Retinal and choroidal changes after anti-VEGF therapy in Neovascular-AMD Patients: A Systematic Review and Meta-Analysis of SD-OCT studies
In recent years, the progress made in the field of optical coherence tomography (OCT) has helped to understand the changes in eye layers in patients with exudative age-related macular degeneration (AMD). Early diagnosis of AMD as a leading cause of irreversible vision impairment is helpful. Therefore, we aim to perform a meta-analysis on OCT measurement alterations before and after anti-VEGF therapy in patients with AMD and controls. (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - April 16, 2024 Category: Opthalmology Authors: Mohammad Amin Salehi, Negin Frounchi, Seyed Sina Zakavi, Soheil Mohammadi, Hamid Harandi, Shayan Shojaei, Mahdi Gouravani, J. Fernando Arevalo Tags: Review article Source Type: research
The role of topical insulin on ocular surface restoration: A review
Corneal epithelial defects are one of the most common ocular disorders.Restoring corneal integrity is crucial to reduce pain and regain function,but in cases of neurotrophic or desensitized corneas,healing can be significantly delayed.Treating neurotrophic corneas is challenging for ophthalmologists,and surgical intervention is often indicated to manage refractory cases that are unresponsive to medical therapy.Over the last decade,as more expensive therapeutics reach the market,topical insulin has returned to the forefront as an affordable option to improve corneal wound healing.There is still a paucity of data on the use ...
Source: Survey of Ophthalmology - April 10, 2024 Category: Opthalmology Authors: Iva Krolo, Jos éphine Behaegel, Karolien Termote, Barbara de Bruyn, Manon De Schepper, Silke Oellerich, Sorcha Ní Dhubhghaill Source Type: research
Advances in management strategies for large and persistent macular hole: an update
The standard of care to treat small- and medium-sized macular holes (400 μm diameter), chronic and persistent macular holes remain a surgical challenge since closure rates and functional results decrease with larger macular hole diameters. (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - March 27, 2024 Category: Opthalmology Authors: Helin Arda, Mathias Maier, Maximilian Schulthei ß, Christos Haritoglou Tags: Review article Source Type: research
Optical coherence tomography angiography in diabetic retinopathy: A major review
Diabetic retinopathy (DR) is characterized by retinal vasculopathy and is a leading cause of visual impairment. Optical coherence tomography angiography (OCTA) is an innovative imaging technology that can detect various pathologies and quantifiable changes in retinal microvasculature. We briefly describe its functional principles and advantages over fluorescein angiography and perform a comprehensive review on its clinical applications in the screening or management of people with prediabetes, diabetes without clinical retinopathy (NDR), nonproliferative DR (NPDR), proliferative DR (PDR), and diabetic macular edema (DME). ...
Source: Survey of Ophthalmology - March 21, 2024 Category: Opthalmology Authors: Hosein Nouri, Seyed-Hossein Abtahi, Mehdi Mazloumi, Sanam Samadikhadem, J Fernando Arevalo, Hamid Ahmadieh Tags: Review article Source Type: research
Biosimilars of anti-vascular endothelial growth factor for ophthalmic diseases: A review
The development of intravitreally injected biologic medicines (biologics) acting against vascular endothelial growth factor (VEGF) substantially improved the clinical outcomes of patients with common VEGF-driven retinal diseases. The relatively high cost of branded agents, however, represents a financial burden for most healthcare systems and patients, likely resulting in impaired access to treatment and poorer clinical outcomes for some patients. Biosimilar medicines (biosimilars) are clinically equivalent, potentially economic alternatives to reference products. (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - March 21, 2024 Category: Opthalmology Authors: Neil M Bressler, Peter K Kaiser, Diana V Do, Quan Dong Nguyen, Kyu Hyung Park, Se Joon Woo, Min Sagong, Mario Bradvica, Mercy Yeeun Kim, Seungkee Kim, SriniVas R Sadda Tags: Review article Source Type: research
Understanding healthcare communication in age-related macular degeneration care: A mixed-methods review of patients ’ perspectives
Age-related macular degeneration (AMD) is the most common cause of irreversible visual impairment among people aged 50 years and older. Earlier research has indicated that the communication process between patients and healthcare professionals (HCPs) leaves considerable room for improvement in AMD care. Effective communication is essential to enhance trust in the professional and understanding of the diagnosis and treatment, and decrease anxiety and stress related to illness. We review patients ’ experiences, needs and preferences regarding information provision, communication style of the HCP and shared decision-making....
Source: Survey of Ophthalmology - March 16, 2024 Category: Opthalmology Authors: Mariska Scheffer, Juliane Menting, Hennie Boeije, Ruth van Nispen, Sandra van Dulmen Source Type: research
A systematic review of economic evaluation of artificial intelligence-based screening for eye diseases: From possibility to reality
Artificial Intelligence (AI) has become a focus of research in the rapidly evolving field of ophthalmology. Nevertheless, there is a lack of systematic studies on the health economics of AI in this field. This review examines studies from the PubMed, Google Scholar, and Web of Science databases that employed quantitative analysis, retrieved up to July 2023. Most of the studies indicate that AI leads to cost savings and improved efficiency in ophthalmology. On the other hand, some studies suggest that using AI in healthcare may raise costs for patients, especially when taking into account factors such as labor costs, infras...
Source: Survey of Ophthalmology - March 14, 2024 Category: Opthalmology Authors: Hongkang Wu, Kai Jin, Chee Chew Yip, Victor Koh, Juan Ye Tags: Review article Source Type: research
Clinical Therapeutics for Proliferative Vitreoretinopathy in Retinal Detachment
Proliferative vitreoretinopathy (PVR) is an abnormal and prolonged healing response to retinal injury (retinal detachment, post-retinal detachment surgery) characterised by: pre/subretinal membrane formation; retinal gliosis and retinal shortening, retinal pigment epithelium cell proliferation; and increased glial (mainly Mu ¨ller cells), fibroblast and inflammatory cell (macrophage, lymphocyte) activity, leading to tractional retinal holes/breaks and multiple costly eye operations suffered by patients. (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - March 14, 2024 Category: Opthalmology Authors: Francesco Sabatino, Philip Banerjee, Mahiul M. K. Muqit Tags: Review article Source Type: research
Current management options for the treatment of refractory postoperative cystoid macular Edema: A systematic review
Post-operative cystoid macular edema (PCME) is an important complication following intraocular surgery that often resolves spontaneously without treatment. In some cases, PCME may persist despite initial medical therapy, which can adversely impact visual outcomes. Various topical, intraocular and systemic treatments exist for the prevention and management of cystoid macular edema; however, there is no consensus on treatment of refractory cases in the post-operative setting. In accordance with the PRISMA guidelines, we systemically reviewed 68 articles describing management options and their outcomes for treatment-resistant...
Source: Survey of Ophthalmology - March 13, 2024 Category: Opthalmology Authors: Layla J Bunjo, Stephen Bacchi, James Pietris, Weng Onn Chan Tags: Review article Source Type: research
Medication-associated orbital inflammation: A systematic review
We performed a comprehensive systematic review to identify medication-associated orbital inflammation and to characterize its clinico-radiological features.We reviewed English-language articles describing medication-associated orbital inflammation (i.e., orbital myositis, dacryoadenitis and orbital fat) published to June 2023. Isolated inflammation of the intraocular structures or globe alone (i.e. uveitis), scleritis, optic neuritis and peri-neuritis) were excluded.In medication-associated orbital inflammation, the extraocular muscles are preferentially affected, occurring in isolation or in combination with other orbital...
Source: Survey of Ophthalmology - March 13, 2024 Category: Opthalmology Authors: Terence Ang, Viraj Chaggar, Jessica Y. Tong, Dinesh Selva Tags: Review article Source Type: research
Clinical Challenge: Looking beyond blurred margins
A 60-year-old man presented to an outside ophthalmology clinic with 1 month of progressive vision loss in the right eye (OD). Right optic disc edema was noted. Brain and orbit magnetic resonance imaging revealed right optic nerve and left occipital lobe enhancement. He was seen initially by neurology and neurosurgery and subsequently referred to neuro-ophthalmology for consideration of optic nerve biopsy. He was seen 3 months after his initial symptom onset where vision was light perception OD and a relative afferent pupillary defect with optic nerve edema. (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - March 12, 2024 Category: Opthalmology Authors: Jimmy S. Chen, Bobby S. Korn, Andrew R. Carey, Peter J. Savino Source Type: research
Clinical outcome measures in vision and eye care
Traditionally, clinical outcome assessments have focused on the patient ’s perspective through patient-reported outcome assessments; however, given the complexity, integration, and interactions of various participants within the clinical ophthalmology setting, we propose that additional diverse clinical perspectives should be explored in order to fully appreciate the value of care provided to patients. In this review we introduce a framework by which clinical outcome assessments (COAs) can be organized. (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - March 12, 2024 Category: Opthalmology Authors: Luke Leidy, Anna Dickinson, Pradeep Ramulu, Joshua Ehrlich, Mona A Kaleem Tags: Review article Source Type: research
Table of Contents
(Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - March 1, 2024 Category: Opthalmology Source Type: research
Comparison of different agents and doses of anti-vascular endothelial growth factors (aflibercept, bevacizumab, conbercept, ranibizumab) versus laser for retinopathy of prematurity: A network meta-analysis
Laser photocoagulation (LPC) and/or intravitreal anti-vascular endothelial growth factor (anti-VEGF) injections constitute the current standard treatment for retinopathy of prematurity (ROP). This network meta-analysis focus on whether a ranking of interventions may be established for different dose levels of intravitreal injection of anti-VEGF agents (aflibercept, bevacizumab, conbercept, ranibizumab) as primary treatments for ROP versus laser in terms of retreatment rate as primary outcome, and time to retreatment and refractive error as secondary endpoints, since best anti-VEGF dosage remains under debate. (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - March 1, 2024 Category: Opthalmology Authors: Amparo Ortiz-Seller, Pablo Martorell, Honorio Barranco, Isabel Pascual-Camps, Esteban Morcillo, Jos é L. Ortiz Tags: Review article Source Type: research
The complement system and diabetic retinopathy
Diabetic retinopathy (DR) is one of the common microvascular complications of diabetes mellitus and is the main cause of visual impairment in diabetic patients. The pathogenesis of DR is still unclear. The complement system, as an important component of the innate immune system, in addition to defending against the invasion of foreign microorganisms, is involved in the occurrence and development of DR through 3 widely recognized complement activation pathways, the complement regulatory system, and many other pathways. (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - February 22, 2024 Category: Opthalmology Authors: Feipeng Jiang, Chunyan Lei, Yingying Chen, Nenghua Zhou, Meixia Zhang Tags: Review article Source Type: research
