian cell metabolism and cultures. We provide a comprehensive overview of past and present developments of CHO-GEMs and in silico methods within the flux balance analysis (FBA) framework, focusing on their practical utility in rational cell line development and bioprocess improvements. There are many opportunities for further augmenting the model coverage and establishing in...
Source: Trends in Biotechnology - March 28, 2024 Category: Biotechnology Authors: Seo-Young Park Dong-Hyuk Choi Jinsung Song Meiyappan Lakshmanan Anne Richelle Seongkyu Yoon Cleo Kontoravdi Nathan E Lewis Dong-Yup Lee Source Type: research
