B cell responses to membrane-presented antigens require the function of the mechanosensitive cation channel Piezo1 | Science Signaling
Mechanosensitive Ca2+ signaling in B cells underlies their preference for membrane-bound over soluble antigens. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - September 26, 2023 Category: Science Source Type: news

Stressed Hippo kinase turns to autophagy | Science Signaling
The Hippo kinase MAP4K2 takes a YAP-independent path to tolerating energy stress. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - September 26, 2023 Category: Science Source Type: news

Opposing roles of RUBCN isoforms in autophagy and memory B cell generation | Science Signaling
Two RUBCN isoforms exert distinct effects on autophagy and the differentiation of memory B cells. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - September 19, 2023 Category: Science Source Type: news

The lncRNA MIR99AHG directs alternative splicing of SMARCA1 by PTBP1 to enable invadopodia formation in colorectal cancer cells | Science Signaling
Colorectal cancer cells become invasive when an lncRNA alters the binding of a splicing factor. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - September 19, 2023 Category: Science Source Type: news

An ion channel ’s high five | Science Signaling
Switching between tetrameric and pentameric states regulates the pore size of the ion channel TRPV3. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - September 19, 2023 Category: Science Source Type: news

TSLP shapes the pathogenic responses of memory CD4+ T cells in eosinophilic esophagitis | Science Signaling
Patients with eosinophilic esophagitis have more inflammatory T cells that respond to the cytokine TSLP. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - September 12, 2023 Category: Science Source Type: news

Fluoxetine restrains allergic inflammation by targeting an Fc ɛRI-ATP positive feedback loop in mast cells | Science Signaling
Fluoxetine inhibits IgE- and ATP-driven driven mast cell function in allergic inflammation. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - September 12, 2023 Category: Science Source Type: news

A spartin approach to lipophagy | Science Signaling
The autophagic degradation of lipid droplets requires the protein spartin. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - September 12, 2023 Category: Science Source Type: news

The Ca2+ channel ORAI1 is a regulator of oral cancer growth and nociceptive pain | Science Signaling
The Ca2+ channel ORAI1 promotes the growth of oral cancer cells and the pain they induce. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - September 5, 2023 Category: Science Source Type: news

Lysine lactylation regulates metabolic pathways and biofilm formation in Streptococcus mutans | Science Signaling
Sucrose stimulates lysine lactylation to alter metabolism in the oral bacterium Streptococcus mutans. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - September 5, 2023 Category: Science Source Type: news

Polycystin goes with the flow | Science Signaling
Asymmetric movement of a polycystin subunit may underlie the initial break in left-right asymmetry in mouse embryos. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - September 5, 2023 Category: Science Source Type: news

The E3/E4 ubiquitin ligase UFD-2 suppresses normal and oncogenic signaling mediated by a Raf ortholog in Caenorhabditis elegans | Science Signaling
A pathway that degrades wild-type and mutant forms of the C. elegans Raf ortholog LIN-45 is identified. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - August 29, 2023 Category: Science Source Type: news

IL-33 –ST2 signaling promotes stemness in subtypes of myeloid leukemia cells through the Wnt and Notch pathways | Science Signaling
The cytokine receptor ST2 perpetuates a stemness-promoting loop in leukemia. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - August 29, 2023 Category: Science Source Type: news

Interferon with ovarian cancer | Science Signaling
Interferon- ε has antitumor activity and activates antitumor immunity in ovarian cancer in mice. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - August 29, 2023 Category: Science Source Type: news

Erratum for the Research Article “Matrix rigidity controls endothelial differentiation and morphogenesis of cardiac precursors” by Kshitiz et al. | Science Signaling
HomeScience SignalingVol. 16, No. 800Erratum for the Research Article “Matrix rigidity controls endothelial differentiation and morphogenesis of cardiac precursors” by Kshitiz et al.Back To Vol. 16, No. 800 Full accessErrata Share on Erratum for the Research Article “Matrix rigidity controls endothelial differentiation and morphogenesis of cardiac precursors” by Kshitiz et al.Science Signaling29 … (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - August 29, 2023 Category: Science Source Type: news