Cross-strata co-occurrence of ripples with theta-frequency oscillations in the hippocampus of foraging rats
J Physiol. 2024 Apr 23. doi: 10.1113/JP284629. Online ahead of print.ABSTRACTBrain rhythms have been postulated to play central roles in animal cognition. A prominently reported dichotomy of hippocampal rhythms links theta-frequency oscillations (4-12 Hz) and ripples (120-250 Hz) exclusively to preparatory and consummatory behaviours, respectively. However, because of the differential power expression of these two signals across hippocampal strata, such exclusivity requires validation through analyses of simultaneous multi-strata recordings. We assessed co-occurrence of theta-frequency oscillations with ripples in multi-ch...
Source: The Journal of Physiology - April 24, 2024 Category: Physiology Authors: Pavithraa Seenivasan Reshma Basak Rishikesh Narayanan Source Type: research
Learning-induced bidirectional enhancement of inhibitory synaptic metaplasticity
J Physiol. 2024 Apr 23. doi: 10.1113/JP284761. Online ahead of print.ABSTRACTTraining rodents in a particularly difficult olfactory-discrimination (OD) task results in the acquisition of the ability to perform the task well, termed 'rule learning'. In addition to enhanced intrinsic excitability and synaptic excitation in piriform cortex pyramidal neurons, rule learning results in increased synaptic inhibition across the whole cortical network to the point where it precisely maintains the balance between inhibition and excitation. The mechanism underlying such precise inhibitory enhancement remains to be explored. Here, we ...
Source: The Journal of Physiology - April 24, 2024 Category: Physiology Authors: Sankhanava Kundu Blesson Paul Iris Reuevni Raphael Lamprecht Edi Barkai Source Type: research
The complex nature of skeletal muscle fatigue: Understanding the interaction of metabolic stress and membrane excitability
J Physiol. 2024 Apr 23. doi: 10.1113/JP286454. Online ahead of print.NO ABSTRACTPMID:38654603 | DOI:10.1113/JP286454 (Source: The Journal of Physiology)
Source: The Journal of Physiology - April 24, 2024 Category: Physiology Authors: Jeppe Blichfeldt Winther Jesper Emil Jakobsgaard Source Type: research
Nitrergic inhibition of sympathetic arteriolar constrictions in the female rodent urethra
J Physiol. 2024 Apr 24. doi: 10.1113/JP285583. Online ahead of print.ABSTRACTDuring the urine storage phase, tonically contracting urethral musculature would have a higher energy consumption than bladder muscle that develops phasic contractions. However, ischaemic dysfunction is less prevalent in the urethra than in the bladder, suggesting that urethral vasculature has intrinsic properties ensuring an adequate blood supply. Diameter changes in rat or mouse urethral arterioles were measured using a video-tracking system. Intercellular Ca2+ dynamics in arteriolar smooth muscle (SMCs) and endothelial cells were visualised usi...
Source: The Journal of Physiology - April 24, 2024 Category: Physiology Authors: Hikaru Hashitani Retsu Mitsui Yuuna Hirai Hidekazu Tanaka Kyoko Miwa-Nishimura Source Type: research
Alterations in skeletal muscle morphology related to impaired mechanical efficiency in immobile older adults
J Physiol. 2024 Apr 22. doi: 10.1113/JP286525. Online ahead of print.NO ABSTRACTPMID:38650455 | DOI:10.1113/JP286525 (Source: The Journal of Physiology)
Source: The Journal of Physiology - April 23, 2024 Category: Physiology Authors: Ever Espino-Gonzalez Caio Yogi Yonamine Source Type: research
Relocating coincidence detection for associative learning
J Physiol. 2024 Apr 23. doi: 10.1113/JP286472. Online ahead of print.NO ABSTRACTPMID:38652560 | DOI:10.1113/JP286472 (Source: The Journal of Physiology)
Source: The Journal of Physiology - April 23, 2024 Category: Physiology Authors: Katharina Bergmann Andrew C Lin Source Type: research
Response to a Letter to the Editor: Physiological and pathophysiological roles of the KCNK3 potassium channel in the pulmonary circulation and the heart
J Physiol. 2024 Apr 22. doi: 10.1113/JP286650. Online ahead of print.NO ABSTRACTPMID:38648379 | DOI:10.1113/JP286650 (Source: The Journal of Physiology)
Source: The Journal of Physiology - April 22, 2024 Category: Physiology Authors: Ana ïs Saint-Martin Willer V éronique Capuano David Montani Fabrice Antigny Source Type: research
Piezo1 stretch-activated channel activity differs between murine bone marrow-derived and cardiac tissue-resident macrophages
This study explores the activity of mechanosensitive ion channels (MSC) in murine MΦBM and compares it to MSC activity in MΦ enzymatically isolated from cardiac tissue (tissue-resident MΦ; MΦTR). We show that MΦBM and MΦTR have stretch-induced currents, indicating the presence of functional MSC in their plasma membrane. The current profiles in MΦBM and in MΦTR show characteristics of cation non-selective MSC such as Piezo1 or transient receptor potential channels. While Piezo1 ion channel activity is detectable in the plasma membrane of MΦBM using the patch-clamp technique, or by measuring cytosolic calcium concen...
Source: The Journal of Physiology - April 20, 2024 Category: Physiology Authors: Ana Simon-Chica Alexander Klesen Ramona Emig Andy Chan Joachim Greiner Dominic Gr ün Achim Lother Ingo Hilgendorf Eva A Rog-Zielinska Ursula Ravens Peter Kohl Franziska Schneider-Warme R émi Peyronnet Source Type: research
Investigating the effects of dopamine on short- and long-latency afferent inhibition
This study increases our understanding of the pharmacological mechanism of SAI and LAI.PMID:38638084 | DOI:10.1113/JP286126 (Source: The Journal of Physiology)
Source: The Journal of Physiology - April 19, 2024 Category: Physiology Authors: Stevie D Foglia Faith C Adams Karishma R Ramdeo Chloe C Drapeau Claudia V Turco Mark Tarnopolsky Jinhui Ma Aimee J Nelson Source Type: research
Delta like 4 regulates cerebrovascular development and endothelial integrity via DLL4-NOTCH-CLDN5 pathway and is vulnerable to neonatal hyperoxia
J Physiol. 2024 Apr 17. doi: 10.1113/JP285716. Online ahead of print.ABSTRACTThe mechanisms governing brain vascularization during development remain poorly understood. A key regulator of developmental vascularization is delta like 4 (DLL4), a Notch ligand prominently expressed in endothelial cells (EC). Exposure to hyperoxia in premature infants can disrupt the development and functions of cerebral blood vessels and lead to long-term cognitive impairment. However, its role in cerebral vascular development and the impact of postnatal hyperoxia on DLL4 expression in mouse brain EC have not been explored. We determined the D...
Source: The Journal of Physiology - April 18, 2024 Category: Physiology Authors: Xingrao Ke Sheng Xia Wei Yu Sherry Mabry Qi Fu Heather L Menden Venkatesh Sampath Robert H Lane Source Type: research
Uterine artery dysfunction in hypoxic pregnancy: a mitochondrial perspective
J Physiol. 2024 Apr 18. doi: 10.1113/JP286475. Online ahead of print.NO ABSTRACTPMID:38635337 | DOI:10.1113/JP286475 (Source: The Journal of Physiology)
Source: The Journal of Physiology - April 18, 2024 Category: Physiology Authors: Krisha H Avalani Noah D Patterson Kevin O Murray Source Type: research
Delta like 4 regulates cerebrovascular development and endothelial integrity via DLL4-NOTCH-CLDN5 pathway and is vulnerable to neonatal hyperoxia
J Physiol. 2024 Apr 17. doi: 10.1113/JP285716. Online ahead of print.ABSTRACTThe mechanisms governing brain vascularization during development remain poorly understood. A key regulator of developmental vascularization is delta like 4 (DLL4), a Notch ligand prominently expressed in endothelial cells (EC). Exposure to hyperoxia in premature infants can disrupt the development and functions of cerebral blood vessels and lead to long-term cognitive impairment. However, its role in cerebral vascular development and the impact of postnatal hyperoxia on DLL4 expression in mouse brain EC have not been explored. We determined the D...
Source: The Journal of Physiology - April 18, 2024 Category: Physiology Authors: Xingrao Ke Sheng Xia Wei Yu Sherry Mabry Qi Fu Heather L Menden Venkatesh Sampath Robert H Lane Source Type: research
Uterine artery dysfunction in hypoxic pregnancy: a mitochondrial perspective
J Physiol. 2024 Apr 18. doi: 10.1113/JP286475. Online ahead of print.NO ABSTRACTPMID:38635337 | DOI:10.1113/JP286475 (Source: The Journal of Physiology)
Source: The Journal of Physiology - April 18, 2024 Category: Physiology Authors: Krisha H Avalani Noah D Patterson Kevin O Murray Source Type: research
Marr's three levels of analysis are useful as a framework for neuroscience
J Physiol. 2024 Apr 16. doi: 10.1113/JP279549. Online ahead of print.NO ABSTRACTPMID:38628044 | DOI:10.1113/JP279549 (Source: The Journal of Physiology)
Source: The Journal of Physiology - April 17, 2024 Category: Physiology Authors: M áté Lengyel Source Type: research
Cross Talk opposing view: Marr's three levels of analysis are not useful as a framework for neuroscience
J Physiol. 2024 Apr 16. doi: 10.1113/JP279550. Online ahead of print.NO ABSTRACTPMID:38628062 | DOI:10.1113/JP279550 (Source: The Journal of Physiology)
Source: The Journal of Physiology - April 17, 2024 Category: Physiology Authors: Jonathan W Pillow Source Type: research
