A machine learning approach to predict mortality due to immune-mediated thrombotic thrombocytopenic purpura
CONCLUSION: The USTMA Mortality Index was acceptable for predicting mortality due to acute iTTP in the USTMA registry, but not sensitive enough to rule out death. Identifying patients at high risk of iTTP-related mortality may help individualize care and ultimately improve iTTP survival outcomes. Further studies are needed to provide external validation. Our model is one of many recent examples where machine learning models may show promise in clinical prediction tools in healthcare.PMID:38651093 | PMC:PMC11033197 | DOI:10.1016/j.rpth.2024.102388 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 23, 2024 Category: Hematology Authors: Mouhamed Yazan Abou-Ismail Chong Zhang Angela P Presson Shruti Chaturvedi Ana G Antun Andrew M Farland Ryan Woods Ara Metjian Yara A Park Gustaaf de Ridder Briana Gibson Raj S Kasthuri Darla K Liles Frank Akwaa Todd Clover Lisa Baumann Kreuziger Meera Sri Source Type: research
Multi-phased kinetics and interaction of protein kinase signaling in glycoprotein VI-induced platelet αIIbβ3 integrin activation and degranulation
CONCLUSION: Kinetic analysis of GPVI-initiated multisite protein phosphorylation in human platelets demonstrates multiple phases and interactions of tyrosine and serine/threonine kinases with activation-altering feedforward and feedback loops partly involving PKC. The protein kinase inhibitor effects on multisite protein phosphorylation and functional readouts reveal that the signaling network of Syk, Btk and PKC controls platelet granule exocytosis and αIIbβ3 integrin activation.PMID:38653482 | DOI:10.1055/a-2311-0117 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 23, 2024 Category: Hematology Authors: Pengyu Zhang Saskia von Ungern-Sternberg Luisa Hastenplug Fiorella Solari Albert Sickmann Marijke Kuijpers Johan Wm Heemskerk Ulrich Walter Kerstin Jurk Source Type: research
A Deep Learning Approach to Predict Bleeding Risk Over Time in Patients on Extended Anticoagulation Therapy
CONCLUSION: Time series follow-up data can improve major bleeding prediction in patients on extended anticoagulation therapy.PMID:38642704 | DOI:10.1016/j.jtha.2024.04.005 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 20, 2024 Category: Hematology Authors: Soroush Shahryari Fard Theodore J Perkins Philip S Wells Source Type: research
Management of Abnormal Uterine Bleeding on Anticoagulation: The Patient-Clinician Perspective
J Thromb Haemost. 2024 Apr 18:S1538-7836(24)00216-2. doi: 10.1016/j.jtha.2024.04.002. Online ahead of print.ABSTRACTBleeding is a well-recognized side effect of anticoagulant therapy, which is used to treat venous thromboembolism (VTE) in individuals of all ages, including those of female sex, who commonly experience VTE as a complication of hormonal therapies and/or pregnancy. Heavy menstrual bleeding (HMB) is also extremely common in reproductive aged individuals of female sex. Despite these overlapping situations, relatively little attention has been paid to the impact of anticoagulant-associated HMB on treatment strate...
Source: Thrombosis and Haemostasis - April 20, 2024 Category: Hematology Authors: Bethany T Samuelson Bannow Source Type: research
Evaluation, analysis, and reporting of medication adherence for clinical trials of anticoagulants in children: Guidance from the ISTH SSC Subcommittee on Pediatric and Neonatal Thrombosis and Hemostasis
J Thromb Haemost. 2024 Apr 18:S1538-7836(24)00217-4. doi: 10.1016/j.jtha.2024.04.003. Online ahead of print.ABSTRACTIn response to growing recognition that non-adherence prevents children, adolescents, and young adults from achieving the therapeutic benefits of anticoagulant medication, the ISTH SSC Subcommittee on Pediatric and Neonatal Thrombosis and Hemostasis convened a working party on medication adherence. The primary aim of this manuscript was to synthesize recommendations from the larger adherence science literature to provide guidance regarding the classification, collection, and interpretation of anticoagulation ...
Source: Thrombosis and Haemostasis - April 20, 2024 Category: Hematology Authors: Meghan E McGrady Vera Ignjatovic Sophie Jones Aisha Bruce Neil A Goldenberg Mattia Rizzi Courtney D Thornburg Kevin E Todd Lori Luchtman-Jones Source Type: research
Next Generation Sequencing strategies in venous thromboembolism: in whom and for what purpose ?
J Thromb Haemost. 2024 Apr 17:S1538-7836(24)00218-6. doi: 10.1016/j.jtha.2024.04.004. Online ahead of print.ABSTRACTThis invited review follows the oral presentation "To Sequence or Not to Sequence, That Is Not the Question; But "When, Who, Which and What For?" Is " given during the State Of the Art session Translational Genomics in Thrombosis: From OMICs to Clinics" of the ISTH 2023 congress. Emphasizing the power of next-generation sequencing technologies and the diverse strategies associated with DNA variant analysis, this review highlights the unresolved questions and challenges in their implementation both for the cli...
Source: Thrombosis and Haemostasis - April 19, 2024 Category: Hematology Authors: David-Alexandre Tr égouët Morange Pierre-Emmanuel Source Type: research
Pharmacokinetics of Edoxaban 15 mg in Very Elderly Patients with Nonvalvular Atrial Fibrillation: A Subanalysis of the ELDERCARE-AF Study
CONCLUSION: PK data support edoxaban 15 mg once daily for very elderly NVAF patients with high bleeding risk, with caution for patients with SRI and/or low body weight.PMID:38641335 | DOI:10.1055/s-0044-1785511 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 19, 2024 Category: Hematology Authors: Takeshi Yamashita Yoshiyuki Igawa Masayuki Fukuzawa Takuya Hayashi Stefanie Hennig Ken Okumura Source Type: research
The Association between Obstructive Sleep Apnea and Venous Thromboembolism: A Bidirectional Two-Sample Mendelian Randomization Study
Conclusion Our bidirectional two-sample MR analysis did not find genetic evidence supporting a significant association between OSA and VTE in either direction.PMID:38631385 | DOI:10.1055/a-2308-2290 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 17, 2024 Category: Hematology Authors: Zhihai Huang Zhenzhen Zheng Lingpin Pang Kaili Fu Junfen Cheng Ming Zhong Lingyue Song Dingyu Guo Qiaoyun Chen Yanxi Li Yongting Lv Riken Chen Xishi Sun Source Type: research
The Association between Obstructive Sleep Apnea and Venous Thromboembolism: A Bidirectional Two-Sample Mendelian Randomization Study
Conclusion Our bidirectional two-sample MR analysis did not find genetic evidence supporting a significant association between OSA and VTE in either direction.PMID:38631385 | DOI:10.1055/a-2308-2290 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 17, 2024 Category: Hematology Authors: Zhihai Huang Zhenzhen Zheng Lingpin Pang Kaili Fu Junfen Cheng Ming Zhong Lingyue Song Dingyu Guo Qiaoyun Chen Yanxi Li Yongting Lv Riken Chen Xishi Sun Source Type: research
Ticagrelor vs clopidogrel when coadministered with bivalirudin in patients with acute coronary syndrome undergoing percutaneous coronary intervention
CONCLUSION: As an initial treatment strategy, bivalirudin plus ticagrelor could reduce the 12-month risk of ischemic events compared with bivalirudin plus clopidogrel significantly without increasing the bleeding risk in ACS patients undergoing PCI.PMID:38623472 | PMC:PMC11017352 | DOI:10.1016/j.rpth.2024.102375 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 16, 2024 Category: Hematology Authors: Yang Li Yi Li Miaohan Qiu Yu Xue Kai Xu Yaling Han Source Type: research
Tranexamic acid for management of heavy vaginal bleeding: barriers to access and myths surrounding its use
Res Pract Thromb Haemost. 2024 Mar 19;8(3):102389. doi: 10.1016/j.rpth.2024.102389. eCollection 2024 Mar.ABSTRACTTranexamic acid is safe and effective for the treatment of heavy vaginal bleeding during menstruation and childbirth. It improves the quality of life, facilitates participation in school and work, and reduces the risk of death from postpartum hemorrhage. Despite its well-established benefits, individual- and structural-level barriers preclude its widespread utilization, hindering effective patient care and perpetuating health inequities in women's health. We first describe the evidence for the use of tranexamic ...
Source: Thrombosis and Haemostasis - April 16, 2024 Category: Hematology Authors: Heather VanderMeulen Grace H Tang Michelle Sholzberg Source Type: research
Testing for the lupus anticoagulant: the good, the bad, and the ugly
Res Pract Thromb Haemost. 2024 Mar 18;8(3):102385. doi: 10.1016/j.rpth.2024.102385. eCollection 2024 Mar.ABSTRACTLupus anticoagulant (LA) represents 1 of the laboratory criteria for classification of patients as having definite antiphospholipid syndrome (APS). The other 2 laboratory criteria are anticardiolipin antibodies and anti-beta2-glycoprotein I antibodies. At least 1 of these antiphospholipid antibody (aPL) tests need to be positive, with evidence of persistence, together with evidence of at least 1 clinical criterion for APS, before a patient can be classified as having definite APS. LA and other aPL assays are als...
Source: Thrombosis and Haemostasis - April 16, 2024 Category: Hematology Authors: Emmanuel J Favaloro Leonardo Pasalic Rita Selby Source Type: research
Clinical Outcomes of Patients with Atrial Fibrillation who Survived from Bleeding Event: The Results from COOL-AF Thailand Registry
CONCLUSION: Patients with AF who have bleeding events have an increased risk for subsequent death and stroke and systemic embolism. These patients should be identified as vulnerable clinically complex patients and require a holistic approach to their AF management.PMID:38626898 | DOI:10.1055/s-0044-1786028 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 16, 2024 Category: Hematology Authors: Arjbordin Winijkul Pontawee Kaewkumdee Ahthit Yindeengam Gregory Y H Lip Rungroj Krittayaphong Source Type: research
The Role of Clot Waveform Analysis and Related Parameters in the Diagnosis and Treatment of Hemophilia A
CONCLUSION: CWA is an economical and practical tool, and its related parameters are associated with the severity of HA. It has promising clinical prospects in predicting FVIII:C levels and individualized treatment when HA patients undergo replacement therapy.PMID:38626899 | DOI:10.1055/s-0044-1786029 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 16, 2024 Category: Hematology Authors: Guanghao Song Yangbin Wang Lilei Zhang Mao Xia Source Type: research
Practical Suggestions for an Optimal Management of Vitamin K Antagonists: Italian Federation of Centers for the Diagnosis of Thrombotic Disorders and the Surveillance of the Antithrombotic Therapies (FCSA) Position Paper
Thromb Haemost. 2024 Apr 16. doi: 10.1055/s-0044-1782688. Online ahead of print.ABSTRACTIn the era of direct oral anticoagulants, vitamin K antagonists retain a clinically relevant role in thrombotic disorders. In Italy, approximately 20% of the patients on anticoagulant therapies receives a VKA, in most cases warfarin. The optimal management of this drug is challenging and cannot disregard its intricate and unpredictable pharmacokinetic properties and patient's thrombotic and bleeding risk. Several clinical issues encountered during warfarin treatment are still unanswered and are tentatively addressed by physicians. In th...
Source: Thrombosis and Haemostasis - April 16, 2024 Category: Hematology Authors: Silvia Galliazzo Paolo Bucciarelli Doris Barcellona Antonio Ciampa Elvira Grandone Giuseppe Malcangi Giuseppe Rescigno Alessandro Squizzato Vincenzo Toschi Sophie Testa Daniela Poli Source Type: research
