Hypotonic polyuria: at the cross-roads of copeptin
Neth J Med. 2020 Dec;78(6):309-314.ABSTRACTThe aetiology of hypotonic polyuria, after excluding solute diuresis, is one of primary polydipsia, central, or nephrogenic diabetes insipidus. Theoretically, these disorders should be relatively easily distinguished based on history and the results of an indirect water deprivation test. Practically, however, there is a significant overlap in diagnostic evaluation, potentially leading to an erroneous diagnosis and deleterious management plan. The ability to measure a stimulated copeptin level, either with hypertonic saline or arginine infusion, has led to greater diagnostic accura...
Source: The Netherlands Journal of Medicine - December 31, 2020 Category: General Medicine Authors: A Gupta D Zimmerman Source Type: research

Severe acute respiratory infections surveillance for early signals in the community
CONCLUSION: This observational study demonstrates that routinely collected data can be used for describing trends of ARI in secondary care and may be suitable for near real-time SARI surveillance. In most seasons, the incidence peaks for ARI in secondary care preceded the peaks in primary care and crude mortality with a considerable time-lag. It would be of great value to add microbiological test results to the incidence data to better explain the difference in time-lag between these surveillance systems.PMID:33380528 (Source: The Netherlands Journal of Medicine)
Source: The Netherlands Journal of Medicine - December 31, 2020 Category: General Medicine Authors: S D Marbus G H Groeneveld L van Asten W van der Hoek M M A de Lange G A Donker P M Schneeberger J T van Dissel A B van Gageldonk-Lafeber Source Type: research

Implementation of 'Choosing Wisely Netherlands' for internal medicine
CONCLUSION: Four years after the introduction, only one-third of physicians and residents of internal medicine were aware of the Choosing Wisely Netherlands campaign. Nevertheless, most Choosing Wisely recommendations were implemented sufficiently in clinical practice. There is room for improvement, mainly in recommendations that need a multidisciplinary approach.PMID:33380529 (Source: The Netherlands Journal of Medicine)
Source: The Netherlands Journal of Medicine - December 31, 2020 Category: General Medicine Authors: B J Laan A A van de Woestijne H A H Kaasjager S E Geerlings Source Type: research

Doppler follow-up after TIPS placement is not routinely indicated. A 16-years single centre experience
CONCLUSION: The use of routine Doppler ultrasound follow-up after PTFE-covered TIPS placement seems unnecessary as it had a very low yield and abnormal Doppler findings were almost always associated with clinical symptoms of TIPS dysfunction.PMID:33380530 (Source: The Netherlands Journal of Medicine)
Source: The Netherlands Journal of Medicine - December 31, 2020 Category: General Medicine Authors: K de Wit O M van Delden U Beuers R B Takkenberg Source Type: research

A healthcare failure mode and effect analysis to optimise the process of blood culture performance
CONCLUSIONS: The analysis provided useful insight into the different steps in the logistics of blood culture performance and facilitated the organisation of actions focused on addressing the most urgent root causes.PMID:33380531 (Source: The Netherlands Journal of Medicine)
Source: The Netherlands Journal of Medicine - December 31, 2020 Category: General Medicine Authors: F V van Daalen M Smeulers E J H Bartels F Holleman C E Visser S E Geerlings Source Type: research

Intraperitoneal treatment for advanced ovarian cancer, the Dutch experience. What did we learn?
CONCLUSION: In daily practice, 54% of patients with advanced OC could complete all scheduled cycles of iv/ ip chemotherapy with acceptable morbidity and toxicity, leading to outcomes comparable with the results of published trials on iv/ip chemotherapy.PMID:33380532 (Source: The Netherlands Journal of Medicine)
Source: The Netherlands Journal of Medicine - December 31, 2020 Category: General Medicine Authors: M J A Rietveld J van der Velden A M Westermann W J van Driel G S Sonke P O Witteveen F K Ploos van Amstel L F A G Massuger P B Ottevanger Source Type: research

Prediction admission in the older population in the Emergency Department: the CLEARED tool
CONCLUSIONS: The developed CLEARED tool reliably predicts admission in elderly patients visiting the ED. It is a promising prompt, although further research is needed to implement the tool and to investigate the benefits in terms of reduction of crowding and LOS in the ED.PMID:33380533 (Source: The Netherlands Journal of Medicine)
Source: The Netherlands Journal of Medicine - December 31, 2020 Category: General Medicine Authors: A Brink J Alsma H S Brink J de Gelder J A Lucke S P Mooijaart R Zietse S C E Schuit H F Lingsma Source Type: research

Liver stiffness improvement in hepatitis C patients after successful treatment
CONCLUSION: Liver stiffness improves significantly after successful direct-acting antiviral agent treatment in chronic hepatitis C patients with advanced fibrosis or cirrhosis prior to DAA treatment. Long-term outcomes regarding occurrence of hepatocellular carcinoma (HCC) in these patients are required to determine whether they can be safely discharged from HCC surveillance.PMID:33380534 (Source: The Netherlands Journal of Medicine)
Source: The Netherlands Journal of Medicine - December 31, 2020 Category: General Medicine Authors: S M Brakenhoff M L Verburgh S B Willemse L C Baak K Brinkman M van der Valk Source Type: research

Fendrix ® compared to Engerix® in HIV-infected patients nonresponding to initial- and re-vaccination schedule
CONCLUSION: These results together, suggest that continuing HBV vaccination in non-responders to a first course of single-dose vaccine and a double-dose revaccination scheme is worth the effort. No superiority of one of the investigated hepatitis B vaccines was shown in this cohort but an appropriate number of patients needed to achieve reliable answers was not achieved.PMID:33380535 (Source: The Netherlands Journal of Medicine)
Source: The Netherlands Journal of Medicine - December 31, 2020 Category: General Medicine Authors: T E M S de Vries-Sluijs E R Andrinopoulou R A de Man M E van der Ende Source Type: research

Brain lesions in a patient with rectal cancer: mind your step
We present a patient on long-term immunosuppressive therapy after kidney transplantation and a recent history of oligometastatic rectal cancer, with cerebral lesions as a result of toxoplasmosis. Heightened awareness of the occurrence of opportunistic infections in patients with cancer who are taking immunosuppressive drugs is needed among clinicians.PMID:33380536 (Source: The Netherlands Journal of Medicine)
Source: The Netherlands Journal of Medicine - December 31, 2020 Category: General Medicine Authors: P Mohammadi M A Heitbrink J F P Wagenaar M P Hendriks Source Type: research

Renal insufficiency due to an orthohantavirus infection in the north of the Netherlands
We describe a patient with an orthohantavirus infection in the north of the Netherlands. Orthohantavirus cases in the Netherlands are rare and most cases occur in the east of the Netherlands. Orthohantavirus infections should be included in the differential diagnosis in travellers and non-travellers, and patients from areas other than the east of the Netherlands if flu-like symptoms and acute renal insufficiency are present.PMID:33380537 (Source: The Netherlands Journal of Medicine)
Source: The Netherlands Journal of Medicine - December 31, 2020 Category: General Medicine Authors: L de Wolff S Vogels G I Andriesse I N Vlasveld Source Type: research

An uncommon side effect of thiamazole treatment in Graves' disease
Neth J Med. 2020 Dec;78(6):389-391.ABSTRACTThionamides (such as thiamazole/methimazole) are a common first line treatment for Graves' disease. Common side effects include rash, urticaria, and arthralgia. However, thionamide treatment has also been associated with a variety of auto-immune syndromes. Here, we describe a patient presenting with mild arthritis after starting thiamazole. Although severe presentation warrants acute withdrawal of the causative agent, our case suggests that milder forms can be successfully treated with anti-inflammatory drugs alone. Recognition of the syndrome is key to warrant timely and effectiv...
Source: The Netherlands Journal of Medicine - December 31, 2020 Category: General Medicine Authors: D van Moorsel R F Tummers-de Lind van Wijngaarden Source Type: research

Hypokalaemia and peripheral oedema in a Cushingoid patient with metastatic prostate cancer
This report describes a case of Cushing's syndrome that was probably caused by ectopic ACTH secretion by a LCNEC of the prostate.PMID:33380539 (Source: The Netherlands Journal of Medicine)
Source: The Netherlands Journal of Medicine - December 31, 2020 Category: General Medicine Authors: L M Schepers J M H Kisters C Wetzels G J Creemers Source Type: research

An impressive chest X-ray …
Neth J Med. 2020 Dec;78(6):392.NO ABSTRACTPMID:33380540 (Source: The Netherlands Journal of Medicine)
Source: The Netherlands Journal of Medicine - December 31, 2020 Category: General Medicine Authors: J Heidt E M van Keulen A E C A B Willemsen J M W van Haarst Source Type: research

Answer to Photoquiz An impressive chest X-ray …
Neth J Med. 2020 Dec;78(6):393-394.NO ABSTRACTPMID:33380541 (Source: The Netherlands Journal of Medicine)
Source: The Netherlands Journal of Medicine - December 31, 2020 Category: General Medicine Authors: J Heidt E M van Keulen A E C A B Willemsen J M W van Haarst Source Type: research