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Yap and Taz promote osteogenesis and prevent chondrogenesis in neural crest cells in vitro and in vivo | Science Signaling
Yap and Taz cooperate with β-catenin to control the fate of neural crest–derived osteochondral progenitors. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - October 25, 2022 Category: Science Source Type: news

Host protein kinases required for SARS-CoV-2 nucleocapsid phosphorylation and viral replication | Science Signaling
Inhibiting host kinases that phosphorylate the SARS-CoV-2 nucleocapsid protein blocks viral replication. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - October 25, 2022 Category: Science Source Type: news

Modulation by macrocyclic peptides | Science Signaling
Cell-permeable, macrocyclic peptides antagonize either the active or the inactive states of G αs to fine-tune signaling. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - October 25, 2022 Category: Science Source Type: news

Taking mitochondria to heart | Science Signaling
Long-chain fatty acids redirect the uptake of mitochondria released from adipocytes from macrophages to the heart. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - October 18, 2022 Category: Science Source Type: news

Fusobacterium nucleatum induces proliferation and migration in pancreatic cancer cells through host autocrine and paracrine signaling | Science Signaling
The host cell response to Fusobacterium infection promotes aggressive pancreatic cancer cell behavior. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - October 18, 2022 Category: Science Source Type: news

Rerouting the drug response: Overcoming metabolic adaptation in KRAS-mutant cancers | Science Signaling
Targeting KRAS-induced metabolic rewiring in the cells in and around the tumor can restore drug sensitivity. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - October 18, 2022 Category: Science Source Type: news

Endocannabinoids produced in photoreceptor cells in response to light activate Drosophila TRP channels | Science Signaling
Light induces the generation of endocannabinoids in photoreceptor cells that activate Drosophila TRP channels. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - October 11, 2022 Category: Science Source Type: news

An N-glycan on the C2 domain of JAGGED1 is important for Notch activation | Science Signaling
N-Glycosylation of JAGGED1 is required for optimal activation of Notch. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - October 11, 2022 Category: Science Source Type: news

Macrophages present antigens in allergic asthma | Science Signaling
Resident macrophages mediate antigen capture and presentation in allergic airway inflammation in mice. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - October 11, 2022 Category: Science Source Type: news

Charting metastasis | Science Signaling
A subpopulation of melanoma cells responds to microenvironmental cues and disseminates from lesions. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - October 4, 2022 Category: Science Source Type: news

Viperin impairs the innate immune response through the IRAK1-TRAF6-TAK1 axis to promote Mtb infection | Science Signaling
A protein with protective effects during antiviral responses promotes infection by Mycobacterium tuberculosis. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - October 4, 2022 Category: Science Source Type: news

The kinase PLK1 promotes the development of Kras/Tp53-mutant lung adenocarcinoma through transcriptional activation of the receptor RET | Science Signaling
The kinase PLK1 fuels lung cancer growth by amplifying tumorigenic MAPK signaling. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - October 4, 2022 Category: Science Source Type: news

Mutations in protein kinase C γ promote spinocerebellar ataxia type 14 by impairing kinase autoinhibition | Science Signaling
Biochemical characterization of mutations that cause a neurodegenerative disease provides pathological insight. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - September 27, 2022 Category: Science Source Type: news

TRAF3 enhances type I interferon receptor signaling in T cells by modulating the phosphatase PTPN22 | Science Signaling
The adaptor protein TRAF3 prevents a tyrosine phosphatase from blocking type I interferon signaling in T cells. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - September 27, 2022 Category: Science Source Type: news

Extracellular vesicles as central regulators of blood vessel function in cancer | Science Signaling
How extracellular vesicles released from cancer cells reprogram endothelial cells is discussed. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - September 27, 2022 Category: Science Source Type: news