Elution behavior of drugs in high-speed counter-current chromatography using on-column complexation with metal ions
In this study, determination of (nitrogen containing) drugs by on-column complexation with metal ions in high-speed counter-current chromatography (HSCCC) was investigated. Bromazepam (BMP) was strongly retained in the organic upper stationary phase (UP) of the two-phase solvent system composed of tert-butyl methyl ether-acetonitrile-water (2:2:3, v/v/v) by eluting the aqueous lower mobile phase (LP) at a flow rate of 2 mL min-1. On the other hand, BMP (200 µg mL-1) was eluted faster without retention to the organic UP with the two-phase system containing 100 μg mL-1 of copper ions (CuCl2) because a very polar BMP-Cu2+ c...
Source: Analytical Sciences : the international journal of the Japan Society for Analytical Chemistry - April 9, 2024 Category: Chemistry Authors: Yukiko Moriiwa Atsushi Shoji Yoichi Shibusawa Akio Yanagida Source Type: research
Elution behavior of drugs in high-speed counter-current chromatography using on-column complexation with metal ions
In this study, determination of (nitrogen containing) drugs by on-column complexation with metal ions in high-speed counter-current chromatography (HSCCC) was investigated. Bromazepam (BMP) was strongly retained in the organic upper stationary phase (UP) of the two-phase solvent system composed of tert-butyl methyl ether-acetonitrile-water (2:2:3, v/v/v) by eluting the aqueous lower mobile phase (LP) at a flow rate of 2 mL min-1. On the other hand, BMP (200 µg mL-1) was eluted faster without retention to the organic UP with the two-phase system containing 100 μg mL-1 of copper ions (CuCl2) because a very polar BMP-Cu2+ c...
Source: Anal Sci - April 9, 2024 Category: Chemistry Authors: Yukiko Moriiwa Atsushi Shoji Yoichi Shibusawa Akio Yanagida Source Type: research
Elution behavior of drugs in high-speed counter-current chromatography using on-column complexation with metal ions
In this study, determination of (nitrogen containing) drugs by on-column complexation with metal ions in high-speed counter-current chromatography (HSCCC) was investigated. Bromazepam (BMP) was strongly retained in the organic upper stationary phase (UP) of the two-phase solvent system composed of tert-butyl methyl ether-acetonitrile-water (2:2:3, v/v/v) by eluting the aqueous lower mobile phase (LP) at a flow rate of 2 mL min-1. On the other hand, BMP (200 µg mL-1) was eluted faster without retention to the organic UP with the two-phase system containing 100 μg mL-1 of copper ions (CuCl2) because a very polar BMP-Cu2+ c...
Source: Analytical Sciences : the international journal of the Japan Society for Analytical Chemistry - April 9, 2024 Category: Chemistry Authors: Yukiko Moriiwa Atsushi Shoji Yoichi Shibusawa Akio Yanagida Source Type: research
Elution behavior of drugs in high-speed counter-current chromatography using on-column complexation with metal ions
In this study, determination of (nitrogen containing) drugs by on-column complexation with metal ions in high-speed counter-current chromatography (HSCCC) was investigated. Bromazepam (BMP) was strongly retained in the organic upper stationary phase (UP) of the two-phase solvent system composed of tert-butyl methyl ether-acetonitrile-water (2:2:3, v/v/v) by eluting the aqueous lower mobile phase (LP) at a flow rate of 2 mL min-1. On the other hand, BMP (200 µg mL-1) was eluted faster without retention to the organic UP with the two-phase system containing 100 μg mL-1 of copper ions (CuCl2) because a very polar BMP-Cu2+ c...
Source: Anal Sci - April 9, 2024 Category: Chemistry Authors: Yukiko Moriiwa Atsushi Shoji Yoichi Shibusawa Akio Yanagida Source Type: research
Tizanidine: Advances in Pharmacology & Therapeutics and Drug Formulations
(Source: Journal of Pain Research)
Source: Journal of Pain Research - March 21, 2024 Category: Anesthesiology Tags: Journal of Pain Research Source Type: research
Comparative Risk of Injury with Concurrent Use of Opioids and Skeletal Muscle Relaxants
In conclusion, the relative injury rate associated with different SMRs used concurrently with the three most dispensed opioids appears to vary depending on the specific opioid and the order of combination initiation. If confirmed by future studies, clinicians should consider the varying injury rates when prescribing SMRs to individuals using hydrocodone, oxycodone, and tramadol.PMID:38482733 | DOI:10.1002/cpt.3248 (Source: Clinical Pharmacology and Therapeutics)
Source: Clinical Pharmacology and Therapeutics - March 14, 2024 Category: Drugs & Pharmacology Authors: Cheng Chen Sean Hennessy Colleen M Brensinger Todd A Miano Warren B Bilker Sascha Dublin Sophie P Chung John R Horn Anika Tiwari Charles E Leonard Source Type: research
Comparative Risk of Injury with Concurrent Use of Opioids and Skeletal Muscle Relaxants
In conclusion, the relative injury rate associated with different SMRs used concurrently with the three most dispensed opioids appears to vary depending on the specific opioid and the order of combination initiation. If confirmed by future studies, clinicians should consider the varying injury rates when prescribing SMRs to individuals using hydrocodone, oxycodone, and tramadol.PMID:38482733 | DOI:10.1002/cpt.3248 (Source: Clinical Pharmacology and Therapeutics)
Source: Clinical Pharmacology and Therapeutics - March 14, 2024 Category: Drugs & Pharmacology Authors: Cheng Chen Sean Hennessy Colleen M Brensinger Todd A Miano Warren B Bilker Sascha Dublin Sophie P Chung John R Horn Anika Tiwari Charles E Leonard Source Type: research
Pharmacological and Non-pharmacological Approaches for the Management of Neuropathic Pain in Multiple Sclerosis
The objective of this ar ticle is to provide an overview of literature on pharmacological and non-pharmacological strategies employed in the management of neuropathic pain in multiple sclerosis. Pharmacological options include cannabinoids, muscle relaxants (tizanidine, baclofen, dantrolene), anticonvulsants (benzodiazepine s, gabapentin, phenytoin, carbamazepine, lamotrigine), antidepressants (duloxetine, venlafaxine, tricyclic antidepressants), opioids (naltrexone), and botulinum toxin variants, which have evidence from various clinical trials. Non-pharmacological approaches for trigeminal neuralgia may include neuro sur...
Source: CNS Drugs - February 29, 2024 Category: Neurology Source Type: research
Tizanidine
(Source: Reactions Weekly)
Source: Reactions Weekly - February 1, 2024 Category: Drugs & Pharmacology Source Type: research
Multifactorial Dependence of Muscle Relaxant Efficacy in Lower Back Pain
We read with interest the article by Abril et al., who reported a study on the efficacy of seven skeletal muscle relaxants (SMRs) for lower back pain (LBP) (1). Four randomized controlled trials were retrospectively pooled and analyzed together for efficacy and adverse-effect profiles of baclofen, metaxalone, tizanidine, diazepam, orphenadrin e, methocarbamol, and cyclobenzaprine compared with placebo and whether efficacy was related to age, sex, or baseline LBP-related functional impairment, as assessed by the Roland-Morris Disability Questionnaire (RMDQ) (1). (Source: The Journal of Emergency Medicine)
Source: The Journal of Emergency Medicine - November 17, 2023 Category: Emergency Medicine Authors: Josef Finsterer, Fulvio A. Scorza Tags: Letter to the Editor Source Type: research
Baclofen and Tizanidine Adverse Effects Observed Among Community-Dwelling Adults Above the Age of 50 Years: A Systematic Review
CONCLUSIONS: This review highlights the importance of using baclofen and tizanidine with caution in older adults.PMID:37589096 | DOI:10.1177/10600280231193080 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - August 17, 2023 Category: Drugs & Pharmacology Authors: Lisa Killam-Worrall Romana Brand Janine R Castro Dipa S Patel Katherine Huynh Bryn Lindley Brittany Palasik Torres Source Type: research
Baclofen and Tizanidine Adverse Effects Observed Among Community-Dwelling Adults Above the Age of 50 Years: A Systematic Review
CONCLUSIONS: This review highlights the importance of using baclofen and tizanidine with caution in older adults.PMID:37589096 | DOI:10.1177/10600280231193080 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - August 17, 2023 Category: Drugs & Pharmacology Authors: Lisa Killam-Worrall Romana Brand Janine R Castro Dipa S Patel Katherine Huynh Bryn Lindley Brittany Palasik Torres Source Type: research
Baclofen and Tizanidine Adverse Effects Observed Among Community-Dwelling Adults Above the Age of 50 Years: A Systematic Review
CONCLUSIONS: This review highlights the importance of using baclofen and tizanidine with caution in older adults.PMID:37589096 | DOI:10.1177/10600280231193080 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - August 17, 2023 Category: Drugs & Pharmacology Authors: Lisa Killam-Worrall Romana Brand Janine R Castro Dipa S Patel Katherine Huynh Bryn Lindley Brittany Palasik Torres Source Type: research
Baclofen and Tizanidine Adverse Effects Observed Among Community-Dwelling Adults Above the Age of 50 Years: A Systematic Review
CONCLUSIONS: This review highlights the importance of using baclofen and tizanidine with caution in older adults.PMID:37589096 | DOI:10.1177/10600280231193080 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - August 17, 2023 Category: Drugs & Pharmacology Authors: Lisa Killam-Worrall Romana Brand Janine R Castro Dipa S Patel Katherine Huynh Bryn Lindley Brittany Palasik Torres Source Type: research
Tizanidine induced hypotension: report of a case and review of literature
CONCLUSION: This patient highlights the need for close monitoring of patients receiving tizanidine co-medication with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers. These drugs have a synergistic effect on reducing the renin-angiotensin-aldosterone system, thereby hypotension and bradycardia.PMID:37489780 | DOI:10.2174/1574886318666230725113855 (Source: Current Drug Safety)
Source: Current Drug Safety - July 25, 2023 Category: Drugs & Pharmacology Authors: Roopali Mahajan Jayantee Kalita Source Type: research
