The International Journal of Biochemistry and Cell Biology 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.The inositol-requiring enzyme 1 (IRE1) endoplasmic reticulum stress pathway promotes MDA-MB-231 cell survival and renewal in response to the aryl-ureido fatty acid CTU
Int J Biochem Cell Biol. 2024 Apr 11;171:106571. doi: 10.1016/j.biocel.2024.106571. Online ahead of print.ABSTRACTCurrent treatment options for triple-negative breast cancer (TNBC) are limited to toxic drug combinations of low efficacy. We recently identified an aryl-substituted fatty acid analogue, termed CTU, that effectively killed TNBC cells in vitro and in mouse xenograft models in vivo without producing toxicity. However, there was a residual cell population that survived treatment. The present study evaluated the mechanisms that underlie survival and renewal in CTU-treated MDA-MB-231 TNBC cells. RNA-seq profiling id...
Source: The International Journal of Biochemistry and Cell Biology - April 12, 2024 Category: Biochemistry Authors: Md Khalilur Rahman Balasubrahmanyam Umashankar Hassan Choucair Kirsi Bourget Tristan Rawling Michael Murray Source Type: research
The inositol-requiring enzyme 1 (IRE1) endoplasmic reticulum stress pathway promotes MDA-MB-231 cell survival and renewal in response to the aryl-ureido fatty acid CTU
Int J Biochem Cell Biol. 2024 Apr 11;171:106571. doi: 10.1016/j.biocel.2024.106571. Online ahead of print.ABSTRACTCurrent treatment options for triple-negative breast cancer (TNBC) are limited to toxic drug combinations of low efficacy. We recently identified an aryl-substituted fatty acid analogue, termed CTU, that effectively killed TNBC cells in vitro and in mouse xenograft models in vivo without producing toxicity. However, there was a residual cell population that survived treatment. The present study evaluated the mechanisms that underlie survival and renewal in CTU-treated MDA-MB-231 TNBC cells. RNA-seq profiling id...
Source: The International Journal of Biochemistry and Cell Biology - April 12, 2024 Category: Biochemistry Authors: Md Khalilur Rahman Balasubrahmanyam Umashankar Hassan Choucair Kirsi Bourget Tristan Rawling Michael Murray Source Type: research
The inositol-requiring enzyme 1 (IRE1) endoplasmic reticulum stress pathway promotes MDA-MB-231 cell survival and renewal in response to the aryl-ureido fatty acid CTU
Int J Biochem Cell Biol. 2024 Apr 10:106571. doi: 10.1016/j.biocel.2024.106571. Online ahead of print.ABSTRACTCurrent treatment options for triple-negative breast cancer (TNBC) are limited to toxic drug combinations of low efficacy. We recently identified an aryl-substituted fatty acid analogue, termed CTU, that effectively killed TNBC cells in vitro and in mouse xenograft models in vivo without producing toxicity. However, there was a residual cell population that survived treatment. The present study evaluated the mechanisms that underlie survival and renewal in CTU-treated MDA-MB-231 TNBC cells. RNA-seq profiling identi...
Source: The International Journal of Biochemistry and Cell Biology - April 12, 2024 Category: Biochemistry Authors: Md Khalilur Rahman Balasubrahmanyam Umashankar Hassan Choucair Kirsi Bourget Tristan Rawling Michael Murray Source Type: research
The inositol-requiring enzyme 1 (IRE1) endoplasmic reticulum stress pathway promotes MDA-MB-231 cell survival and renewal in response to the aryl-ureido fatty acid CTU
Int J Biochem Cell Biol. 2024 Apr 10:106571. doi: 10.1016/j.biocel.2024.106571. Online ahead of print.ABSTRACTCurrent treatment options for triple-negative breast cancer (TNBC) are limited to toxic drug combinations of low efficacy. We recently identified an aryl-substituted fatty acid analogue, termed CTU, that effectively killed TNBC cells in vitro and in mouse xenograft models in vivo without producing toxicity. However, there was a residual cell population that survived treatment. The present study evaluated the mechanisms that underlie survival and renewal in CTU-treated MDA-MB-231 TNBC cells. RNA-seq profiling identi...
Source: The International Journal of Biochemistry and Cell Biology - April 12, 2024 Category: Biochemistry Authors: Md Khalilur Rahman Balasubrahmanyam Umashankar Hassan Choucair Kirsi Bourget Tristan Rawling Michael Murray Source Type: research
The inositol-requiring enzyme 1 (IRE1) endoplasmic reticulum stress pathway promotes MDA-MB-231 cell survival and renewal in response to the aryl-ureido fatty acid CTU
Int J Biochem Cell Biol. 2024 Apr 10:106571. doi: 10.1016/j.biocel.2024.106571. Online ahead of print.ABSTRACTCurrent treatment options for triple-negative breast cancer (TNBC) are limited to toxic drug combinations of low efficacy. We recently identified an aryl-substituted fatty acid analogue, termed CTU, that effectively killed TNBC cells in vitro and in mouse xenograft models in vivo without producing toxicity. However, there was a residual cell population that survived treatment. The present study evaluated the mechanisms that underlie survival and renewal in CTU-treated MDA-MB-231 TNBC cells. RNA-seq profiling identi...
Source: The International Journal of Biochemistry and Cell Biology - April 12, 2024 Category: Biochemistry Authors: Md Khalilur Rahman Balasubrahmanyam Umashankar Hassan Choucair Kirsi Bourget Tristan Rawling Michael Murray Source Type: research
INHBA regulates Hippo signaling to confer 5-FU chemoresistance mediated by cellular senescence in colon cancer cells
This study intended to investigate mechanisms of INHBA (inhibin A) in 5-FU resistance mediated by cellular senescence in colon cancer. Bioinformatics analysis of INHBA expression in colon cancer tissues, survival analysis, and correlation analysis of cellular senescence markers were performed. The effects of INHBA on the biological characteristics and 5-FU resistance of colon cancer cells were examined through loss/gain-of-function and molecular assays. Finally, a xenograft mouse model was built to validate the mechanism of INHBA in vivo. INHBA was upregulated in colon cancer and was significantly positively correlated wit...
Source: The International Journal of Biochemistry and Cell Biology - April 8, 2024 Category: Biochemistry Authors: Zhan Zhang Lili Chen Qiao Yang Xiaowan Tang Jianhua Li Guangwen Zhang Youqun Wang Hui Huang Source Type: research
INHBA regulates Hippo signaling to confer 5-FU chemoresistance mediated by cellular senescence in colon cancer cells
This study intended to investigate mechanisms of INHBA (inhibin A) in 5-FU resistance mediated by cellular senescence in colon cancer. Bioinformatics analysis of INHBA expression in colon cancer tissues, survival analysis, and correlation analysis of cellular senescence markers were performed. The effects of INHBA on the biological characteristics and 5-FU resistance of colon cancer cells were examined through loss/gain-of-function and molecular assays. Finally, a xenograft mouse model was built to validate the mechanism of INHBA in vivo. INHBA was upregulated in colon cancer and was significantly positively correlated wit...
Source: The International Journal of Biochemistry and Cell Biology - April 8, 2024 Category: Biochemistry Authors: Zhan Zhang Lili Chen Qiao Yang Xiaowan Tang Jianhua Li Guangwen Zhang Youqun Wang Hui Huang Source Type: research
INHBA regulates Hippo signaling to confer 5-FU chemoresistance mediated by cellular senescence in colon cancer cells
This study intended to investigate mechanisms of INHBA (inhibin A) in 5-FU resistance mediated by cellular senescence in colon cancer. Bioinformatics analysis of INHBA expression in colon cancer tissues, survival analysis, and correlation analysis of cellular senescence markers were performed. The effects of INHBA on the biological characteristics and 5-FU resistance of colon cancer cells were examined through loss/gain-of-function and molecular assays. Finally, a xenograft mouse model was built to validate the mechanism of INHBA in vivo. INHBA was upregulated in colon cancer and was significantly positively correlated wit...
Source: The International Journal of Biochemistry and Cell Biology - April 8, 2024 Category: Biochemistry Authors: Zhan Zhang Lili Chen Qiao Yang Xiaowan Tang Jianhua Li Guangwen Zhang Youqun Wang Hui Huang Source Type: research
INHBA regulates Hippo signaling to confer 5-FU chemoresistance mediated by cellular senescence in colon cancer cells
This study intended to investigate mechanisms of INHBA (inhibin A) in 5-FU resistance mediated by cellular senescence in colon cancer. Bioinformatics analysis of INHBA expression in colon cancer tissues, survival analysis, and correlation analysis of cellular senescence markers were performed. The effects of INHBA on the biological characteristics and 5-FU resistance of colon cancer cells were examined through loss/gain-of-function and molecular assays. Finally, a xenograft mouse model was built to validate the mechanism of INHBA in vivo. INHBA was upregulated in colon cancer and was significantly positively correlated wit...
Source: The International Journal of Biochemistry and Cell Biology - April 8, 2024 Category: Biochemistry Authors: Zhan Zhang Lili Chen Qiao Yang Xiaowan Tang Jianhua Li Guangwen Zhang Youqun Wang Hui Huang Source Type: research
Mitochondrial regulation of diabetic endothelial dysfunction: Pathophysiological links
Int J Biochem Cell Biol. 2024 Mar 30;170:106569. doi: 10.1016/j.biocel.2024.106569. Online ahead of print.ABSTRACTMicro- and macrovascular complications frequently occur in patients with diabetes, with endothelial dysfunction playing a key role in the development and progression of the complications. For the early diagnosis and optimal treatment of vascular complications associated with diabetes, it is imperative to comprehend the cellular and molecular mechanisms governing the function of diabetic endothelial cells. Mitochondria function as crucial sensors of environmental and cellular stress regulating endothelial cell v...
Source: The International Journal of Biochemistry and Cell Biology - March 31, 2024 Category: Biochemistry Authors: Xinyi Fang Yanjiao Zhang Haoran Wu Han Wang Runyu Miao Jiahua Wei Yuxin Zhang Jiaxing Tian Xiaolin Tong Source Type: research
Mitochondrial regulation of diabetic endothelial dysfunction: Pathophysiological links
Int J Biochem Cell Biol. 2024 Mar 30;170:106569. doi: 10.1016/j.biocel.2024.106569. Online ahead of print.ABSTRACTMicro- and macrovascular complications frequently occur in patients with diabetes, with endothelial dysfunction playing a key role in the development and progression of the complications. For the early diagnosis and optimal treatment of vascular complications associated with diabetes, it is imperative to comprehend the cellular and molecular mechanisms governing the function of diabetic endothelial cells. Mitochondria function as crucial sensors of environmental and cellular stress regulating endothelial cell v...
Source: The International Journal of Biochemistry and Cell Biology - March 31, 2024 Category: Biochemistry Authors: Xinyi Fang Yanjiao Zhang Haoran Wu Han Wang Runyu Miao Jiahua Wei Yuxin Zhang Jiaxing Tian Xiaolin Tong Source Type: research
Mitochondrial regulation of diabetic endothelial dysfunction: Pathophysiological links
Int J Biochem Cell Biol. 2024 Mar 30;170:106569. doi: 10.1016/j.biocel.2024.106569. Online ahead of print.ABSTRACTMicro- and macrovascular complications frequently occur in patients with diabetes, with endothelial dysfunction playing a key role in the development and progression of the complications. For the early diagnosis and optimal treatment of vascular complications associated with diabetes, it is imperative to comprehend the cellular and molecular mechanisms governing the function of diabetic endothelial cells. Mitochondria function as crucial sensors of environmental and cellular stress regulating endothelial cell v...
Source: The International Journal of Biochemistry and Cell Biology - March 31, 2024 Category: Biochemistry Authors: Xinyi Fang Yanjiao Zhang Haoran Wu Han Wang Runyu Miao Jiahua Wei Yuxin Zhang Jiaxing Tian Xiaolin Tong Source Type: research
Mitochondrial regulation of diabetic endothelial dysfunction: Pathophysiological links
Int J Biochem Cell Biol. 2024 Mar 30;170:106569. doi: 10.1016/j.biocel.2024.106569. Online ahead of print.ABSTRACTMicro- and macrovascular complications frequently occur in patients with diabetes, with endothelial dysfunction playing a key role in the development and progression of the complications. For the early diagnosis and optimal treatment of vascular complications associated with diabetes, it is imperative to comprehend the cellular and molecular mechanisms governing the function of diabetic endothelial cells. Mitochondria function as crucial sensors of environmental and cellular stress regulating endothelial cell v...
Source: The International Journal of Biochemistry and Cell Biology - March 31, 2024 Category: Biochemistry Authors: Xinyi Fang Yanjiao Zhang Haoran Wu Han Wang Runyu Miao Jiahua Wei Yuxin Zhang Jiaxing Tian Xiaolin Tong Source Type: research
Mitochondrial regulation of diabetic endothelial dysfunction: Pathophysiological links
Int J Biochem Cell Biol. 2024 Mar 30;170:106569. doi: 10.1016/j.biocel.2024.106569. Online ahead of print.ABSTRACTMicro- and macrovascular complications frequently occur in patients with diabetes, with endothelial dysfunction playing a key role in the development and progression of the complications. For the early diagnosis and optimal treatment of vascular complications associated with diabetes, it is imperative to comprehend the cellular and molecular mechanisms governing the function of diabetic endothelial cells. Mitochondria function as crucial sensors of environmental and cellular stress regulating endothelial cell v...
Source: The International Journal of Biochemistry and Cell Biology - March 31, 2024 Category: Biochemistry Authors: Xinyi Fang Yanjiao Zhang Haoran Wu Han Wang Runyu Miao Jiahua Wei Yuxin Zhang Jiaxing Tian Xiaolin Tong Source Type: research
Mitochondrial regulation of diabetic endothelial dysfunction: pathophysiological links
Int J Biochem Cell Biol. 2024 Mar 29:106569. doi: 10.1016/j.biocel.2024.106569. Online ahead of print.ABSTRACTMicro- and macrovascular complications frequently occur in patients with diabetes, with endothelial dysfunction playing a key role in the development and progression of the complications. For the early diagnosis and optimal treatment of vascular complications associated with diabetes, it is imperative to comprehend the cellular and molecular mechanisms governing the function of diabetic endothelial cells. Mitochondria function as crucial sensors of environmental and cellular stress regulating endothelial cell viabi...
Source: The International Journal of Biochemistry and Cell Biology - March 31, 2024 Category: Biochemistry Authors: Xinyi Fang Yanjiao Zhang Haoran Wu Han Wang Runyu Miao Jiahua Wei Yuxin Zhang Jiaxing Tian Xiaolin Tong Source Type: research
