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Pleiotropic functions of TAO kinases and their dysregulation in neurological disorders | Science Signaling
The roles of TAOKs in neurophysiology and neuropathology are explored. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - January 2, 2024 Category: Science Source Type: news

The expanding footprint of basic biology research in India | Science Signaling
Basic biology research in India has expanded in recent years, and addressing key challenges should enable this momentum to continue. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - January 2, 2024 Category: Science Source Type: news

A noncanonical IRAK4-IRAK1 pathway counters DNA damage –induced apoptosis independently of TLR/IL-1R signaling | Science Signaling
Separate to their role in innate immunity, IRAK kinases mediate resistance to DNA-damaging agents. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - December 19, 2023 Category: Science Source Type: news

Inhibition of the lysine demethylase LSD1 modulates the balance between inflammatory and antiviral responses against coronaviruses | Science Signaling
LSD1 inhibition blocks the inflammatory response to coronaviruses but spares the interferon response. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - December 19, 2023 Category: Science Source Type: news

RHOAL57V drives the development of diffuse gastric cancer through IGF1R-PAK1-YAP1 signaling | Science Signaling
The pathway by which RHOAL57V activates oncogenic gene expression in diffuse gastric cancer is revealed. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - December 19, 2023 Category: Science Source Type: news

RHOA drivers take alternate routes in gastric cancer | Science Signaling
L57V and Y42C RHOA mutants promote gastric cancer through different pathways (Schaefer et al., in 19 December 2023 issue). (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - December 19, 2023 Category: Science Source Type: news

TB impairs DNA repair | Science Signaling
A Mycobacterium tuberculosis virulence factor promotes foam cell formation by inhibiting DNA repair. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - December 19, 2023 Category: Science Source Type: news

Proximity proteomic analysis of the NRF family reveals the Parkinson ’s disease protein ZNF746/PARIS as a co-complexed repressor of NRF2 | Science Signaling
Suppression of NRF2 activity by ZNF746 drives oxidative stress and apoptosis in a neuronal model. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - December 12, 2023 Category: Science Source Type: news

Nonself RNA rewires IFN- β signaling: A mathematical model of the innate immune response | Science Signaling
Feedback between viral detection and interferon signaling pathways converts interferon-responding cells into interferon-producing cells. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - December 12, 2023 Category: Science Source Type: news

A caspase finds a target | Science Signaling
The noncanonical caspase caspase-4 processes the pro form of IL-18 in response to LPS. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - December 12, 2023 Category: Science Source Type: news

Palmitoylated Sept8-204 modulates learning and anxiety by regulating filopodia arborization and actin dynamics | Science Signaling
The lipid modification S-palmitoylation enables a neuronal variant of Sept8 to facilitate cognition. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - December 5, 2023 Category: Science Source Type: news

STAT3 palmitoylation initiates a positive feedback loop that promotes the malignancy of hepatocellular carcinoma cells in mice | Science Signaling
Liver tumor growth in mice is exacerbated by a feed-forward loop triggered by the palmitoylation of STAT3. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - December 5, 2023 Category: Science Source Type: news

Get moving to clear β-amyloid | Science Signaling
Physical exercise stimulates brain cells to secrete a β-amyloid–degrading enzyme. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - December 5, 2023 Category: Science Source Type: news

PD-1 inhibits T cell actin remodeling at the immunological synapse independently of its signaling motifs | Science Signaling
A mechanism by which the inhibitory receptor PD-1 suppresses T cell activation is revealed. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - November 28, 2023 Category: Science Source Type: news

PI3K-C2 β limits mTORC1 signaling and angiogenic growth | Science Signaling
PI3K-C2 β restrains endothelial cell size and vessel growth by suppressing the activity of mTORC1. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - November 28, 2023 Category: Science Source Type: news