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Frizzled does not get bent out of shape by Wnt | Science Signaling
Ligand and effector binding to the Wnt receptor Frizzled are not allosterically coupled (Mahoney et al., in 23 August 2022 issue). (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - August 23, 2022 Category: Science Source Type: news

Innate depression | Science Signaling
Restoring AHI1 in macrophages may improve antiviral immunity in patients with depression. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - August 23, 2022 Category: Science Source Type: news

A BRET Ca2+ sensor enables high-throughput screening in the presence of background fluorescence | Science Signaling
Bioluminescent sensors outperform fluorescent sensors in high-throughput screening. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - August 16, 2022 Category: Science Source Type: news

IGF-binding proteins secreted by cancer-associated fibroblasts induce context-dependent drug sensitization of lung cancer cells | Science Signaling
Specific CAFs can signal to suppress or enhance drug resistance depending on the tumor. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - August 16, 2022 Category: Science Source Type: news

The β2AR gets SNOed | Science Signaling
S-nitrosylation of the β2-adrenergic receptor induces its desensitization and internalization. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - August 16, 2022 Category: Science Source Type: news

A genetic platform for functionally profiling odorant receptors in olfactory cilia ex vivo | Science Signaling
Cilia isolated from the olfactory sensory neurons of transgenic mice can be used to profile human odorant receptors. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - August 9, 2022 Category: Science Source Type: news

Functional and biological heterogeneity of KRASQ61 mutations | Science Signaling
Comparison of Gln61 (Q61) mutations in KRAS reveals a potential therapeutic opportunity. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - August 9, 2022 Category: Science Source Type: news

Heterogeneity in RAS mutations: One size does not fit all | Science Signaling
The distinct biochemistry and biology of KRAS Gln61 mutants are revealed (Huynh et al., in 09 August 2022 issue). (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - August 9, 2022 Category: Science Source Type: news

Hungry in the sun | Science Signaling
Ultraviolet exposure elicits the production of an appetite-stimulating hormone in males but not in females. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - August 9, 2022 Category: Science Source Type: news

Antibiotic-induced inflammation | Science Signaling
Bacterial stress caused by antibiotics increases a second messenger that directly stimulates host inflammation. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - August 2, 2022 Category: Science Source Type: news

Antibiotic-induced inflammation
Bacterial stress caused by antibiotics increases a second messenger that directly stimulates host inflammation. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - August 2, 2022 Category: Science Source Type: news

CD9 mediates the uptake of extracellular vesicles from cancer-associated fibroblasts that promote pancreatic cancer cell aggressiveness
A subset of extracellular vesicles from the tumor stroma may enhance pancreatic cancer progression. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - August 2, 2022 Category: Science Source Type: news

Stemming metabolic stress | Science Signaling
Inhibition of a zinc transporter improves the maturation and survival of β cells. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - July 26, 2022 Category: Science Source Type: news

Osteoarthritis and chronic pain: Interleukin-6 as a common denominator and therapeutic target | Science Signaling
Drugs that target IL-6 effectors may be useful for osteoarthritis therapy (Liao et al., in 26 July 2022 issue). (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - July 26, 2022 Category: Science Source Type: news

Intravital calcium imaging in myeloid leukocytes identifies calcium frequency spectra as indicators of functional states
Decoding intracellular calcium signals in immune cells in live mice reveals their functional status during inflammation. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - July 26, 2022 Category: Science Source Type: news