Optimal Method for Assessing Right Ventricular to Pulmonary Arterial Coupling and Subclinical Right Ventricular Dysfunction in Older Aged Healthy Adults: The Multi-Ethnic Study of Atherosclerosis.
The ability of the right ventricle (RV) to adapt to increasing afterload, particularly in diseases such as pulmonary arterial hypertension (PAH)1, is a primary determinant of morbidity and mortality. In the early stages of pulmonary hypertension (PH), cardiac output is maintained through compensatory hypertrophy of the RV chamber to enhance contractility. However, with sustained pressure overload, these maladaptive compensatory mechanisms are insufficient, and the chamber begins to dilate to maintain cardiac output, known as uncoupling of the RV to pulmonary artery (PA) and the onset of clinical heart failure (HF)2,3. (Sou...
Source: The American Journal of Cardiology - April 18, 2024 Category: Cardiology Authors: Vivek P. Jani, Jordan B. Strom, Abhishek Gami, Lauren Beussink-Nelson, Ravi Patel, Erin D. Michos, Sanjiv J. Shah, Benjamin H. Freed, Monica Mukherjee Source Type: research

Trends of Cardiovascular Disease Related Mortality in Breast Cancer in the United States From 1999 to 2019
Cardiovascular disease (CVD) is the second leading cause of mortality and morbidity among breast cancer (BC) survivors (1). This has been attributed to shared risk factors (2), and the effects of radiotherapy and chemotherapeutics (1). Despite the existing evidence of elevated cardiovascular mortality among small cohort studies of BC patients; there remains a need for a comprehensive nationwide study. We used a national database of death certificates to study the trends of CVD-related mortality in BC in females. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - April 18, 2024 Category: Cardiology Authors: Mohil Garg, Patrick Creechan, Anita Sadeghpour, Dmitry Abramov, Sourbha S. Dani, Sarju Ganatra, Sadeer G. Al-Kindi, Erin D. Michos, Arunima Misra, Anita Deswal, Nicolas L. Palaskas, Salim S. Virani, Vijay Nambi, Abdul Mannan Khan Minhas Tags: Brief report Source Type: research

Computed tomography and frailty assessment in transcatheter aortic valve implantation candidates: can we kill two birds with one stone?
“What walks on four feet in the morning,two in the afternoon,and three at night?” (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - April 18, 2024 Category: Cardiology Authors: Giuseppe D. Sanna, Gavino Casu Source Type: research

Understanding the Electrical Substrates Contributing to ‘Ablation-Resistant’ Atrial Fibrillation?
Atrial fibrillation was largely ignored by cardiac electrophysiologists until it was first suggested in 1998 that it might be amenable to catheter ablation. In the 25 years since then, a vast literature has emerged, initially reporting the ‘hypes and hopes’ that ablation was appropriate for all, but more recently acknowledging that not all patients benefit from this approach. The atrial fibrillation ‘epidemic’ and more holistic understanding of the complex contributors to its development question whether, it is even meaningful , to consider atrial fibrillation a single condition that is always responsive to ablatio...
Source: The American Journal of Cardiology - April 18, 2024 Category: Cardiology Authors: John P. Bourke Tags: Editorial Source Type: research

No Penalty for Going Distal Radial
Transradial access (TRA) has become the dominant access site for coronary procedures over the past two decades1. Its ability to decrease access site complications and costs without a decrease in procedural success has led to an increase in adoption2. Fairly early in the process of adoption, patient comfort was found to be superior with radial access compared to femoral access3. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - April 18, 2024 Category: Cardiology Authors: Samir B. Pancholy, Tejas M. Patel Tags: Editorial Source Type: research

Clinical Protocol for Selecting Intracardiac or Transesophageal Echocardiography-Guided Left Atrial Appendage Occlusion
Left atrial appendage occlusion (LAAO) provides an effective alternative to oral anticoagulation (OAC) to reduce stroke risk in patients with nonvalvular atrial fibrillation (NVAF).1,2 Transesophageal echocardiography (TEE) has been the standard for LAAO guidance, but intracardiac echocardiography (ICE) use is increasing.3-5 Benefits of TEE include its familiarity to cardiologists, excellent image quality, and reproducibility.6 Conversely, ICE eliminates the need for general anesthesia with its associated complications and coordination while improving patient comfort. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - April 18, 2024 Category: Cardiology Authors: Kara Stout, Calvin Craig, Jaclyn Rivington, Elizabeth Lyden, Jason J. Payne, Andrew M. Goldsweig Source Type: research

The feasibility of left ventricular strain and strain rate for evaluating patients with risk factors of sudden cardiac death in hypertrophic cardiomyopathy by Feature-tracking Cardiac Magnetic Resonance
Sudden cardiac death (SCD) represents the most severe complication of hypertrophic cardiomyopathy (HCM). However, the relationship between strain, strain rate, and risk factors in SCD risk stratification remains elusive. The study aimed to assess the attenuation of strain and strain rate in HCM by feature-tracking cardiac magnetic resonance (FT-CMR). All strain and strain rates were obtained automatically by FT, with manual adjustment of endocardial and epicardial borders. Strain indicators included left ventricular (LV) global longitudinal (GLS), circumferential (GCS), radial strain (GRS), peak diastolic-longitudinal (PD-...
Source: The American Journal of Cardiology - April 18, 2024 Category: Cardiology Authors: Xinyu Zhu, Yuan Tian, Ying Shi, Jianxiu Lian, Honghu Shen, Lulu Li, Haishan Wu, Pengfei Liu Source Type: research

Association between chronic liver disease and adverse in-hospital outcomes in patients undergoing CABG: A propensity score-matched analysis of a 5-year national inpatient sample data from 2016-2020
This study investigates the association between CLD and in-hospital outcomes in CABG patients using retrospective data from the National Inpatient Sample (NIS) database (2016-2020) including 7,945 CLD patients undergoing CABG that were propensity score matched with an equivalent number of patients with no CLD undergoing CABG. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - April 18, 2024 Category: Cardiology Authors: Bekure B. Siraw, Parth Patel, Abdulrahim Y. Mehadi, Eli A. Zaher, Yordanos T. Tafesse Source Type: research

Trends In Percutaneous Device Use For The Treatment Of Venous Thromboembolism Over Time In The PINC AI Healthcare Database And The National Inpatient Sample
The number of different methodologies of reperfusion therapy to treat venous thromboembolism (VTE) has increased substantially. Nevertheless, investigation of data representativeness and device-level usage in administrative databases has been limited. Using the National Inpatient Sample (NIS) and the PINC AI Healthcare Database (PHD), all hospital encounters with a diagnosis code of VTE were identified between 1/1/2016 and 12/31/2020. Patient demographics and trends in treatment modalities were evaluated over time. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - April 17, 2024 Category: Cardiology Authors: Suzanne J. Baron, C. Michael Gibson, Ripal T. Gandhi, Derek Mittleider, David Dexter, Wissam A Jaber Source Type: research

Kidney and Cardiovascular Effectiveness of Empagliflozin Compared to Dipeptidyl Peptidase-4 Inhibitors in Patients with Type 2 Diabetes
Placebo-controlled trials of sodium-glucose cotransporter-2 inhibitors (SGLT2i) demonstrate kidney and cardiovascular benefits for people with type 2 diabetes (T2D) and chronic kidney disease (CKD). We used real-world data to compare the kidney and cardiovascular effectiveness of empagliflozin to dipeptidyl peptidase-4 inhibitors (DPP4i), a commonly prescribed antiglycemic medication, in a diverse population with and without CKD. Using electronic health record data from 20 large US health systems, we leveraged propensity overlap weighting to compare outcomes for empagliflozin and DPP4i initiators with T2D between 2016 and ...
Source: The American Journal of Cardiology - April 17, 2024 Category: Cardiology Authors: Daniel Edmonston, Hillary Mulder, Elizabeth Lydon, Karen Chiswell, Zachary Lampron, Christina Shay, Keith Marsolo, W. Schuyler Jones, Javed Butler, Raj C. Shah, Alanna M. Chamberlain, Daniel E. Ford, Howard S. Gordon, Wenke Hwang, Alexander Chang, Ajaykum Source Type: research

Transcatheter or Surgical Aortic Valve Replacement in Women with Small Annuli at Low or Intermediate Surgical Risk
While severe patient-prothesis mismatch (PPM) has been associated with increased mortality after surgical aortic valve replacement,1-3 the impact of PPM following transcatheter aortic valve replacement (TAVR) on hard clinical outcomes is still a matter of debate.4 In studies of PPM, particular attention has been paid to small aortic annuli, since it has been reported that these patients showed the greatest benefit of TAVR when compared to surgery, with significantly lower frequency of moderate and severe PPM post-procedure. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - April 17, 2024 Category: Cardiology Authors: Thomas Modine, John K. Forrest, Nicolas M. Van Mieghem, G. Michael Deeb, Steven J. Yakubov, Walid Ben Ali, Didier Tch étché, Ka Yan Lam, Jae K. Oh, Jian Huang, Roxana Mehran, Michael J. Reardon Source Type: research

Editorial Board
(Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - April 16, 2024 Category: Cardiology Source Type: research

Contents
(Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - April 16, 2024 Category: Cardiology Source Type: research

Prosthesis Infolding Incidence And Short-Term Outcomes In TAVI Using Evolut Self-Expandable Device: A Multicenter Study
Transcatheter aortic valve implantation (TAVI) is an established treatment strategy in aortic valve disease. Infolding, as a non-uniform expansion of the prosthesis leading to introflection of part of the device circumference, is a complication specific to self-expandable prostheses. The aim of the study is to determine incidence, predictors, treatment strategy and outcomes of infolding during Medtronic ™ Evolut TAVI. Between January 2018 and March 2022 all patients treated with Evolut TAVI were included in a multicenter observational retrospective study. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - April 16, 2024 Category: Cardiology Authors: Andrea Bezzeccheri, Enrico Poletti, Paul Vermeersch, Verena Veulemans, Jarkko Piuhola, Seija Kerkel ä, Heidi Lehtola, Ole De Backer, Angelo Quagliana, Concetta Mammone, Flavio Ribichini, Edgard Prihadi, Benjamin Scott, Carlo Zivelonghi, Stefan Verheye, P Source Type: research

Improved Hemodynamics with Self-Expanding Compared to Balloon Expandable Transcatheter Aortic Valve Implantation in Small Annulus Patients: A Propensity-Matched Analysis
The objective of this study was to compare clinical and hemodynamic outcomes of self-expandable valves (SEV) versus balloon-expandable valves (BEV) transcatheter aortic valve implantation (TAVI) in patients with severe aortic stenosis and SAA. All patients who underwent TAVI for severe native aortic stenosis with a SAA between January 2018 and December 2022 were retrospectively included in the study from a single center. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - April 16, 2024 Category: Cardiology Authors: Massimo Baudo, Serge Sicouri, Yoshiyuki Yamashita, Khalid Ridwan, Amer Kadri, Scott M. Goldman, Roberto Rodriguez, Eric M. Gnall, Paul M. Coady, Michael J. Reardon, Hemal Gada, William A. Gray, Basel Ramlawi Source Type: research