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The pan-liver network theory: From traditional chinese medicine to western medicine
Chin J Physiol. 2023 Nov-Dec;66(6):401-436. doi: 10.4103/cjop.CJOP-D-22-00131.ABSTRACTIn traditional Chinese medicine (TCM), the liver is the "general organ" that is responsible for governing/maintaining the free flow of qi over the entire body and storing blood. According to the classic five elements theory, zang-xiang theory, yin-yang theory, meridians and collaterals theory, and the five-viscera correlation theory, the liver has essential relationships with many extrahepatic organs or tissues, such as the mother-child relationships between the liver and the heart, and the yin-yang and exterior-interior relationships bet...
Source: The Chinese Journal of Physiology - December 27, 2023 Category: Physiology Authors: Yaxing Zhang Xian-Ming Fang Source Type: research

Icariside II suppresses ferroptosis to protect against MPP + -Induced Parkinson's disease through Keap1/Nrf2/GPX4 signaling
Chin J Physiol. 2023 Nov-Dec;66(6):437-445. doi: 10.4103/cjop.CJOP-D-23-00107.ABSTRACTParkinson's disease (PD) is recognized as a degenerative and debilitating neurodegenerative disorder. The novel protective role of icariside II (ICS II) as a plant-derived flavonoid compound in neurodegenerative diseases has aroused much attention. Herein, the definite impacts of ICS II on the process of PD and the relevant action mechanism were studied. Human neuroblastoma SK-N-SH cells were challenged with 1-methyl-4-phenylpyridinium ion (MPP+) to construct the PD cell model. MTT assay and flow cytometry analysis, respectively, appraise...
Source: The Chinese Journal of Physiology - December 27, 2023 Category: Physiology Authors: Wenbo Fan Jianwu Zhou Source Type: research

Impacts of delta 9-tetrahydrocannabinol against myocardial ischemia/reperfusion injury in diabetic rats: Role of PTEN/PI3K/Akt signaling pathway
This study revealed the cardioprotective effects of THC against IR-induced myocardial injury in diabetic rats and also suggested that the mechanism may be associated with enhanced activity of the PI3K/Akt signaling pathway through the reduction of PTEN phosphorylation.PMID:38149557 | DOI:10.4103/cjop.CJOP-D-23-00103 (Source: The Chinese Journal of Physiology)
Source: The Chinese Journal of Physiology - December 27, 2023 Category: Physiology Authors: Xiaohua Zhao Zhao Gao Wenbin Wen Shikang Zheng Source Type: research

Sevoflurane attenuates proliferative and migratory activity of lung cancer cells via mediating the microRNA-100-3p/sterol O-Acyltransferase 1 axis
This article provides a new idea for further study of the pathogenesis of lung cancer.PMID:38149558 | DOI:10.4103/cjop.CJOP-D-22-00124 (Source: The Chinese Journal of Physiology)
Source: The Chinese Journal of Physiology - December 27, 2023 Category: Physiology Authors: Bicheng Fu Fucheng Zhou Jian Zhang Xianglong Kong Boxiong Ni Jianlong Bu Shidong Xu Changjun He Source Type: research

ADAMTS13 inhibits H 2 O 2 -induced human venous endothelial cell injury to attenuate deep-vein thrombosis by blocking the p38/ERK signaling pathway
This study was aimed to explore the role of ADAMTS13 in endothelial cell injury during DVT and the possible mechanism. First, human umbilical vein endothelial cells (HUVECs) were exposed to hydrogen peroxide (H2O2). Then, the mRNA and protein expressions of ADAMTS13 were evaluated with the reverse transcription-quantitative polymerase chain reaction and western blot. After treatment with recombinant ADAMTS13 (rADAMTS13; rA13), the viability and apoptosis of H2O2-induced HUVECs were assessed by cell counting kit-8 assay and terminal-deoxynucleoitidyl transferase-mediated nick end labeling staining. In addition, the levels o...
Source: The Chinese Journal of Physiology - December 27, 2023 Category: Physiology Authors: Guangfeng Zheng Qiang Zhang Chuanyong Li Weijian Fan Zhichang Pan Yuting Zhou Yan Chen Jianjie Rong Source Type: research

Long non-coding RNA LINC00565 regulates ADAM19 expression through sponging microRNA-532-3p, thereby facilitating clear cell renal cell carcinoma progression
In conclusion, LINC00565 upregulated ADAM19 via absorbing miR-532-3p, thereby facilitating the progression of ccRCC cells.PMID:38149560 | DOI:10.4103/cjop.CJOP-D-23-00078 (Source: The Chinese Journal of Physiology)
Source: The Chinese Journal of Physiology - December 27, 2023 Category: Physiology Authors: Bin Meng Pengfei Wang Chaofei Zhao Guangwei Yin Xin Meng Lin Li Shengyong Cai Chengquan Yan Source Type: research

Beta-hydroxy-beta-methylbutyrate supplementation preserves fat-free mass in collegiate boxers during acute body mass loss
This study investigated the effect of HMB supplementation on body composition and sport-specific performance in well-trained boxers consuming a hypocaloric diet. Twelve male college boxers were divided into the HMB and placebo (PLA) groups using a body weight-matched single-blind parallel design. The study comprised a 6-day weight loss period (days 1-6), followed by a 3-day competition period (days 7-9). The participants in both the groups consumed 16 kcal/kg/day, including 1.6-1.7 g/kg of carbohydrates, 1.2-1.3 g/kg of protein, and 0.45-0.5 g/kg of fat during the 9-day period. The HMB group consumed 3 g/day HMB. Body comp...
Source: The Chinese Journal of Physiology - December 27, 2023 Category: Physiology Authors: Chen-Kang Chang Shih-Yen Kao Chung-Yuan Wang Source Type: research

Ophiopogonin D improves oxidative stress and mitochondrial dysfunction in pancreatic β cells induced by hydrogen peroxide through Keap1/Nrf2/ARE pathway in diabetes mellitus
In conclusion, OP-D improves oxidative stress and mitochondrial dysfunction in pancreatic β cells induced by H2O2 through activating Keap1/Nrf2/ARE pathway in DM.PMID:38149562 | DOI:10.4103/cjop.CJOP-D-23-00069 (Source: The Chinese Journal of Physiology)
Source: The Chinese Journal of Physiology - December 27, 2023 Category: Physiology Authors: Hongyan Zhang Xuezhi Kang Jun Ruan Li Ma Wenbo Peng Haonan Shang Bing Wang Yongning Sun Source Type: research

Parkin enhances sensitivity of paclitaxel to nasopharyngeal carcinoma by activating BNIP3/NIX-mediated mitochondrial autophagy
This study was performed to explore the possible mechanism of Parkin related to B-cell lymphoma-2 (Bcl-2)/adenovirus E1B 19 kDa interacting protein 3 (BNIP3)/BNIP3-like (NIX)-mediated mitochondrial autophagy in NPC cells. Initially, after Parkin overexpression or silencing, cell viability and proliferation were evaluated by lactate dehydrogenase and colony formation assays. JC-1 staining was used to assess the mitochondrial membrane potential. In addition, the levels of cellular reactive oxygen species (ROS) and mitochondrial ROS were detected using DCFH-DA staining and mitochondrial ROS (MitoSOX) red staining. The express...
Source: The Chinese Journal of Physiology - December 27, 2023 Category: Physiology Authors: Haifeng Ni Renhui Liu Zhen Zhou Bo Jiang Bin Wang Source Type: research

Irbesartan eases lipopolysaccharide-induced lung injury In Vitro and In Vivo 
Chin J Physiol. 2023 Nov-Dec;66(6):516-525. doi: 10.4103/cjop.CJOP-D-23-00131.ABSTRACTAcute lung injury (ALI) is classified as a devastating pulmonary disorder contributing to significant incidence and fatality rate. Irbesartan (IRB) is an angiotensin II receptor blocker that has been proposed to protect against oleic acid-induced ALI. To this end, the current study is concentrated on ascertaining the role of IRB in ALI and figuring out the probable action mechanism. First, cell counting kit-8 (CCK-8) appraised the viability of human pulmonary microvascular endothelial cells (HPMVECs) exposed to ascending concentrations of...
Source: The Chinese Journal of Physiology - December 27, 2023 Category: Physiology Authors: Zhongyuan Zhang Wei Wang Source Type: research

Effects of electroacupuncture combined with acupoint catgut embedding on gastrointestinal motility and gastrointestinal hormones in rats with functional dyspepsia
Chin J Physiol. 2023 Nov-Dec;66(6):526-533. doi: 10.4103/cjop.CJOP-D-23-00059.ABSTRACTElectroacupuncture (EA) or acupoint catgut embedding (ACE) plays a therapeutic role in functional dyspepsia (FD). Herein, we aimed to elucidate the influences of EA combined with ACE on gastrointestinal motility and gastrointestinal hormones in rats with FD. Sprague-Dawley rats were randomized into the control group, model group, EA group, ACE group, and EA + ACE group (n = 10). Except for the control group, the rats in all groups were modeled by combining neonatal iodoacetamide gastrogavage and modified tail-clamping stimulation. The rat...
Source: The Chinese Journal of Physiology - December 27, 2023 Category: Physiology Authors: Hui Yu Huiqian Deng Wei Zhou Zhenling Liang Source Type: research

Anti-oncogenic mechanism of KLF17 in colon cancer by repressing cell migration and invasion via FHL1 upregulation
This study sought to investigate Kruppel-like factor 17 (KLF17) mechanism in the development of colon cancer through four-and-a-half-LIM domain protein 1 (FHL1). In colon cancer cells, KLF17 and FHL1 expression was detected by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and Western blot. After gain- and loss-of-function experiments in colon cancer cells, cell proliferative, invasive, and migrating abilities were tested by cell counting kit-8, transwell, and scratch assays, respectively. The expression of epithelial-mesenchymal transition (EMT)-related genes, E-cadherin, N-cadherin, and Vimentin, ...
Source: The Chinese Journal of Physiology - December 27, 2023 Category: Physiology Authors: Shengen Yi Ming Luo Yanjin Peng Yong Chen Dan Yu Source Type: research

Long non-coding RNA NBR2 suppresses the progression of colorectal cancer by downregulating miR-19a to regulate M2 macrophage polarization
Chin J Physiol. 2023 Nov-Dec;66(6):546-557. doi: 10.4103/cjop.CJOP-D-23-00064.ABSTRACTColorectal cancer (CRC) is a malignant tumor of the gastrointestinal tract that significantly impacts the health of patients and lacks promising methods of diagnosis. Tumor-associated macrophages (TAMs) are involved in CRC progression, and their function is regulated by long non-coding RNAs (lncRNAs). The lncRNA NBR2 was recently reported as an oncogene, whose function in CRC remains uncertain. The present study aimed to investigate the biological function of lncRNA NBR2 in the progression of CRC and its underlying molecular mechanisms. T...
Source: The Chinese Journal of Physiology - December 27, 2023 Category: Physiology Authors: Xiaoting Yang Ye Luo Mengying Li Zhan Jin Gao Chen Chunchun Gan Source Type: research

The effect of long-term moderate exercise on myocardial metabolome in rats
This study is aimed to investigate the effect of long-term moderate exercise on myocardial metabolome in rats. Thirteen male Sprague-Dawley rats were randomly assigned into the control group (C) and the long-term moderate exercise group (E). The targeted metabolomics of the myocardium was analyzed by ultra-performance liquid chromatography coupled to tandem mass spectrometry (UPLC-MS/MS) system. Results showed that the metabolites categories of bile acids (BAs), fatty acids (FAs), and phenylpropanoic acids were significantly decreased. The biosynthesis of unsaturated FAs pathway was significantly downregulated. The altered...
Source: The Chinese Journal of Physiology - December 27, 2023 Category: Physiology Authors: Zheng Ping Xiao Li Zhang Zi Wen Wang Xue Bin Cao Source Type: research