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Increased prevalence of germline pathogenic CHEK2 variants in individuals with pituitary adenomas
CONCLUSIONS: This is the first study to suggest a role for the breast cancer predisposition gene, CHEK2, in pituitary tumorigenesis, with pathogenic/likely pathogenic variants found in 3% of patients with pituitary adenomas. As pituitary adenomas are relatively common and typically lack classical autosomal dominant family histories, risk alleles - such as these variants found in CHEK2 - might be a significant contributor to pituitary adenoma risk in the general population.PMID:38651569 | DOI:10.1210/clinem/dgae268 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 23, 2024 Category: Endocrinology Authors: Sunita M C De Sousa Ann McCormack Andreas Orsmond Angeline Shen Christopher J Yates Roderick Clifton-Bligh Stephen Santoreneos James King Jinghua Feng John Toubia David J Torpy Hamish S Scott Source Type: research

Medullary Thyroid Cancer: Single Institute Experience over Three Decades and Risk Factors for Recurrence
CONCLUSION: One of 4 patients undergoing surgery for MTC will recur. Risk factors associated with recurrence are male gender, lateral LN metastasis and high/highest MTC risk level mutations, but not necessarily surgery type. Preoperative calcitonin>2,175 pg/mL is suggestive of advanced disease and should prompt further evaluation.PMID:38651609 | DOI:10.1210/clinem/dgae279 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 23, 2024 Category: Endocrinology Authors: Sara Abou Azar Joseph Tobias Megan Applewhite Peter Angelos Xavier M Keutgen Source Type: research

Approach to the patient: Concept and application of targeted radiotherapy in the paraganglioma patient
J Clin Endocrinol Metab. 2024 Apr 23:dgae252. doi: 10.1210/clinem/dgae252. Online ahead of print.ABSTRACTParagangliomas can metastasize, posing potential challenges in both symptomatic management and disease control. Systemic targeted radiotherapies using 131I-MIBG and 177Lu-DOTATATE are a mainstay in the treatment of metastatic paragangliomas. This clinical scenario and discussion aim to enhance physicians' knowledge of the stepwise approach to treat these patients with paraganglioma targeted radiotherapies. It comprehensively discusses current approaches to selecting paraganglioma patients for targeted radiotherapies and...
Source: The Journal of Clinical Endocrinology and Metabolism - April 23, 2024 Category: Endocrinology Authors: Karel Pacak David Taieb Frank I Lin Abhishek Jha Source Type: research

SHBG gene polymorphisms and their influence on serum SHBG, total and free testosterone concentrations in men
CONCLUSION: In these men, analyzed SNPs were relatively prevalent and affected serum concentrations of total T and SHBG but not calculated or measured free T except for a higher trend in rs6259 homozygotes.PMID:38652149 | DOI:10.1210/clinem/dgae280 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 23, 2024 Category: Endocrinology Authors: Joeri Walravens Bas Sleumer Michel J Vos Gido Snaterse Nick Narinx Leen Antonio Tim Reyns Tom Fiers Ido P Kema Jean-Marc Kaufman Nico C van de Merbel Bruno Lapauw Source Type: research

Dipeptidyl peptidase 4 inhibitors vs. metformin for new-onset dementia: a propensity score-matched cohort study
CONCLUSION: In this real-world study, we found that DPP4 inhibitors presented an association with a lower risk of dementia in individuals with type 2 diabetes than metformin, particularly in older people and those without diabetes-related comorbidities.PMID:38652239 | DOI:10.1210/clinem/dgae281 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 23, 2024 Category: Endocrinology Authors: Siyang Liu Heng Wan Sheng Nie Huanyi Cao Lan Liu Hua Liang Hong Xu Bicheng Liu Chunbo Chen Huafeng Liu Qiongqiong Yang Hua Li Yaozhong Kong Guisen Li Qijun Wan Yan Zha Ying Hu Gang Xu Yongjun Shi Yilun Zhou Guobin Su Ying Tang Mengchun Gong Aixin Guo Jian Source Type: research

Correction to: "Increased Risk of Vertebral Fractures in Patients With Mild Autonomous Cortisol Secretion"
J Clin Endocrinol Metab. 2024 Apr 22:dgae246. doi: 10.1210/clinem/dgae246. Online ahead of print.NO ABSTRACTPMID:38648187 | DOI:10.1210/clinem/dgae246 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 22, 2024 Category: Endocrinology Source Type: research

Hemostatic Effects of Exercise-Related Hypoglycemia in Male Persons With Type 1 Diabetes
CONCLUSION: Individuals with T1D exhibit a hypercoagulable hemostatic profile compared to healthy controls and exercise-related hypoglycemia may increase the susceptibility to thrombosis via both procoagulant and antifibrinolytic effects.PMID:38642404 | DOI:10.1210/clinem/dgae278 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 20, 2024 Category: Endocrinology Authors: Per Gustav Hagelqvist Andreas Andersen Kaisar Maytham Christine Rode Andreasen Susanne Engberg Ulrik Pedersen-Bjergaard Julie Lyng Forman P är Johansson Jens Lykkesfeldt Filip Krag Knop Tina Vilsb øll Source Type: research

Genetic underpinnings of fasting and oral glucose-stimulated based insulin sensitivity indices
CONCLUSION: Even though the IS indices mostly share a common genetic background, notable differences emerged between OGTT0,120 indices. The fasting and OGTT based indices have distinct associations with T2D risk variants. This work provides a basis for future large-scale genetic investigations into the differences between IS indices.PMID:38635292 | DOI:10.1210/clinem/dgae275 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 18, 2024 Category: Endocrinology Authors: Sufyan Suleman Anne L Madsen Lars H Ängquist Mikkel Schubert Allan Linneberg Ruth J F Loos Torben Hansen Niels Grarup Source Type: research

Obesity, Inflammation, and Clinical Outcomes in COVID-19: A Multicenter Prospective Cohort Study
CONCLUSION: Obesity is associated with worse outcomes in COVID-19, notably in younger participants and in the pre-Omicron era. Inflammation, as measured by suPAR, is a significant mediator of the association between obesity and COVID-19 outcomes.PMID:38635301 | DOI:10.1210/clinem/dgae273 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 18, 2024 Category: Endocrinology Authors: Christina G Hutten Kishan Padalia Alexi Vasbinder Yiyuan Huang Anis Ismail Ian Pizzo Kristen Machado Diaz Tonimarie Catalan Feriel Presswalla Elizabeth Anderson Grace Erne Brayden Bitterman Pennelope Blakely Evangelos J Giamarellos-Bourboulis Sven H Loose Source Type: research

Effects of hypertriglyceridemia with or without NEFA elevation on β-cell function and insulin clearance and sensitivity
CONCLUSION: In healthy non-obese subjects, mild acute hypertriglyceridemia directly reduces glucose tolerance, insulin sensitivity and clearance, and has selective and opposite effects on β-cell function that are neutralized by NEFAs. These findings provide new insight into plausible biological signals that generate and sustain insulin resistance and chronic hyperinsulinemia in the development of T2D.PMID:38635405 | DOI:10.1210/clinem/dgae276 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 18, 2024 Category: Endocrinology Authors: Domenico Tric ò Eleni Rebelos Brenno Astiarraga Simona Baldi Tiziana Scozzaro Luca Sacchetta Martina Chiriac ò Andrea Mari Ele Ferrannini Elza Muscelli Andrea Natali Source Type: research

Expression of bile acid receptors and transporters along the intestine of patients with type 2 diabetes and controls
CONCLUSIONS: We demonstrate distinct expression patterns of bile acid transporters and receptors through the intestinal tract with signs of reduced ASBT, OSTα/β, FXR and FGF19 mRNAs in T2D.PMID:38636096 | DOI:10.1210/clinem/dgae261 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 18, 2024 Category: Endocrinology Authors: Henriette H Nerild Hannah Gilliam-Vigh Anne-Marie Ellegaard Julie L Forman Tina Vilsb øll David P Sonne Andreas Br ønden Filip K Knop Source Type: research

LDL-C and TC mediate the risk of PNPLA3 inhibition on cardiovascular diseases
CONCLUSION: This study suggests that PNPLA3 inhibition increases the risk of major CVDs. Moreover, blood LDL-C and TC may mediate a significant proportion of the associations between PNPLA3 inhibition and coronary atherosclerosis, coronary heart disease, or myocardial infarction.PMID:38636099 | DOI:10.1210/clinem/dgae264 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 18, 2024 Category: Endocrinology Authors: Genshan Zhang Wei Jiang Fangxun He Jie Fu Xiangshang Xu Xuelai Luo Zhixin Cao Source Type: research

Growth and Adult Height Attainment in Danish Transgender Adolescents Treated with GnRH Analog and Sex Hormones
CONCLUSION: The minor reduction in adult height of trans girls after hormone treatment may be beneficial to some, whereas trans boys did not experience height gain.PMID:38627922 | DOI:10.1210/clinem/dgae263 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 17, 2024 Category: Endocrinology Authors: Pernille Badsberg Norup Mette Ewers Haahr Peter Christiansen Lise Aksglaede Line Cleemann Trine Holm Johannsen Anders Juul Katharina M Main Source Type: research

Letter to the Editor from A.H. Jan Danser and Ingrid M. Garrelds: The clinical impact of sample storage at -20 °C on renin reference intervals and aldosterone-renin ratio calculations
J Clin Endocrinol Metab. 2024 Apr 17:dgae243. doi: 10.1210/clinem/dgae243. Online ahead of print.NO ABSTRACTPMID:38629832 | DOI:10.1210/clinem/dgae243 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 17, 2024 Category: Endocrinology Authors: A H Jan Danser Ingrid M Garrelds Source Type: research

Approach to the Neonate with Hypoglycemia
J Clin Endocrinol Metab. 2024 Apr 17:dgae267. doi: 10.1210/clinem/dgae267. Online ahead of print.ABSTRACTAfter birth, healthy neonates undergo a period of altered glucose metabolism, known as "transitional hypoglycemia". During the first 0-4 hours of life, the mean plasma glucose concentration decreases to 57 mg/dL, then by 72-96 hours of life increases to 82 mg/dL, well within the normal adult range. Recent data suggests that transitional hypoglycemia is due to persistence of the fetal beta cell's lower threshold for insulin release, resulting in a transient hyperinsulinemic state. While hypoglycemia is an expected part o...
Source: The Journal of Clinical Endocrinology and Metabolism - April 17, 2024 Category: Endocrinology Authors: Katherine Lord Diva D De Le ón Source Type: research