The drug efflux pump MDR1 promotes intrinsic and acquired resistance to PROTACs in cancer cells | Science Signaling
Lapatinib may boost the efficacy of protein-degrading drugs by blocking drug efflux pumps. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - August 30, 2022 Category: Science Source Type: news

Blocking beige fat biogenesis | Science Signaling
A ubiquitin E3 ligase complex limits the generation of beige fat. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - August 30, 2022 Category: Science Source Type: news

PI(4,5)P2-stimulated positive feedback drives the recruitment of Dishevelled to Frizzled in Wnt –β-catenin signaling | Science Signaling
The phospholipid PI(4,5)P2 promotes Wnt signaling by enhancing the recruitment of Dishevelled to the membrane. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - August 23, 2022 Category: Science Source Type: news

The APP intracellular domain promotes LRRK2 expression to enable feed-forward neurodegenerative mechanisms in Parkinson ’s disease | Science Signaling
A feed-forward loop between an APP fragment and the kinase LRRK2 promotes Parkinson ’s disease pathology. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - August 23, 2022 Category: Science Source Type: news

Frizzled does not get bent out of shape by Wnt | Science Signaling
Ligand and effector binding to the Wnt receptor Frizzled are not allosterically coupled (Mahoney et al., in 23 August 2022 issue). (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - August 23, 2022 Category: Science Source Type: news

Innate depression | Science Signaling
Restoring AHI1 in macrophages may improve antiviral immunity in patients with depression. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - August 23, 2022 Category: Science Source Type: news

A BRET Ca2+ sensor enables high-throughput screening in the presence of background fluorescence | Science Signaling
Bioluminescent sensors outperform fluorescent sensors in high-throughput screening. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - August 16, 2022 Category: Science Source Type: news

IGF-binding proteins secreted by cancer-associated fibroblasts induce context-dependent drug sensitization of lung cancer cells | Science Signaling
Specific CAFs can signal to suppress or enhance drug resistance depending on the tumor. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - August 16, 2022 Category: Science Source Type: news

The β2AR gets SNOed | Science Signaling
S-nitrosylation of the β2-adrenergic receptor induces its desensitization and internalization. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - August 16, 2022 Category: Science Source Type: news

A genetic platform for functionally profiling odorant receptors in olfactory cilia ex vivo | Science Signaling
Cilia isolated from the olfactory sensory neurons of transgenic mice can be used to profile human odorant receptors. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - August 9, 2022 Category: Science Source Type: news

Functional and biological heterogeneity of KRASQ61 mutations | Science Signaling
Comparison of Gln61 (Q61) mutations in KRAS reveals a potential therapeutic opportunity. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - August 9, 2022 Category: Science Source Type: news

Heterogeneity in RAS mutations: One size does not fit all | Science Signaling
The distinct biochemistry and biology of KRAS Gln61 mutants are revealed (Huynh et al., in 09 August 2022 issue). (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - August 9, 2022 Category: Science Source Type: news

Hungry in the sun | Science Signaling
Ultraviolet exposure elicits the production of an appetite-stimulating hormone in males but not in females. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - August 9, 2022 Category: Science Source Type: news

Antibiotic-induced inflammation | Science Signaling
Bacterial stress caused by antibiotics increases a second messenger that directly stimulates host inflammation. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - August 2, 2022 Category: Science Source Type: news

Antibiotic-induced inflammation
Bacterial stress caused by antibiotics increases a second messenger that directly stimulates host inflammation. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - August 2, 2022 Category: Science Source Type: news